36 results on '"Scheid, Isabelle"'
Search Results
2. Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism
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Laidi, Charles, Boisgontier, Jennifer, de Pierrefeu, Amicie, Duchesnay, Edouard, Hotier, Sevan, d'Albis, Marc-Antoine, Delorme, Richard, Bolognani, Federico, Czech, Christian, Bouquet, Céline, Amestoy, Anouck, Petit, Julie, Holiga, Štefan, Dukart, Juergen, Gaman, Alexandru, Toledano, Elie, Ly-Le Moal, Myriam, Scheid, Isabelle, Leboyer, Marion, and Houenou, Josselin
- Abstract
Autism spectrum disorder (ASD) is a developmental disorder under-diagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population.
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- 2019
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3. Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism
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Laidi, Charles, Boisgontier, Jennifer, de Pierrefeu, Amicie, Duchesnay, Edouard, Hotier, Sevan, d’Albis, Marc-Antoine, Delorme, Richard, Bolognani, Federico, Czech, Christian, Bouquet, Céline, Amestoy, Anouck, Petit, Julie, Holiga, Štefan, Dukart, Juergen, Gaman, Alexandru, Toledano, Elie, Ly-Le Moal, Myriam, Scheid, Isabelle, Leboyer, Marion, and Houenou, Josselin
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- 2019
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4. Postural control and emotion in children with autism spectrum disorders
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Gouleme Nathalie, Scheid Isabelle, Peyre Hugo, Seassau Magali, Maruani Anna, Clarke Julia, Delorme Richard, and Bucci Maria Pia
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autistic spectrum disorders ,childrens ,dual tasks ,emotional faces ,postural controls ,eye movements ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Autism Spectrum Disorders subjects (ASD) are well known to have deficits in social interaction. We recorded simultaneously eye movements and postural sway during exploration of emotional faces in children with ASD and typically developing children (TD). We analyzed several postural and ocular parameters. The results showed that all postural parameters were significantly greater in children with ASD; ASD made significantly fewer saccades and had shorter fixation time than TD, particularly in the eyes, and especially for unpleasant emotions. These results suggest that poor postural control of ASD and their impaired visual strategies could be due to a lack of interest in social cognition, causing a delay in the development of the cortical areas, and thus could have an effect on their postural control.
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- 2017
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5. Spatial and temporal analysis of postural control in children with high functioning Autism Spectrum Disorder
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Goulème, Nathalie, Scheid, Isabelle, Peyre, Hugo, Maruani, Anna, Clarke, Julia, Delorme, Richard, and Bucci, Maria Pia
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- 2017
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6. Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events?
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Bennabi, Meriem, Tarantino, Nadine, Gaman, Alexandru, Scheid, Isabelle, Krishnamoorthy, Rajagopal, Debré, Patrice, Bouleau, Arthur, Caralp, Mireille, Gueguen, Sonia, Le-Moal, Myriam Ly, Bouvard, Manuel, Amestoy, Anouck, Delorme, Richard, Leboyer, Marion, Tamouza, Ryad, and Vieillard, Vincent
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- 2019
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7. Overlap of anxiety, depression, irritability and aggressiveness in autism spectrum disorder: an exploratory study using cluster analysis
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Jean, Francois A.M., primary, Jouni, Ali, additional, Bouvard, Manuel P., additional, Camelot, Guillaume, additional, Beggiato, Anita, additional, Scheid, Isabelle, additional, Gaman, Alexandru, additional, Bouquet, Celine, additional, Ly-Le Moal, Myryam, additional, Houenou, Josselin, additional, Delorme, Richard, additional, Leboyer, Marion, additional, and Amestoy, Anouck, additional
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- 2021
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8. Genetic variations of the melatonin pathway in patients with attention-deficit and hyperactivity disorders
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Chaste, Pauline, Clement, Nathalie, Botros, Hany Goubran, Guillaume, Jean-Luc, Konyukh, Marina, Pagan, Cécile, Scheid, Isabelle, Nygren, Gudrun, Anckarsäter, Henrik, Rastam, Maria, Ståhlberg, Ola, Gillberg, Carina I., Melke, Jonas, Delorme, Richard, Leblond, Claire, Toro, Roberto, Huguet, Guillaume, Fauchereau, Fabien, Durand, Christelle, Boudarene, Lydia, Serrano, Emilie, Lemière, Nathalie, Launay, Jean Marie, Leboyer, Marion, Jockers, Ralf, Gillberg, Christopher, and Bourgeron, Thomas
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- 2011
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9. “Reading the Mind in the Eyes” in Autistic Adults is Modulated by Valence and Difficulty: An InFoR Study
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Baltazar, Matias, primary, Geoffray, Marie‐Maude, additional, Chatham, Christopher, additional, Bouvard, Manuel, additional, Martinez Teruel, Axelle, additional, Monnet, David, additional, Scheid, Isabelle, additional, Murzi, Eleonora, additional, Couffin‐Cadiergues, Sandrine, additional, Umbricht, Daniel, additional, Murtagh, Lorraine, additional, Delorme, Richard, additional, Ly Le‐Moal, Myriam, additional, Leboyer, Marion, additional, and Amestoy, Anouck, additional
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- 2020
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10. Short White Matter Tracts Myelinization is Associated With Impaired Social Cognition in Autism Spectrum Disorder: A NODDI and Relaxometry Study
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d'Albis, Marc-Antoine, primary, Sarrazin, Samuel, additional, Mangin, Jean-François, additional, Guevara, Pamela, additional, Guevara, Miguel, additional, Laidi, Charles, additional, Boisgontier, Jennifer, additional, Delorme, Richard, additional, Holiga, Stephane, additional, Bouquet, Céline, additional, Ly-Le Moal, Myrian, additional, Amestoy, Anouck, additional, Scheid, Isabelle, additional, Leboyer, Marion, additional, Poupon, Cyril, additional, and Houenou, Josselin, additional
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- 2020
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11. Genetic and Functional ascertainment of the Melatonin Pathway in Patients with Attention Deficit and Hyperactivity Disorders
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Chaste, Pauline, Clement, Nathalie, Botros, Hany, Guillaume, Jean-Luc, Konyukh, Marina, Pagan, Cécile, Scheid, Isabelle, Nygren, Gudrun, Anckarsäter, Henrik, Råstam, Maria, Ståhlberg, Ola, Gillberg, I. Carina, Melke, Jonas, Delorme, Richard, Leblond, Claire, Toro, Roberto, Huguet, Guillaume, Fauchereau, Fabien, Durand, Christelle, Boudarene, Lydia, Serrano, Emilie, Lemière, Nathalie, Launay, Jean Marie, Leboyer, Marion, Jockers, Ralf, Gillberg, Christopher, Bourgeron, Thomas, Génétique Humaine et Fonctions Cognitives, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Cochin (UMR_S567 / UMR 8104), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Göteborgs Universitet (GU), Lund University [Lund], AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut fédératif de Recherche Lariboisière (IFR_139), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Fondation FondaMental [Créteil], This work was supported by the Institut Pasteur, Université Paris Diderot, INSERM, CNRS, FP6 ENI‐NET, Fondation FondaMental and Fondation pour la Recherche Médicale (‘Equipe FRM’, RJ)., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), and Toro, Roberto
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[SDV] Life Sciences [q-bio] ,ASMT ,[SDV]Life Sciences [q-bio] ,AA-NAT ,ADHD ,receptors ,melatonin ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,genes - Abstract
Sleep wake cycles are frequently disturbed in patients with Attention Deficit and Hyperactivity Disorders. We hypothesized that the origin of the sleep problems may be the consequence of an abnormal circadian clock setting regulated by the melatonin pathway. Here, we sequenced all the genes of the melatonin pathway AA-NAT, ASMT, MTNR1A, MTNR1B and GPR50 in 328 individuals from Sweden including 108 patients with ADHD and 220 from the general population. Non-synonymous mutations were identified in all genes at a similar frequency in patients with ADHD and in controls. Among the functional variations, a splice site mutation (IVS5+2T>C) in ASMT and one stop mutation (Y170X) in MTNR1A were only detected in patients with ADHD. Biochemical analyses indicated that these mutations abolish the activity of ASMT and MTNR1A. We also identified clusters of SNPs within MTNR1B showing significant difference in the allelic frequency between ADHD patients and control (maximum signal at rs10830961 P=0.0002). Taken together, these genetic and functional results shed light on one new compelling candidate pathway for susceptibility to circadian rhythms alterations that could help clinicians for providing better treatments of patients with ADHD and sleep problems.
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- 2018
12. Patients with autism spectrum disorders display reproducible functional connectivity alterations
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Holiga, Štefan, primary, Hipp, Joerg F., additional, Chatham, Christopher H., additional, Garces, Pilar, additional, Spooren, Will, additional, D’Ardhuy, Xavier Liogier, additional, Bertolino, Alessandro, additional, Bouquet, Céline, additional, Buitelaar, Jan K., additional, Bours, Carsten, additional, Rausch, Annika, additional, Oldehinkel, Marianne, additional, Bouvard, Manuel, additional, Amestoy, Anouck, additional, Caralp, Mireille, additional, Gueguen, Sonia, additional, Ly-Le Moal, Myriam, additional, Houenou, Josselin, additional, Beckmann, Christian F., additional, Loth, Eva, additional, Murphy, Declan, additional, Charman, Tony, additional, Tillmann, Julian, additional, Laidi, Charles, additional, Delorme, Richard, additional, Beggiato, Anita, additional, Gaman, Alexandru, additional, Scheid, Isabelle, additional, Leboyer, Marion, additional, d’Albis, Marc-Antoine, additional, Sevigny, Jeff, additional, Czech, Christian, additional, Bolognani, Federico, additional, Honey, Garry D., additional, and Dukart, Juergen, additional
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- 2019
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13. Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism
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Laidi, Charles, primary, Boisgontier, Jennifer, additional, de Pierrefeu, Amicie, additional, Duchesnay, Edouard, additional, Hotier, Sevan, additional, d’Albis, Marc-Antoine, additional, Delorme, Richard, additional, Bolognani, Federico, additional, Czech, Christian, additional, Bouquet, Céline, additional, Amestoy, Anouck, additional, Petit, Julie, additional, Holiga, Štefan, additional, Dukart, Juergen, additional, Gaman, Alexandru, additional, Toledano, Elie, additional, Ly-Le Moal, Myriam, additional, Scheid, Isabelle, additional, Leboyer, Marion, additional, and Houenou, Josselin, additional
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- 2018
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14. Mutation screening of NOS1AP gene in a large sample of psychiatric patients and controls
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Nygren Gudrun, Schuroff Franck, Jamain Stéphane, Chaste Pauline, Anckarsäter Henrik, Scheid Isabelle, Betancur Catalina, Delorme Richard, Herbrecht Evelyn, Dumaine Anne, Mouren Marie, Råstam Maria, Leboyer Marion, Gillberg Christopher, and Bourgeron Thomas
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Internal medicine ,RC31-1245 ,Genetics ,QH426-470 - Abstract
Abstract Background The gene encoding carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase (NOS1AP) is located on chromosome 1q23.3, a candidate region for schizophrenia, autism spectrum disorders (ASD) and obsessive-compulsive disorder (OCD). Previous genetic and functional studies explored the role of NOS1AP in these psychiatric conditions, but only a limited number explored the sequence variability of NOS1AP. Methods We analyzed the coding sequence of NOS1AP in a large population (n = 280), including patients with schizophrenia (n = 72), ASD (n = 81) or OCD (n = 34), and in healthy volunteers controlled for the absence of personal or familial history of psychiatric disorders (n = 93). Results Two non-synonymous variations, V37I and D423N were identified in two families, one with two siblings with OCD and the other with two brothers with ASD. These rare variations apparently segregate with the presence of psychiatric conditions. Conclusions Coding variations of NOS1AP are relatively rare in patients and controls. Nevertheless, we report the first non-synonymous variations within the human NOS1AP gene that warrant further genetic and functional investigations to ascertain their roles in the susceptibility to psychiatric disorders.
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- 2010
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15. "Reading the Mind in the Eyes" in Autistic Adults is Modulated by Valence and Difficulty: An InFoR Study.
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Baltazar, Matias, Geoffray, Marie‐Maude, Chatham, Christopher, Bouvard, Manuel, Martinez Teruel, Axelle, Monnet, David, Scheid, Isabelle, Murzi, Eleonora, Couffin‐Cadiergues, Sandrine, Umbricht, Daniel, Murtagh, Lorraine, Delorme, Richard, Ly Le‐Moal, Myriam, Leboyer, Marion, and Amestoy, Anouck
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Autism spectrum disorders (ASD) are heterogeneous and complex neurodevelopmental conditions that urgently need reliable and sensitive measures to inform diagnosis properly. The Reading the Mind in the Eyes Task (or Eyes Test from now on) is widely used for this purpose. A recent study showed that subcategories of items of the children version of the Eyes Test could be especially discriminative to distinguish ASD and control children. Here, we analyzed the performance on the Eyes Test of 30 high functioning (IQ > 70) adults with ASD and 29 controls from the InFoR cohort multicentric study, using a Generalized Linear Mixed Model. We found that valence and difficulty modulate the performance on the Eyes Test, with easy and positive items being the most discriminative to distinguish ASD and controls. In particular, we suggest this result might be actionable to discriminate ASD patients from controls in subgroups where their overall scores show less difference with controls. We propose for future research the computation of two additional indexes when using the Eyes Test: the first focusing on the easy and positive items (applying a threshold of 70% of correct responses for these items, above which people are at very low risk of having ASD) and the second focusing on the performance gain from difficult to easy items (with a progression of less than 15% showing high risk of having ASD). Our findings open the possibility for a major change in how the Eyes Test is used to inform diagnosis in ASD. Lay Summary: The Eyes Test is used worldwide to inform autism spectrum disorders (ASD) diagnosis. We show here that ASD and neurotypical adults show the most difference in performance on subgroups of items: ASD adults do not improve as expected when comparing easy and difficult items, and they do not show an improvement for items displaying a positive feeling. We advise clinicians to focus on these comparisons to increase the property of the test to distinguish people with ASD from neurotypical adults. [ABSTRACT FROM AUTHOR]
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- 2021
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16. Shared mechanism for emotion processing in adolescents with and without autism
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Ioannou, Christina, Zein, Marwa El, Wyart, Valentin, Scheid, Isabelle, Amsellem, Frédérique, Delorme, Richard, Chevallier, Coralie, Grèzes, Julie, Laboratoire de Neurosciences Cognitives & Computationnelles (LNC2), Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Fondation FondaMental [Créteil], AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), This research was supported by Fondation ROGER DE SPOELBERCH, ANR-11-EMCO-00902, ANR-10-LABX-0087 IEC, ANR-10-IDEX-0001-02 PSL* and by INSERM., The authors would very much like to thank Raphael Delage for assisting with the patients’ recruitment, Mme Rukmini Rao for the organisation of the testing of the control participants, and Michèle Chadwick for carefully proofreading this manuscript, ANR-11-EMCO-0003,STREEM,Les STratégies de REgulation EMotionnelle : approches multimodale, vie entière, et interculturelle.(2011), ANR-10-IDEX-0001,PSL,Paris Sciences et Lettres(2010), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Institut Pasteur [Paris]-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Bidault, Floran, Emotion(s), cognition, comportement - Les STratégies de REgulation EMotionnelle : approches multimodale, vie entière, et interculturelle. - - STREEM2011 - ANR-11-EMCO-0003 - EMCO - VALID, and Initiative d'excellence - Paris Sciences et Lettres - - PSL2010 - ANR-10-IDEX-0001 - IDEX - VALID
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Male ,Emotion ,Adolescent ,[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,Autism Spectrum Disorder ,[SDV]Life Sciences [q-bio] ,Emotions ,[SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,[SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences ,Recognition, Psychology ,Fear ,Anger ,Autism spectrum disorders ,Article ,Facial Expression ,[SDV] Life Sciences [q-bio] ,Human behaviour ,Reaction Time ,Humans ,Female ,Cues ,Child ,Photic Stimulation ,[SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences - Abstract
International audience; Although, the quest to understand emotional processing in individuals with Autism Spectrum Disorders (ASD) has led to an impressive number of studies, the picture that emerges from this research remains inconsistent. Some studies find that Typically Developing (TD) individuals outperform those with ASD in emotion recognition tasks, others find no such difference. In this paper, we move beyond focusing on potential group differences in behaviour to answer what we believe is a more pressing question: do individuals with ASD use the same mechanisms to process emotional cues? To this end, we rely on model-based analyses of participants' accuracy during an emotion categorisation task in which displays of anger and fear are paired with direct vs. averted gaze. Behavioural data of 20 ASD and 20 TD adolescents revealed that the ASD group displayed lower overall performance. Yet, gaze direction had a similar impact on emotion categorisation in both groups, i.e. improved accuracy for salient combinations (anger-direct, fear-averted). Critically, computational modelling of participants' behaviour reveals that the same mechanism, i.e. increased perceptual sensitivity, underlies the contextual impact of gaze in both groups. We discuss the specific experimental conditions that may favour emotion processing and the automatic integration of contextual information in ASD.
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- 2017
17. Increased risk of ADHD in families with ASD
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Septier, Mathilde, primary, Peyre, Hugo, additional, Amsellem, Fréderique, additional, Beggiato, Anita, additional, Maruani, Anna, additional, Poumeyreau, Marion, additional, Amestoy, Anouck, additional, Scheid, Isabelle, additional, Gaman, Alexandru, additional, Bolognani, Federico, additional, Honey, Garry, additional, Bouquet, Céline, additional, Ly-Le Moal, Myriam, additional, Bouvard, Manuel, additional, Leboyer, Marion, additional, Bourgeron, Thomas, additional, and Delorme, Richard, additional
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- 2018
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18. HLA-class II haplotypes and Autism Spectrum Disorders
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Bennabi, Meriem, primary, Gaman, Alexandru, additional, Delorme, Richard, additional, Boukouaci, Wahid, additional, Manier, Céline, additional, Scheid, Isabelle, additional, Si Mohammed, Nassima, additional, Bengoufa, Djaouida, additional, Charron, Dominique, additional, Krishnamoorthy, Rajagopal, additional, Leboyer, Marion, additional, and Tamouza, Ryad, additional
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- 2018
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19. Reproducible functional connectivity alterations are associated with autism spectrum disorder
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Holiga, Štefan, primary, Hipp, Joerg F., additional, Chatham, Christopher H., additional, Garces, Pilar, additional, Spooren, Will, additional, D’Ardhuy, Xavier Liogier, additional, Bertolino, Alessandro, additional, Bouquet, Céline, additional, Buitelaar, Jan K, additional, Bours, Carsten, additional, Rausch, Annika, additional, Oldehinkel, Marianne, additional, Bouvard, Manuel, additional, Amestoy, Anouck, additional, Caralp, Mireille, additional, Gueguen, Sonia, additional, Moal, Myriam Ly-Le, additional, Houenou, Josselin, additional, Beckmann, Christian F., additional, Loth, Eva, additional, Murphy, Declan, additional, Charman, Tony, additional, Tillmann, Julian, additional, Laidi, Charles, additional, Delorme, Richard, additional, Beggiato, Anita, additional, Gaman, Alexandru, additional, Scheid, Isabelle, additional, Leboyer, Marion, additional, d’Albis, Marc-Antoine, additional, Sevigny, Jeff, additional, Czech, Christian, additional, Bolognani, Federico, additional, Honey, Garry D., additional, and Dukart, Juergen, additional
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- 2018
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20. Cerebellar anatomical alterations and attention to eyes in autism
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Laidi, Charles, primary, Boisgontier, Jennifer, additional, Chakravarty, M. Mallar, additional, Hotier, Sevan, additional, d’Albis, Marc-Antoine, additional, Mangin, Jean-François, additional, Devenyi, Gabriel A., additional, Delorme, Richard, additional, Bolognani, Federico, additional, Czech, Christian, additional, Bouquet, Céline, additional, Toledano, Elie, additional, Bouvard, Manuel, additional, Gras, Doriane, additional, Petit, Julie, additional, Mishchenko, Marina, additional, Gaman, Alexandru, additional, Scheid, Isabelle, additional, Leboyer, Marion, additional, Zalla, Tiziana, additional, and Houenou, Josselin, additional
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- 2017
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21. Discriminant validity of spatial and temporal postural index in children with neurodevelopmental disorders
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Bucci, Maria Pia, primary, Goulème, Nathalie, additional, Stordeur, Coline, additional, Acquaviva, Eric, additional, Scheid, Isabelle, additional, Lefebvre, Aline, additional, Gerard, Christophe‐Loïc, additional, Peyre, Hugo, additional, and Delorme, Richard, additional
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- 2017
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22. Clinical and autoimmune features of a patient with autism spectrum disorder seropositive for anti—NMDA-receptor autoantibody
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Gréa, Hélène, primary, Scheid, Isabelle, additional, Gaman, Alexandru, additional, Rogemond, Véronique, additional, Gillet, Sandy, additional, Honnorat, Jérôme, additional, Bolognani, Federico, additional, Czech, Christian, additional, Bouquet, Céline, additional, Toledano, Elie, additional, Bouvard, Manuel, additional, Delorme, Richard, additional, Groc, Laurent, additional, and Leboyer, Marion, additional
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- 2017
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23. Gender differences in autism spectrum disorders: Divergence among specific core symptoms
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Beggiato, Anita, primary, Peyre, Hugo, additional, Maruani, Anna, additional, Scheid, Isabelle, additional, Rastam, Maria, additional, Amsellem, Frederique, additional, Gillberg, Carina I., additional, Leboyer, Marion, additional, Bourgeron, Thomas, additional, Gillberg, Christopher, additional, and Delorme, Richard, additional
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- 2016
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24. Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism.
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Boisgontier, Jennifer, Laidi, Charles, Hotier, Sevan, d'Albis, Marc-Antoine, Houenou, Josselin, Gaman, Alexandru, Scheid, Isabelle, Leboyer, Marion, Toledano, Elie, Ly-Le Moal, Myriam, Delorme, Richard, de Pierrefeu, Amicie, Duchesnay, Edouard, Petit, Julie, Bolognani, Federico, Czech, Christian, Bouquet, Céline, Holiga, Štefan, Dukart, Juergen, and Amestoy, Anouck
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DIAGNOSIS of autism ,LIMBIC system ,MAGNETIC resonance imaging ,PEOPLE with disabilities ,ADULTS - Abstract
Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population. [ABSTRACT FROM AUTHOR]
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- 2019
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25. Increased risk of ADHD in families with ASD.
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Septier, Mathilde, Peyre, Hugo, Amsellem, Fréderique, Beggiato, Anita, Maruani, Anna, Poumeyreau, Marion, Amestoy, Anouck, Scheid, Isabelle, Gaman, Alexandru, Bolognani, Federico, Honey, Garry, Bouquet, Céline, Ly-Le Moal, Myriam, Bouvard, Manuel, Leboyer, Marion, Bourgeron, Thomas, and Delorme, Richard
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AUTISM risk factors ,ATTENTION-deficit hyperactivity disorder ,SIBLINGS ,FAMILIES ,MULTIVARIATE analysis ,PARENTS ,EXTENDED families ,SOCIOECONOMIC factors ,STRUCTURAL equation modeling ,DESCRIPTIVE statistics - Abstract
Attention Deficit and Hyperactive Disorder (ADHD) and Autism Spectrum Disorders (ASD) are frequent comorbid neurodevelopmental conditions and the overlap between both disorders remains to be delineated. A more complete understanding of the shared genetic and environmental factors is needed. Using a family-based method, we evaluated the risk of ADHD in a group of relatives with an ASD proband (ASD−) and a group of relatives with an ASD and ADHD proband (ASD+). We enrolled 1245 individuals in the study: 499 probands, their 746 first-degree relatives and 140 controls. We used a multivariate generalized estimating equation (GEE) model, in which the dependent variable was the ADHD diagnosis in the relatives and the independent variable the ASD+ or ASD− in probands. We adjusted for sociodemographic factors (age, sex, IQ) and for the nature of the familial relationship with the affected proband (parent or sibling). Among the probands, there were 287 ASD− and 212 ASD+ individuals. ADHD was more frequent in relatives (19%) than in the control group (7%) (p = 0.001). The risk of ADHD was higher in the ASD+ relatives group than in the ASD− relatives group (GEE model OR 1.58 [95% CI 1.04-2.38], p = 0.032). This result was found in parents (OR 1.96 [95% CI 1.14-3.36], but not in siblings (OR 1.28 [95% CI 0.84-1.94], p = 0.434). Our study provides a representative estimate of the family distribution of ADHD in relatives of ASD probands but supports the modest effect of shared genetic and environmental factors between both disorders. [ABSTRACT FROM AUTHOR]
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- 2019
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26. Local structural connectivity is associated with social cognition in autism spectrum disorder.
- Author
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d'Albis, Marc-Antoine, Guevara, Pamela, Guevara, Miguel, Laidi, Charles, Boisgontier, Jennifer, Sarrazin, Samuel, Duclap, Delphine, Delorme, Richard, Bolognani, Federico, Czech, Christian, Bouquet, Céline, Ly-Le Moal, Myriam, Holiga, Stefan, Amestoy, Anouck, Scheid, Isabelle, Gaman, Alexandru, Leboyer, Marion, Poupon, Cyril, Mangin, Jean-François, and Houenou, Josselin
- Subjects
SOCIAL perception ,AUTISM spectrum disorders ,WHITE matter (Nerve tissue) ,WECHSLER Adult Intelligence Scale ,NEUROPSYCHOLOGY - Abstract
The current theory implying local, short-range overconnectivity in autism spectrum disorder, contrasting with long-range underconnectivity, is based on heterogeneous results, on limited data involving functional connectivity studies, on heterogeneous paediatric populations and non-specific methodologies. In this work, we studied short-distance structural connectivity in a homogeneous population of males with high-functioning autism spectrum disorder and used a novel methodology specifically suited for assessing U-shaped short-distance tracts, including a recently developed tractography-based atlas of the superficial white matter fibres. We acquired diffusion-weighted MRI for 58 males (27 subjects with high-functioning autism spectrum disorder and 31 control subjects) and extracted the mean generalized fractional anisotropy of 63 short-distance tracts. Neuropsychological evaluation included Wechsler Adult Intelligence Scale IV (WAIS-IV), Communication Checklist-Adult, Empathy Quotient, Social Responsiveness Scale and Behaviour Rating Inventory of Executive Function-Adult (BRIEF-A). In contradiction with the models of short-range over-connectivity in autism spectrum disorder, we found that patients with autism spectrum disorder had a significantly decreased anatomical connectivity in a component comprising 13 short tracts compared to controls. Specific short-tract atypicalities in temporal lobe and insula were significantly associated with clinical manifestations of autism spectrum disorder such as social awareness, language structure, pragmatic skills and empathy, emphasizing their importance in social dysfunction. Short-range decreased anatomical connectivity may thus be an important substrate of social deficits in autism spectrum disorder, in contrast with current models. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
27. Gender differences in autism spectrum disorders: Divergence among specific core symptoms.
- Author
-
Beggiato, Anita, Peyre, Hugo, Maruani, Anna, Scheid, Isabelle, Rastam, Maria, Amsellem, Frederique, Gillberg, Carina I., Leboyer, Marion, Bourgeron, Thomas, Gillberg, Christopher, and Delorme, Richard
- Abstract
Community-based studies have consistently shown a sex ratio heavily skewed towards males in autism spectrum disorders (ASD). The factors underlying this predominance of males are largely unknown, but the way girls score on standardized categorical diagnostic tools might account for the underrecognition of ASD in girls. Despite the existence of different norms for boys and girls with ASD on several major screening tests, the algorithm of the Autism Diagnosis Interview-Revised (ADI-R) has not been reformulated. The aim of our study was to investigate which ADI-R items discriminate between males and females, and to evaluate their weighting in the final diagnosis of autism. We then conducted discriminant analysis (DA) on a sample of 594 probands including 129 females with ASD, recruited by the Paris Autism Research International Sibpair (PARIS) Study. A replication analysis was run on an independent sample of 1716 probands including 338 females with ASD, recruited through the Autism Genetics Resource Exchange (AGRE) program. Entering the raw scores for all ADI-R items as independent variables, the DA correctly classified 78.9% of males and 72.9% of females ( P < 0.001) in the PARIS cohort, and 72.2% of males and 68.3% of females ( P < 0.0001) in the AGRE cohort. Among the items extracted by the stepwise DA, four belonged to the ADI-R algorithm used for the final diagnosis of ASD. In conclusion, several items of the ADI-R that are taken into account in the diagnosis of autism significantly differentiates between males and females. The potential gender bias thus induced may participate in the underestimation of the prevalence of ASD in females. Autism Res 2016,. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. Autism Res 2017, 10: 680-689. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]
- Published
- 2017
- Full Text
- View/download PDF
28. Heterozygous FA2H mutations in autism spectrum disorders
- Author
-
Scheid, Isabelle, primary, Maruani, Anna, additional, Huguet, Guillaume, additional, Leblond, Claire S, additional, Nygren, Gudrun, additional, Anckarsäter, Henrik, additional, Beggiato, Anita, additional, Rastam, Maria, additional, Amsellem, Fréderique, additional, Gillberg, I Carina, additional, Elmaleh, Monique, additional, Leboyer, Marion, additional, Gillberg, Christopher, additional, Betancur, Catalina, additional, Coleman, Mary, additional, Hama, Hiroko, additional, Cook, Edwin H, additional, Bourgeron, Thomas, additional, and Delorme, Richard, additional
- Published
- 2013
- Full Text
- View/download PDF
29. Identification of Pathway-Biased and Deleterious Melatonin Receptor Mutants in Autism Spectrum Disorders and in the General Population
- Author
-
Chaste, Pauline, primary, Clement, Nathalie, additional, Mercati, Oriane, additional, Guillaume, Jean-Luc, additional, Delorme, Richard, additional, Botros, Hany Goubran, additional, Pagan, Cécile, additional, Périvier, Samuel, additional, Scheid, Isabelle, additional, Nygren, Gudrun, additional, Anckarsäter, Henrik, additional, Rastam, Maria, additional, Ståhlberg, Ola, additional, Gillberg, Carina, additional, Serrano, Emilie, additional, Lemière, Nathalie, additional, Launay, Jean Marie, additional, Mouren-Simeoni, Marie Christine, additional, Leboyer, Marion, additional, Gillberg, Christopher, additional, Jockers, Ralf, additional, and Bourgeron, Thomas, additional
- Published
- 2010
- Full Text
- View/download PDF
30. Mutation screening of NOS1AP gene in a large sample of psychiatric patients and controls
- Author
-
Delorme, Richard, primary, Betancur, Catalina, additional, Scheid, Isabelle, additional, Anckarsäter, Henrik, additional, Chaste, Pauline, additional, Jamain, Stéphane, additional, Schuroff, Franck, additional, Nygren, Gudrun, additional, Herbrecht, Evelyn, additional, Dumaine, Anne, additional, Mouren, Marie Christine, additional, Råstam, Maria, additional, Leboyer, Marion, additional, Gillberg, Christopher, additional, and Bourgeron, Thomas, additional
- Published
- 2010
- Full Text
- View/download PDF
31. Additional file 1: of Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events?
- Author
-
Meriem Bennabi, Tarantino, Nadine, Gaman, Alexandru, Scheid, Isabelle, Rajagopal Krishnamoorthy, DebrĂŠ, Patrice, Bouleau, Arthur, Caralp, Mireille, Gueguen, Sonia, Le-Moal, Myriam, Bouvard, Manuel, Amestoy, Anouck, Delorme, Richard, Leboyer, Marion, Tamouza, Ryad, and Vieillard, Vincent
- Subjects
mental disorders ,behavioral disciplines and activities ,3. Good health - Abstract
Table S1. Baseline characteristics of CD3â CD56+ NK cells from the InFoR and EFS control groups. Table S2. KIR/HLA genotypes and HLA-ligand combinations in hf-ASD patients, compared with controls from EFS. Table S3. IgG serology test of different pathogens in hf-ASD patients and controls from EFS. Figure S1. Phenotypic expression of CD56dim and CD56bright NK cell subsets from patients with hf-ASD. Figure S2. Expression of supplementary cell-surface markers in NK cells from patients with hf-ASD. Figure S3. Functional activity of NK cells from patients with hf-ASD. (DOCX 6113 kb)
32. Additional file 1: of Persistence of dysfunctional natural killer cells in adults with high-functioning autism spectrum disorders: stigma/consequence of unresolved early infectious events?
- Author
-
Meriem Bennabi, Tarantino, Nadine, Gaman, Alexandru, Scheid, Isabelle, Rajagopal Krishnamoorthy, DebrĂŠ, Patrice, Bouleau, Arthur, Caralp, Mireille, Gueguen, Sonia, Le-Moal, Myriam, Bouvard, Manuel, Amestoy, Anouck, Delorme, Richard, Leboyer, Marion, Tamouza, Ryad, and Vieillard, Vincent
- Subjects
mental disorders ,behavioral disciplines and activities ,3. Good health - Abstract
Table S1. Baseline characteristics of CD3â CD56+ NK cells from the InFoR and EFS control groups. Table S2. KIR/HLA genotypes and HLA-ligand combinations in hf-ASD patients, compared with controls from EFS. Table S3. IgG serology test of different pathogens in hf-ASD patients and controls from EFS. Figure S1. Phenotypic expression of CD56dim and CD56bright NK cell subsets from patients with hf-ASD. Figure S2. Expression of supplementary cell-surface markers in NK cells from patients with hf-ASD. Figure S3. Functional activity of NK cells from patients with hf-ASD. (DOCX 6113 kb)
33. "Reading the Mind in the Eyes" in Autistic Adults is Modulated by Valence and Difficulty: An InFoR Study.
- Author
-
Baltazar M, Geoffray MM, Chatham C, Bouvard M, Martinez Teruel A, Monnet D, Scheid I, Murzi E, Couffin-Cadiergues S, Umbricht D, Murtagh L, Delorme R, Ly Le-Moal M, Leboyer M, and Amestoy A
- Subjects
- Adult, Emotions, Humans, Autism Spectrum Disorder diagnosis
- Abstract
Autism spectrum disorders (ASD) are heterogeneous and complex neurodevelopmental conditions that urgently need reliable and sensitive measures to inform diagnosis properly. The Reading the Mind in the Eyes Task (or Eyes Test from now on) is widely used for this purpose. A recent study showed that subcategories of items of the children version of the Eyes Test could be especially discriminative to distinguish ASD and control children. Here, we analyzed the performance on the Eyes Test of 30 high functioning (IQ > 70) adults with ASD and 29 controls from the InFoR cohort multicentric study, using a Generalized Linear Mixed Model. We found that valence and difficulty modulate the performance on the Eyes Test, with easy and positive items being the most discriminative to distinguish ASD and controls. In particular, we suggest this result might be actionable to discriminate ASD patients from controls in subgroups where their overall scores show less difference with controls. We propose for future research the computation of two additional indexes when using the Eyes Test: the first focusing on the easy and positive items (applying a threshold of 70% of correct responses for these items, above which people are at very low risk of having ASD) and the second focusing on the performance gain from difficult to easy items (with a progression of less than 15% showing high risk of having ASD). Our findings open the possibility for a major change in how the Eyes Test is used to inform diagnosis in ASD. LAY SUMMARY: The Eyes Test is used worldwide to inform autism spectrum disorders (ASD) diagnosis. We show here that ASD and neurotypical adults show the most difference in performance on subgroups of items: ASD adults do not improve as expected when comparing easy and difficult items, and they do not show an improvement for items displaying a positive feeling. We advise clinicians to focus on these comparisons to increase the property of the test to distinguish people with ASD from neurotypical adults., (© 2020 The Authors. Autism Research published by International Society for Autism Research and Wiley Periodicals LLC.)
- Published
- 2021
- Full Text
- View/download PDF
34. Local structural connectivity is associated with social cognition in autism spectrum disorder.
- Author
-
d'Albis MA, Guevara P, Guevara M, Laidi C, Boisgontier J, Sarrazin S, Duclap D, Delorme R, Bolognani F, Czech C, Bouquet C, Ly-Le Moal M, Holiga S, Amestoy A, Scheid I, Gaman A, Leboyer M, Poupon C, Mangin JF, and Houenou J
- Subjects
- Adult, Diffusion Magnetic Resonance Imaging, Empathy, Humans, Image Processing, Computer-Assisted, Male, Neural Pathways pathology, Neuropsychological Tests, White Matter pathology, Autism Spectrum Disorder pathology, Autism Spectrum Disorder psychology, Brain pathology, Cognition, Social Behavior
- Abstract
The current theory implying local, short-range overconnectivity in autism spectrum disorder, contrasting with long-range underconnectivity, is based on heterogeneous results, on limited data involving functional connectivity studies, on heterogeneous paediatric populations and non-specific methodologies. In this work, we studied short-distance structural connectivity in a homogeneous population of males with high-functioning autism spectrum disorder and used a novel methodology specifically suited for assessing U-shaped short-distance tracts, including a recently developed tractography-based atlas of the superficial white matter fibres. We acquired diffusion-weighted MRI for 58 males (27 subjects with high-functioning autism spectrum disorder and 31 control subjects) and extracted the mean generalized fractional anisotropy of 63 short-distance tracts. Neuropsychological evaluation included Wechsler Adult Intelligence Scale IV (WAIS-IV), Communication Checklist-Adult, Empathy Quotient, Social Responsiveness Scale and Behaviour Rating Inventory of Executive Function-Adult (BRIEF-A). In contradiction with the models of short-range over-connectivity in autism spectrum disorder, we found that patients with autism spectrum disorder had a significantly decreased anatomical connectivity in a component comprising 13 short tracts compared to controls. Specific short-tract atypicalities in temporal lobe and insula were significantly associated with clinical manifestations of autism spectrum disorder such as social awareness, language structure, pragmatic skills and empathy, emphasizing their importance in social dysfunction. Short-range decreased anatomical connectivity may thus be an important substrate of social deficits in autism spectrum disorder, in contrast with current models.
- Published
- 2018
- Full Text
- View/download PDF
35. Gender differences in autism spectrum disorders: Divergence among specific core symptoms.
- Author
-
Beggiato A, Peyre H, Maruani A, Scheid I, Rastam M, Amsellem F, Gillberg CI, Leboyer M, Bourgeron T, Gillberg C, and Delorme R
- Subjects
- Adolescent, Asperger Syndrome classification, Asperger Syndrome diagnosis, Autism Spectrum Disorder classification, Autistic Disorder classification, Autistic Disorder diagnosis, Child, Diagnostic Errors, Female, Humans, Male, Prevalence, Reference Values, Sex Factors, Autism Spectrum Disorder diagnosis
- Abstract
Community-based studies have consistently shown a sex ratio heavily skewed towards males in autism spectrum disorders (ASD). The factors underlying this predominance of males are largely unknown, but the way girls score on standardized categorical diagnostic tools might account for the underrecognition of ASD in girls. Despite the existence of different norms for boys and girls with ASD on several major screening tests, the algorithm of the Autism Diagnosis Interview-Revised (ADI-R) has not been reformulated. The aim of our study was to investigate which ADI-R items discriminate between males and females, and to evaluate their weighting in the final diagnosis of autism. We then conducted discriminant analysis (DA) on a sample of 594 probands including 129 females with ASD, recruited by the Paris Autism Research International Sibpair (PARIS) Study. A replication analysis was run on an independent sample of 1716 probands including 338 females with ASD, recruited through the Autism Genetics Resource Exchange (AGRE) program. Entering the raw scores for all ADI-R items as independent variables, the DA correctly classified 78.9% of males and 72.9% of females (P < 0.001) in the PARIS cohort, and 72.2% of males and 68.3% of females (P < 0.0001) in the AGRE cohort. Among the items extracted by the stepwise DA, four belonged to the ADI-R algorithm used for the final diagnosis of ASD. In conclusion, several items of the ADI-R that are taken into account in the diagnosis of autism significantly differentiates between males and females. The potential gender bias thus induced may participate in the underestimation of the prevalence of ASD in females. Autism Res 2016,. © 2016 International Society for Autism Research, Wiley Periodicals, Inc. Autism Res 2017, 10: 680-689. © 2016 International Society for Autism Research, Wiley Periodicals, Inc., (© 2016 International Society for Autism Research, Wiley Periodicals, Inc.)
- Published
- 2017
- Full Text
- View/download PDF
36. Using videotaped vignettes to improve the teaching quality in child and adolescent psychiatry.
- Author
-
Delorme R, Chaste P, Scheid I, Cortese S, and Mouren MC
- Subjects
- Humans, Adolescent Psychiatry education, Child Psychiatry education, Quality of Health Care, Teaching methods, Videotape Recording
- Published
- 2010
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