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We investigate the gravitational Aharonov-Bohm effect, by placing a quantum system in free-fall around a gravitating body {\it e.g.} a satellite orbiting the Earth. Since the system is in free-fall, by the equivalence principle, the quantum system is locally in flat, gravity-free space-time - it is screened from the gravitational field. For a slightly elliptical orbit, the gravitational potential will change with time. This leads to the energy levels of the quantum system developing side bands which is the signature for this version of the Aharonov-Bohm effect. This contrasts with the normal signature of the Aharonov-Bohm effect of shifting of interference fringes., Comment: Published version

Atomically thin films, like transition metal dichalcogenides, can now be synthesized at wafer scale, achieving the same extreme aspect ratio (~10^8) that a sheet of paper would have if it covered an entire city. Yet, the intrinsic (i.e. unconfined) three-dimensional shape of these extreme membranes remains a mystery because of the very fundamentals of mechanical measurements: to measure such an ultra-thin film, one first needs to simultaneously free it and stabilize it without introducing confining boundaries. Here, we introduce a counter-intuitive solution to this problem: place atomically thin films on water. Using atomic force microscopy (AFM) and Raman spectroscopy adapted to water's surface, we reveal that large-scale freestanding membranes spontaneously self-wrinkle into a universal mechanical state with long emergent length scales that follow robust scaling trends. Our analytical and numerical models suggest that these universal trends are controlled by mesoscopic parameters of the polycrystalline domains instead of atomistic details. Moreover, we demonstrate experimentally that the wrinkles result in a large and tunable reduction of elastic stiffness by up to 2 orders of magnitude. The present work illuminates the physical properties of the world's thinnest materials at length scales never probed before and highlights their potential for tunable strain-controlled nanomechanical devices., Comment: Includes main text with 4 figures and supplementary text with 10 supplementary figures

Chiral fluids - such as fluids under rotation or a magnetic field as well as synthetic and biological active fluids - flow in a different way than ordinary ones. Due to symmetries broken at the microscopic level, chiral fluids may have asymmetric stress and viscosity tensors, for example giving rise to a hydrostatic torque or non-dissipative (odd) and parity-violating viscosities. In this article, we investigate the motion of rigid bodies in such an anisotropic fluid in the incompressible Stokes regime through the mobility matrix, which encodes the response of a solid body to forces and torques. We demonstrate how the form of the mobility matrix, which is usually determined by particle geometry, can be analogously controlled by the symmetries of the fluid. By computing the mobility matrix for simple shapes in a three-dimensional anisotropic chiral fluid, we predict counter-intuitive phenomena such as motion perpendicular to applied forces and spinning under the force of gravity., Comment: 33 pages, 8 figures

Excitable media, ranging from bioelectric tissues and chemical oscillators to forest fires and competing populations, are nonlinear, spatially extended systems capable of spiking. Most investigations of excitable media consider situations where the amplifying and suppressing forces necessary for spiking coexist at every point in space. In this case, spiking requires a fine-tuned ratio between local amplification and suppression strengths. But, in Nature and engineered systems, these forces can be segregated in space, forming structures like interfaces and boundaries. Here, we show how boundaries can generate and protect spiking if the reacting components can spread out: even arbitrarily weak diffusion can cause spiking at the edge between two non-excitable media. This edge spiking is a robust phenomenon that can occur even if the ratio between amplification and suppression does not allow spiking when the two sides are homogeneously mixed. We analytically derive a spiking phase diagram that depends on two parameters: (i) the ratio between the system size and the characteristic diffusive length-scale, and (ii) the ratio between the amplification and suppression strengths. Our analysis explains recent experimental observations of action potentials at the interface between two non-excitable bioelectric tissues. Beyond electrophysiology, we highlight how edge spiking emerges in predator-prey dynamics and in oscillating chemical reactions. Our findings provide a theoretical blueprint for a class of interfacial excitations in reaction-diffusion systems, with potential implications for spatially controlled chemical reactions, nonlinear waveguides and neuromorphic computation, as well as spiking instabilities, such as cardiac arrhythmias, that naturally occur in heterogeneous biological media., Comment: 31 pages. 15 figures. Supplemental videos available at: https://home.uchicago.edu/~vitelli/videos.html

A novel version of the electric Aharonov-Bohm effect is proposed where the quantum system which picks up the Aharonov-Bohm phase is confined to a Faraday cage with a time varying, spatially uniform scalar potential. The electric and magnetic fields in this region are effectively zero for the entire period of the experiment. The observable consequence of this version of the electric Aharonov-Bohmn effect is to shift the energy levels of the quantum system rather than shift the fringes of the 2-slit interference pattern. We show a strong mathematical connection between this version of the scalar electric AB effect and the AC Stark effect., Comment: 14 pages revtex, 4 figures. Added references and changes made to address referee comments. To be published in PRA

Odd elasticity encompasses active elastic systems whose stress-strain relationship is not compatible with a potential energy. As the requirement of energy conservation is lifted from linear elasticity, new anti-symmetric (odd) components appear in the elastic tensor. In this work, we study the odd elasticity and non-Hermitian wave dynamics of active surfaces, specifically plates of moderate thickness. We find that a free-standing moderately thick, isotropic plate can exhibit two odd-elastic moduli, both of which are related to shear deformations of the plate. These odd moduli can endow the vibrational modes of the plate with a nonzero topological invariant known as the first Chern number. Within continuum elastic theory, we show that the Chern number is related to the presence of unidirectional shearing waves that are hosted at the plate's boundary. We show that the existence of these chiral edge waves hinges on a distinctive two-step mechanism: the finite thickness of the sample gaps the shear modes and the odd elasticity endows them with chirality., Comment: 13 pages, 6 figures

Elasticity typically refers to a material's ability to store energy, while viscosity refers to a material's tendency to dissipate it. In this review, we discuss fluids and solids for which this is not the case. These materials display additional linear response coefficients known as odd viscosity and odd elasticity. We first introduce odd elasticity and odd viscosity from a continuum perspective, with an emphasis on their rich phenomenology, including transverse responses, modified dislocation dynamics, and topological waves. We then provide an overview of systems that display odd viscosity and odd elasticity. These systems range from quantum fluids, to astrophysical gasses, to active and driven matter. Finally, we comment on microscopic mechanisms by which odd elasticity and odd viscosity arise., Comment: 30 pages, 7 figures

We provide a perspective on soft metamaterials and biomatter with a special emphasis on future research directions at the interface between material intelligence and adaptation., Comment: 7 pages, 2 figures

The flow of momentum and energy in a fluid is typically associated with dissipative transport coefficients: viscosity and thermal conductivity. Fluids that break certain symmetries such as mirror symmetry and time-reversal invariance can display non-dissipative transport coefficients called odd (or Hall) viscosities and thermal conductivities. The goal of this paper is to elucidate the microscopic origin of these dissipationless transport coefficients using kinetic theory. We show that odd viscosity and odd thermal conductivity arise when the linearized collision operator is not Hermitian. This symmetry breaking occurs when collisions are chiral, i.e. not mirror symmetric. To capture this feature in a minimalistic way, we introduce a modified relaxation time approximation in which the distribution function is rotated by an angle characterizing the average chirality of the collisions. In the limit of an infinitesimal rotation, the effect of the parity-violating collisions can be described as an emergent effective magnetic field., Comment: 5 pages, 3 figures + SI

The increasing availability of brain data within and outside the biomedical field, combined with the application of artificial intelligence (AI) to brain data analysis, poses a challenge for ethics and governance. We identify distinctive ethical implications of brain data acquisition and processing, and outline a multi-level governance framework. This framework is aimed at maximizing the benefits of facilitated brain data collection and further processing for science and medicine whilst minimizing risks and preventing harmful use. The framework consists of four primary areas of regulatory intervention: binding regulation, ethics and soft law, responsible innovation, and human rights.

Active matter composed of energy-generating microscopic constituents is a promising platform to create autonomous functional materials. However, the very presence of these microscopic energy sources is what makes active matter prone to dynamical instabilities and hence hard to control. Here, we show that these instabilities can be coaxed into work-generating limit cycles that turn active matter into robots. We illustrate this general principle in odd active media, model systems whose interaction forces are as simple as textbook molecular bonds yet not constrained to be the gradient of a potential. These emergent robotic functionalities are demonstrated by revisiting what is arguably the oldest of inventions: the wheel. Unlike common wheels that are driven by external torques, an odd wheel undergoes work-generating limit cycles that allow it to roll autonomously uphill by virtue of its own deformation, as demonstrated by our prototypes. Similarly, familiar scattering phenomena, like a ball bouncing off a wall, turn into basic robotic manipulations when either the ball or the wall is odd. Using continuum mechanics, we reveal collective robotic mechanisms that steer the outcome of collisions or influence the absorption of impacts in experiments. Beyond robotics, work-generating limit cycles can also control the non-linear dynamics of active soft materials, biological systems and driven nanomechanical devices., Comment: 4 Figures, Methods and SI. Supplemental videos at https://home.uchicago.edu/~vitelli/videos.html

Our scoping review aims to assess what legal, ethical, and socio-technical factors contribute or inhibit the success of national eHealth system implementations. In addition, our review seeks to describe the characteristics and benefits of eHealth systems. We conducted a scoping review of literature published in English between January 2000 and 2020 using a keyword search on five databases; PubMed, Scopus, Web of Science, IEEEXplore, and ProQuest. After removal of duplicates, abstract screening and full-text filtering, 86 articles were included from 8276 search results. We identified 17 stakeholder groups, 6 eHealth Systems areas, and 15 types of legal regimes and standards. In-depth textual analysis revealed challenges mainly in implementation, followed by ethico-legal and data related aspects. Key factors influencing success include promoting trust of the system, ensuring wider acceptance amongst users, reconciling the system with legal requirements and ensuring an adaptable technical platform. Results revealed support for decentralised implementations because they carry less implementation and engagement challenges than centralised ones. Simultaneously, due to decentralised systems interoperability issues, federated implementations (with a set of national standards) might be preferable. This study identifies the primary socio-technical, legal and ethical factors that challenge and contribute to the success of eHealth system implementations. This study also describes the complexities and characteristics of existing eHealth implementation programs, and surmises suggested guidance for resolving the identified challenges., Comment: 28 pages, 4 figures, 2 tables

Crystallography typically studies collections of point particles whose interaction forces are the gradient of a potential. Lifting this assumption generically gives rise in the continuum limit to a form of elasticity with additional moduli known as odd elasticity. We show that such odd elastic moduli modify the strain induced by topological defects and their interactions, even reversing the stability of, otherwise, bound dislocation pairs. Beyond continuum theory, isolated dislocations can self propel via microscopic work cycles active at their cores that compete with conventional Peach-Koehler forces caused, for example, by an ambient torque density. We perform molecular dynamics simulations isolating active plastic processes and discuss their experimental relevance to solids composed of spinning particles, vortex-like objects, and robotic metamaterials., Comment: 34 pages and 13 figures with Supplementary Information; Updated Journal Reference

The Stokes equation describes the motion of fluids when inertial forces are negligible compared to viscous forces. In this article, we explore the consequence of parity-violating and non-dissipative (i.e. odd) viscosities on Stokes flows in three dimensions. Parity-violating viscosities are coefficients of the viscosity tensor that are not invariant under mirror reflections of space, while odd viscosities are those which do not contribute to dissipation of mechanical energy. These viscosities can occur in systems ranging from synthetic and biological active fluids to magnetised and rotating fluids. We first systematically enumerate all possible parity-violating viscosities compatible with cylindrical symmetry, highlighting their connection to potential microscopic realizations. Then, using a combination of analytical and numerical methods, we analyze the effects of parity-violating viscosities on the Stokeslet solution, on the flow past a sphere or a bubble, and on many-particle sedimentation. In all the cases we analyze, parity-violating viscosities give rise to an azimuthal flow even when the driving force is parallel to the axis of cylindrical symmetry. For a few sedimenting particles, the azimuthal flow bends the trajectories compared to a traditional Stokes flow. For a cloud of particles, the azimuthal flow impedes the transformation of the spherical cloud into a torus and the subsequent breakup into smaller parts that would otherwise occur. The presence of azimuthal flows in cylindrically symmetric systems (sphere, bubble, cloud of particles) can serve as a probe for parity-violating viscosities in experimental systems., Comment: 39 pages, 12 figures. Supplementary movies at https://home.uchicago.edu/~vitelli/videos.html

Multisite medical data sharing is critical in modern clinical practice and medical research. The challenge is to conduct data sharing that preserves individual privacy and data usability. The shortcomings of traditional privacy-enhancing technologies mean that institutions rely on bespoke data sharing contracts. These contracts increase the inefficiency of data sharing and may disincentivize important clinical treatment and medical research. This paper provides a synthesis between two novel advanced privacy enhancing technologies (PETs): Homomorphic Encryption and Secure Multiparty Computation (defined together as Multiparty Homomorphic Encryption or MHE). These PETs provide a mathematical guarantee of privacy, with MHE providing a performance advantage over separately using HE or SMC. We argue MHE fulfills legal requirements for medical data sharing under the General Data Protection Regulation (GDPR) which has set a global benchmark for data protection. Specifically, the data processed and shared using MHE can be considered anonymized data. We explain how MHE can reduce the reliance on customized contractual measures between institutions. The proposed approach can accelerate the pace of medical research whilst offering additional incentives for healthcare and research institutes to employ common data interoperability standards., Comment: 19 pages, 2 figures, 1 table

Materials made from active, living, or robotic components can display emergent properties arising from local sensing and computation. Here, we realize a freestanding active metabeam with piezoelectric elements and electronic feed-forward control that gives rise to an odd micropolar elasticity absent in energy-conserving media. The non-reciprocal odd modulus enables bending and shearing cycles that convert electrical energy into mechanical work, and vice versa. The sign of this elastic modulus is linked to a non-Hermitian topological index that determines the localization of vibrational modes to sample boundaries. At finite frequency, we can also tune the phase angle of the active modulus to produce a direction-dependent bending modulus and control non-Hermitian vibrational properties. Our continuum approach, built on symmetries and conservation laws, could be exploited to design others systems such as synthetic biofilaments and membranes with feed-forward control loops., Comment: Main text, 6 figures, methods, and supplementary information

Our chapter presents a scoping review of published scientific studies or case studies of scientific studies that utilise both citizen scientists and Internet of Things devices. Specifically, we selected studies where the authors had included at least a short discussion of the ethical issues encountered during the research process. Having conducted a search of five databases (IEEE Xplore, Scopus, Web of Science, ProQuest, and PubMed), we identified 631 potential results. Following abstract and title screening, and then full text eligibility assessment, we identified 34 published articles that matched our criteria. We then analysed the full text for these articles inductively and deductively, coding ethical issues into three main categories. These categories were autonomy and data privacy, data quality, and intellectual property. We also analysed the full text of these articles to see what strategies researchers took to resolve these ethical issues, as well as any legal implications raised. Following this analysis, our discussion provides recommendations for researchers who wish to integrate citizen scientists and Internet of Things devices into their research. First, all citizen science projects should integrate a data privacy protocol to protect the confidentiality of participants. Secondly, scientific researchers should consider any potential issues of data quality, including whether compromises might be required, before establishing a project. Finally, all intellectual property issues should be clarified both at the start of the project and during its lifecycle. Researchers should also consider any ethical issues that might flow from the use of commercially available Internet of Things devices for research., Comment: Authors' version; 17 pages, 4 tables

Data collection and processing via digital public health technologies are being promoted worldwide by governments and private companies as strategic remedies for mitigating the COVID-19 pandemic and loosening lockdown measures. However, the ethical and legal boundaries of deploying digital tools for disease surveillance and control purposes are unclear, and a rapidly evolving debate has emerged globally around the promises and risks of mobilizing digital tools for public health. To help scientists and policymakers navigate technological and ethical uncertainty, we present a typology of the primary digital public health applications currently in use. Namely: proximity and contact tracing, symptom monitoring, quarantine control, and flow modeling. For each, we discuss context-specific risks, cross-sectional issues, and ethical concerns. Finally, in recognition of the need for practical guidance, we propose a navigation aid for policymakers made up of ten steps for the ethical use of digital public health tools., Comment: 14 pages, 3 figures

We report on linewidth analysis of optical transitions in InAs/GaAs coupled quantum dots as a function of bias voltage, temperature, and tunnel coupling strength. A significant line broadening up to 100 $\mu$eV is observed at hole tunneling resonances where the coherent tunnel coupling between spatially direct and indirect exciton states is maximized, corresponding to a phonon-assisted transition rate of 150 ns${}^{-1}$ at 20 K. With increasing temperature, the linewidth shows broadening characteristic of single-phonon transitions. The linewidth as a function of tunnel coupling strength tracks the theoretical prediction of linewidth broadening due to phonon-assisted transitions, and is maximized with an energy splitting between the two exciton branches of 0.8$-$0.9 meV. This report highlights the linewidth broadening mechanisms and fundamental aspects of the interaction between these systems and the local environment., Comment: 11 pages, 7 figures

A geometry-based mechanism for inducing circulation of photons is illustrated by a metastructure consisting of quantum dots arranged in a triangle coupled to photonic structures. The coupling between the photons and the excitons in the quantum dots leads to a photon blockade and limits the number of photons participating in the transport. In the steady state described by the quantum master equation of photons, the local photonic currents exhibit distinct circulation patterns, which originate from the wave nature in a multi-path geometry. The geometry-based mechanism does not require an artificial gauge field from light-matter interactions. The phase diagrams showing where different patterns of circulation can be found saturate as the number of photons allowed on each site increases. By using the third-quantization formalism, we show the circulation survives without any photon blockade in the noninteracting case. Moreover, we demonstrate the decoupling of the direction of the local current from the density difference and propose possible applications of the local photonic transport., Comment: 10 pages, 7 figures, submitted

Statistical mechanics provides the foundation for describing complex materials using only a few thermodynamic variables. No such framework currently exists far from equilibrium. In this Letter, we demonstrate how thermodynamics emerges far from equilibrium, using fluids composed of active spinners as a case study. Activity gives rise to a single effective temperature that parameterizes both the equation of state and the emergent Boltzmann statistics. The same effective temperature, renormalized by velocity correlations, controls the linear response through canonical Green-Kubo relations for both the familiar shear viscosity and the odd (or Hall) viscosity observed in chiral fluids. The full frequency dependence of these viscosities can be derived analytically by modeling the active-spinner fluid as a random walker undergoing cyclotron motion in shear-stress space. More generally, we provide a first-principles derivation of the Green-Kubo relations valid for a broader class of fluids far from equilibrium. Besides advancing non-equilibrium thermodynamics, our work demonstrates in silico a non-invasive microrheology of active fluids., Comment: Supplementary movies at https://www.youtube.com/playlist?list=PLnzJw7B7T8cKLck3wSoMRJVTSFSdrExeh

Solids built out of active components can exhibit non-reciprocal elastic coefficients that give rise to non-Hermitian wave phenomena. Here, we investigate non-Hermitian effects present at the boundary of two-dimensional active elastic media obeying two general assumptions: their microscopic forces conserve linear momentum and arise only from static deformations. Using continuum equations, we demonstrate the existence of the non-Hermitian skin effect in which the boundary hosts an extensive number of localized modes. Furthermore, lattice models reveal non-Hermitian topological transitions mediated by exceptional rings driven by the activity level of individual bonds., Comment: Three figures with supplementary information

Hooke's law states that the forces or stresses experienced by an elastic object are proportional to the applied deformations or strains. The number of coefficients of proportionality between stress and strain, i.e., the elastic moduli, is constrained by energy conservation. In this Letter, we lift this restriction and generalize linear elasticity to active media with non-conservative microscopic interactions that violate mechanical reciprocity. This generalized framework, which we dub odd elasticity, reveals that two additional moduli can exist in a two-dimensional isotropic solid with active bonds. Such an odd-elastic solid can be regarded as a distributed engine: work is locally extracted, or injected, during quasi-static cycles of deformation. Using continuum equations, coarse-grained microscopic models, and numerical simulations, we uncover phenomena ranging from activity-induced auxetic behavior to wave propagation powered by self-sustained active elastic cycles. Besides providing insights beyond existing hydrodynamic theories of active solids, odd elasticity suggests design principles for emergent autonomous materials., Comment: 15 pages including Supplementary Information, 5 figures. See https://www.youtube.com/playlist?list=PLnzJw7B7T8cIc1EjLVq3AU_hOe1PEAdt9 for Supplementary Movies

Advances in fabrication and control of quantum dots allow the realization of metastructures that may exhibit novel electrical transport phenomena. Here, we investigate the electrical current passing through one such metastructure, a system composed of quantum dots placed at the vertices of a triangle. The wave natural of quantum particles leads to internal current circulation within the metastructure in the absence of any external magnetic field. We uncover the relation between its steady-state total current and the internal circulation. By calculating the electronic correlations in quantum transport exactly, we present phase diagrams showing where different types of current circulation can be found as a function of the correlation strength and the coupling between the quantum dots. Finally, we show that the regimes of current circulation can be further enhanced or reduced depending on the local spatial distribution of the interactions, suggesting a single-particle scattering mechanism is at play even in the strongly-correlated regime. We suggest experimental realizations of actual quantum-dot metastructures where our predictions can be directly tested., Comment: 5 pages, 4 figures, the Supplemental Information is attached at the end

We report the observation and physical characterization of the possible dwarf planet \UZ\ ("DeeDee"), a dynamically detached trans-Neptunian object discovered at 92 AU. This object is currently the second-most distant known trans-Neptunian object with reported orbital elements, surpassed in distance only by the dwarf planet Eris. The object was discovered with an $r$-band magnitude of 23.0 in data collected by the Dark Energy Survey between 2014 and 2016. Its 1140-year orbit has $(a,e,i) = (109~\mathrm{AU}, 0.65, 26.8^{\circ})$. It will reach its perihelion distance of 38 AU in the year 2142. Integrations of its orbit show it to be dynamically stable on Gyr timescales, with only weak interactions with Neptune. We have performed followup observations with ALMA, using 3 hours of on-source integration time to measure the object's thermal emission in the Rayleigh-Jeans tail. The signal is detected at 7$\sigma$ significance, from which we determine a $V$-band albedo of $13.1^{+3.3}_{-2.4}\mathrm{(stat)}^{+2.0}_{-1.4}\mathrm{(sys)}$ percent and a diameter of $635^{+57}_{-61}\mathrm{(stat)}^{+32}_{-39}\mathrm{(sys)}$~km, assuming a spherical body with uniform surface properties., Comment: 13 pages, 4 figures, accepted by ApJ Letters

We theoretically model the electronic dynamics of a coupled quantum dot pair in a static electric field. We then investigate the possibility of polarization-entangled photon emission from the radiative cascade of the molecular biexciton state. Through numerical simulations, we analyze the dependence of entanglement fidelity on temperature and electric field, as well as tunnel coupling. We establish a regime of direct-indirect exciton detunings for which coupled quantum dots are superior to single dots for entangled photon generation, yielding near-unit fidelity over a larger range of exchange splittings., Comment: 9 pages, 4 figures

Excited states in single quantum dots (QDs) have been shown to be useful for spin state initialization and manipulation. For scalable quantum information processing it is necessary to have multiple spins interacting. Therefore, we present initial results from photoluminescence excitation studies of excited states in coupled quantum dots (CQDs). Due to the rich set of possible excitation and recombination possibilities, a technique for visualizing photoluminescence excitation in coupled quantum dots is discussed, by which both the interaction between the dots and the type of absorption and emission that generated the photoluminescence is easily and clearly revealed. As an example, this technique is applied to characterize the shell structure of the hole in the top dot and the results are compared with those using Level Anti-Crossing Spectroscopy (LACS)., Comment: 6 pages, 4 figures