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In this article, we analyze the National Cancer Institute’s Virus Cancer Programs (1964–1978). The NCI’s organizational mandate established program goals that iteratively braided together both scientific research and public health outcomes. The distinctive environment of the NCI as a federal research institute made scientific programs accountable to evaluations of both experimental and administrative appropriateness. To this end, NCI scientist-administrators adopted management techniques drawn from the Cold War defense industry to direct open-ended exploratory research on virally induced cancers, aimed at developing a vaccine as a public health solution to cancer. Facing the limitations of the state of viral cancer research as simultaneously an administrative and experimental problem, the Programs launched a monumental effort to develop infrastructure for cancer virus studies through long-term planning initiatives utilizing defense-style networks of contracted academic laboratories throughout the US. The organizational mandate guiding the Programs contributed to conceptual and experimental changes that directly led to the subversion of its fundamental presupposition of viral causation in favor of the cellular oncogene theory. We thus propose a reinterpretation of the historiography of the oncogene hypothesis as a radical break from viral explanations of cancer etiology, a reinterpretation that re-centers the direct contributions this federal vaccine program made to current molecular biological explanations of cancer causation.

© 2020 by The History of Science Society. In the 1920s, scientists at the University of Cambridge’s Sir William Dunn Institute of Biochemistry made major contributions to the emerging discipline of biochemistry while also devoting considerable time and energy to the production of a humor journal entitled Brighter Biochemistry. Although humor is frequently regarded as peripheral to the work of science, the journal provides an opportunity to understand how it contributes to the social infrastructure of scientific communities as modern workplaces. Taking methodological cues from cultural history, ethnography, and humor studies, this essay conducts a close and contextual reading of Brighter Biochemistry. This reading demonstrates how humor served as a central means through which members of the Dunn confronted workplace issues, including creating cooperative work teams, responding to gender discrimination, addressing funding anxiety, and defining professional identity. These conclusions provide a new perspective on the well-documented history of the Dunn and also offer a model for how historians of science can approach humor when its traces are encountered in other settings.