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109 results on '"Scheenen, Tom W.J."'

2. Prostate-Specific Membrane Antigen–Targeted Radioguided Pelvic Lymph Node Dissection in Newly Diagnosed Prostate Cancer Patients with a Suspicion of Locoregional Lymph Node Metastases: The DETECT Trial

Author

Schilham, Melline G.M., primary, Somford, Diederik M., additional, Küsters-Vandevelde, Heidi V.N., additional, Hermsen, Rick, additional, van Basten, Jean Paul A., additional, Hoekstra, Robert J., additional, Scheenen, Tom W.J., additional, Gotthardt, Martin, additional, Sedelaar, J.P. Michiel, additional, and Rijpkema, Mark, additional

Published
2024
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5. Utilizing MRI, [18F]FDG-PET and [ 89Zr]Zr-DFO-28H1 FAP-PET tracer to assess inflammation and fibrogenesis in a reproducible lung injury rat model: a multimodal imaging study.

Author

Boswinkel, Milou, Raavé, René, Veltien, Andor, Scheenen, Tom W.J., Petterson, Nina Fransén, in ‘t Zandt, René, Olsson, Lars E., von Wachenfeldt, Karin, Heskamp, Sandra, and Persson, Irma Mahmutovic

Subjects
LUNG injuries, DIAGNOSTIC imaging, ANIMAL disease models, MAGNETIC resonance imaging, INTERSTITIAL lung diseases, LUNG diseases, PULMONARY fibrosis
Abstract

Objective: Accurate imaging biomarkers that indicate disease progression at an early stage are highly important to enable timely mitigation of symptoms in progressive lung disease. In this context, reproducible experimental models and readouts are key. Here, we aim to show reproducibility of a lung injury rat model, by inducing disease and assessing disease progression by multi-modal non-invasive imaging techniques at two different research sites. Furthermore, we evaluated the potential of fibroblast activating protein (FAP) as an imaging biomarker in the early stage of lung fibrosis. Methods: An initial lung injury rat model was set up at one research site (Lund University, Lund, Sweden) and repeated at a second site (Radboudumc, Nijmegen, The Netherlands). To induce lung injury, Sprague-Dawley rats received intratracheal instillation of bleomycin as one single dose (1,000 iU in 200 µL) or saline as control. Thereafter, longitudinal images were acquired to track inflammation in the lungs, at 1 and 2 weeks after the bleomycin challenge by magnetic resonance imaging (MRI) and [18F]FDG-PET. After the final [18F]FDG-PET scan, rats received an intravenous tracer [89Zr]Zr-DFO-28H1 (anti-FAP antibody) and were imaged at day 15, to track fibrogenesis. Upon termination, bronchoalveolar lavage (BAL) was performed to assess cell and protein concentration. Subsequently, the biodistribution of [89Zr]Zr-DFO-28H1 was measured ex vivo and the spatial distribution in lung tissue was studied by autoradiography. Lung sections were stained, and fibrosis assessed using the modified Ashcroft score. Results: Bleomycin-challenged rats showed body weight loss and increased numbers of immune cells and protein concentrations after BAL compared with control animals. The initiation and progression of the disease were reproduced at both research sites. Lung lesions in bleomycin-exposed rats were visualized by MRI and confirmed by histology. [18F]FDG uptake was higher in the lungs of bleomycin-challenged rats compared with the controls, similar to that observed in the Lund study. [89Zr]Zr-DFO-28H1 tracer uptake in the lung was increased in bleomycin-challenged rats compared with control rats (p = 0.03). Conclusion: Here, we demonstrate a reproducible lung injury model and monitored disease progression using conventional imaging biomarkers MRI and [18F]FDG-PET. Furthermore, we showed the first proof-of-concept of FAP imaging. This reproducible and robust animal model and imaging experimental set-up allows for future research on new therapeutics or biomarkers in lung disease. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Supplementary Data from Lutetium-177-PSMA-617 in Low-Volume Hormone-Sensitive Metastatic Prostate Cancer: A Prospective Pilot Study

Author

Privé, Bastiaan M., primary, Peters, Steffie M.B., primary, Muselaers, Constantijn H.J., primary, van Oort, Inge M., primary, Janssen, Marcel J.R., primary, Sedelaar, J.P. Michiel, primary, Konijnenberg, Mark W., primary, Zámecnik, Patrik, primary, Uijen, Maike J.M., primary, Schilham, Melline G.M., primary, Eek, Annemarie, primary, Scheenen, Tom W.J., primary, Verzijlbergen, J. Fred, primary, Gerritsen, Winald R., primary, Mehra, Niven, primary, Kerkmeijer, Linda G.W., primary, Smeenk, Robert J., primary, Somford, Diederik M., primary, van Basten, Jean-Paul A., primary, Heskamp, Sandra, primary, Barentsz, Jelle O., primary, Gotthardt, Martin, primary, Witjes, J. Alfred, primary, and Nagarajah, James, primary

Published
2023
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7. Glucose versus fructose metabolism in the liver measured with deuterium metabolic imaging

Author

Highfield Research Group, Cancer, Circulatory Health, Hendriks, Arjan D., Veltien, Andor, Voogt, Ingmar J., Heerschap, Arend, Scheenen, Tom W.J., Prompers, Jeanine J., Highfield Research Group, Cancer, Circulatory Health, Hendriks, Arjan D., Veltien, Andor, Voogt, Ingmar J., Heerschap, Arend, Scheenen, Tom W.J., and Prompers, Jeanine J.

Published
2023

8. Author Correction: A consensus protocol for functional connectivity analysis in the rat brain (Nature Neuroscience, (2023), 26, 4, (673-681), 10.1038/s41593-023-01286-8)

Author

In Vivo NMR ISI, Trialbureau Beeld, Brain, Circulatory Health, Stroke, Hubrecht Institute with UMC, Projectafdeling KIND, Grandjean, Joanes, Desrosiers-Gregoire, Gabriel, Anckaerts, Cynthia, Angeles-Valdez, Diego, Ayad, Fadi, Barrière, David A., Blockx, Ines, Bortel, Aleksandra, Broadwater, Margaret, Cardoso, Beatriz M., Célestine, Marina, Chavez-Negrete, Jorge E., Choi, Sangcheon, Christiaen, Emma, Clavijo, Perrin, Colon-Perez, Luis, Cramer, Samuel, Daniele, Tolomeo, Dempsey, Elaine, Diao, Yujian, Doelemeyer, Arno, Dopfel, David, Dvořáková, Lenka, Falfán-Melgoza, Claudia, Fernandes, Francisca F., Fowler, Caitlin F., Fuentes-Ibañez, Antonio, Garin, Clément M., Gelderman, Eveline, Golden, Carla E.M., Guo, Chao C.G., Henckens, Marloes J.A.G., Hennessy, Lauren A., Herman, Peter, Hofwijks, Nita, Horien, Corey, Ionescu, Tudor M., Jones, Jolyon, Kaesser, Johannes, Kim, Eugene, Lambers, Henriette, Lazari, Alberto, Lee, Sung Ho, Lillywhite, Amanda, Liu, Yikang, Liu, Yanyan Y., López -Castro, Alejandra, López-Gil, Xavier, Ma, Zilu, MacNicol, Eilidh, Madularu, Dan, Mandino, Francesca, Marciano, Sabina, McAuslan, Matthew J., McCunn, Patrick, McIntosh, Alison, Meng, Xianzong, Meyer-Baese, Lisa, Missault, Stephan, Moro, Federico, Naessens, Daphne M.P., Nava-Gomez, Laura J., Nonaka, Hiroi, Ortiz, Juan J., Paasonen, Jaakko, Peeters, Lore M., Pereira, Mickaël, Perez, Pablo D., Pompilus, Marjory, Prior, Malcolm, Rakhmatullin, Rustam, Reimann, Henning M., Reinwald, Jonathan, Del Rio, Rodrigo Triana, Rivera-Olvera, Alejandro, Ruiz-Pérez, Daniel, Russo, Gabriele, Rutten, Tobias J., Ryoke, Rie, Sack, Markus, Salvan, Piergiorgio, Sanganahalli, Basavaraju G., Schroeter, Aileen, Seewoo, Bhedita J., Selingue, Erwan, Seuwen, Aline, Shi, Bowen, Sirmpilatze, Nikoloz, Smith, Joanna A.B., Smith, Corrie, Sobczak, Filip, Stenroos, Petteri J., Straathof, Milou, Strobelt, Sandra, Sumiyoshi, Akira, Takahashi, Kengo, Torres-García, Maria E., Tudela, Raul, van den Berg, Monica, van der Marel, Kajo, van Hout, Aran T.B., Vertullo, Roberta, Vidal, Benjamin, Vrooman, Roël M., Wang, Victora X., Wank, Isabel, Watson, David J.G., Yin, Ting, Zhang, Yongzhi, Zurbruegg, Stefan, Achard, Sophie, Alcauter, Sarael, Auer, Dorothee P., Barbier, Emmanuel L., Baudewig, Jürgen, Beckmann, Christian F., Beckmann, Nicolau, Becq, Guillaume J.P.C., Blezer, Erwin L.A., Bolbos, Radu, Boretius, Susann, Bouvard, Sandrine, Budinger, Eike, Buxbaum, Joseph D., Cash, Diana, Chapman, Victoria, Chuang, Kai Hsiang, Ciobanu, Luisa, Coolen, Bram F., Dalley, Jeffrey W., Dhenain, Marc, Dijkhuizen, Rick M., Esteban, Oscar, Faber, Cornelius, Febo, Marcelo, Feindel, Kirk W., Forloni, Gianluigi, Fouquet, Jérémie, Garza-Villarreal, Eduardo A., Gass, Natalia, Glennon, Jeffrey C., Gozzi, Alessandro, Gröhn, Olli, Harkin, Andrew, Heerschap, Arend, Helluy, Xavier, Herfert, Kristina, Heuser, Arnd, Homberg, Judith R., Houwing, Danielle J., Hyder, Fahmeed, Ielacqua, Giovanna Diletta, Jelescu, Ileana O., Johansen-Berg, Heidi, Kaneko, Gen, Kawashima, Ryuta, Keilholz, Shella D., Keliris, Georgios A., Kelly, Clare, Kerskens, Christian, Khokhar, Jibran Y., Kind, Peter C., Langlois, Jean Baptiste, Lerch, Jason P., López-Hidalgo, Monica A., Manahan-Vaughan, Denise, Marchand, Fabien, Mars, Rogier B., Marsella, Gerardo, Micotti, Edoardo, Muñoz-Moreno, Emma, Near, Jamie, Niendorf, Thoralf, Otte, Willem M., Pais-Roldán, Patricia, Pan, Wen Ju, Prado-Alcalá, Roberto A., Quirarte, Gina L., Rodger, Jennifer, Rosenow, Tim, Sampaio-Baptista, Cassandra, Sartorius, Alexander, Sawiak, Stephen J., Scheenen, Tom W.J., Shemesh, Noam, Shih, Yen Yu Ian, Shmuel, Amir, Soria, Guadalupe, Stoop, Ron, Thompson, Garth J., Till, Sally M., Todd, Nick, Van Der Linden, Annemie, van der Toorn, Annette, van Tilborg, Geralda A.F., Vanhove, Christian, Veltien, Andor, Verhoye, Marleen, Wachsmuth, Lydia, Weber-Fahr, Wolfgang, Wenk, Patricia, Yu, Xin, Zerbi, Valerio, Zhang, Nanyin, Zhang, Baogui B., Zimmer, Luc, Devenyi, Gabriel A., Chakravarty, M. Mallar, Hess, Andreas, In Vivo NMR ISI, Trialbureau Beeld, Brain, Circulatory Health, Stroke, Hubrecht Institute with UMC, Projectafdeling KIND, Grandjean, Joanes, Desrosiers-Gregoire, Gabriel, Anckaerts, Cynthia, Angeles-Valdez, Diego, Ayad, Fadi, Barrière, David A., Blockx, Ines, Bortel, Aleksandra, Broadwater, Margaret, Cardoso, Beatriz M., Célestine, Marina, Chavez-Negrete, Jorge E., Choi, Sangcheon, Christiaen, Emma, Clavijo, Perrin, Colon-Perez, Luis, Cramer, Samuel, Daniele, Tolomeo, Dempsey, Elaine, Diao, Yujian, Doelemeyer, Arno, Dopfel, David, Dvořáková, Lenka, Falfán-Melgoza, Claudia, Fernandes, Francisca F., Fowler, Caitlin F., Fuentes-Ibañez, Antonio, Garin, Clément M., Gelderman, Eveline, Golden, Carla E.M., Guo, Chao C.G., Henckens, Marloes J.A.G., Hennessy, Lauren A., Herman, Peter, Hofwijks, Nita, Horien, Corey, Ionescu, Tudor M., Jones, Jolyon, Kaesser, Johannes, Kim, Eugene, Lambers, Henriette, Lazari, Alberto, Lee, Sung Ho, Lillywhite, Amanda, Liu, Yikang, Liu, Yanyan Y., López -Castro, Alejandra, López-Gil, Xavier, Ma, Zilu, MacNicol, Eilidh, Madularu, Dan, Mandino, Francesca, Marciano, Sabina, McAuslan, Matthew J., McCunn, Patrick, McIntosh, Alison, Meng, Xianzong, Meyer-Baese, Lisa, Missault, Stephan, Moro, Federico, Naessens, Daphne M.P., Nava-Gomez, Laura J., Nonaka, Hiroi, Ortiz, Juan J., Paasonen, Jaakko, Peeters, Lore M., Pereira, Mickaël, Perez, Pablo D., Pompilus, Marjory, Prior, Malcolm, Rakhmatullin, Rustam, Reimann, Henning M., Reinwald, Jonathan, Del Rio, Rodrigo Triana, Rivera-Olvera, Alejandro, Ruiz-Pérez, Daniel, Russo, Gabriele, Rutten, Tobias J., Ryoke, Rie, Sack, Markus, Salvan, Piergiorgio, Sanganahalli, Basavaraju G., Schroeter, Aileen, Seewoo, Bhedita J., Selingue, Erwan, Seuwen, Aline, Shi, Bowen, Sirmpilatze, Nikoloz, Smith, Joanna A.B., Smith, Corrie, Sobczak, Filip, Stenroos, Petteri J., Straathof, Milou, Strobelt, Sandra, Sumiyoshi, Akira, Takahashi, Kengo, Torres-García, Maria E., Tudela, Raul, van den Berg, Monica, van der Marel, Kajo, van Hout, Aran T.B., Vertullo, Roberta, Vidal, Benjamin, Vrooman, Roël M., Wang, Victora X., Wank, Isabel, Watson, David J.G., Yin, Ting, Zhang, Yongzhi, Zurbruegg, Stefan, Achard, Sophie, Alcauter, Sarael, Auer, Dorothee P., Barbier, Emmanuel L., Baudewig, Jürgen, Beckmann, Christian F., Beckmann, Nicolau, Becq, Guillaume J.P.C., Blezer, Erwin L.A., Bolbos, Radu, Boretius, Susann, Bouvard, Sandrine, Budinger, Eike, Buxbaum, Joseph D., Cash, Diana, Chapman, Victoria, Chuang, Kai Hsiang, Ciobanu, Luisa, Coolen, Bram F., Dalley, Jeffrey W., Dhenain, Marc, Dijkhuizen, Rick M., Esteban, Oscar, Faber, Cornelius, Febo, Marcelo, Feindel, Kirk W., Forloni, Gianluigi, Fouquet, Jérémie, Garza-Villarreal, Eduardo A., Gass, Natalia, Glennon, Jeffrey C., Gozzi, Alessandro, Gröhn, Olli, Harkin, Andrew, Heerschap, Arend, Helluy, Xavier, Herfert, Kristina, Heuser, Arnd, Homberg, Judith R., Houwing, Danielle J., Hyder, Fahmeed, Ielacqua, Giovanna Diletta, Jelescu, Ileana O., Johansen-Berg, Heidi, Kaneko, Gen, Kawashima, Ryuta, Keilholz, Shella D., Keliris, Georgios A., Kelly, Clare, Kerskens, Christian, Khokhar, Jibran Y., Kind, Peter C., Langlois, Jean Baptiste, Lerch, Jason P., López-Hidalgo, Monica A., Manahan-Vaughan, Denise, Marchand, Fabien, Mars, Rogier B., Marsella, Gerardo, Micotti, Edoardo, Muñoz-Moreno, Emma, Near, Jamie, Niendorf, Thoralf, Otte, Willem M., Pais-Roldán, Patricia, Pan, Wen Ju, Prado-Alcalá, Roberto A., Quirarte, Gina L., Rodger, Jennifer, Rosenow, Tim, Sampaio-Baptista, Cassandra, Sartorius, Alexander, Sawiak, Stephen J., Scheenen, Tom W.J., Shemesh, Noam, Shih, Yen Yu Ian, Shmuel, Amir, Soria, Guadalupe, Stoop, Ron, Thompson, Garth J., Till, Sally M., Todd, Nick, Van Der Linden, Annemie, van der Toorn, Annette, van Tilborg, Geralda A.F., Vanhove, Christian, Veltien, Andor, Verhoye, Marleen, Wachsmuth, Lydia, Weber-Fahr, Wolfgang, Wenk, Patricia, Yu, Xin, Zerbi, Valerio, Zhang, Nanyin, Zhang, Baogui B., Zimmer, Luc, Devenyi, Gabriel A., Chakravarty, M. Mallar, and Hess, Andreas

Published
2023

9. A Single-Arm, Multicenter Validation Study of Prostate Cancer Localization and Aggressiveness With a Quantitative Multiparametric Magnetic Resonance Imaging Approach

Author

Maas, Marnix C., Litjens, Geert J.S., Wright, Alan J., Attenberger, Ulrike I., Haider, Masoom A., Helbich, Thomas H., Kiefer, Berthold, Macura, Katarzyna J., Margolis, Daniel J.A., Padhani, Anwar R., Selnæs, Kirsten M., Villeirs, Geert M., Fütterer, Jurgen J., and Scheenen, Tom W.J.

Published
2019
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11. 19F MRI Imaging Strategies to Reduce Isoflurane Artifacts in In Vivo Images

Author

Staal, Alexander H.J., Veltien, Andor, Srinivas, Mangala, Scheenen, Tom W.J., Staal, Alexander H.J., Veltien, Andor, Srinivas, Mangala, and Scheenen, Tom W.J.

Abstract

Purpose: Isoflurane (ISO) is the most commonly used preclinical inhalation anesthetic. This is a problem in 19F MRI of fluorine contrast agents, as ISO signals cause artifacts that interfere with unambiguous image interpretation and quantification; the two most attractive properties of heteronuclear MRI. We aimed to avoid these artifacts using MRI strategies that can be applied by any pre-clinical researcher. Procedures: Three strategies to avoid ISO chemical shift displacement artifacts (CSDA) in 19F MRI are described and demonstrated with measurements of 19F-containing agents in phantoms and in vivo (n = 3 for all strategies). The success of these strategies is compared to a standard Rapid Acquisition with Relaxation Enhancement (RARE) sequence, with phantom and in vivo validation. ISO artifacts can successfully be avoided by (1) shifting them outside the region of interest using a narrow signal acquisition bandwidth, (2) suppression of ISO by planning a frequency-selective suppression pulse before signal acquisition or by (3) preventing ISO excitation with a 3D sequence with a narrow excitation bandwidth. Results: All three strategies result in complete ISO signal avoidance (p < 0.0001 for all methods). Using a narrow acquisition bandwidth can result in loss of signal to noise ratio and distortion of the image, and a frequency-selective suppression pulse can be incomplete when B1-inhomogeneities are present. Preventing ISO excitation with a narrow excitation pulse in a 3D sequence yields the most robust results (relative SNR 151 ± 28% compared to 2D multislice methods, p = 0.006). Conclusion: We optimized three easily implementable methods to avoid ISO signal artifacts and validated their performance in phantoms and in vivo. We make recommendation on the parameters that pre-clinical studies should report in their method section to make the used approach insightful.

Published
2022

12. Validation of In Vivo Nodal Assessment of Solid Malignancies with USPIO-Enhanced MRI: A Workflow Protocol

Author

Pathologie Pathologen staf, Cancer, Driessen, Daphne A.J.J., de Gouw, Didi J.J.M., Stijns, Rutger C.H., Litjens, Geke, Israël, Bas, Philips, Bart W.J., Hermans, John J., Dijkema, Tim, Klarenbeek, Bastiaan R., van der Post, Rachel S., Nagtegaal, Iris D., van Engen-Van Grunsven, Adriana C.H., Brosens, Lodewijk A.A., Veltien, Andor, Zámecnik, Patrik, Scheenen, Tom W.J., Pathologie Pathologen staf, Cancer, Driessen, Daphne A.J.J., de Gouw, Didi J.J.M., Stijns, Rutger C.H., Litjens, Geke, Israël, Bas, Philips, Bart W.J., Hermans, John J., Dijkema, Tim, Klarenbeek, Bastiaan R., van der Post, Rachel S., Nagtegaal, Iris D., van Engen-Van Grunsven, Adriana C.H., Brosens, Lodewijk A.A., Veltien, Andor, Zámecnik, Patrik, and Scheenen, Tom W.J.

Published
2022

13. A Comprehensive Grading System for a Magnetic Sentinel Lymph Node Biopsy Procedure in Head and Neck Cancer Patients

Author

MS Hoofd-Hals Chirurgische Oncologie, Cancer, Nieuwenhuis, Eliane R., Kolenaar, Barry, Hof, Jurrit J., Baarlen, Joop van, van Bemmel, Alexander J.M., Christenhusz, Anke, Scheenen, Tom W.J., Ten Haken, Bernard, de Bree, Remco, Alic, Lejla, MS Hoofd-Hals Chirurgische Oncologie, Cancer, Nieuwenhuis, Eliane R., Kolenaar, Barry, Hof, Jurrit J., Baarlen, Joop van, van Bemmel, Alexander J.M., Christenhusz, Anke, Scheenen, Tom W.J., Ten Haken, Bernard, de Bree, Remco, and Alic, Lejla

Published
2022

16. Advanced single voxel 1H magnetic resonance spectroscopy techniques in humans: Experts' consensus recommendations

Author

Öz, Gülin, Deelchand, Dinesh K., Wijnen, Jannie P., Mlynárik, Vladimír, Xin, Lijing, Mekle, Ralf, Noeske, Ralph, Scheenen, Tom W.J., Tkáč, Ivan, Andronesi, Ovidiu, Barker, Peter B., Bartha, Robert, Berrington, Adam, Boer, Vincent, Cudalbu, Christina, Emir, Uzay E., Ernst, Thomas, Fillmer, Ariane, Heerschap, Arend, Henry, Pierre Gilles, Hurd, Ralph E., Joers, James M., Juchem, Christoph, Kan, Hermien E., Klomp, Dennis W.J., Kreis, Roland, Landheer, Karl, Mangia, Silvia, Marjańska, Małgorzata, Near, Jamie, Ratai, Eva M., and Ronen, Itamar

Subjects
Scanner, Computer science, Single voxel, brain, computer.software_genre, B1 field, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, chemical shift displacement, 0302 clinical medicine, Voxel, SPECIAL, shimming, Radiology, Nuclear Medicine and imaging, reproducibility, Spectroscopy, metabolites, Shift displacement, business.industry, Shim (magnetism), Pattern recognition, semiadiabatic LASER, body, Molecular Medicine, Artificial intelligence, business, Proton mrs, Quality assurance, computer, 030217 neurology & neurosurgery
Abstract

Conventional proton MRS has been successfully utilized to noninvasively assess tissue biochemistry in conditions that result in large changes in metabolite levels. For more challenging applications, namely, in conditions which result in subtle metabolite changes, the limitations of vendor-provided MRS protocols are increasingly recognized, especially when used at high fields (≥3 T) where chemical shift displacement errors, B0 and B1 inhomogeneities and limitations in the transmit B1 field become prominent. To overcome the limitations of conventional MRS protocols at 3 and 7 T, the use of advanced MRS methodology, including pulse sequences and adjustment procedures, is recommended. Specifically, the semiadiabatic LASER sequence is recommended when TE values of 25-30 ms are acceptable, and the semiadiabatic SPECIAL sequence is suggested as an alternative when shorter TE values are critical. The magnetic field B0 homogeneity should be optimized and RF pulses should be calibrated for each voxel. Unsuppressed water signal should be acquired for eddy current correction and preferably also for metabolite quantification. Metabolite and water data should be saved in single shots to facilitate phase and frequency alignment and to exclude motion-corrupted shots. Final averaged spectra should be evaluated for SNR, linewidth, water suppression efficiency and the presence of unwanted coherences. Spectra that do not fit predefined quality criteria should be excluded from further analysis. Commercially available tools to acquire all data in consistent anatomical locations are recommended for voxel prescriptions, in particular in longitudinal studies. To enable the larger MRS community to take advantage of these advanced methods, a list of resources for these advanced protocols on the major clinical platforms is provided. Finally, a set of recommendations are provided for vendors to enable development of advanced MRS on standard platforms, including implementation of advanced localization sequences, tools for quality assurance on the scanner, and tools for prospective volume tracking and dynamic linear shim corrections.

Published
2021

22. Lutetium-177-PSMA-617 in Low-Volume Hormone-Sensitive Metastatic Prostate Cancer: A Prospective Pilot Study

Author

Privé, Bastiaan M., primary, Peters, Steffie M.B., additional, Muselaers, Constantijn H.J., additional, van Oort, Inge M., additional, Janssen, Marcel J.R., additional, Sedelaar, J.P. Michiel, additional, Konijnenberg, Mark W., additional, Zámecnik, Patrik, additional, Uijen, Maike J.M., additional, Schilham, Melline G.M., additional, Eek, Annemarie, additional, Scheenen, Tom W.J., additional, Verzijlbergen, J. Fred, additional, Gerritsen, Winald R., additional, Mehra, Niven, additional, Kerkmeijer, Linda G.W., additional, Smeenk, Robert J., additional, Somford, Diederik M., additional, van Basten, Jean-Paul A., additional, Heskamp, Sandra, additional, Barentsz, Jelle O., additional, Gotthardt, Martin, additional, Witjes, J. Alfred, additional, and Nagarajah, James, additional

Published
2021
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25. Macroscopic heterogeneties in electroosmotic and pressure-driven flow through fixed beds at low column-to-particle diameter ratio

Author

Tallarek, Ulrich, Scheenen, Tom W.J., and Van As, Henk

Subjects
Electro-osmosis -- Research, Nuclear magnetic resonance -- Usage, Chemicals, plastics and rubber industries
Abstract

The existence of specific wall effects in electroosmotic and pressure-driven flows through a fixed bed at low column-to-particle diameter ration is demonstrated using dynamic NMR microscopy with 40 mu spatial resolution. The results concluded that these wall effects are very systematic along the column axis for both types of fluid flow.

Published
2001

26. Validation of in vivo nodal staging of solid malignancies with USPIO-enhanced MRI: a workflow protocol

Author

Driessen, Daphne A.J.J., primary, Gouw, Didi J.J.M. de, additional, Stijns, Rutger C.H., additional, Litjens, Geke, additional, Israël, Bas, additional, Philips, Bart W.J., additional, Hermans, John J., additional, Dijkema, Tim, additional, Klarenbeek, Bastiaan R., additional, Post, Rachel S. van der, additional, Nagtegaal, Iris D., additional, Grunsven, Adriana C.H. van Engen-van, additional, Brosens, Lodewijk A.A., additional, Veltien, Andor, additional, Zámecnik, Patrik, additional, and Scheenen, Tom W.J., additional

Published
2020
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27. Pyruvate‐lactate exchange and glucose uptake in human prostate cancer cell models. A study in xenografts and suspensions by hyperpolarized [1‐13C]pyruvate MRS and [18F]FDG‐PET

Author

Heijster, Frits H.A., primary, Heskamp, Sandra, additional, Breukels, Vincent, additional, Veltien, Andor, additional, Franssen, Gerben M., additional, Jansen, Kees (C).F.J., additional, Boerman, Otto C., additional, Schalken, Jack A., additional, Scheenen, Tom W.J., additional, and Heerschap, Arend, additional

Published
2020
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29. Methodological consensus on clinical proton MRS of the brain : Review and recommendations

Author

Wilson, Martin, Andronesi, Ovidiu, Barker, Peter B., Bartha, Robert, Bizzi, Alberto, Bolan, Patrick J., Brindle, Kevin M., Choi, In Young, Cudalbu, Cristina, Dydak, Ulrike, Emir, Uzay E., Gonzalez, Ramon G., Gruber, Stephan, Gruetter, Rolf, Gupta, Rakesh K., Heerschap, Arend, Henning, Anke, Hetherington, Hoby P., Huppi, Petra S., Hurd, Ralph E., Kantarci, Kejal, Kauppinen, Risto A., Klomp, Dennis W.J., Kreis, Roland, Kruiskamp, Marijn J., Leach, Martin O., Lin, Alexander P., Luijten, Peter R., Marjańska, Małgorzata, Maudsley, Andrew A., Meyerhoff, Dieter J., Mountford, Carolyn E., Mullins, Paul G., Murdoch, James B., Nelson, Sarah J., Noeske, Ralph, Öz, Gülin, Pan, Julie W., Peet, Andrew C., Poptani, Harish, Posse, Stefan, Ratai, Eva Maria, Salibi, Nouha, Scheenen, Tom W.J., Smith, Ian C.P., Soher, Brian J., Tkáč, Ivan, Vigneron, Daniel B., Howe, Franklyn A., Wilson, Martin, Andronesi, Ovidiu, Barker, Peter B., Bartha, Robert, Bizzi, Alberto, Bolan, Patrick J., Brindle, Kevin M., Choi, In Young, Cudalbu, Cristina, Dydak, Ulrike, Emir, Uzay E., Gonzalez, Ramon G., Gruber, Stephan, Gruetter, Rolf, Gupta, Rakesh K., Heerschap, Arend, Henning, Anke, Hetherington, Hoby P., Huppi, Petra S., Hurd, Ralph E., Kantarci, Kejal, Kauppinen, Risto A., Klomp, Dennis W.J., Kreis, Roland, Kruiskamp, Marijn J., Leach, Martin O., Lin, Alexander P., Luijten, Peter R., Marjańska, Małgorzata, Maudsley, Andrew A., Meyerhoff, Dieter J., Mountford, Carolyn E., Mullins, Paul G., Murdoch, James B., Nelson, Sarah J., Noeske, Ralph, Öz, Gülin, Pan, Julie W., Peet, Andrew C., Poptani, Harish, Posse, Stefan, Ratai, Eva Maria, Salibi, Nouha, Scheenen, Tom W.J., Smith, Ian C.P., Soher, Brian J., Tkáč, Ivan, Vigneron, Daniel B., and Howe, Franklyn A.

Published
2019

30. Methodological consensus on clinical proton MRS of the brain: Review and recommendations

Author

Highfield Research Group, Brain, Circulatory Health, Regenerative Medicine and Stem Cells, Cancer, Fysica Radiotherapie Research, Divisie Beeld & Oncologie, Divisie Beeld, Wilson, Martin, Andronesi, Ovidiu, Barker, Peter B., Bartha, Robert, Bizzi, Alberto, Bolan, Patrick J., Brindle, Kevin M., Choi, In Young, Cudalbu, Cristina, Dydak, Ulrike, Emir, Uzay E., Gonzalez, Ramon G., Gruber, Stephan, Gruetter, Rolf, Gupta, Rakesh K., Heerschap, Arend, Henning, Anke, Hetherington, Hoby P., Huppi, Petra S., Hurd, Ralph E., Kantarci, Kejal, Kauppinen, Risto A., Klomp, Dennis W.J., Kreis, Roland, Kruiskamp, Marijn J., Leach, Martin O., Lin, Alexander P., Luijten, Peter R., Marjańska, Małgorzata, Maudsley, Andrew A., Meyerhoff, Dieter J., Mountford, Carolyn E., Mullins, Paul G., Murdoch, James B., Nelson, Sarah J., Noeske, Ralph, Öz, Gülin, Pan, Julie W., Peet, Andrew C., Poptani, Harish, Posse, Stefan, Ratai, Eva Maria, Salibi, Nouha, Scheenen, Tom W.J., Smith, Ian C.P., Soher, Brian J., Tkáč, Ivan, Vigneron, Daniel B., Howe, Franklyn A., Highfield Research Group, Brain, Circulatory Health, Regenerative Medicine and Stem Cells, Cancer, Fysica Radiotherapie Research, Divisie Beeld & Oncologie, Divisie Beeld, Wilson, Martin, Andronesi, Ovidiu, Barker, Peter B., Bartha, Robert, Bizzi, Alberto, Bolan, Patrick J., Brindle, Kevin M., Choi, In Young, Cudalbu, Cristina, Dydak, Ulrike, Emir, Uzay E., Gonzalez, Ramon G., Gruber, Stephan, Gruetter, Rolf, Gupta, Rakesh K., Heerschap, Arend, Henning, Anke, Hetherington, Hoby P., Huppi, Petra S., Hurd, Ralph E., Kantarci, Kejal, Kauppinen, Risto A., Klomp, Dennis W.J., Kreis, Roland, Kruiskamp, Marijn J., Leach, Martin O., Lin, Alexander P., Luijten, Peter R., Marjańska, Małgorzata, Maudsley, Andrew A., Meyerhoff, Dieter J., Mountford, Carolyn E., Mullins, Paul G., Murdoch, James B., Nelson, Sarah J., Noeske, Ralph, Öz, Gülin, Pan, Julie W., Peet, Andrew C., Poptani, Harish, Posse, Stefan, Ratai, Eva Maria, Salibi, Nouha, Scheenen, Tom W.J., Smith, Ian C.P., Soher, Brian J., Tkáč, Ivan, Vigneron, Daniel B., and Howe, Franklyn A.

Published
2019

31. Advanced single voxel 1H magnetic resonance spectroscopy techniques in humans: Experts' consensus recommendations.

Author

Öz, Gülin, Deelchand, Dinesh K., Wijnen, Jannie P., Mlynárik, Vladimír, Xin, Lijing, Mekle, Ralf, Noeske, Ralph, Scheenen, Tom W.J., Tkáč, Ivan, Andronesi, Ovidiu, Barker, Peter B., Bartha, Robert, Berrington, Adam, Boer, Vincent, Cudalbu, Christina, Emir, Uzay E., Ernst, Thomas, Fillmer, Ariane, Heerschap, Arend, and Henry, Pierre‐Gilles

Subjects
NUCLEAR magnetic resonance spectroscopy, WATER efficiency
Abstract

Conventional proton MRS has been successfully utilized to noninvasively assess tissue biochemistry in conditions that result in large changes in metabolite levels. For more challenging applications, namely, in conditions which result in subtle metabolite changes, the limitations of vendor‐provided MRS protocols are increasingly recognized, especially when used at high fields (≥3 T) where chemical shift displacement errors, B0 and B1 inhomogeneities and limitations in the transmit B1 field become prominent. To overcome the limitations of conventional MRS protocols at 3 and 7 T, the use of advanced MRS methodology, including pulse sequences and adjustment procedures, is recommended. Specifically, the semiadiabatic LASER sequence is recommended when TE values of 25‐30 ms are acceptable, and the semiadiabatic SPECIAL sequence is suggested as an alternative when shorter TE values are critical. The magnetic field B0 homogeneity should be optimized and RF pulses should be calibrated for each voxel. Unsuppressed water signal should be acquired for eddy current correction and preferably also for metabolite quantification. Metabolite and water data should be saved in single shots to facilitate phase and frequency alignment and to exclude motion‐corrupted shots. Final averaged spectra should be evaluated for SNR, linewidth, water suppression efficiency and the presence of unwanted coherences. Spectra that do not fit predefined quality criteria should be excluded from further analysis. Commercially available tools to acquire all data in consistent anatomical locations are recommended for voxel prescriptions, in particular in longitudinal studies. To enable the larger MRS community to take advantage of these advanced methods, a list of resources for these advanced protocols on the major clinical platforms is provided. Finally, a set of recommendations are provided for vendors to enable development of advanced MRS on standard platforms, including implementation of advanced localization sequences, tools for quality assurance on the scanner, and tools for prospective volume tracking and dynamic linear shim corrections. [ABSTRACT FROM AUTHOR]

Published
2021
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32. 3D 31P MR spectroscopic imaging of the human brain at 3 T with a 31P receive array: An assessment of 1H decoupling, T1 relaxation times, 1H‐31P nuclear Overhauser effects and NAD+

Author

Peeters, Tom H., Uden, Mark J., Rijpma, Anne, Scheenen, Tom W.J., and Heerschap, Arend

Subjects
OVERHAUSER effect (Nuclear physics), SPECTROSCOPIC imaging, MAGNETIC resonance imaging, BRAIN imaging, SIGNAL-to-noise ratio
Abstract

31P MR spectroscopic imaging (MRSI) is a versatile technique to study phospholipid precursors and energy metabolism in the healthy and diseased human brain. However, mainly due to its low sensitivity, 31P MRSI is currently limited to research purposes. To obtain 3D 31P MRSI spectra with improved signal‐to‐noise ratio on clinical 3 T MR systems, we used a coil combination consisting of a dual‐tuned birdcage transmit coil and a 31P eight‐channel phased‐array receive insert. To further increase resolution and sensitivity we applied WALTZ4 1H decoupling and continuous wave nuclear Overhauser effect (NOE) enhancement and acquired high‐quality MRSI spectra with nominal voxel volumes of ~ 17.6 cm3 (effective voxel volume ~ 51 cm3) in a clinically relevant measurement time of ~ 13 minutes, without exceeding SAR limits. Steady‐state NOE enhancements ranged from 15 ± 9% (γ‐ATP) and 33 ± 3% (phosphocreatine) to 48 ± 11% (phosphoethanolamine). Because of these improvements, we resolved and detected all 31P signals of metabolites that have also been reported for ultrahigh field strengths, including resonances for NAD+, NADH and extracellular inorganic phosphate. T1 times of extracellular inorganic phosphate were longer than for intracellular inorganic phosphate (3.8 ± 1.4s vs 1.8 ± 0.65 seconds). A comparison of measured T1 relaxation times and NOE enhancements at 3 T with published values between 1.5 and 9.4 T indicates that T1 relaxation of 31P metabolite spins in the human brain is dominated by dipolar relaxation for this field strength range. Even although intrinsic sensitivity is higher at ultrahigh fields, we demonstrate that at a clinical field strength of 3 T, similar 31P MRSI information content can be obtained using a sophisticated coil design combined with 1H decoupling and NOE enhancement. [ABSTRACT FROM AUTHOR]

Published
2021
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35. High field imaging of large-scale neurotransmitter networks: proof of concept and initial application to epilepsy

Author

van Veenendaal, Tamar M., Backes, Walter H., Tse, Desmond H.Y., Scheenen, Tom W.J., Klomp, Dennis W., Hofman, Paul A.M., Rouhl, Rob P.W., Vlooswijk, Marielle C.G., Aldenkamp, Albert P., Jansen, Jacobus F.A., van Veenendaal, Tamar M., Backes, Walter H., Tse, Desmond H.Y., Scheenen, Tom W.J., Klomp, Dennis W., Hofman, Paul A.M., Rouhl, Rob P.W., Vlooswijk, Marielle C.G., Aldenkamp, Albert P., and Jansen, Jacobus F.A.

Abstract

The brain can be considered a network, existing of multiple interconnected areas with various functions. MRI provides opportunities to map the large-scale network organization of the brain. We tap into the neurobiochemical dimension of these networks, as neuronal functioning and signal trafficking across distributed brain regions relies on the release and presence of neurotransmitters. Using high-field MR spectroscopic imaging at 7.0 T, we obtained a non-invasive snapshot of the spatial distribution of the neurotransmitters GABA and glutamate, and investigated interregional associations of these neurotransmitters. We demonstrate that interregional correlations of glutamate and GABA concentrations can be conceptualized as networks. Furthermore, patients with epilepsy display an increased number of glutamate and GABA connections and increased average strength of the GABA network. The increased glutamate and GABA connectivity in epilepsy might indicate a disrupted neurotransmitter balance. In addition to epilepsy, the ‘neurotransmitter networks’ concept might also provide new insights for other neurological diseases.

Published
2018

37. Pyruvate‐lactate exchange and glucose uptake in human prostate cancer cell models. A study in xenografts and suspensions by hyperpolarized [1‐13C]pyruvate MRS and [18F]FDG‐PET.

Author

Heijster, Frits H.A., Heskamp, Sandra, Breukels, Vincent, Veltien, Andor, Franssen, Gerben M., Jansen, Kees (C).F.J., Boerman, Otto C., Schalken, Jack A., Scheenen, Tom W.J., and Heerschap, Arend

Subjects
LACTATES, CANCER cells, POLARIZATION (Nuclear physics), CELL suspensions, GLUCOSE, ENERGY metabolism, PROSTATE cancer
Abstract

Reprogramming of energy metabolism in the development of prostate cancer can be exploited for a better diagnosis and treatment of the disease. The goal of this study was to determine whether differences in glucose and pyruvate metabolism of human prostate cancer cells with dissimilar aggressivenesses can be detected using hyperpolarized [1‐13C]pyruvate MRS and [18F]FDG‐PET imaging, and to evaluate whether these measures correlate. For this purpose, we compared murine xenografts of human prostate cancer LNCaP cells with those of more aggressive PC3 cells. [1‐13C]pyruvate was hyperpolarized by dissolution dynamic nuclear polarization (dDNP) and [1‐13C]pyruvate to lactate conversion was followed by 13C MRS. Subsequently [18F]FDG uptake was investigated by static and dynamic PET measurements. Standard uptake values (SUVs) for [18F]FDG were significantly higher for xenografts of PC3 compared with those of LNCaP. However, we did not observe a difference in the average apparent rate constant kpl of 13C label exchange from pyruvate to lactate between the tumor variants. A significant negative correlation was found between SUVs from [18F]FDG PET measurements and kpl values for the xenografts of both tumor types. The kpl rate constant may be influenced by various factors, and studies with a range of prostate cancer cells in suspension suggest that LDH inhibition by pyruvate may be one of these. Our results indicate that glucose and pyruvate metabolism in the prostate cancer cell models differs from that in other tumor models and that [18F]FDG‐PET can serve as a valuable complementary tool in dDNP studies of aggressive prostate cancer with [1‐13C]pyruvate. [ABSTRACT FROM AUTHOR]

Published
2020
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39. Multi-component quantitative magnetic resonance imaging by phasor representation

Author

Vergeldt, Frank J., Prusova, Alena, Fereidouni, Farzad, Van Amerongen, Herbert, Van As, Henk, Scheenen, Tom W.J., Bader, Arjen N., Vergeldt, Frank J., Prusova, Alena, Fereidouni, Farzad, Van Amerongen, Herbert, Van As, Henk, Scheenen, Tom W.J., and Bader, Arjen N.

Abstract

Quantitative magnetic resonance imaging (qMRI) is a versatile, non-destructive and non-invasive tool in life, material, and medical sciences. When multiple components contribute to the signal in a single pixel, however, it is difficult to quantify their individual contributions and characteristic parameters. Here we introduce the concept of phasor representation to qMRI to disentangle the signals from multiple components in imaging data. Plotting the phasors allowed for decomposition, unmixing, segmentation and quantification of our in vivo data from a plant stem, a human and mouse brain and a human prostate. In human brain images, we could identify 3 main T2 components and 3 apparent diffusion coefficients; in human prostate 5 main contributing spectral shapes were distinguished. The presented phasor analysis is model-free, fast and accurate. Moreover, we also show that it works for undersampled data.

Published
2017

41. Repeatability of 31P MR spectroscopic imaging in the human brain at 7 T with and without the Nuclear Overhauser Effect

Author

Lagemaat, Miriam W., van de Bank, Bart L., Sati, Pascal, Li, Shizhe, Maas, Marnix C., and Scheenen, Tom W.J.

Subjects
inorganic chemicals, Adult, Male, Young Adult, Imaging, Three-Dimensional, Magnetic Resonance Spectroscopy, Metabolome, Brain, Humans, Reproducibility of Results, Female, Phosphorus, Article
Abstract

An often-employed strategy to enhance signals in (31) P MRS is the generation of the nuclear Overhauser effect (NOE) by saturation of the water resonance. However, NOE allegedly increases the variability of the (31) P data, because variation is reported in NOE enhancements. This would negate the signal-to-noise (SNR) gain it generates. We hypothesized that the variation in NOE enhancement values is not caused by the variability in NOE itself, but is attributable to measurement uncertainties in the values used to calculate the enhancement. If true, the expected increase in SNR with NOE would improve the repeatability of (31) P MRS measurements. To verify this hypothesis, a repeatability study of native and NOE-enhanced (31) P MRSI was performed in the brains of seven healthy volunteers at 7 T. The repeatability coefficient (RC) and the coefficient of variation in repeated measurements (CoVrepeat ) were determined for each method, and the 95% limits of agreement (LoAs) between native and NOE-enhanced signals were calculated. The variation between the methods, defined by the LoA, is at least as great as that predicted by the RC of each method. The sources of variation in NOE enhancements were determined using variance component analysis. In the seven metabolites with a positive NOE enhancement (nine metabolite resonances assessed), CoVrepeat improved, on average, by 15%. The LoAs could be explained by the RCs of the individual methods for the majority of the metabolites, generally confirming our hypothesis. Variation in NOE enhancement was mainly attributable to the factor repeat, but between-voxel effects were also present for phosphoethanolamine and (glycero)phosphocholine. CoVrepeat and fitting error were strongly correlated and improved with positive NOE. Our findings generally indicate that NOE enhances the signal of metabolites, improving the repeatability of metabolite measurements. Additional variability as a result of NOE was minimal. These findings encourage the use of NOE-enhanced (31) P MRSI. Copyright © 2015 John WileySons, Ltd.

Published
2015

42. 1H-MRS processing parameters affect metabolite quantification: The urgent need for uniform and transparent standardization

Author

Bhogal, Alex A., primary, Schür, Remmelt R., additional, Houtepen, Lotte C., additional, van de Bank, Bart, additional, Boer, Vincent O., additional, Marsman, Anouk, additional, Barker, Peter B., additional, Scheenen, Tom W.J., additional, Wijnen, Jannie P., additional, Vinkers, Christiaan H., additional, and Klomp, Dennis W.J., additional

Published
2017
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46. Simple and broadly applicable automatic quality control for 3D 1H MR spectroscopic imaging data of the prostate.

Author

Tayari, Nassim, Obels, Jiri, Kobus, Thiele, Scheenen, Tom W.J., and Heerschap, Arend

Abstract

Purpose: Quality control (QC) is a prerequisite for clinical MR spectroscopic imaging (MRSI) to avoid that bad spectra hamper data interpretation. The aim of this work was to present a simple automatic QC for prostate 1H MRSI that can handle data obtained with different commonly used pulse sequences, echo times, field strengths, and MR platforms. Methods: A QC method was developed with a ratio (Qratio) where the numerator and the denominator are functions of several signal heights, logically combined for their positive or negative contribution to spectral quality. This Qratio was tested on 4 data sets obtained at 1.5, 3, and 7T, with and without endorectal coil and different localization sequences and echo times. Spectra of 25,248 voxels in 26 prostates were labeled as acceptable or unacceptable by MRS experts as gold standard. A threshold value was determined for Qratio from a subset of voxels, labeled in consensus by 4 experts, for an optimal accuracy to separate spectra. Results: Applying this Qratio threshold to the remaining test voxels, an automatic separation of good and bad spectra was possible with an accuracy of 0.88, similar to manual separation between the 2 classes. Qratio values were used to generate maps representing spectral quality on a binary or continuous scale. Conclusion: Automated QC of prostate 1H MRSI by Qratio is fast, simple, easily transferable and more practical than supervised feature extraction methods and therefore easy to integrate into different clinical MR systems. Moreover, quality maps can be generated to read the reliability of spectra in each voxel. [ABSTRACT FROM AUTHOR]

Published
2019
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