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2. Abnormal torsion and helical flow patterns of the neo-aorta in hypoplastic left heart syndrome assessed with 4D-flow MRI

Author

Gabbert, Dominik Daniel, Trotz, Patrick, Kheradvar, Arash, Jerosch-Herold, Michael, Scheewe, Jens, Kramer, Hans-Heiner, Voges, Inga, and Rickers, Carsten

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Rare Diseases, Cardiovascular, Heart Disease, Biomedical Imaging, Hypoplastic left heart syndrome, kinking, torsion, neoaorta, helicity, 4D flow MRI, Cardiovascular medicine and haematology
Abstract

BackgroundThe Norwood procedure is the first stage of correction for patients with hypoplastic left heart syndrome (HLHS) and may lead to an abnormal neoaortic anatomy. We prospectively studied the neoaorta's fluid dynamics and the abnormal twist of the neoaorta by MRI examinations of HLHS patients in Fontan circulation. This study for the first time investigates the hypothesis that the neoaorta twist is associated with increased helical flow patterns, which may lead to an increased workload for the systemic right ventricle (RV) and ultimately to RV hypertrophy.MethodsA group of forty-two HLHS patients with a median age of 4.9 (2.9-17.0) years, at NYHA I was studied along with a control group of eleven subjects with healthy hearts and a median age of 12.1 (4.0-41.6). All subjects underwent MRI of the thoracic aorta including ECG-gated 2D balanced SSFP cine for an axial slice stack and 4D-flow MRI for a sagittal volume slab covering the thoracic aorta. The twist of the neoaortic arch was quantified by the effective geometric torsion, defined as the product of curvature and geometric torsion. Fluid dynamics and geometry in the neoaorta, including the flow helicity index, were evaluated using an in-house analysis software (MeVisLab-based). Myocardial mass of the systemic ventricle at end-diastole was estimated by planimetry of the short-axis stack.ResultsCompared to the control group, the neoaorta in the HLHS patients shows an increased twist (P=0.04) and higher peak helicity density (P=0.03). The maximum helicity density was correlated with maximum effective torsion of the ascending neoaorta (P

Published
2021

3. Myocardial Perfusion in Hypoplastic Left Heart Syndrome

Author

Rickers, Carsten, Wegner, Philip, Silberbach, Michael, Madriago, Erin, Gabbert, Dominik Daniel, Kheradvar, Arash, Voges, Inga, Scheewe, Jens, Attmann, Tim, Jerosch-Herold, Michael, and Kramer, Hans-Heiner

Subjects
Pediatric, Heart Disease, Cardiovascular, Rare Diseases, Heart Disease - Coronary Heart Disease, Infant Mortality, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Child, Child, Preschool, Coronary Circulation, Echocardiography, Doppler, Female, Follow-Up Studies, Humans, Hypoplastic Left Heart Syndrome, Magnetic Resonance Imaging, Cine, Male, Microcirculation, Myocardial Ischemia, Myocardial Perfusion Imaging, Oxygen Saturation, Prospective Studies, heart defects, congenital, hypoplastic left heart syndrome, Fontan circulation, magnetic resonance imaging, myocardial perfusion imaging, heart defects, congenital, Clinical Sciences, Cardiovascular System & Hematology
Abstract

BackgroundThe status of the systemic right ventricular coronary microcirculation in hypoplastic left heart syndrome (HLHS) is largely unknown. It is presumed that the systemic right ventricle's coronary microcirculation exhibits unique pathophysiological characteristics of HLHS in Fontan circulation. The present study sought to quantify myocardial blood flow by cardiac magnetic resonance imaging and evaluate the determinants of microvascular coronary dysfunction and myocardial ischemia in HLHS.MethodsOne hundred nineteen HLHS patients (median age, 4.80 years) and 34 healthy volunteers (median age, 5.50 years) underwent follow-up cardiac magnetic resonance imaging ≈1.8 years after total cavopulmonary connection. Right ventricle volumes and function, myocardial perfusion, diffuse fibrosis, and late gadolinium enhancement were assessed in 4 anatomic HLHS subtypes. Myocardial blood flow (MBF) was quantified at rest and during adenosine-induced hyperemia. Coronary conductance was estimated from MBF at rest and catheter-based measurements of mean aortic pressure (n=99).ResultsHyperemic MBF in the systemic ventricle was lower in HLHS compared with controls (1.89±0.57 versus 2.70±0.84 mL/g per min; P

Published
2021

4. Publisher Correction: Heart beat but not respiration is the main driving force of the systemic venous return in the Fontan circulation.

Author

Gabbert, Dominik Daniel, Hart, Christopher, Jerosch-Herold, Michael, Wegner, Philip, Salehi Ravesh, Mona, Voges, Inga, Kristo, Ines, Bulushi, Abdullah AL, Scheewe, Jens, Kheradvar, Arash, Kramer, Hans-Heiner, and Rickers, Carsten

Subjects
Cardiovascular, Biochemistry and Cell Biology, Other Physical Sciences
Abstract

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Published
2019

5. Heart beat but not respiration is the main driving force of the systemic venous return in the Fontan circulation.

Author

Gabbert, Dominik Daniel, Hart, Christopher, Jerosch-Herold, Michael, Wegner, Philip, Salehi Ravesh, Mona, Voges, Inga, Kristo, Ines, Bulushi, Abdullah AL, Scheewe, Jens, Kheradvar, Arash, Kramer, Hans-Heiner, and Rickers, Carsten

Subjects
Cardiovascular, Pediatric, Perinatal Period - Conditions Originating in Perinatal Period, Digestive Diseases, Heart Disease, Biochemistry and Cell Biology, Other Physical Sciences
Abstract

The Fontan procedure provides relief from cyanosis in patients with univentricular hearts. A major clinical unmet need is to understand whether the venous flow patterns of the Fontan circulation lead to the development of congestive hepatopathy and other life-threatening complications. Currently, there is no consensus on whether heart beat or respiration is the main driving force of venous return and which one affects the periodic flow changes for the most (i. e., pulsatility). The present study, for the first time, quantified respiratory and cardiac components of the venous flow in the inferior vena cava (IVC) of 14 Fontan patients and 11 normal controls using a novel approach ("physio-matrix"). We found that in contrast to the normal controls, respiration in Fontan patients had a significant effect on venous flow pulsatility, and the ratio of respiration-dependent to the cardiac-dependent pulsatility was positively associated with the retrograde flow. Nevertheless, the main driving force of net IVC flow was the heart beat and not respiration. The separate analysis of the effects of respiration and heart beat provides new insights into the abnormal venous return patterns that may be responsible for adverse effects on liver and bowel of the patients with Fontan circulation.

Published
2019

7. Results after pulmonary valve reconstruction

Author

Jussli-Melchers, Jill, primary, Hansen, Jan Hinnerk, additional, Scheewe, Jens, additional, Attmann, Tim, additional, Eide, Martin, additional, Logoteta, Jana, additional, Franz, Jeremy, additional, Dütschke, Peter, additional, Salehi Ravesh, Mona, additional, Warnecke, Gregor, additional, Uebing, Anselm, additional, and Voges, Inga, additional

Published
2024
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9. 4D flow streamline characteristics of the great arteries twenty years after Lecompte and direct spiral arterial switch operation (DSASO) in simple TGA.

Author

Sievers, Hans-Hinrich, Putman, Léon M, Kheradvar, Arash, Gabbert, Dominik, Wegner, Philip, Scheewe, Jens, Salehi-Ravesh, Mona, Kramer, Hans-Heiner, and Rickers, Carsten

Abstract

Transposition of the great arteries (TGA) is caused by discordance between the great arteries and the ventricles. If left untreated, this anomaly has a disastrous perspective. More recent surgical approach for correction includes the Lecompte technique in which the pulmonary bifurcation is transposed anterior to the aorta, which may be less physiologic. Although the early results are excellent, there is potential for future problems involving the great arteries and semilunar valves1. These potential problems necessitate the development of other improved surgical techniques2. Here we report an MRI 4D flow study related to a case of simple TGA whose primary surgical correction - direct spiral arterial switch operation (DSASO) - was performed twenty years ago in an attempt to restore physiologic arrangement among the great arteries and semilunar valves.

Published
2016

10. Is the Lecompte technique the last word on transposition of the great arteries repair for all patients? A magnetic resonance imaging study including a spiral technique two decades postoperatively

Author

Rickers, Carsten, Kheradvar, Arash, Sievers, Hans-Hinrich, Falahatpisheh, Ahmad, Wegner, Philip, Gabbert, Dominik, Jerosch-Herold, Michael, Hart, Chris, Voges, Inga, Putman, Léon M, Kristo, Ines, Fischer, Gunther, Scheewe, Jens, and Kramer, Hans-Heiner

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Clinical Research, Biomedical Imaging, Heart Disease, Cardiovascular, 4.2 Evaluation of markers and technologies, Detection, screening and diagnosis, Anastomosis, Surgical, Aorta, Thoracic, Female, Follow-Up Studies, Hemodynamics, Humans, Imaging, Three-Dimensional, Magnetic Resonance Imaging, Cine, Male, Postoperative Care, Pulmonary Artery, Time Factors, Transposition of Great Vessels, Vascular Surgical Procedures, Young Adult, Transposition of great vessels, Magnetic resonance imaging, Lecompte technique, Physiological spiral anastomosis, Medical Biotechnology, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectivesTo compare the Lecompte technique and the spiral anastomosis (complete anatomic correction) two decades after arterial switch operation (ASO).MethodsNine patients after primary ASO with Lecompte and 6 selected patients after spiral anastomosis were evaluated 20.8 ± 2.1 years after ASO versus matched controls. Blood flow dynamics and flow profiles (e.g. vorticity, helicity) in the great arteries were quantified from time-resolved 3D magnetic resonance imaging (MRI) phase contrast flow measurements (4D flow MR) in addition to a comprehensive anatomical and functional cardiovascular MRI analysis.ResultsCompared with spiral reconstruction, patients with Lecompte showed more vortex formation, supranatural helical blood flow (relative helicity in aorta: 0.036 vs 0.089; P < 0.01), a reduced indexed cross-sectional area of the left pulmonary artery (155 vs 85 mm²/m²; P < 0.001) and more semilunar valve dysfunctions (n = 5 vs 1). There was no difference in elastic aortic wall properties, ventricular function, myocardial perfusion and myocardial fibrosis between the two groups. Cross-sectional area of the aortic sinus was larger in patients than in controls (669 vs 411 mm²/m²; P < 0.01). In the spiral group, the pulmonary root was rotated after ASO more towards the normal left position (P < 0.01).ConclusionsIn this study, selected patients with spiral anastomoses showed, two decades after ASO, better physiologically adapted blood flow dynamics, and attained a closer to normal anatomical position of their great arteries, as well as less valve dysfunction. Considering the limitations related to the small number of patients and the novel MRI imaging techniques, these data may provoke reconsidering the optimal surgical approaches to transposition of the great arteries repair.

Published
2016

11. Somatic Development in Children with Congenital Heart Defects

Author

Kerst, Gunter, Vazquez-Jimenez, Jaime F., Gkalpakiotis, Dimitrios, Schedifka, Andrea, Buheitel, Gernot, Streble, Joachim, II, Kececioglu, Deniz, Sandica, Eugen, Trusen, Burkhard, Berger, Felix, Miera, Oliver, Ovroutski, Stanislav, Peters, Björn, Schmitt, Katharina, Schubert, Stephan, Photiadis, Joachim, Opgen-Rhein, Bernd, Weiss, Katja, Berns, Christoph, Blumenthal-Barby, Carl-Christian, Boeckel, Thomas, Krusche, Susanne, Busse, Jürgen, Kästner, Andreas, Koch, Heike, Köpcke, Christian, Streichan, Frank, Timme, Jens, Franzbach, Birgit, Senft, Gabriela, Beyer, Frank, Winter, Klaus, Breuer, Johannes, Welz, Armin, Bahlmann, Jens, Griese, Eberhard, Lê, Trong Phi, Hebe, Joachim, Nürnberg, Jan-Hendrik, Magsaam, Annette, Müller, Ronald, Potthoff, Ludger, Voigt, Renate, Krüger, Tim, Gerleve, Hubert, Kleideiter, Ulrich, Schneider-Kulla, Dirk, Feil, Elmo, Menke, Thomas, Lehn, Martin, Grohmann, Martina, Tomczak, Helge, Krogmann, Otto N., Tarusinov, Gleb, Scheld, Michael, Mayatepek, Ertan, Pillekamp, Frank, Lichtenberg, Artur, Terpeluk, Christiane, von Jan, Veronika, Dittrich, Sven, Gundlach, Ulrike, Cesnjevar, Robert, Neudorf, Ulrich, Morf, Geert, Esmaeili, Anoosh, Backhoff, Stephan, Stiller, Brigitte, Beyersdorf, Friedhelm, Kroll, Johannes, Wildberg, Anke, Siaplaouras, Jannos, Masri-Zada, Antje, Jux, Christian, Böning, Andreas, Akintürk, Hakan, Paul, Thomas, Tirilomis, Theodor, Schürer, Gabriele, Hartmann, Johannes, Grabitz, Ralph, Liebaug, Uta, Rotzsch, Claudius, Kozlik-Feldmann, Rainer, Sachweh, Jörg, Riso, Arlindo, Petersen, Volker, Friedrich, Bernd, Schlobohm, Otmar, Beerbaum, Philipp, Böthig, Dietmar, Horke, Alexander, Bauersachs, Johann, Westhoff-Bleck, Mechthild, Gorenflo, Matthias, Karck, Matthias, Loukanov, Tsvetomir, Sebening, Christian, Schrüfer, Hermann, Wilken, Martin, Abdul-Khaliq, Hashim, Rädle-Hurst, Tanja, Rentzsch, Axel, Schäfers, Hans-Joachim, Reichert, Hagen, Kriebel, Thomas, Boysen, Arnulf, Kramer, Hans-Heiner, Cremer, Joachim Thomas, Scheewe, Jens, Buchholz-Berdau, Regina, Möller, Peter, Ram, Wolfgang, Brockmeier, Konrad, Bennink, Gerardus B.W.E., Gillor, Alex, Niehues, Tim, Terhoeven, Peter, Leidig, Steffen, Dähnert, Ingo, Kinzel, Peter, Kostelka, Martin, Kändler, Liane, Bethge, Martin, Köster, Stefan, Schröder, Christoph, Karstedt, Jens, Seitz, Uwe, Kampmann, Christoph, Vahl, Christian-Friedrich, Stahl, Frank, Barth, Helmut, Müller-Scholden, Joachim, Ewert, Peter, Hager, Alfred, Kaemmerer, Harald, Nagdyman, Nicole, Schoetzau, Jörg, Tutarel, Oktay, Lange, Rüdiger, Haas, Nikolaus A., Hakami, Lale, Hauser, Michael, Roithmaier, Alexander, Kehl, Hans Gerd, Malec, Edward, Baumgartner, Helmut, Diller, Gerhard, Bahle, Roswitha, Hofner, Gerald, Zink, Stefan, Reif, Roland, Parlasca, Christoph, Freund, Matthias W., Schumacher, Michael, Darrelmann, Christine, Motz, Reinald, Willmann, Olaf, Schmiedl, Norbert, Quick, Peter, Hillebrand, Dirk, Hirsemann, Petra, Eiselt, Stephan Michele, Nekarda, Torsten, Eberhard, Michael, Schneider, Martin, Asfour, Boulos, Baier, Georg, Uhlemann, Frank, Scheid, Michael, Beyer, Alexander, Binz, Gudrun, Teufel, Thomas, Handke, Ronald-Peter, Hofbeck, Michael, Kaulitz, Renate, Sieverding, Ludger, Schlensak, Christian, Apitz, Christian, Kupferschmid, Christoph, Holtvogt, Jürgen, Wippermann, Carl-Friedrich, Heusch, Andreas, Wirbelauer, Johannes, Brosi, Wolfgang, Poryo, Martin, Paes, Laura Antonia, Pickardt, Thomas, Bauer, Ulrike M.M., Meyer, Sascha, and Wagenpfeil, Stefan

Published
2018
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18. Somatic Development in Children with Congenital Heart Defects

Author

Poryo, Martin, Paes, Laura Antonia, Pickardt, Thomas, Bauer, Ulrike M.M., Meyer, Sascha, Wagenpfeil, Stefan, Abdul-Khaliq, Hashim, Kerst, Gunter, Vazquez-Jimenez, Jaime F., Gkalpakiotis, Dimitrios, Schedifka, Andrea, Buheitel, Gernot, Streble, Joachim, II, Kececioglu, Deniz, Sandica, Eugen, Trusen, Burkhard, Berger, Felix, Miera, Oliver, Ovroutski, Stanislav, Peters, Björn, Schmitt, Katharina, Schubert, Stephan, Photiadis, Joachim, Opgen-Rhein, Bernd, Weiss, Katja, Berns, Christoph, Blumenthal-Barby, Carl-Christian, Boeckel, Thomas, Krusche, Susanne, Busse, Jürgen, Kästner, Andreas, Koch, Heike, Köpcke, Christian, Streichan, Frank, Timme, Jens, Franzbach, Birgit, Senft, Gabriela, Beyer, Frank, Winter, Klaus, Breuer, Johannes, Welz, Armin, Bahlmann, Jens, Griese, Eberhard, Lê, Trong Phi, Hebe, Joachim, Nürnberg, Jan-Hendrik, Magsaam, Annette, Müller, Ronald, Potthoff, Ludger, Voigt, Renate, Krüger, Tim, Gerleve, Hubert, Kleideiter, Ulrich, Schneider-Kulla, Dirk, Feil, Elmo, Menke, Thomas, Lehn, Martin, Grohmann, Martina, Tomczak, Helge, Krogmann, Otto N., Tarusinov, Gleb, Scheld, Michael, Mayatepek, Ertan, Pillekamp, Frank, Lichtenberg, Artur, Terpeluk, Christiane, von Jan, Veronika, Dittrich, Sven, Gundlach, Ulrike, Cesnjevar, Robert, Neudorf, Ulrich, Morf, Geert, Esmaeili, Anoosh, Backhoff, Stephan, Stiller, Brigitte, Beyersdorf, Friedhelm, Kroll, Johannes, Wildberg, Anke, Siaplaouras, Jannos, Masri-Zada, Antje, Jux, Christian, Böning, Andreas, Akintürk, Hakan, Paul, Thomas, Tirilomis, Theodor, Schürer, Gabriele, Hartmann, Johannes, Grabitz, Ralph, Liebaug, Uta, Rotzsch, Claudius, Kozlik-Feldmann, Rainer, Sachweh, Jörg, Riso, Arlindo, Petersen, Volker, Friedrich, Bernd, Schlobohm, Otmar, Beerbaum, Philipp, Böthig, Dietmar, Horke, Alexander, Bauersachs, Johann, Westhoff-Bleck, Mechthild, Gorenflo, Matthias, Karck, Matthias, Loukanov, Tsvetomir, Sebening, Christian, Schrüfer, Hermann, Wilken, Martin, Abdul-Khaliq, Hashim, Rädle-Hurst, Tanja, Rentzsch, Axel, Schäfers, Hans-Joachim, Reichert, Hagen, Kriebel, Thomas, Boysen, Arnulf, Kramer, Hans-Heiner, Cremer, Joachim Thomas, Scheewe, Jens, Buchholz-Berdau, Regina, Möller, Peter, Ram, Wolfgang, Brockmeier, Konrad, Bennink, Gerardus B.W.E., Gillor, Alex, Niehues, Tim, Terhoeven, Peter, Leidig, Steffen, Dähnert, Ingo, Kinzel, Peter, Kostelka, Martin, Kändler, Liane, Bethge, Martin, Köster, Stefan, Schröder, Christoph, Karstedt, Jens, Seitz, Uwe, Kampmann, Christoph, Vahl, Christian-Friedrich, Stahl, Frank, Barth, Helmut, Müller-Scholden, Joachim, Ewert, Peter, Hager, Alfred, Kaemmerer, Harald, Nagdyman, Nicole, Schoetzau, Jörg, Tutarel, Oktay, Lange, Rüdiger, Haas, Nikolaus A., Hakami, Lale, Hauser, Michael, Roithmaier, Alexander, Kehl, Hans Gerd, Malec, Edward, Baumgartner, Helmut, Diller, Gerhard, Bahle, Roswitha, Hofner, Gerald, Zink, Stefan, Reif, Roland, Parlasca, Christoph, Freund, Matthias W., Schumacher, Michael, Darrelmann, Christine, Motz, Reinald, Willmann, Olaf, Schmiedl, Norbert, Quick, Peter, Hillebrand, Dirk, Hirsemann, Petra, Eiselt, Stephan Michele, Nekarda, Torsten, Eberhard, Michael, Schneider, Martin, Asfour, Boulos, Baier, Georg, Uhlemann, Frank, Scheid, Michael, Beyer, Alexander, Binz, Gudrun, Teufel, Thomas, Handke, Ronald-Peter, Hofbeck, Michael, Kaulitz, Renate, Sieverding, Ludger, Schlensak, Christian, Apitz, Christian, Kupferschmid, Christoph, Holtvogt, Jürgen, Wippermann, Carl-Friedrich, Heusch, Andreas, Wirbelauer, Johannes, and Brosi, Wolfgang

Published
2018
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19. Impact of Right Ventricular Pressure Load After Repair of Tetralogy of Fallot

Author

Latus, Heiner, primary, Stammermann, Jana, additional, Voges, Inga, additional, Waschulzik, Birgit, additional, Gutberlet, Matthias, additional, Diller, Gerhard‐Paul, additional, Schranz, Dietmar, additional, Ewert, Peter, additional, Beerbaum, Philipp, additional, Kühne, Titus, additional, Sarikouch, Samir, additional, Kerst, Gunter, additional, Kanaan, Majed, additional, Lebherz, Corinna, additional, Rüffer, André, additional, Gkalpakiotis, Dimitrios, additional, Schedifka, Andrea, additional, Buheitel, Gernot, additional, Streble, Joachim, additional, Willing, Rainer, additional, Schubert, Stephan, additional, Laser, Kai Thorsten, additional, Sandica, Eugen, additional, Trusen, Burkhard, additional, Berger, Felix, additional, Miera, Oliver, additional, Ovroutski, Stanislav, additional, Schmitt, Katharina, additional, Photiadis, Joachim, additional, Opgen‐Rhein, Bernd, additional, Weiss, Katja, additional, Klaassen, Sabine, additional, Berns, Christoph, additional, Boeckel, Thomas, additional, Haverkämper, Guido, additional, Kästner, Andreas, additional, Koch, Heike, additional, Peters, Björn, additional, Schmidt, Florian, additional, Timme, Jens, additional, Engel, Konstanze, additional, Franzbach, Birgit, additional, Senft, Gabriela, additional, Beyer, Frank, additional, Winter, Klaus, additional, Breuer, Johannes, additional, Schneider, Martin, additional, Bahlmann, Jens, additional, Griese, Eberhard, additional, Lê, Trong Phi, additional, Hebe, Joachim, additional, Nürnberg, Jan‐Hendrik, additional, Magsaam, Annette, additional, Müller, Ronald, additional, Potthoff, Ludger, additional, Voigt, Renate, additional, Krüger, Tim, additional, Gerleve, Hubert, additional, Kleideiter, Ulrich, additional, Schneider‐Kulla, Dirk, additional, Krülls‐Münch, Jürgen, additional, Menke, Thomas, additional, Lehn, Martin, additional, Heilmann, Antje, additional, Tomczak, Helge, additional, Tarusinov, Gleb, additional, Scheid, Michael, additional, Mayatepek, Ertan, additional, Pillekamp, Frank, additional, Lichtenberg, Artur, additional, Terpeluk, Christiane, additional, Kolterer, Bruno, additional, Dittrich, Sven, additional, Gundlach, Ulrike, additional, Cesnjevar, Robert, additional, Müntjes, Carsten, additional, Morf, Geert, additional, Esmaeili, Anoosh, additional, Backhoff, Stephan, additional, Stiller, Brigitte, additional, Beyersdorf, Friedhelm, additional, Kroll, Johannes, additional, Häffner, Nicole, additional, Siaplaouras, Jannos, additional, Masri‐Zada, Antje, additional, Jux, Christian, additional, Böning, Andreas, additional, Akintürk, Hakan, additional, Paul, Thomas, additional, Sigler, Matthias, additional, Tirilomis, Theodor, additional, Schürer, Gabriele, additional, Hartmann, Johannes, additional, Grabitz, Ralph, additional, Liebaug, Uta, additional, Rotzsch, Claudius, additional, Kozlik‐Feldmann, Rainer, additional, Rickers, Carsten, additional, Mir, Thomas, additional, Hübler, Michael, additional, Sachweh, Jörg, additional, Renz, Stefan, additional, Schemm, Andreas, additional, Friedrich, Bernd, additional, Schlobohm, Otmar, additional, Böthig, Dietmar, additional, Wermter, Burkhard, additional, Kelter‐Klöpping, Andrea, additional, Horke, Alexander, additional, Bauersachs, Johann, additional, Westhoff‐Bleck, Mechthild, additional, Gorenflo, Matthias, additional, Karck, Matthias, additional, Loukanov, Tsvetomir, additional, Schrüfer, Hermann, additional, Wilken, Martin, additional, Abdul‐Khaliq, Hashim, additional, Rädle‐Hurst, Tanja, additional, Rentzsch, Axel, additional, Schäfers, Hans‐Joachim, additional, Reichert, Hagen, additional, Vilser, Daniel, additional, Kriebel, Thomas, additional, Boysen, Arnulf, additional, Uebing, Anselm, additional, Attmann, Tim, additional, Cremer, Joachim Thomas, additional, Scheewe, Jens, additional, Buchholz‐Berdau, Regina, additional, Möller, Peter, additional, Horter, Thorsten, additional, Brockmeier, Konrad, additional, Bennink, Gerardus B. W. E, additional, Baldus, Stephan, additional, Gillor, Alex, additional, Niehues, Tim, additional, Lawrenz, Wolfgang, additional, Leidig, Steffen, additional, Dähnert, Ingo, additional, Riede, Frank‐Thomas, additional, Kostelka, Martin, additional, Kändler, Liane, additional, Bethge, Martin, additional, Köster, Stefan, additional, Schröder, Christoph, additional, Karstedt, Jens, additional, Seitz, Uwe, additional, Kampmann, Christoph, additional, Dohle, Daniel‐Sebastian, additional, Stahl, Frank, additional, Abedini, Mojtaba, additional, Müller‐Scholden, Joachim, additional, Hager, Alfred, additional, Huntgeburth, Michael, additional, Kaemmerer, Harald, additional, Nagdyman, Nicole, additional, Schoetzau, Jörg, additional, Tutarel, Oktay, additional, Lange, Rüdiger, additional, Hörer, Jürgen, additional, Haas, Nikolaus A, additional, Hauser, Michael, additional, Roithmaier, Alexander, additional, Kehl, Hans‐Gerd, additional, Lammers, Astrid, additional, Malec, Edward, additional, Baumgartner, Helmut, additional, Diller, Gerhard, additional, Bahle, Roswitha, additional, Hofner, Gerald, additional, Zink, Stefan, additional, Reif, Roland, additional, Singer, Helmut, additional, Parlasca, Christoph, additional, Freund, Matthias W, additional, Schumacher, Michael, additional, Dewald, Oliver, additional, Darrelmann, Christine, additional, Willmann, Olaf, additional, Schmiedl, Norbert, additional, Quick, Peter, additional, Hillebrand, Dirk, additional, Michele Eiselt, Stephan, additional, Nekarda, Torsten, additional, Eberhard, Michael, additional, Baier, Georg, additional, Uhlemann, Frank, additional, Tzanavaros, Ioannis, additional, Beyer, Alexander, additional, Binz, Gudrun, additional, Hess, Steffen, additional, Teufel, Thomas, additional, Handke, Ronald‐Peter, additional, Hofbeck, Michael, additional, Kaulitz, Renate, additional, Sieverding, Ludger, additional, Schlensak, Christian, additional, Apitz, Christian, additional, Kaestner, Michael, additional, Holtvogt, Jürgen, additional, Wippermann, Carl‐Friedrich, additional, Hinz, Sönke, additional, Heusch, Andreas, additional, Wirbelauer, Johannes, additional, and Brosi, Wolfgang, additional

Published
2022
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37. Serial right ventricular assessment in patients with hypoplastic left heart syndrome: a multiparametric cardiovascular magnetic resonance study.

Author

Sobh, Mohamed, Freitag-Wolf, Sandra, Scheewe, Jens, Kanngiesser, Luca M, Uebing, Anselm S, Gabbert, Dominik D, and Voges, Inga

Subjects
HYPOPLASTIC left heart syndrome, MAGNETIC resonance, OLDER patients, CARDIAC magnetic resonance imaging
Abstract

Open in new tab Download slide Open in new tab Download slide OBJECTIVES The aim of this study was to assess single right ventricular (RV) function in a large cohort of hypoplastic left heart syndrome (HLHS) patients after the completion of total cavopulmonary connection by analysing serial cardiovascular magnetic resonance (CMR) studies. METHODS CMR studies from 95 HLHS patients were analysed. RV end-diastolic and end-systolic volumes (RVEDV, RVESV), ejection fraction (RVEF) and long-axis strain (LAS) were measured from cine images. RESULTS All 95 patients had at least 2 CMR scans and 35 patients had 3 CMR scans. The median age (first quartile–third quartile) at the 3 examinations was 4.2 (3.3–6.1), 9.4 (6.1–11.4) and 14.6 (11.8–16.8) years. RV indexed volumes (RVEDVi and RVESVi) increased from first to the second and from the first and second examination to the third examination in patients with >10 years of age (P  < 0.05). There was a slight decrease in RVEF and LAS throughout the examinations, but this was not statistically significant. Correlations were found between RVEF and LAS (r  = −0.23; P  < 0.01). Both RVEF and LAS correlated with RVEDVi and RVESVi (r  = −0.17 to 0.43; P  < 0.05). CONCLUSIONS Serial assessment of CMR studies in HLHS patients after total cavopulmonary connection completion demonstrate an increase in indexed RV volumes in older HLHS patients but only mild reduction in RVEF and LAS. The correlation of indexed RV volumes with RVEF and LAS together with the significant increase in RV volumes over time suggests that indexed RV volumes might be superior to RV functional markers to monitor the RV in HLHS patients. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Additional file 5: of DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs

Author

Hoff, Kirstin, Lemme, Marta, Anne-Karin Kahlert, Runde, Kerstin, Audain, Enrique, Schuster, Dorit, Scheewe, Jens, Attmann, Tim, Pickardt, Thomas, Caliebe, Almuth, Siebert, Reiner, Hans-Heiner Kramer, Milting, Hendrik, Hansen, Arne, Ammerpohl, Ole, and Marc-Phillip Hitz

Subjects
animal structures, embryonic structures, human activities
Abstract

Figure S5. Regulatory features and associations to UCSC gene regions among 168 differentially methylated atrial-ventricular CpGs. Regulatory features and UCSC gene regions of all 168 CpGs (‘overall’), of ventricular-hypo/atrial-hypermethylated CpGs (‘ventricle hypo/ atrium hyper’ n = 44 CpGs) and ventricular-hyper/atrial-hypomethylated CpGs (‘ventricle hyper/ atrium hypo’ n = 124 CpGs) of 450K array analysis are depicted. Highest percentage of overlap with regulatory features (ENCODE) could be shown in enhancer elements (ENH) (50% (84/168) of CpGs), CpG island shores (29% (48/168) of CpGs) and DNAse I hypersensitivity sites (DHS) with 14% (24/168). Associations to UCSC gene regions showed highest proportion in gene bodies (30% (51/168) of CpGs). Besides CpG island shores, which showed a higher proportion in ‘ventricle hypo/ atrium hyper’-CpGs as compared to ‘ventricle hyper/ atrium hypo’-CpGs, all other regulatory features or gene regions did not show any difference between heart tissues. Shore, 0–2 kb from of UCSC CpG island; shelf, 2–4 kb from UCSC CpG island. TSS200, 0–200 bases upstream of the transcriptional start site, TSS1500, 0.2–1.5 kb upstream of the TSS. DMR: differentially methylated region (RDMR: DMR in reprogrammed cells). Gene regions of the CpGs are given according to Illumina’s 450K array classifications and UCSC classifications. (PDF 299 kb)

Published
2019
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39. Additional file 6: of DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs

Author

Hoff, Kirstin, Lemme, Marta, Anne-Karin Kahlert, Runde, Kerstin, Audain, Enrique, Schuster, Dorit, Scheewe, Jens, Attmann, Tim, Pickardt, Thomas, Caliebe, Almuth, Siebert, Reiner, Hans-Heiner Kramer, Milting, Hendrik, Hansen, Arne, Ammerpohl, Ole, and Marc-Phillip Hitz

Abstract

Figure S6. Transcription factor binding sites subject to differential DNA methylation among 168 CpGs. Analysis of 168 differentially methylated CpGs between atrial and ventricular heart tissue revealed an overlap of 54% (90/168) of CpG loci being associated to TFBSs in various cell lines from ChIP-seq experiments performed by ENCODE (Factorbook Motifs [32]). The ten most common TFs showing TFBSs among the 168 CpGs are labelled: POLR2A, EZH2, EP300, GATA2, FOS, RUNX3, CEBPB, TCF7L2, MAX and TEAD4. Only TFBSs with Cluster Scores (out of 1000) >â 300 are listed (Additional file 15: Table S2). (PDF 354 kb)

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2019
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40. Additional file 1: of DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs

Author

Hoff, Kirstin, Lemme, Marta, Anne-Karin Kahlert, Runde, Kerstin, Audain, Enrique, Schuster, Dorit, Scheewe, Jens, Attmann, Tim, Pickardt, Thomas, Caliebe, Almuth, Siebert, Reiner, Hans-Heiner Kramer, Milting, Hendrik, Hansen, Arne, Ammerpohl, Ole, and Marc-Phillip Hitz

Subjects
cardiovascular system
Abstract

Figure S1. Principal component analysis of cardiac disease type among 448,814 loci. The segregation of β-values of 448,814 loci from 49 different cardiac tissue samples (mean values of biological replicates, for detailed information see Additional file 14: Table S1) that were subjected to 450K array DNA methylation analysis is depicted. Cardiac disease types are given in different colours and shapes: AVSD (red round dots), DCM (yellow triangles), HLHS (green solid squares), HRHS (blue crosses), LV-Aneurysm (purple squares). No differences in DNA methylation could be observed between different types of cardiac disease. (PDF 1442 kb)

Published
2019
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41. Additional file 9: of DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs

Author

Hoff, Kirstin, Lemme, Marta, Anne-Karin Kahlert, Runde, Kerstin, Audain, Enrique, Schuster, Dorit, Scheewe, Jens, Attmann, Tim, Pickardt, Thomas, Caliebe, Almuth, Siebert, Reiner, Hans-Heiner Kramer, Milting, Hendrik, Hansen, Arne, Ammerpohl, Ole, and Marc-Phillip Hitz

Abstract

Figure S9. Correlation between methylation values of 450K array and bisulfite pyrosequencing (DNAH2, FGFR2, IRX4 and LINC00982). Linear regression analysis of methylation values (percentage) at four candidate CpG loci (on DNAH2, FGFR2, IRX4 and LINC00982) from 11 cardiac tissue samples that have been subjected to 450K array analysis (β-values as percentage on x-axis) and bisulfite pyrosequencing (y-axis). The 11 samples of the verification set are listed in Additional file 14: Table S1. At all four candidate CpG loci a high correlation of the methylation values (R2 ranging from 0.98 to 0.99, and p values ranging from p = 1.7 × 10−7 to p = 8.2 × 10−10) from the two platforms, 450K array and bisulfite pyrosequencing, could be verified. (PDF 1201 kb)

Published
2019
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42. Additional file 8: of DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs

Author

Hoff, Kirstin, Lemme, Marta, Anne-Karin Kahlert, Runde, Kerstin, Audain, Enrique, Schuster, Dorit, Scheewe, Jens, Attmann, Tim, Pickardt, Thomas, Caliebe, Almuth, Siebert, Reiner, Hans-Heiner Kramer, Milting, Hendrik, Hansen, Arne, Ammerpohl, Ole, and Marc-Phillip Hitz

Subjects
cardiovascular system, cardiovascular diseases
Abstract

Figure S8. Boxplots (t test) of 16 candidate CpG loci with differential atrial-ventricular methylation pattern. Differential DNA methylation (β-value) of 16 candidate CpG loci in atrial (n = 44) and ventricular (n = 5) cardiac tissue samples being either hypomethylated or hypermethylated in atrial tissue (coloured blue) compared to ventricular tissue (coloured red). Highly significant DNA methylation differences (p ≤ 0.0001) in atrial vs. ventricular tissues have been detected at 13 of 16 CpG loci (Welch Two Sample t test) with 9 loci displaying p values

Published
2019
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43. Additional file 2: of DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs

Author

Hoff, Kirstin, Lemme, Marta, Anne-Karin Kahlert, Runde, Kerstin, Audain, Enrique, Schuster, Dorit, Scheewe, Jens, Attmann, Tim, Pickardt, Thomas, Caliebe, Almuth, Siebert, Reiner, Hans-Heiner Kramer, Milting, Hendrik, Hansen, Arne, Ammerpohl, Ole, and Marc-Phillip Hitz

Abstract

Figure S2. Principal component analysis of 450K array sentrix ID among 448,814 loci. The segregation of β-values of 448,814 loci from 49 different cardiac tissue samples (mean values of biological replicates, for detailed information see Additional file 14: Table S1) that were subjected to 450K array DNA methylation analysis is depicted. Sentrix IDs of different array slides are given in different colours and shapes as described in the figure legend. No batch effects due to sample distribution on the array occurred. (PDF 2126 kb)

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2019
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44. Additional file 4: of DNA methylation profiling allows for characterization of atrial and ventricular cardiac tissues and hiPSC-CMs

Author

Hoff, Kirstin, Lemme, Marta, Anne-Karin Kahlert, Runde, Kerstin, Audain, Enrique, Schuster, Dorit, Scheewe, Jens, Attmann, Tim, Pickardt, Thomas, Caliebe, Almuth, Siebert, Reiner, Hans-Heiner Kramer, Milting, Hendrik, Hansen, Arne, Ammerpohl, Ole, and Marc-Phillip Hitz

Subjects
cardiovascular system
Abstract

Figure S4. Unsupervised principal component analysis of β-values from 49 cardiac tissue samples. The segregation of β-values of 2045 CpG loci (σ/σmax > 0.4) of 49 different cardiac tissue samples (IAS, LA, RA, LV, RV) that were subjected to 450K array analysis is depicted. Subgroups of atrial and ventricular samples are marked as dashed and solid edging, respectively. IAS: red spheres, LA: pink spheres, RA: green spheres, LV: blue spheres, RV: yellow spheres. Tendencies of segregation into two groups, atrial and ventricular cardiac tissues, could already be noticed in unsupervised analysis. (PDF 252 kb)

Published
2019
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50. Right ventricular outflow tract reconstruction with the Labcor® stentless valved pulmonary conduit.

Author

Jussli-Melchers, Jill, Scheewe, Jens, Hansen, Jan Hinnerk, Grothusen, Christina, Steer, Julia, Voges, Inga, Logoteta, Jana, Dütschke, Peter, Kramer, Hans-Heiner, and Attmann, Tim

Subjects
*TETRALOGY of Fallot, *PULMONARY artery, *VENTRICULAR outflow obstruction, *CARDIAC surgery, *CONFIDENCE intervals, *LONGEVITY
Abstract

Open in new tab Download slide Open in new tab Download slide OBJECTIVES The right ventricular outflow tract reconstruction is a common necessity in congenital cardiac surgery. As homograft availability is limited, alternatives need to be evaluated. The Labcor® conduit consists of a porcine tricomposite valve assembled inside a bovine pericardium tube. This study presents intermediate-term results for its utilization for right ventricular outflow tract reconstruction. METHODS Labcor conduits were implanted in 53 patients (February 2009–July 2016). We analysed perioperative data, freedom from conduit failure and risk factors for conduit dysfunction. RESULTS The most common diagnosis was Tetralogy of Fallot (n  = 20, 37.7%). The median age at surgery was 10.0 [interquartile range (IQR) 4.9–14.3] years. Pulmonary artery plasty (n  = 37, 69.8%) and augmentation of the right ventricular outflow tract (n  = 16, 30.2%) were often part of the procedure. The median conduit size was 21 (range 11–25) mm. There was no in-hospital death. The median follow-up after surgery was 4.6 (IQR 3.4–5.6) years. Fourteen patients (27.5%) developed conduit failure with stenosis being the main cause. Freedom from conduit failure was 98.0% at 2 and 80.5% at 5 years. The median longevity of the conduit was 7.4 years (95% confidence interval 5.1–9.8 years). Younger age and smaller conduit size were related to conduit failure. CONCLUSIONS Utilization of the Labcor conduit revealed acceptable intermediate-term results. The conduit appeared to be functioning sufficiently well within the first 5 years in the majority of patients. The higher rate of failure concerning smaller conduits might be associated with somatic outgrowth; however, conduit degeneration as common and long-term outcome still needs to be evaluated. [ABSTRACT FROM AUTHOR]

Published
2020
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