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3. Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-R). A study of the International Working Group for Prognosis in Myelodysplasia (IWG-PM)

Author

Della Porta, M G, Tuechler, H, Malcovati, L, Schanz, J, Sanz, G, Garcia-Manero, G, Solé, F, Bennett, J M, Bowen, D, Fenaux, P, Dreyfus, F, Kantarjian, H, Kuendgen, A, Levis, A, Cermak, J, Fonatsch, C, Le Beau, M M, Slovak, M L, Krieger, O, Luebbert, M, Maciejewski, J, Magalhaes, S M M, Miyazaki, Y, Pfeilstöcker, M, Sekeres, M A, Sperr, W R, Stauder, R, Tauro, S, Valent, P, Vallespi, T, van de Loosdrecht, A A, Germing, U, Haase, D, Greenberg, P L, and Cazzola, M

Published
2015
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5. Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-R). A study of the International Working Group for Prognosis in Myelodysplasia (IWG-PM)

Author

Porta, Della MG, Tuechler, H, Malcovati, L, Schanz, J, Sanz, G, Garcia-Manero, G, Solé, F, Bennett, J M, Bowen, D, Fenaux, P, Dreyfus, F, Kantarjian, H, Kuendgen, A, Levis, A, Cermak, J, Fonatsch, C, Le Beau, M M, Slovak, M L, Krieger, O, Luebbert, M, Maciejewski, J, Magalhaes, S MM, Miyazaki, Y, Pfeilstöcker, M, Sekeres, M A, Sperr, W R, Stauder, R, Tauro, S, Valent, P, Vallespi, T, van de Loosdrecht, A A, Germing, U, Haase, D, Greenberg, P L, and Cazzola, M

Published
2015
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6. Monosomal karyotype in MDS: explaining the poor prognosis?

Author

Schanz, J, Tüchler, H, Solé, F, Mallo, M, Luño, E, Cervera, J, Grau, J, Hildebrandt, B, Slovak, M L, Ohyashiki, K, Steidl, C, Fonatsch, C, Pfeilstöcker, M, Nösslinger, T, Valent, P, Giagounidis, A, Aul, C, Lübbert, M, Stauder, R, Krieger, O, Le Beau, M M, Bennett, J M, Greenberg, P, Germing, U, and Haase, D

Published
2013
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8. Survival, prognostic factors and rates of leukemic transformation in 381 untreated patients with MDS and del(5q): A multicenter study

Author

Germing, U, Lauseker, M, Hildebrandt, B, Symeonidis, A, Cermak, J, Fenaux, P, Kelaidi, C, Pfeilstöcker, M, Nösslinger, T, Sekeres, M, Maciejewski, J, Haase, D, Schanz, J, Seymour, J, Kenealy, M, Weide, R, Lübbert, M, Platzbecker, U, Valent, P, Götze, K, Stauder, R, Blum, S, Kreuzer, K-A, Schlenk, R, Ganser, A, Hofmann, W-K, Aul, C, Krieger, O, Kündgen, A, Haas, R, Hasford, J, and Giagounidis, A

Published
2012
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9. Impact of adjunct cytogenetic abnormalities for prognostic stratification in patients with myelodysplastic syndrome and deletion 5q

Author

Mallo, M, Cervera, J, Schanz, J, Such, E, García-Manero, G, Luño, E, Steidl, C, Espinet, B, Vallespí, T, Germing, U, Blum, S, Ohyashiki, K, Grau, J, Pfeilstöcker, M, Hernández, J M, Noesslinger, T, Giagounidis, A, Aul, C, Calasanz, M J, Martín, M L, Valent, P, Collado, R, Haferlach, C, Fonatsch, C, Lübbert, M, Stauder, R, Hildebrandt, B, Krieger, O, Pedro, C, Arenillas, L, Sanz, M Á, Valencia, A, Florensa, L, Sanz, G F, Haase, D, and Solé, F

Published
2011
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13. Bioartifizielle menschliche Gewebe mit eigener Gefäßversorgung als Implantate für die rekonstruktive Chirurgie: Implantatentwicklung und erste klinische Erfahrungen

Author

Walles, T., Friedel, G., Schanz, J., Steger, V., Schandar, M., Hansmann, J., Mertsching, H., Buhr, H. J., editor, Hölscher, A., editor, Izbicki, J. R., editor, Jauch, K. W., editor, Post, S., editor, Allgayer, H., editor, Bartsch, D. K., editor, Fries, H., editor, Ghadimi, B. M., editor, Habermann, J. K., editor, Kalthoff, H., editor, Schackert, H. K., editor, Bruns, C. J., editor, Duda, D. N., editor, Fändrich, F., editor, Heberer, M., editor, Nüssler, A. K., editor, Stark, G. B., editor, Brückner, U. B., editor, Ertel, W., editor, Faist, E., editor, Heidecke, C. D., editor, Kalff, J. C., editor, Menger, M. D., editor, Schade, U. F., editor, Vollmar, B., editor, Bechstein, W. O., editor, Klar, E., editor, Klempnauer, J., editor, Minor, T., editor, Neuhaus, P., editor, Schmidt, J., editor, Langer, S., editor, Laschke, M. W., editor, Machens, H. G., editor, Steinau, H. U., editor, Südkamp, N., editor, Vogt, P., editor, Berger, D., editor, Klinge, U., editor, Schachtrupp, A., editor, Schilling, M. K., editor, Schumpelick, V., editor, Altendorf-Hofmann, A., editor, Bollschweiler, E., editor, Bruch, H. -P., editor, Lehnert, T., editor, Lorenz, W., editor, Neugebauer, E., editor, Ohmann, C., editor, Seiler, C. M., editor, Becker, H., editor, Betzler, M., editor, Bittner, R., editor, Broelsch, C., editor, Büchler, M. W., editor, Bumm, R., editor, Dralle, H., editor, Friess, H., editor, Frilling, A., editor, Germer, C. T., editor, Hopt, U., editor, Jonas, S., editor, Jost, J., editor, Markus, B., editor, Raab, H. R., editor, Reith, H. B., editor, Schlag, P. M., editor, Teichmann, W., editor, Uhl, W., editor, Wenisch, H., editor, and Zornig, C., editor

Published
2009
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15. Author Correction: Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

Author

Bernard E, Nannya Y, Hasserjian RP, Devlin SM, Tuechler H, Medina-Martinez JS, Yoshizato T, Shiozawa Y, Saiki R, Malcovati L, Levine MF, Arango JE, Zhou Y, Solé F, Cargo CA, Haase D, Creignou M, Germing U, Zhang Y, Gundem G, Sarian A, van de Loosdrecht AA, Jädersten M, Tobiasson M, Kosmider O, Follo MY, Thol F, Pinheiro RF, Santini V, Kotsianidis I, Boultwood J, Santos FPS, Schanz J, Kasahara S, Ishikawa T, Tsurumi H, Takaori-Kondo A, Kiguchi T, Polprasert C, Bennett JM, Klimek VM, Savona MR, Belickova M, Ganster C, Palomo L, Sanz G, Ades L, Della Porta MG, Smith AG, Werner Y, Patel M, Viale A, Vanness K, Neuberg DS, Stevenson KE, Menghrajani K, Bolton KL, Fenaux P, Pellagatti A, Platzbecker U, Heuser M, Valent P, Chiba S, Miyazaki Y, Finelli C, Voso MT, Shih LY, Fontenay M, Jansen JH, Cervera J, Atsuta Y, Gattermann N, Ebert BL, Bejar R, Greenberg PL, Cazzola M, Hellström-Lindberg E, Ogawa S, and Papaemmanuil E

Published
2021

21. Data from the German-Austrian-Suisse MDS registry (D-A-CH MDS registry): V954

Author

Germing, U., Giagounidis, A. A., Aul, C., Kündgen, A., Haase, D., Schanz, J., Pfeilstöcker, M., Noesslinger, T., Platzbecker, U., Götze, K., Lübbert, M., Blum, S., Hildebrandt, B., Valent, P., Krieger, O., Stauder, R., Hofmann, W.-K., Braess, J., Schulte, K., Kreutzer, K.-A., Büsche, G., Kreipe, H., Stadler, M., Ganser, A., Schlenk, R., Meckenstock, G., Bug, G., Runde, V., Haas, R., Tüchler, H., Lauseker, M., Hasford, J., and Gattermann, N.

Published
2011

22. Characterization and prognostic significance of cytogenetically unrelated clones in myelodysplastic syndromes and acute myeloid leukemia: V68

Author

Schanz, J., Keels, S., Haferlach, C., Bardi, G., Gourgouveli, E., Slovak, M. L., Johansson, B., Ohyashiki, K., Solé, F., Eclache, V., Wimzal, F., Pfeilstöcker, M., Nösslinger, T., Fonatsch, C., Lübbert, M., Giagounidis, A., Stauder, R., Krieger, O., Prescher, G., Hildebrandt, B., Greenberg, P., LeBeau, M. M., Bennett, J. M., Germing, U., and Haase, D.

Published
2011

26. Loss of the Y Chromosome in MDS: Clonal abnormality or age-related accident?: V749

Author

Ganster, C., Schanz, J., Braulke, F., Shirneshan, K., Solé, F., Hildebrandt, B., Slovak, M. L., Ohyashiki, K., Steidl, C., Fonatsch, C., Pfeilstöcker, M., Nösslinger, T., Valent, P., Giagounidis, A., Aul, C., Lübbert, M., Stauder, R., Krieger, O., Le Beau, M., Bennett, J., Greenberg, P., Germing, U., and Haase, D.

Published
2010

28. Cytogenetic Risk Features in MDS - Update and Present State: V371

Author

Schanz, J., Tüchler, H., Solé, F., Mallo, M., Hildebrandt, B., Slovak, M., Ohyashiki, K., Steidl, C., Fonatsch, C., Pfeilstöcker, M., Noesslinger, T., Valent, P., Giagounidis, A., Lübbert, M., Stauder, R., Krieger, O., LeBeau, M. M., Bennett, J., Greenberg, P., Germing, U., and Haase, D.

Published
2009

30. Impact of somatic mutations in myelodysplastic patients with isolated partial or total loss of chromosome 7

Author

Crisà E, Kulasekararaj AG, Adema V, Such E, Schanz J, Haase D, Shirneshan K, Best S, Mian SA, Kizilors A, Cervera J, Lea N, Ferrero D, Germing U, Hildebrandt B, Martínez ABV, Santini V, Sanz GF, Solé F, and Mufti GJ

Subjects
DISORDERS, ABNORMALITIES, 7Q, MONOSOMY-7, KARYOTYPE, BONE-MARROW FIBROSIS, PROGNOSTIC SCORING SYSTEM, LEUKEMIA, METHYLTRANSFERASE GENE EZH2, ASSOCIATIONS
Abstract

Monosomy 7 [-7] and/or partial loss of chromosome 7 [del(7q)] are associated with poor and intermediate prognosis, respectively, in myelodysplastic syndromes (MDS), but somatic mutations may also play a key complementary role. We analyzed the impact on the outcomes of deep targeted mutational screening in 280 MDS patients with -7/del(7q) as isolated cytogenetic abnormality (86 with del(7q) and 194 with -7). Patients with del(7q) or -7 had similar demographic and disease-related characteristics. Somatic mutations were detected in 79% (93/117) of patients (82% in -7 and 73% in del(7q) group). Median number of mutations per patient was 2 (range 0-8). There was no difference in mutation frequency between the two groups. Patients harbouring =2 mutations had a worse outcome than patients with

Published
2020

31. Implications ofTP53allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

Author

Bernard, E, Nannya, Y, Hasserjian, RP, Devlin, SM, Tuechler, H, Medina-Martinez, JS, Yoshizato, T, Shiozawa, Y, Saiki, R, Malcovati, L, Levine, MF, Arango, JE, Zhou, YY, Sole, F, Cargo, CA, Haase, D, Creignou, M, Germing, U, Zhang, YM, Gundem, G, Sarian, A, van de Loosdrecht, AA, Jadersten, M, Tobiasson, M, Kosmider, O, Follo, MY, Thol, F, Pinheiro, RF, Santini, V, Kotsianidis, I, Boultwood, J, Santos, FPS, Schanz, J, Kasahara, S, Ishikawa, T, Tsurumi, H, Takaori-Kondo, A, Kiguchi, T, Polprasert, C, Bennett, JM, Klimek, VM, Savona, MR, Belickova, M, Ganster, C, Palomo, L, SANZ, G, Ades, L, Della Porta, MG, Smith, AG, Werner, Y, Patel, M, Viale, A, Vanness, K, Neuberg, DS, Stevenson, KE, Menghrajani, K, Bolton, KL, Fenaux, P, Pellagatti, A, Platzbecker, U, Heuser, M, Valent, P, Chiba, S, Miyazaki, Y, Finelli, C, Voso, MT, Shih, LY, Fontenay, M, Jansen, JH, Cervera, J, Atsuta, Y, Gattermann, N, Ebert, BL, Bejar, R, Greenberg, PL, Cazzola, M, Hellstrom-Lindberg, E, Ogawa, S, and Papaemmanuil, E

Abstract

Clinical sequencing across a large prospective cohort of patients with myelodysplasic syndrome uncovers distinct associations between the mono- and biallelic states ofTP53and clinical presentation Tumor protein p53 (TP53) is the most frequently mutated gene in cancer(1,2). In patients with myelodysplastic syndromes (MDS),TP53mutations are associated with high-risk disease(3,4), rapid transformation to acute myeloid leukemia (AML)(5), resistance to conventional therapies(6-8)and dismal outcomes(9). Consistent with the tumor-suppressive role ofTP53, patients harbor both mono- and biallelic mutations(10). However, the biological and clinical implications ofTP53allelic state have not been fully investigated in MDS or any other cancer type. We analyzed 3,324 patients with MDS forTP53mutations and allelic imbalances and delineated two subsets of patients with distinct phenotypes and outcomes. One-third ofTP53-mutated patients had monoallelic mutations whereas two-thirds had multiple hits (multi-hit) consistent with biallelic targeting. Established associations with complex karyotype, few co-occurring mutations, high-risk presentation and poor outcomes were specific to multi-hit patients only.TP53multi-hit state predicted risk of death and leukemic transformation independently of the Revised International Prognostic Scoring System (IPSS-R)(11). Surprisingly, monoallelic patients did not differ fromTP53wild-type patients in outcomes and response to therapy. This study shows that consideration ofTP53allelic state is critical for diagnostic and prognostic precision in MDS as well as in future correlative studies of treatment response.

Published
2020

33. Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

Author

Bernard, E., Nannya, Y., Hasserjian, R.P., Devlin, S.M., Tuechler, H., Medina-Martinez, J.S., Yoshizato, T., Shiozawa, Y., Saiki, R., Malcovati, L., Levine, M.F., Arango, J.E., Zhou, Y, Solé, F., Cargo, C.A., Haase, D., Creignou, M., Germing, U., Zhang, Y., Gundem, G., Sarian, A., Loosdrecht, A.A. van de, Jädersten, M., Tobiasson, M., Kosmider, O., Follo, M.Y., Thol, F., Pinheiro, R.F., Santini, V., Kotsianidis, I., Boultwood, J., Santos, F.P.S., Schanz, J., Kasahara, S., Ishikawa, T., Tsurumi, H., Takaori-Kondo, A., Kiguchi, T., Polprasert, C., Bennett, J.M., Klimek, V.M., Savona, M.R., Belickova, M., Ganster, C., Palomo, L., Sanz, G., Ades, L., Porta, M.G. Della, Smith, A.G., Werner, Y., Patel, M., Viale, A., Vanness, K., Neuberg, D.S., Stevenson, K.E., Menghrajani, K., Bolton, K.L., Fenaux, P., Pellagatti, A., Platzbecker, U., Heuser, M., Valent, P., Chiba, S., Miyazaki, Y., Finelli, C., Voso, M.T., Shih, L.Y., Fontenay, M., Jansen, J.H., Cervera, J., Atsuta, Y., Gattermann, N., Ebert, B.L., Bejar, R., Greenberg, P.L., Cazzola, M., Hellström-Lindberg, E., Ogawa, S., Papaemmanuil, E., Bernard, E., Nannya, Y., Hasserjian, R.P., Devlin, S.M., Tuechler, H., Medina-Martinez, J.S., Yoshizato, T., Shiozawa, Y., Saiki, R., Malcovati, L., Levine, M.F., Arango, J.E., Zhou, Y, Solé, F., Cargo, C.A., Haase, D., Creignou, M., Germing, U., Zhang, Y., Gundem, G., Sarian, A., Loosdrecht, A.A. van de, Jädersten, M., Tobiasson, M., Kosmider, O., Follo, M.Y., Thol, F., Pinheiro, R.F., Santini, V., Kotsianidis, I., Boultwood, J., Santos, F.P.S., Schanz, J., Kasahara, S., Ishikawa, T., Tsurumi, H., Takaori-Kondo, A., Kiguchi, T., Polprasert, C., Bennett, J.M., Klimek, V.M., Savona, M.R., Belickova, M., Ganster, C., Palomo, L., Sanz, G., Ades, L., Porta, M.G. Della, Smith, A.G., Werner, Y., Patel, M., Viale, A., Vanness, K., Neuberg, D.S., Stevenson, K.E., Menghrajani, K., Bolton, K.L., Fenaux, P., Pellagatti, A., Platzbecker, U., Heuser, M., Valent, P., Chiba, S., Miyazaki, Y., Finelli, C., Voso, M.T., Shih, L.Y., Fontenay, M., Jansen, J.H., Cervera, J., Atsuta, Y., Gattermann, N., Ebert, B.L., Bejar, R., Greenberg, P.L., Cazzola, M., Hellström-Lindberg, E., Ogawa, S., and Papaemmanuil, E.

Abstract

Contains fulltext : 229615.pdf (Publisher’s version ) (Closed access)

Published
2020

42. PF553 CLONES WITH COMPLEX ABERRATIONS AND TP53 MUTATIONS RESPOND TO AZACITIDINE IN MYELODYSPLASTIC SYNDROMES AND ACUTE MYELOID LEUKEMIA

Author

Ganster, C., primary, Mazzeo, P., additional, Elmaagacli, A., additional, Dierks, S., additional, Shirneshan, K., additional, Scharnberg, P., additional, Martin, R., additional, Rittscher, K., additional, Götze, K., additional, Glass, B., additional, Braulke, F., additional, Schanz, J., additional, and Haase, D., additional

Published
2019
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43. Proposed diagnostic criteria for classical chronic myelomonocytic leukemia (CMML), CMML variants and pre-CMML conditions

Author

Valent, P., Orazi, A., Savona, M.R., Patnaik, M.M., Onida, F., Loosdrecht, A.A. van de, Haase, D., Haferlach, T, Elena, C., Pleyer, L., Kern, W., Pemovska, T., Vladimer, G.I., Schanz, J., Keller, A., Lubbert, M., Lion, T., Sotlar, K., Reiter, A., Witte, T.J. de, Pfeilstocker, M., Geissler, K., Padron, E., Deininger, M., Orfao, A., Horny, H.P., Greenberg, P.L., Arber, D.A., Malcovati, L., Bennett, J.M., Valent, P., Orazi, A., Savona, M.R., Patnaik, M.M., Onida, F., Loosdrecht, A.A. van de, Haase, D., Haferlach, T, Elena, C., Pleyer, L., Kern, W., Pemovska, T., Vladimer, G.I., Schanz, J., Keller, A., Lubbert, M., Lion, T., Sotlar, K., Reiter, A., Witte, T.J. de, Pfeilstocker, M., Geissler, K., Padron, E., Deininger, M., Orfao, A., Horny, H.P., Greenberg, P.L., Arber, D.A., Malcovati, L., and Bennett, J.M.

Abstract

Contains fulltext : 215300.pdf (publisher's version ) (Open Access), Chronic myelomonocytic leukemia (CMML) is a myeloid neoplasm characterized by dysplasia, abnormal production and accumulation of monocytic cells and an elevated risk of transforming into acute leukemia. Over the past two decades, our knowledge about the pathogenesis and molecular mechanisms in CMML has increased substantially. In parallel, better diagnostic criteria and therapeutic strategies have been developed. However, many questions remain regarding prognostication and optimal therapy. In addition, there is a need to define potential pre-phases of CMML and special CMML variants, and to separate these entities from each other and from conditions mimicking CMML. To address these unmet needs, an international consensus group met in a Working Conference in August 2018 and discussed open questions and issues around CMML, its variants, and pre-CMML conditions. The outcomes of this meeting are summarized herein and include diag nostic criteria and a proposed classification of pre-CMML conditions as well as refined minimal diagnostic criteria for classical CMML and special CMML variants, including oligomonocytic CMML and CMML associated with systemic mastocytosis. Moreover, we propose diagnostic standards and tools to distinguish between 'normal', pre-CMML and CMML entities. These criteria and standards should facilitate diagnostic and prognostic evaluations in daily practice and clinical studies in applied hematology.

Published
2019

44. P030 Prognostic impact on survival of an unsuccessful conventional cytogenetic study in patients with myelodysplastic syndromes (MDS)

Author

Cervera, J., Solé, F., Haase, D., Luño, E., Such, E., Nomdedeu, B., Costa, D., Bernal, T., Vallespí, T., Bueno, J., Pedro, C., Mallo, M., Ardanaz, M.T., Calasanz, M.J., del Cañizo, C., Hernández-Rivas, J.M., Schanz, J., Steidl, C., Hildebrandt, B., Carbonell, F., Orero, M., Ramos, F., Marco, V., Tormo, M., Gomez, V., Andreu, R., Xicoy, B., Amigo, M.L., Muñoz, J.A., Bonanad, S., Arrizabalaga, B., Senent, M.L., Germing, U., and Sanz, G.F.

Published
2009
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45. P028 Survival, prognostic factors, and leukemic transformation in a multicenter study of 241 patients with MDS and del(5q)

Author

Germing, U., Hildebrandt, B., Symeonidis, A., Cermak, J., Pfeilstoecker, M., Nösslinger, T., Sekkeres, M., Maciejewski, J., Haase, D., Schlenk, R., Schanz, J., Seymour, J., Kenealy, M., Köppler, H., Lübbert, M., Platzbecker, U., Valent, P., Blum, S., Ottmann, O., Götze, K., Stauder, R., Kreuzer, K.A., Aul, C., Kündgen, A., and Giagounidis, A.

Published
2009
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46. C005 Prognostic impact of the proportion of aberrant metaphases in patients with a primary myelodysplastic syndrome

Author

Mallo, M., Cervera, J., Schanz, J., Espinet, B., Duch, E., Luño, E., Steidl, C., Martín, M.L., Germing, U., Grau, J., Pfeilstoecker, M., Hernández-Rivas, J.M., Noesslinger, T., Calasanz, M.J., Collado, R., Fonatsch, C., Bureo, E., Lübbert, M., Ríos, R., Stauder, R., Arranz, E., Hildebrandt, B., Slovak, M., Cigudosa, J.C., Krieger, O., Pedro, C., Salido, M., Arenillas, L., Sanz, G.F., Sanz, M.Á., Valencia, A., Florensa, L., Novell, L., del Cañizo, C., García-Manero, G., Vallespí, T., Ohyashiki, K., Benlloch, L., Haase, D., and Solé, F.

Published
2009
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47. 12 Updated cytogenetic risk features in MDS – present state

Author

Haase, D., Schanz, J., Tuechler, H., Sole, F., Mallo, M., Hildebrandt, B., Slovak, M.L., Ohyashiki, K., Steidl, C., Fonatsch, C., Pfeilstoecker, M., Noesslinger, T., Valent, P., Giagounidis, A., Luebbert, M., Stauder, R., Krieger, O., LeBeau, M., Bennett, J., Greenberg, P., and Germing, U.

Published
2009
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50. Chromosomal Aberrations in Therapy-Related Myelodysplastic Syndromes – Relations to Primary Disease, Therapy and Prognostic Significance

Author

Nomdedeu, M., primary, Tuechler, H., additional, Kuendgen, A., additional, Solé, F., additional, Schanz, J., additional, Hildebrandt, B., additional, Grau, J., additional, Pereira, A., additional, García-Manero, G., additional, Sekeres, M.A., additional, Komrokji, R.S., additional, Voso, M.T., additional, List, A.F., additional, Cazzola, M., additional, Sill, H., additional, Stauder, R., additional, Greenberg, P., additional, Germing, U., additional, Sanz, G., additional, and Haase, D., additional

Published
2017
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