440 results on '"Scharenberg, Andrew M."'
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2. Addendum to: Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases
3. A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells
4. Improved CRISPR genome editing using small highly active and specific engineered RNA-guided nucleases
5. In Vivo Outcome of Homology-Directed Repair at the HBB Gene in HSC Using Alternative Donor Template Delivery Methods
6. Receptor-Mediated Regulation of the TRPM7 Channel through Its Endogenous Protein Kinase Domain
7. Abstract 1787: Design of bispecific adapters for universal CAR T cell therapies of solid tumors
8. Abstract 4099: Dual targeting of tumor cells and cancer associated fibroblasts enhances CAR T efficacy in solid tumors
9. Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells
10. Supplementary Methods from Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies
11. Supplementary Figures 1 - 5, Tables 1 - 3 from Multiplex Genome-Edited T-cell Manufacturing Platform for “Off-the-Shelf” Adoptive T-cell Immunotherapies
12. Preclinical proof of concept for VivoVec, a lentiviral-based platform for in vivo CAR T-cell engineering
13. Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases
14. Ethical and regulatory aspects of genome editing
15. Targeted gene editing restores regulated CD40L function in X-linked hyper-IgM syndrome
16. Calcium signaling, ion channels and more
17. Analysis of cellular Mg2+ in DT40 cells
18. A chemically inducible IL-2 receptor signaling complex allows for effective in vitroand in vivoselection of engineered CD4+ T cells
19. Molecular mechanism of paired immunoglobulin-like receptor B (PIR-B)-mediated inhibitory signal
20. Tapping natural reservoirs of homing endonucleases for targeted gene modification
21. Assembly and Characterization of megaTALs for Hyperspecific Genome Engineering Applications
22. Stable hematopoietic cell engraftment after low-intensity nonmyeloablative conditioning in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome
23. Protein Kinase C Redistribution Within CA3 Stratum Oriens During Acquisition of Nictitating Membrane Conditioning in the Rabbit
24. Engineering and Flow-Cytometric Analysis of Chimeric LAGLIDADG Homing Endonucleases from Homologous I-OnuI-Family Enzymes
25. Homing Endonuclease Target Determination Using SELEX Adapted for Yeast Surface Display
26. Development and Validation of a Cell-Based High-Throughput Screening Assay for TRPM2 Channel Modulators
27. Zinc-finger nucleases: a powerful tool for genetic engineering of animals
28. Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus
29. megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
30. Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks
31. Exploitation of binding energy for catalysis and design
32. Development and Validation of a Cell-Based High-Throughput Screening Assay for TRPM2 Channel Modulators
33. Flow Cytometric Assays for Interrogating LAGLIDADG Homing Endonuclease DNA-Binding and Cleavage Properties
34. TRPM2 and TRPM7: channel/enzyme fusions to generate novel intracellular sensors
35. TRPM7 provides an ion channel mechanism for cellular entry of trace metal ions
36. LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viability
37. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology
38. TRPM4 is a Ca(sup)2+ -activated nonselective cation channel mediating cell membrane depolarization
39. Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases
40. Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects
41. Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space
42. Novel reporter systems for facile evaluation of I-SceI-mediated genome editing
43. Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1
44. Gene editing to induce FOXP3 expression in human CD4 + T cells leads to a stable regulatory phenotype and function
45. Advances in Engineering Homing Endonucleases for Gene Targeting: Ten Years After Structures
46. Enabling Gene-Edited, Regulatory-like, T Cells (edTreg) for Treatment of IPEX and Other Autoimmune Disorders
47. Manufacture and In Vivo Support of Gene-Edited, Regulatory-like, T-Cells (edTreg) Using a Synthetic IL2 Receptor
48. High-resolution profiling of homing endonuclease binding and catalytic specificity using yeast surface display
49. Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation
50. Flow cytometric analysis of DNA binding and cleavage by cell surface-displayed homing endonucleases
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