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1. Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration

Author

Di Credico, Gioia, Polesel, Jerry, Dal Maso, Luigino, Pauli, Francesco, Torelli, Nicola, Luce, Daniele, Radoï, Loredana, Matsuo, Keitaro, Serraino, Diego, Brennan, Paul, Holcatova, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Canova, Cristina, Richiardi, Lorenzo, Healy, Claire M, Kjaerheim, Kristina, Conway, David I, Macfarlane, Gary J, Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Franceschi, Silvia, Herrero, Rolando, Toporcov, Tatiana N, Moyses, Raquel A, Muscat, Joshua, Negri, Eva, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander W, Koifman, Rosalina, Wunsch-Filho, Victor, Olshan, Andrew F, Zevallos, Jose P, Sturgis, Erich M, Li, Guojun, Levi, Fabio, Zhang, Zuo-Feng, Morgenstern, Hal, Smith, Elaine, Lazarus, Philip, La Vecchia, Carlo, Garavello, Werner, Chen, Chu, Schwartz, Stephen M, Zheng, Tongzhang, Vaughan, Thomas L, Kelsey, Karl, McClean, Michael, Benhamou, Simone, Hayes, Richard B, Purdue, Mark P, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, Chuang, Shu-Chun, Boffetta, Paolo, Hashibe, Mia, Yuan-Chin, Amy Lee, and Edefonti, Valeria

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Dental/Oral and Craniofacial Disease, Clinical Research, Cancer, Substance Misuse, Clinical Trials and Supportive Activities, Digestive Diseases, Prevention, Rare Diseases, Alcoholism, Alcohol Use and Health, Tobacco Smoke and Health, Tobacco, 2.2 Factors relating to the physical environment, Oral and gastrointestinal, Good Health and Well Being, Adolescent, Adult, Aged, Aged, 80 and over, Alcohol Drinking, Case-Control Studies, Female, Head and Neck Neoplasms, Humans, Laryngeal Neoplasms, Male, Middle Aged, Mouth Neoplasms, Oropharyngeal Neoplasms, Risk Factors, Severity of Illness Index, Smoking, Time Factors, Young Adult, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundAlcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk.MethodsData from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking.ResultsFor all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx).ConclusionsPresent results further encourage the reduction of alcohol intensity to mitigate HNC risk.

Published
2020

2. Risk Prediction Models for Head and Neck Cancer in the US Population From the INHANCE Consortium

Author

Lee, Yuan-Chin Amy, Al-Temimi, Mohammed, Ying, Jian, Muscat, Joshua, Olshan, Andrew F, Zevallos, Jose P, Winn, Deborah M, Li, Guojun, Sturgis, Erich M, Morgenstern, Hal, Zhang, Zuo-Feng, Smith, Elaine, Kelsey, Karl, McClean, Michael, Vaughan, Thomas L, Lazarus, Philip, Chen, Chu, Schwartz, Stephen M, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, D’Souza, Gypsyamber, Gross, Neil, Monroe, Marcus, Kim, Jaewhan, Boffetta, Paolo, and Hashibe, Mia

Subjects
Health Services and Systems, Health Sciences, Cancer, Rare Diseases, Tobacco, Substance Misuse, Tobacco Smoke and Health, Digestive Diseases, Prevention, Dental/Oral and Craniofacial Disease, Good Health and Well Being, Aged, Case-Control Studies, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Models, Theoretical, Risk Assessment, United States, absolute risk, head and neck cancer, hypopharyngeal cancer, laryngeal cancer, oral cavity cancer, oropharyngeal cancer, risk prediction, Mathematical Sciences, Medical and Health Sciences, Epidemiology
Abstract

Head and neck cancer (HNC) risk prediction models based on risk factor profiles have not yet been developed. We took advantage of the large database of the International Head and Neck Cancer Epidemiology (INHANCE) Consortium, including 14 US studies from 1981-2010, to develop HNC risk prediction models. Seventy percent of the data were used to develop the risk prediction models; the remaining 30% were used to validate the models. We used competing-risk models to calculate absolute risks. The predictors included age, sex, education, race/ethnicity, alcohol drinking intensity, cigarette smoking duration and intensity, and/or family history of HNC. The 20-year absolute risk of HNC was 7.61% for a 60-year-old woman who smoked more than 20 cigarettes per day for over 20 years, consumed 3 or more alcoholic drinks per day, was a high school graduate, had a family history of HNC, and was non-Hispanic white. The 20-year risk for men with a similar profile was 6.85%. The absolute risks of oropharyngeal and hypopharyngeal cancers were generally lower than those of oral cavity and laryngeal cancers. Statistics for the area under the receiver operating characteristic curve (AUC) were 0.70 or higher, except for oropharyngeal cancer in men. This HNC risk prediction model may be useful in promoting healthier behaviors such as smoking cessation or in aiding persons with a family history of HNC to evaluate their risks.

Published
2020

3. Dietary glycaemic index, glycaemic load and head and neck cancer risk: a pooled analysis in an international consortium

Author

Chang, Chun-Pin, La Vecchia, Carlo, Serraino, Diego, Olshan, Andrew F, Zevallos, Jose P, Morgenstern, Hal, Levi, Fabio, Garavello, Werner, Kelsey, Karl, McClean, Michael, Chen, Chu, Schwartz, Stephen M, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Parpinel, Maria, Augustin, Livia SA, Turati, Federica, Zhang, Zuo-Feng, and Edefonti, Valeria

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Dental/Oral and Craniofacial Disease, Cancer, Digestive Diseases, Nutrition, Prevention, Rare Diseases, Case-Control Studies, Female, Glycemic Index, Glycemic Load, Head and Neck Neoplasms, Humans, Male, Surveys and Questionnaires, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

High dietary glycaemic index (GI) and glycaemic load (GL) may increase cancer risk. However, limited information was available on GI and/or GL and head and neck cancer (HNC) risk. We conducted a pooled analysis on 8 case-control studies (4081 HNC cases; 7407 controls) from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) of HNC, and its subsites, from fixed- or mixed-effects logistic models including centre-specific quartiles of GI or GL. GI, but not GL, had a weak positive association with HNC (ORQ4 vs. Q1 = 1.16; 95% CI = 1.02-1.31). In subsites, we found a positive association between GI and laryngeal cancer (ORQ4 vs. Q1 = 1.60; 95% CI = 1.30-1.96) and an inverse association between GL and oropharyngeal cancer (ORQ4 vs. Q1 = 0.78; 95% CI = 0.63-0.97). This pooled analysis indicates a modest positive association between GI and HNC, mainly driven by laryngeal cancer.

Published
2020

4. Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

Author

Chang, Chun-Pin, Chang, Shen-Chih, Chuang, Shu-Chun, Berthiller, Julien, Ferro, Gilles, Matsuo, Keitaro, Wünsch-Filho, Victor, Toporcov, Tatiana N, de Carvalho, Marcos Brasilino, La Vecchia, Carlo, Olshan, Andrew F, Zevallos, Jose P, Serraino, Diego, Muscat, Joshua, Sturgis, Erich M, Li, Guojun, Morgenstern, Hal, Levi, Fabio, Dal Maso, Luigino, Smith, Elaine, Kelsey, Karl, McClean, Michael, Vaughan, Thomas L, Lazarus, Philip, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M, Winn, Deborah M, Bosetti, Cristina, Edefonti, Valeria, Garavello, Werner, Negri, Eva, Hayes, Richard B, Purdue, Mark P, Boccia, Stefania, Cadoni, Gabriella, Shangina, Oxana, Koifman, Rosalina, Curado, Maria Paula, Vilensky, Marta, Swiatkowska, Beata, Herrero, Rolando, Franceschi, Silvia, Benhamou, Simone, Fernandez, Leticia, Menezes, Ana MB, Daudt, Alexander W, Mates, Dana, Schantz, Stimson, Yu, Guo-Pei, Lissowska, Jolanta, Brenner, Hermann, Fabianova, Eleonora, Rudnai, Peter, Brennan, Paul, Boffetta, Paolo, Zhang, Zuo-Feng, Hashibe, Mia, and Lee, Yuan-Chin Amy

Subjects
Biomedical and Clinical Sciences, Epidemiology, Health Services and Systems, Health Sciences, Public Health, Oncology and Carcinogenesis, Tobacco, Tobacco Smoke and Health, Substance Misuse, Prevention, Cancer, Dental/Oral and Craniofacial Disease, Rare Diseases, Good Health and Well Being, Adult, Age Factors, Aged, Case-Control Studies, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Risk Factors, Tobacco Products, Age at start of tobacco use, Head and neck cancer, Oral cancer, Oropharyngeal cancer, Hypopharyngeal cancer, Laryngeal cancer, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundTobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk.MethodsWe analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models.ResultsWithout adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR

Published
2019

5. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach

Author

Di Credico, Gioia, Edefonti, Valeria, Polesel, Jerry, Pauli, Francesco, Torelli, Nicola, Serraino, Diego, Negri, Eva, Luce, Daniele, Stucker, Isabelle, Matsuo, Keitaro, Brennan, Paul, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander W, Koifman, Rosalina, Wunsch-Filho, Victor, Holcatova, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Simonato, Lorenzo, Richiardi, Lorenzo, Healy, Claire, Kjaerheim, Kristina, Conway, David I, Macfarlane, Tatiana V, Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Rios, Leonardo F Boaventura, Toporcov, Tatiana N, Franceschi, Silvia, Herrero, Rolando, Muscat, Joshua, Olshan, Andrew F, Zevallos, Jose P, La Vecchia, Carlo, Winn, Deborah M, Sturgis, Erich M, Li, Guojun, Fabianova, Eleonora, Lissowska, Jolanda, Mates, Dana, Rudnai, Peter, Shangina, Oxana, Swiatkowska, Beata, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Smith, Elaine, Lazarus, Philip, Bosetti, Cristina, Garavello, Werner, Kelsey, Karl, McClean, Michael, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M, Vaughan, Thomas L, Zheng, Tongzhang, Menvielle, Gwenn, Boccia, Stefania, Cadoni, Gabriella, Hayes, Richard B, Purdue, Mark, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, Brenner, Hermann, D'Souza, Gypsyamber, Gross, Neil D, Chuang, Shu-Chun, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, and Dal Maso, Luigino

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Tobacco Smoke and Health, Rare Diseases, Prevention, Dental/Oral and Craniofacial Disease, Substance Misuse, Tobacco, Cancer, 2.2 Factors relating to the physical environment, Good Health and Well Being, Adult, Aged, Aged, 80 and over, Case-Control Studies, Cigarette Smoking, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Risk Factors, Bivariate spline models, Cigarette smoking duration, Cigarette smoking intensity, Head and neck cancer, INHANCE, Laryngeal cancer, Oral cavity and pharyngeal cancers, Dentistry, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

ObjectivesThis study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures.Materials and methodsWe pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework.ResultsFor oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30  years. In former smokers who quit ≥10  years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers.ConclusionReferring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.

Published
2019

6. Racial differences in the relationship between tobacco, alcohol, and the risk of head and neck cancer: pooled analysis of US studies in the INHANCE Consortium

Author

Voltzke, Kristin J, Lee, Yuan-Chin Amy, Zhang, Zuo-Feng, Zevallos, Jose P, Yu, Guo-Pei, Winn, Deborah M, Vaughan, Thomas L, Sturgis, Erich M, Smith, Elaine, Schwartz, Stephen M, Schantz, Stimson, Muscat, Joshua, Morgenstern, Hal, McClean, Michael, Li, Guojun, Lazarus, Philip, Kelsey, Karl, Gillison, Maura, Chen, Chu, Boffetta, Paolo, Hashibe, Mia, and Olshan, Andrew F

Subjects
Epidemiology, Biomedical and Clinical Sciences, Public Health, Health Sciences, Digestive Diseases, Dental/Oral and Craniofacial Disease, Prevention, Cancer, Alcoholism, Alcohol Use and Health, Tobacco Smoke and Health, Tobacco, Rare Diseases, Substance Misuse, Good Health and Well Being, Alcohol Drinking, Case-Control Studies, Head and Neck Neoplasms, Humans, Racial Groups, Risk Factors, Tobacco Use, United States, Head and neck cancer, Alcohol, Cigarette smoking, African American, Racial difference, Oncology and Carcinogenesis, Public Health and Health Services, Oncology and carcinogenesis
Abstract

There have been few published studies on differences between Blacks and Whites in the estimated effects of alcohol and tobacco use on the incidence of head and neck cancer (HNC) in the United States. Previous studies have been limited by small numbers of Blacks. Using pooled data from 13 US case-control studies of oral, pharyngeal, and laryngeal cancers in the International Head and Neck Cancer Epidemiology Consortium, this study comprised a large number of Black HNC cases (n = 975). Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI) for several tobacco and alcohol consumption characteristics. Blacks were found to have consistently stronger associations than Whites for the majority of tobacco consumption variables. For example, compared to never smokers, Blacks who smoked cigarettes for > 30 years had an OR 4.53 (95% CI 3.22-6.39), which was larger than that observed in Whites (OR 3.01, 95% CI 2.73-3.33; pinteraction

Published
2018

7. Dietary fiber intake and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology consortium

Author

Kawakita, Daisuke, Lee, Yuan‐Chin Amy, Turati, Federica, Parpinel, Maria, Decarli, Adriano, Serraino, Diego, Matsuo, Keitaro, Olshan, Andrew F, Zevallos, Jose P, Winn, Deborah M, Moysich, Kirsten, Zhang, Zuo‐Feng, Morgenstern, Hal, Levi, Fabio, Kelsey, Karl, McClean, Michael, Bosetti, Cristina, Garavello, Werner, Schantz, Stimson, Yu, Guo‐Pei, Boffetta, Paolo, Chuang, Shu‐Chun, Hashibe, Mia, Ferraroni, Monica, La Vecchia, Carlo, and Edefonti, Valeria

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Substance Misuse, Cancer, Rare Diseases, Dental/Oral and Craniofacial Disease, Alcoholism, Alcohol Use and Health, Digestive Diseases, Good Health and Well Being, Adult, Aged, Alcohol Drinking, Carcinoma, Squamous Cell, Case-Control Studies, Dietary Fiber, Female, Head and Neck Neoplasms, Humans, Laryngeal Neoplasms, Male, Middle Aged, Pharyngeal Neoplasms, Risk Factors, Squamous Cell Carcinoma of Head and Neck, Nicotiana, dietary fiber intake, INHANCE, head and neck cancer, laryngeal cancer, oral cavity and pharyngeal cancer, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

The possible role of dietary fiber in the etiology of head neck cancers (HNCs) is unclear. We used individual-level pooled data from ten case-control studies (5959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium, to examine the association between fiber intake and cancer of the oral cavity/pharynx and larynx. Odds Ratios (ORs) and their 95% Confidence Intervals (CIs) were estimated using unconditional multiple logistic regression applied to quintile categories of non-alcohol energy-adjusted fiber intake and adjusted for tobacco and alcohol use and other known or putative confounders. Fiber intake was inversely associated with oral and pharyngeal cancer combined (OR for 5th vs. 1st quintile category = 0.49, 95% CI: 0.40-0.59; p for trend

Published
2017

8. Smokeless Tobacco Use and the Risk of Head and Neck Cancer: Pooled Analysis of US Studies in the INHANCE Consortium

Author

Wyss, Annah B, Hashibe, Mia, Lee, Yuan-Chin Amy, Chuang, Shu-Chun, Muscat, Joshua, Chen, Chu, Schwartz, Stephen M, Smith, Elaine, Zhang, Zuo-Feng, Morgenstern, Hal, Wei, Qingyi, Li, Guojun, Kelsey, Karl T, McClean, Michael, Winn, Deborah M, Schantz, Stimson, Yu, Guo-Pei, Gillison, Maura L, Zevallos, Jose P, Boffetta, Paolo, and Olshan, Andrew F

Subjects
Epidemiology, Health Services and Systems, Health Sciences, Dental/Oral and Craniofacial Disease, Cancer, Substance Misuse, Digestive Diseases, Rare Diseases, Tobacco Smoke and Health, Tobacco, Good Health and Well Being, Adolescent, Adult, Aged, Cigarette Smoking, Female, Head and Neck Neoplasms, Humans, Logistic Models, Male, Middle Aged, Mouth Neoplasms, Tobacco Use, Tobacco, Smokeless, United States, Young Adult, chewing tobacco, head and neck neoplasms, snuff, tobacco, smokeless, Mathematical Sciences, Medical and Health Sciences
Abstract

Previous studies on smokeless tobacco use and head and neck cancer (HNC) have found inconsistent and often imprecise estimates, with limited control for cigarette smoking. Using pooled data from 11 US case-control studies (1981-2006) of oral, pharyngeal, and laryngeal cancers (6,772 cases and 8,375 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium, we applied hierarchical logistic regression to estimate odds ratios and 95% confidence intervals for ever use, frequency of use, and duration of use of snuff and chewing tobacco separately for never and ever cigarette smokers. Ever use (versus never use) of snuff was strongly associated with HNC among never cigarette smokers (odds ratio (OR) = 1.71, 95% confidence interval (CI): 1.08, 2.70), particularly for oral cavity cancers (OR = 3.01, 95% CI: 1.63, 5.55). Although ever (versus never) tobacco chewing was weakly associated with HNC among never cigarette smokers (OR = 1.20, 95% CI: 0.81, 1.77), analyses restricted to cancers of the oral cavity showed a stronger association (OR = 1.81, 95% CI: 1.04, 3.17). Few or no associations between each type of smokeless tobacco and HNC were observed among ever cigarette smokers, possibly reflecting residual confounding by smoking. Smokeless tobacco use appears to be associated with HNC, especially oral cancers, with snuff being more strongly associated than chewing tobacco.

Published
2016

9. Mouthwash use and cancer of the head and neck

Author

Boffetta, Paolo, Hayes, Richard B, Sartori, Samantha, Lee, Yuan-Chin A, Muscat, Joshua, Olshan, Andrew, Winn, Deborah M, Castellsagué, Xavier, Zhang, Zuo-Feng, Morgenstern, Hal, Chen, Chu, Schwartz, Stephen M, Vaughan, Thomas L, Wunsch-Filho, Victor, Purdue, Mark, Koifman, Sergio, Curado, Maria P, Vilensky, Marta, Gillison, Maura, Fernandez, Leticia, Menezes, Ana, Daudt, Alexander W, Schantz, Stimson, Yu, Guopei, D’Souza, Gypsyamber, Haddad, Robert I, La Vecchia, Carlo, and Hashibe, Mia

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Digestive Diseases, Rare Diseases, Cancer, Alcoholism, Alcohol Use and Health, Tobacco, Tobacco Smoke and Health, Dental/Oral and Craniofacial Disease, Substance Misuse, 2.2 Factors relating to the physical environment, Oral and gastrointestinal, Good Health and Well Being, Adult, Case-Control Studies, Female, Follow-Up Studies, Head and Neck Neoplasms, Humans, International Agencies, Male, Meta-Analysis as Topic, Mouthwashes, Prevalence, Prognosis, Retrospective Studies, Risk Factors, alcohol, head and neck cancer, laryngeal cancer, mouthwash, oral cancer, pharyngeal cancer, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis, Public health
Abstract

Most mouthwashes contain alcohol, a known cause of head and neck cancer (oral cavity, pharynx, larynx), likely through the carcinogenic activity of acetaldehyde, formed in the oral cavity from alcohol. We carried out a pooled analysis of 8981 cases of head and neck cancer and 10 090 controls from 12 case-control studies with comparable information on mouthwash use in the International Head and Neck Cancer Epidemiology Consortium. Logistic regression was used to assess the association of mouthwash use with cancers of the oral cavity, oropharynx, hypopharynx, and larynx, adjusting for study, age, sex, pack-years of tobacco smoking, number of alcoholic drinks/day, and education. Compared with never users of mouthwash, the odds ratio (OR) of all head and neck cancers was 1.01 [95% confidence interval (CI): 0.94-1.08] for ever users, based on 12 studies. The corresponding ORs of cancer of the oral cavity and oropharynx were 1.11 (95% CI: 1.00-1.23) and 1.28 (95% CI: 1.06-1.56), respectively. OR for all head and neck cancer was 1.15 (95% CI: 1.01-1.30) for use for more than 35 years, based on seven studies (P for linear trend=0.01), and OR 1.31 (95% CI: 1.09-1.58) for use more than one per day, based on five studies (P for linear trend

Published
2016

10. Carotenoid intake and head and neck cancer: a pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

Author

Leoncini, Emanuele, Edefonti, Valeria, Hashibe, Mia, Parpinel, Maria, Cadoni, Gabriella, Ferraroni, Monica, Serraino, Diego, Matsuo, Keitaro, Olshan, Andrew F, Zevallos, Jose P, Winn, Deborah M, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Kelsey, Karl, McClean, Michael, Bosetti, Cristina, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Lee, Yuan-Chin Amy, Chuang, Shu-Chun, Decarli, Adriano, La Vecchia, Carlo, and Boccia, Stefania

Subjects
Public Health, Health Sciences, Prevention, Rare Diseases, Nutrition, Substance Misuse, Dental/Oral and Craniofacial Disease, Tobacco, Cancer, Tobacco Smoke and Health, Alcoholism, Alcohol Use and Health, Digestive Diseases, Oral and gastrointestinal, Good Health and Well Being, Adult, Aged, Aged, 80 and over, Antioxidants, Carcinoma, Squamous Cell, Carotenoids, Case-Control Studies, Epidemiologic Studies, Europe, Female, Head and Neck Neoplasms, Humans, Japan, Middle Aged, Squamous Cell Carcinoma of Head and Neck, United States, Head and neck cancer, Nutrients, Diet, Public Health and Health Services, Epidemiology
Abstract

Food and nutrition play an important role in head and neck cancer (HNC) etiology; however, the role of carotenoids remains largely undefined. We explored the relation of HNC risk with the intake of carotenoids within the International Head and Neck Cancer Epidemiology Consortium. We pooled individual-level data from 10 case-control studies conducted in Europe, North America, and Japan. The analysis included 18,207 subjects (4414 with oral and pharyngeal cancer, 1545 with laryngeal cancer, and 12,248 controls), categorized by quintiles of carotenoid intake from natural sources. Comparing the highest with the lowest quintile, the risk reduction associated with total carotenoid intake was 39 % (95 % CI 29-47 %) for oral/pharyngeal cancer and 39 % (95 % CI 24-50 %) for laryngeal cancer. Intakes of β-carotene equivalents, β-cryptoxanthin, lycopene, and lutein plus zeaxanthin were associated with at least 18 % reduction in the rate of oral and pharyngeal cancer (95 % CI 6-29 %) and 17 % reduction in the rate of laryngeal cancer (95 % CI 0-32 %). The overall protective effect of carotenoids on HNC was stronger for subjects reporting greater alcohol consumption (p

Published
2016

11. Natural vitamin C intake and the risk of head and neck cancer: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

Author

Edefonti, Valeria, Hashibe, Mia, Parpinel, Maria, Turati, Federica, Serraino, Diego, Matsuo, Keitaro, Olshan, Andrew F, Zevallos, Jose P, Winn, Deborah M, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Kelsey, Karl, McClean, Michael, Bosetti, Cristina, Galeone, Carlotta, Schantz, Stimson, Yu, Guo-Pei, Boffetta, Paolo, Amy Lee, Yuan-Chin, Chuang, Shu-Chun, La Vecchia, Carlo, and Decarli, Adriano

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Nutrition, Cancer, Digestive Diseases, Dental/Oral and Craniofacial Disease, Oral and gastrointestinal, Good Health and Well Being, Ascorbic Acid, Case-Control Studies, Head and Neck Neoplasms, Humans, International Agencies, Italy, Japan, Logistic Models, Risk Factors, Surveys and Questionnaires, Switzerland, United States, Vitamins, head and neck cancer, INHANCE, laryngeal cancer, oral and pharyngeal cancer, vitamin C, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Evidence of associations between single nutrients and head and neck cancer (HNC) is still more limited and less consistent than that for fruit and vegetables. However, clarification of the protective mechanisms of fruit and vegetables is important to our understanding of HNC etiology. We investigated the association between vitamin C intake from natural sources and cancer of the oral cavity/pharynx and larynx using individual-level pooled data from ten case-control studies (5,959 cases and 12,248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. After harmonization of study-specific exposure information via the residual method, adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using unconditional multiple logistic regression models on quintile categories of 'non-alcohol energy-adjusted' vitamin C intake. In the presence of heterogeneity of the estimated ORs among studies, we derived those estimates from generalized linear mixed models. Higher intakes of vitamin C were inversely related to oral and pharyngeal (OR = 0.54, 95% CI: 0.45-0.65, for the fifth quintile category versus the first one, p for trend

Published
2015

12. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case‐control studies from 27 countries

Author

Conway, David I, Brenner, Darren R, McMahon, Alex D, Macpherson, Lorna MD, Agudo, Antonio, Ahrens, Wolfgang, Bosetti, Cristina, Brenner, Hermann, Castellsague, Xavier, Chen, Chu, Curado, Maria Paula, Curioni, Otávio A, Dal Maso, Luigino, Daudt, Alexander W, de Gois Filho, José F, D'Souza, Gypsyamber, Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Gillison, Maura, Hayes, Richard B, Healy, Claire M, Herrero, Rolando, Holcatova, Ivana, Jayaprakash, Vijayvel, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Sergio, La Vecchia, Carlo, Lagiou, Pagona, Lazarus, Philip, Levi, Fabio, Lissowska, Jolanta, Luce, Daniele, Macfarlane, Tatiana V, Mates, Dana, Matos, Elena, McClean, Michael, Menezes, Ana M, Menvielle, Gwenn, Merletti, Franco, Morgenstern, Hal, Moysich, Kirsten, Müller, Heiko, Muscat, Joshua, Olshan, Andrew F, Purdue, Mark P, Ramroth, Heribert, Richiardi, Lorenzo, Rudnai, Peter, Schantz, Stimson, Schwartz, Stephen M, Shangina, Oxana, Simonato, Lorenzo, Smith, Elaine, Stucker, Isabelle, Sturgis, Erich M, Szeszenia‐Dabrowska, Neonila, Talamini, Renato, Thomson, Peter, Vaughan, Thomas L, Wei, Qingyi, Winn, Deborah M, Wunsch‐Filho, Victor, Yu, Guo‐Pei, Zhang, Zuo‐Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Chuang, Shu‐Chun, Ghodrat, Marianoosh, Lee, Yuan‐Chin Amy, Hashibe, Mia, and Brennan, Paul

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Substance Misuse, Rare Diseases, Behavioral and Social Science, Dental/Oral and Craniofacial Disease, Cancer, Prevention, Tobacco, Tobacco Smoke and Health, Reduced Inequalities, Good Health and Well Being, Alcohol Drinking, Case-Control Studies, Education, Female, Follow-Up Studies, Global Health, Head and Neck Neoplasms, Humans, Income, Male, Meta-Analysis as Topic, Middle Aged, Prognosis, Risk Factors, Smoking, Socioeconomic Factors, head and neck cancer, socioeconomic inequalities, epidemiology, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the association in terms of behavioral risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR = 2.50; 95% CI = 2.02 - 3.09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviors; and it remained elevated among never users of tobacco and nondrinkers (OR = 1.61; 95% CI = 1.13 - 2.31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviors: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low versus high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioral risk factors for these cancers and which varies across cancer sites, sexes, countries and country income inequality levels.

Published
2015

13. Folate intake and the risk of oral cavity and pharyngeal cancer: A pooled analysis within the International Head and Neck Cancer Epidemiology Consortium

Author

Galeone, Carlotta, Edefonti, Valeria, Parpinel, Maria, Leoncini, Emanuele, Matsuo, Keitaro, Talamini, Renato, Olshan, Andrew F, Zevallos, Jose P, Winn, Deborah M, Jayaprakash, Vijayvel, Moysich, Kirsten, Zhang, Zuo‐Feng, Morgenstern, Hal, Levi, Fabio, Bosetti, Cristina, Kelsey, Karl, McClean, Michael, Schantz, Stimson, Yu, Guo‐Pei, Boffetta, Paolo, Lee, Yuan‐Chin Amy, Hashibe, Mia, La Vecchia, Carlo, and Boccia, Stefania

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Dietary Supplements, Cancer, Nutrition, Rare Diseases, Complementary and Integrative Health, Digestive Diseases, Prevention, Dental/Oral and Craniofacial Disease, Good Health and Well Being, Administration, Oral, Anticarcinogenic Agents, Case-Control Studies, Folic Acid, Humans, Mouth Neoplasms, Pharyngeal Neoplasms, Risk, oral cancer, folate intake, diet, epidemiology, risk factor, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

There are suggestions of an inverse association between folate intake and serum folate levels and the risk of oral cavity and pharyngeal cancers (OPCs), but most studies are limited in sample size, with only few reporting information on the source of dietary folate. Our study aims to investigate the association between folate intake and the risk of OPC within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium. We analyzed pooled individual-level data from ten case-control studies participating in the INHANCE consortium, including 5,127 cases and 13,249 controls. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were estimated for the associations between total folate intake (natural, fortification and supplementation) and natural folate only, and OPC risk. We found an inverse association between total folate intake and overall OPC risk (the adjusted OR for the highest vs. the lowest quintile was 0.65, 95% CI: 0.43-0.99), with a stronger association for oral cavity (OR = 0.57, 95% CI: 0.43-0.75). A similar inverse association, though somewhat weaker, was observed for folate intake from natural sources only in oral cavity cancer (OR = 0.64, 95% CI: 0.45-0.91). The highest OPC risk was observed in heavy alcohol drinkers with low folate intake as compared to never/light drinkers with high folate (OR = 4.05, 95% CI: 3.43-4.79); the attributable proportion (AP) owing to interaction was 11.1% (95% CI: 1.4-20.8%). Lastly, we reported an OR of 2.73 (95% CI:2.34-3.19) for those ever tobacco users with low folate intake, compared with nevere tobacco users and high folate intake (AP of interaction =10.6%, 95% CI: 0.41-20.8%). Our project of a large pool of case-control studies supports a protective effect of total folate intake on OPC risk.

Published
2015

14. Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

Author

Toporcov, Tatiana Natasha, Znaor, Ariana, Zhang, Zuo-Feng, Yu, Guo-Pei, Winn, Deborah M, Wei, Qingyi, Vilensky, Marta, Vaughan, Thomas, Thomson, Peter, Talamini, Renato, Szeszenia-Dabrowska, Neonila, Sturgis, Erich M, Smith, Elaine, Shangina, Oxana, Schwartz, Stephen M, Schantz, Stimson, Rudnai, Peter, Richiardi, Lorenzo, Ramroth, Heribert, Purdue, Mark P, Olshan, Andrew F, Eluf-Neto, José, Muscat, Joshua, Moyses, Raquel Ajub, Morgenstern, Hal, Menezes, Ana, McClean, Michael, Matsuo, Keitaro, Mates, Dana, Macfarlane, Tatiana V, Lissowska, Jolanta, Levi, Fabio, Lazarus, Philip, La Vecchia, Carlo, Lagiou, Pagona, Koifman, Sergio, Kjaerheim, Kristina, Kelsey, Karl, Holcatova, Ivana, Herrero, Rolando, Healy, Claire, Hayes, Richard B, Franceschi, Silvia, Fernandez, Leticia, Fabianova, Eleonora, Daudt, Alexander W, Curioni, Otávio Alberto, Maso, Luigino Dal, Curado, Maria Paula, Conway, David I, Chen, Chu, Castellsague, Xavier, Canova, Cristina, Cadoni, Gabriella, Brennan, Paul, Boccia, Stefania, Antunes, José Leopoldo Ferreira, Ahrens, Wolfgang, Agudo, Antonio, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, and Filho, Victor Wünsch

Subjects
Health Services and Systems, Health Sciences, Rare Diseases, Aging, Dental/Oral and Craniofacial Disease, Tobacco, Prevention, Cancer, Tobacco Smoke and Health, Clinical Research, Good Health and Well Being, Adult, Age Factors, Alcohol Drinking, Case-Control Studies, Female, Genetic Predisposition to Disease, Head and Neck Neoplasms, Humans, Incidence, Male, Middle Aged, Odds Ratio, Registries, Risk Factors, Sex Factors, Smoking, Head and neck neoplasms, adult, smoking, alcohol drinking, diet, Statistics, Public Health and Health Services, Epidemiology, Public health
Abstract

BackgroundIncreasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients.MethodsWe pooled data from 25 case-control studies and conducted separate analyses for adults ≤ 45 years old ('young adults', 2010 cases and 4042 controls) and >45 years old ('older adults', 17700 cases and 22 704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs).ResultsThe young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, = 19.9% (95% CI=9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking=5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young [OR=2.27 (95% CI=1.26, 4.10)], but not in the older adults [OR=1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2.41%, 5.80%) in older adults.ConclusionsDifferences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced length of exposure due to the lower age. Other characteristics, such as those that are inherited, may play a more important role in HNC in young adults compared with older adults.

Published
2015

15. Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium

Author

Leoncini, Emanuele, Ricciardi, Walter, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Paludetti, Gaetano, Brennan, Paul, Luce, Daniele, Stucker, Isabelle, Matsuo, Keitaro, Talamini, Renato, La Vecchia, Carlo, Olshan, Andrew F, Winn, Deborah M, Herrero, Rolando, Franceschi, Silvia, Castellsague, Xavier, Muscat, Joshua, Morgenstern, Hal, Zhang, Zuo-Feng, Levi, Fabio, Dal Maso, Luigino, Kelsey, Karl, McClean, Michael, Vaughan, Thomas L, Lazarus, Philip, Purdue, Mark P, Hayes, Richard B, Chen, Chu, Schwartz, Stephen M, Shangina, Oxana, Koifman, Sergio, Ahrens, Wolfgang, Matos, Elena, Lagiou, Pagona, Lissowska, Jolanta, Szeszenia-Dabrowska, Neonila, Fernandez, Leticia, Menezes, Ana, Agudo, Antonio, Daudt, Alexander W, Richiardi, Lorenzo, Kjaerheim, Kristina, Mates, Dana, Betka, Jaroslav, Yu, Guo-Pei, Schantz, Stimson, Simonato, Lorenzo, Brenner, Hermann, Conway, David I, Macfarlane, Tatiana V, Thomson, Peter, Fabianova, Eleonora, Znaor, Ariana, Rudnai, Peter, Healy, Claire, Boffetta, Paolo, Chuang, Shu-Chun, Lee, Yuan-Chin Amy, Hashibe, Mia, and Boccia, Stefania

Subjects
Epidemiology, Public Health, Health Sciences, Tobacco, Tobacco Smoke and Health, Prevention, Rare Diseases, Clinical Research, Substance Misuse, Cancer, Digestive Diseases, Dental/Oral and Craniofacial Disease, Good Health and Well Being, Adult, Aged, Alcohol Drinking, Body Height, Case-Control Studies, Educational Status, Female, Head and Neck Neoplasms, Humans, Incidence, Interviews as Topic, Logistic Models, Male, Middle Aged, Odds Ratio, Overweight, Risk Factors, Smoking, Height, Consortium, Head and neck neoplasms, Public Health and Health Services
Abstract

Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95% CI 0.86-0.95 for men; adjusted OR = 0.86, 95% CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

Published
2014

16. Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium

Author

Chuang, Shu-Chun, Jenab, Mazda, Heck, Julia E, Bosetti, Cristina, Talamini, Renato, Matsuo, Keitaro, Castellsague, Xavier, Franceschi, Silvia, Herrero, Rolando, Winn, Deborah M, Vecchia, Carlo La, Morgenstern, Hal, Zhang, Zuo-Feng, Levi, Fabio, Maso, Luigino Dal, Kelsey, Karl, McClean, Michael D, Vaughan, Thomas, Lazarus, Philip, Muscat, Joshua, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M, Eluf-Neto, Jose, Hayes, Richard B, Purdue, Mark, Boccia, Stefania, Cadoni, Gabriella, Zaridze, David, Koifman, Sergio, Curado, Maria Paula, Ahrens, Wolfgang, Benhamou, Simone, Matos, Elena, Lagiou, Pagona, Szeszenia-Dabrowska, Neonilla, Olshan, Andrew F, Fernandez, Leticia, Menezes, Ana, Agudo, Antonio, Daudt, Alexander W, Merletti, Franco, Macfarlane, Gary J, Kjaerheim, Kristina, Mates, Dana, Holcatova, Ivana, Schantz, Stimson, Yu, Guo-Pei, Simonato, Lorenzo, Brenner, Hermann, Mueller, Heiko, Conway, David I, Thomson, Peter, Fabianova, Eleonora, Znaor, Ariana, Rudnai, Peter, Healy, Claire M, Ferro, Gilles, Brennan, Paul, Boffetta, Paolo, and Hashibe, Mia

Subjects
Public Health, Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Nutrition, Cancer, Prevention, Dental/Oral and Craniofacial Disease, Digestive Diseases, Rare Diseases, Oral and gastrointestinal, Adult, Aged, Case-Control Studies, Diet, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Risk Factors, Head and neck cancer, Fruit and vegetable, Red meat, Processed meat, Oncology and Carcinogenesis, Public Health and Health Services, Epidemiology, Oncology and carcinogenesis
Abstract

We investigated the association between diet and head and neck cancer (HNC) risk using data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. The INHANCE pooled data included 22 case-control studies with 14,520 cases and 22,737 controls. Center-specific quartiles among the controls were used for food groups, and frequencies per week were used for single food items. A dietary pattern score combining high fruit and vegetable intake and low red meat intake was created. Odds ratios (OR) and 95% confidence intervals (CI) for the dietary items on the risk of HNC were estimated with a two-stage random-effects logistic regression model. An inverse association was observed for higher-frequency intake of fruit (4th vs. 1st quartile OR = 0.52, 95% CI = 0.43-0.62, p (trend) < 0.01) and vegetables (OR = 0.66, 95% CI = 0.49-0.90, p (trend) = 0.01). Intake of red meat (OR = 1.40, 95% CI = 1.13-1.74, p (trend) = 0.13) and processed meat (OR = 1.37, 95% CI = 1.14-1.65, p (trend) < 0.01) was positively associated with HNC risk. Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR = 0.90, 95% CI = 0.84-0.97).

Published
2012

17. Diet and the risk of head and neck cancer: A pooled analysis in the INHANCE consortium

Author

Chuang, Shu-Chun, Jenab, Mazda, Heck, Julia, Olshan, Andrew, Bencko, Vladimir, Schantz, Stimson, Paula Curado, Maria, Mates, Dana, McClean, Michael, Daudt, Alexander, Franceschi, Silvia, Zaridze, David, Koifman, Sergio, Lazarus, Philip, Herrero, Rolando, Fabianova, Eleonora, Maso Luigino, Dal, Zhang, Zuo-Feng, Muscat, Joshua, Talamini, Renato, Rudnai, Peter, Fernandez, Leticia, Lissowska, Jola, Menezes, Ana, Levi, Fabio, Hayes, Richard, Benhamou, Simone, Eluf-Neto, Jose, Boccia, Stefania, and Matos, Elena

Subjects
Oncology & Carcinogenesis, Oncology and Carcinogenesis
Published
2009

23. Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer

Author

Bravi, Francesca, Lee, Yuan‐Chin Amy, Hashibe, Mia, Boffetta, Paolo, Conway, David I., Ferraroni, Monica, La Vecchia, Carlo, Edefonti, Valeria, Agudo, Antonio, Ahrens, Wolfgang, Benhamou, Simone, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Chuang, Shu‐Chun, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W., D'Souza, Gypsyamber, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Garavello, Werner, Gillison, Maura, Gross, Neil D., Hayes, Richard B., Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Rosalina, Lagiou, Pagona, Lazarus, Philip, Levi, Fabio, Li, Guojun, Lissowska, Jolanta, Luce, Daniele, Macfarlane, Gary J., Mates, Dana, Matsuo, Keitaro, McClean, Michael, Menezes, Ana, Menvielle, Gwenn, Morgenstern, Hal, Moyses, Raquel A., Moysich, Kirsten, Muscat, Joshua, Negri, Eva, Olshan, Andrew F., Pandics, Tamas, Polesel, Jerry, Purdue, Mark P., Radoï, Loredana, Ramroth, Heribert, Richiardi, Lorenzo, Schantz, Stimson, Schwartz, Stephen M., Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M., Świątkowska, Beata, Thomson, Peter, Toporcov, Tatiana N., Vaughan, Thomas L., Vilensky, Marta, Winn, Deborah M., Wunsch‐Filho, Victor, Yu, Guo‐Pei, Zevallos, Jose P, Zhang, Zuo‐Feng, Zheng, Tongzhang, Znaor, Ariana, Bravi, F, Lee, Y, Hashibe, M, Boffetta, P, Conway, D, Ferraroni, M, La Vecchia, C, Edefonti, V, Agudo, A, Ahrens, W, Benhamou, S, Boccia, S, Brennan, P, Brenner, H, Cadoni, G, Canova, C, Chen, C, Chuang, S, Curado, M, Dal Maso, L, Daudt, A, D'Souza, G, Fabianova, E, Fernandez, L, Franceschi, S, Garavello, W, Gillison, M, Gross, N, Hayes, R, Healy, C, Herrero, R, Holcatova, I, Kelsey, K, Kjaerheim, K, Koifman, R, Lagiou, P, Lazarus, P, Levi, F, Li, G, Lissowska, J, Luce, D, Macfarlane, G, Mates, D, Matsuo, K, Mcclean, M, Menezes, A, Menvielle, G, Morgenstern, H, Moyses, R, Moysich, K, Muscat, J, Negri, E, Olshan, A, Pandics, T, Polesel, J, Purdue, M, Radoi, L, Ramroth, H, Richiardi, L, Schantz, S, Schwartz, S, Serraino, D, Shangina, O, Smith, E, Sturgis, E, Swiatkowska, B, Thomson, P, Toporcov, T, Vaughan, T, Vilensky, M, Winn, D, Wunsch-Filho, V, Yu, G, Zevallos, J, Zhang, Z, Zheng, T, Znaor, A, Bravi F., Lee Y.-C.A., Hashibe M., Boffetta P., Conway D.I., Ferraroni M., La Vecchia C., Edefonti V., Agudo A., Ahrens W., Benhamou S., Boccia S., Brennan P., Brenner H., Cadoni G., Canova C., Chen C., Chuang S.-C., Curado M.P., Dal Maso L., Daudt A.W., D'Souza G., Fabianova E., Fernandez L., Franceschi S., Garavello W., Gillison M., Gross N.D., Hayes R.B., Healy C., Herrero R., Holcatova I., Kelsey K., Kjaerheim K., Koifman R., Lagiou P., Lazarus P., Levi F., Li G., Lissowska J., Luce D., Macfarlane G.J., Mates D., Matsuo K., McClean M., Menezes A., Menvielle G., Morgenstern H., Moyses R.A., Moysich K., Muscat J., Negri E., Olshan A.F., Pandics T., Polesel J., Purdue M.P., Radoi L., Ramroth H., Richiardi L., Schantz S., Schwartz S.M., Serraino D., Shangina O., Smith E., Sturgis E.M., Swiatkowska B., Thomson P., Toporcov T.N., Vaughan T.L., Vilensky M., Winn D.M., Wunsch-Filho V., Yu G.-P., Zevallos J.P., Zhang Z.-F., Zheng T., and Znaor A.

Subjects
INHANCE, medicine.medical_specialty, Oral health, Cancer recurrence, Article, Tobacco Use, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Epidemiology, medicine, Humans, pooled analysi, prognostic factor, General Dentistry, Beneficial effects, Head and Neck Neoplasm, business.industry, Incidence (epidemiology), Head and neck cancer, oral cavity cancer, Case-control study, prognostic factors, 030206 dentistry, medicine.disease, risk factor, Otorhinolaryngology, Head and Neck Neoplasms, Case-Control Studies, 030220 oncology & carcinogenesis, Family medicine, Etiology, laryngeal cancer, head and neck cancer, Settore MED/31 - OTORINOLARINGOIATRIA, pooled analysis, Neoplasm Recurrence, Local, Case-Control Studie, business, Human
Abstract

Objective:\ud \ud To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium.\ud \ud Subjects and Methods:\ud \ud INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual‐level data on a large scale. We summarize results from recent INHANCE‐based publications updating our 2015 overview.\ud \ud Results:\ud \ud Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow‐up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall‐ and disease‐specific 5‐year‐survival of 51% and 57%, respectively.\ud \ud Conclusions:\ud \ud The number and importance of INHANCE scientific findings provides further evidence of the advantages of large‐scale internationally collaborative projects and will support the development of prevention strategies.

Published
2020
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24. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE Consortium

Author

Goyal, Neerav, Hennessy, Max, Lehman, Erik, Lin, Wenxue, Agudo, Antonio, Ahrens, Wolfgang, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Conway, David, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W, Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Garavello, Werner, Gillison, Maura, Hayes, Richard B, Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kanda, Jossy L, Kelsey, Karl, Hansen, Bo T, Koifman, Rosalina, Lagiou, Pagona, La Vecchia, Carlo, Levi, Fabio, Li, Guojun, Lissowska, Jolanta, Mendoza López, Rossana, Luce, Danièle, Macfarlane, Gary, Mates, Dana, Matsuo, Keitaro, Mcclean, Michael, Menezes, Ana, Menvielle, Gwenn, Morgenstern, Hal, Moysich, Kirsten, Negri, Eva, Olshan, Andrew F, Pandics, Tama, Polesel, Jerry, Purdue, Mark, Radoi, Loredana, Ramroth, Heribert, Richiardi, Lorenzo, Schantz, Stimson, Schwartz, Stephen M, Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M, Świątkowska, Beata, Thomson, Peter, Vaughan, Thomas L, Vilensky, Marta, Winn, Deborah M, Wunsch-Filho, Victor, Yu, Guo-Pei, Zevallos, Jose P, Zhang, Zuo-Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Muscat, Joshua E, Boccia, Stefania (ORCID:0000-0002-1864-749X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Goyal, Neerav, Hennessy, Max, Lehman, Erik, Lin, Wenxue, Agudo, Antonio, Ahrens, Wolfgang, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Conway, David, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W, Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Garavello, Werner, Gillison, Maura, Hayes, Richard B, Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kanda, Jossy L, Kelsey, Karl, Hansen, Bo T, Koifman, Rosalina, Lagiou, Pagona, La Vecchia, Carlo, Levi, Fabio, Li, Guojun, Lissowska, Jolanta, Mendoza López, Rossana, Luce, Danièle, Macfarlane, Gary, Mates, Dana, Matsuo, Keitaro, Mcclean, Michael, Menezes, Ana, Menvielle, Gwenn, Morgenstern, Hal, Moysich, Kirsten, Negri, Eva, Olshan, Andrew F, Pandics, Tama, Polesel, Jerry, Purdue, Mark, Radoi, Loredana, Ramroth, Heribert, Richiardi, Lorenzo, Schantz, Stimson, Schwartz, Stephen M, Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M, Świątkowska, Beata, Thomson, Peter, Vaughan, Thomas L, Vilensky, Marta, Winn, Deborah M, Wunsch-Filho, Victor, Yu, Guo-Pei, Zevallos, Jose P, Zhang, Zuo-Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Muscat, Joshua E, Boccia, Stefania (ORCID:0000-0002-1864-749X), and Cadoni, Gabriella (ORCID:0000-0001-8244-784X)

Abstract

Objective: We analyzed the pooled case-control data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium to compare cigarette smoking and alcohol consumption risk factors for head and neck cancer between less developed and more developed countries. Subjects and methods: The location of each study was categorized as either a less developed or more developed country. We compared the risk of overall head and neck cancer and cancer of specific anatomic subsites associated with cigarette smoking and alcohol consumption. Additionally, age and sex distribution between categories was compared. Results: The odds ratios for head and neck cancer sites associated with smoking duration differed between less developed and more developed countries. Smoking greater than 20 years conferred a higher risk for oral cavity and laryngeal cancer in more developed countries, whereas the risk was greater for oropharynx and hypopharynx cancer in less developed countries. Alcohol consumed for more than 20 years conferred a higher risk for oropharynx, hypopharynx and larynx cancer in less developed countries. The proportion of cases that were young (<45 years) or female differed by country type for some HNC subsites. Conclusion: These findings suggest the degree of industrialization and economic development affects the relationship between smoking-and alcohol with head and neck cancer.

Published
2022

25. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium

Author

Goyal, Neerav, primary, Hennessy, Max, additional, Lehman, Erik, additional, Lin, Wenxue, additional, Agudo, Antonio, additional, Ahrens, Wolfgang, additional, Boccia, Stefania, additional, Brennan, Paul, additional, Brenner, Hermann, additional, Cadoni, Gabriella, additional, Canova, Cristina, additional, Chen, Chu, additional, Conway, David, additional, Curado, Maria Paula, additional, Dal Maso, Luigino, additional, Daudt, Alexander W., additional, Edefonti, Valeria, additional, Fabianova, Eleonora, additional, Fernandez, Leticia, additional, Franceschi, Silvia, additional, Garavello, Werner, additional, Gillison, Maura, additional, Hayes, Richard B., additional, Healy, Claire, additional, Herrero, Rolando, additional, Holcatova, Ivana, additional, Kanda, Jossy L., additional, Kelsey, Karl, additional, Hansen, Bo T., additional, Koifman, Rosalina, additional, Lagiou, Pagona, additional, La Vecchia, Carlo, additional, Levi, Fabio, additional, Li, Guojun, additional, Lissowska, Jolanta, additional, Mendoza López, Rossana, additional, Luce, Danièle, additional, Macfarlane, Gary, additional, Mates, Dana, additional, Matsuo, Keitaro, additional, McClean, Michael, additional, Menezes, Ana, additional, Menvielle, Gwenn, additional, Morgenstern, Hal, additional, Moysich, Kirsten, additional, Negri, Eva, additional, Olshan, Andrew F., additional, Pandics, Tamas, additional, Polesel, Jerry, additional, Purdue, Mark, additional, Radoi, Loredana, additional, Ramroth, Heribert, additional, Richiardi, Lorenzo, additional, Schantz, Stimson, additional, Schwartz, Stephen M., additional, Serraino, Diego, additional, Shangina, Oxana, additional, Smith, Elaine, additional, Sturgis, Erich M., additional, Świątkowska, Beata, additional, Thomson, Peter, additional, Vaughan, Thomas L., additional, Vilensky, Marta, additional, Winn, Deborah M., additional, Wunsch‐Filho, Victor, additional, Yu, Guo‐Pei, additional, Zevallos, Jose P., additional, Zhang, Zuo‐Feng, additional, Zheng, Tongzhang, additional, Znaor, Ariana, additional, Boffetta, Paolo, additional, Hashibe, Mia, additional, Lee, Yuan‐Chin A., additional, and Muscat, Joshua E., additional

Published
2022
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30. Androgen receptor activation decreases proliferation in thyroid cancer cells

Author

Jones, Melanie E., primary, O'Connell, Timmy J., additional, Zhao, Hong, additional, Darzynkiewicz, Zgibniew, additional, Gupta, Anvita, additional, Buchsbaum, Joseph, additional, Shin, Edward, additional, Iacob, Codrin, additional, Suslina, Nina, additional, Moscatello, Augustine, additional, Schantz, Stimson, additional, Tiwari, Raj, additional, and Geliebter, Jan, additional

Published
2021
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31. Cigarette, Cigar, and Pipe Smoking and the Risk of Head and Neck Cancers: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

Author

Wyss, Annah, Hashibe, Mia, Chuang, Shu-Chun, Lee, Yuan-Chin Amy, Zhang, Zuo-Feng, Yu, Guo-Pei, Winn, Deborah M., Wei, Qingyi, Talamini, Renato, Szeszenia-Dabrowska, Neonila, Sturgis, Erich M., Smith, Elaine, Shangina, Oxana, Schwartz, Stephen M., Schantz, Stimson, Rudnai, Peter, Purdue, Mark P., Eluf-Neto, Jose, Muscat, Joshua, Morgenstern, Hal, Michaluart, Pedro, Jr, Menezes, Ana, Matos, Elena, Mates, Ioan Nicolae, Lissowska, Jolanta, Levi, Fabio, Lazarus, Philip, La Vecchia, Carlo, Koifman, Sergio, Herrero, Rolando, Hayes, Richard B., Franceschi, Silvia, Wünsch-Filho, Victor, Fernandez, Leticia, Fabianova, Eleonora, Daudt, Alexander W., Dal Maso, Luigino, Curado, Maria Paula, Chen, Chu, Castellsague, Xavier, de Carvalho, Marcos Brasilino, Cadoni, Gabriella, Boccia, Stefania, Brennan, Paul, Boffetta, Paolo, and Olshan, Andrew F.

Published
2013
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34. Vitamin or mineral supplement intake and the risk of head and neck cancer: pooled analysis in the INHANCE consortium

Author

Li, Qian, Chuang, Shu-Chun, Eluf-Neto, Jose, Menezes, Ana, Matos, Elena, Koifman, Sergio, Wünsch-Filho, Victor, Fernandez, Leticia, Daudt, Alexander W., Curado, Maria Paula, Winn, Deborah M., Franceschi, Silvia, Herrero, Rolando, Castellsague, Xavier, Morgenstern, Hal, Zhang, Zuo-Feng, Lazarus, Philip, Muscat, Joshua, McClean, Michael, Kelsey, Karl T., Hayes, Richard B., Purdue, Mark P., Schwartz, Stephen M., Chen, Chu, Benhamou, Simone, Olshan, Andrew F., Yu, Guopei, Schantz, Stimson, Ferro, Gilles, Brennan, Paul, Boffetta, Paolo, and Hashibe, Mia

Published
2012
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