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Your search keyword '"Scheideler, Angelika"' showing total 9 results
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9 results on '"Scheideler, Angelika"'

1. The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation

Author

Fischer, Katrin, Fenzl, Anna, Liu, Dianxin, Dyar, Kenneth A., Kleinert, Maximilian, Brielmeier, Markus, Clemmensen, Christoffer, Fedl, Anna, Finan, Brian, Gessner, Andre, Jastroch, Martin, Huang, Jianfeng, Keipert, Susanne, Klingenspor, Martin, Brüning, Jens C., Kneilling, Manfred, Maier, Florian C., Othman, Ahmed E., Pichler, Bernd J., Pramme-Steinwachs, Ines, Sachs, Stephan, Scheideler, Angelika, Thaiss, Wolfgang M., Uhlenhaut, Henriette, Ussar, Siegfried, Woods, Stephen C., Zorn, Julia, Stemmer, Kerstin, Collins, Sheila, Diaz-Meco, Maria, Moscat, Jorge, Tschöp, Matthias H., and Müller, Timo D.

Published
2020
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2. A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

Author

Schonhuber, Nina, Seidler, Barbara, Schuck, Kathleen, Veltkamp, Christian, Schachtler, Christina, Zukowska, Magdalena, Eser, Stefan, Feyerabend, Thorsten B., Paul, Mariel C., Eser, Philipp, Klein, Sabine, Lowy, Andrew M., Banerjee, Ruby, Yang, Fangtang, Lee, Chang-Lung, Moding, Everett J., Kirsch, David G., Scheideler, Angelika, Alessi, Dario R., Varela, Ignacio, Bradley, Allan, Kind, Alexander, Schnieke, Angelika E., Rodewald, Hans- Reimer, Rad, Roland, Schmid, Roland M., Schneider, Gunter, and Saur, Dieter

Subjects
Pancreatic cancer -- Research -- Analysis -- Genetic aspects, Biological sciences, Health
Abstract

Genetically engineered mouse models (GEMMs) have dramatically improved our understanding of tumor evolution and therapeutic resistance. However, sequential genetic manipulation of gene expression and targeting of the host is almost impossible using conventional Cre-loxP-based models. We have developed an inducible dual-recombinase system by combining flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies to improve GEMMs of pancreatic cancer. This enables investigation of multistep carcinogenesis, genetic manipulation of tumor subpopulations (such as cancer stem cells), selective targeting of the tumor microenvironment and genetic validation of therapeutic targets in autochthonous tumors on a genome-wide scale. As a proof of concept, we performed tumor cell-autonomous and nonautonomous targeting, recapitulated hallmarks of human multistep carcinogenesis, validated genetic therapy by 3-phosphoinositide-dependent protein kinase inactivation as well as cancer cell depletion and show that mast cells in the tumor microenvironment, which had been thought to be key oncogenic players, are dispensable for tumor formation., Pancreatic ductal adenocarcinoma (PDAC) is a fearsome disease, with a mortality rate >95% that has remained unchanged for decades (1). GEMMs that faithfully recapitulate the histological, molecular, genetic and clinical [...]

Published
2014
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3. Understanding gene functions and disease mechanisms: Phenotyping pipelines in the German Mouse Clinic

Author

Fuchs, Helmut, primary, Aguilar-Pimentel, Juan Antonio, additional, Amarie, Oana V., additional, Becker, Lore, additional, Calzada-Wack, Julia, additional, Cho, Yi-Li, additional, Garrett, Lillian, additional, Hölter, Sabine M., additional, Irmler, Martin, additional, Kistler, Martin, additional, Kraiger, Markus, additional, Mayer-Kuckuk, Philipp, additional, Moreth, Kristin, additional, Rathkolb, Birgit, additional, Rozman, Jan, additional, da Silva Buttkus, Patricia, additional, Treise, Irina, additional, Zimprich, Annemarie, additional, Gampe, Kristine, additional, Hutterer, Christine, additional, Stöger, Claudia, additional, Leuchtenberger, Stefanie, additional, Maier, Holger, additional, Miller, Manuel, additional, Scheideler, Angelika, additional, Wu, Moya, additional, Beckers, Johannes, additional, Bekeredjian, Raffi, additional, Brielmeier, Markus, additional, Busch, Dirk H., additional, Klingenspor, Martin, additional, Klopstock, Thomas, additional, Ollert, Markus, additional, Schmidt-Weber, Carsten, additional, Stöger, Tobias, additional, Wolf, Eckhard, additional, Wurst, Wolfgang, additional, Yildirim, Ali Önder, additional, Zimmer, Andreas, additional, Gailus-Durner, Valérie, additional, and Hrabě de Angelis, Martin, additional

Published
2018
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4. Laboratory mouse housing conditions can be improved using common environmental enrichment without compromising data

Author

André, Viola, primary, Gau, Christine, additional, Scheideler, Angelika, additional, Aguilar-Pimentel, Juan A., additional, Amarie, Oana V., additional, Becker, Lore, additional, Garrett, Lillian, additional, Hans, Wolfgang, additional, Hölter, Sabine M., additional, Janik, Dirk, additional, Moreth, Kristin, additional, Neff, Frauke, additional, Östereicher, Manuela, additional, Racz, Ildiko, additional, Rathkolb, Birgit, additional, Rozman, Jan, additional, Bekeredjian, Raffi, additional, Graw, Jochen, additional, Klingenspor, Martin, additional, Klopstock, Thomas, additional, Ollert, Markus, additional, Schmidt-Weber, Carsten, additional, Wolf, Eckhard, additional, Wurst, Wolfgang, additional, Gailus-Durner, Valérie, additional, Brielmeier, Markus, additional, Fuchs, Helmut, additional, and Hrabé de Angelis, Martin, additional

Published
2018
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