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Your search keyword '"Schallenberger, Karoline"' showing total 11 results
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11 results on '"Schallenberger, Karoline"'

1. Viral isolation allows characterization of early samples of SARS-CoV-2 lineage B1.1.33 with unique mutations (S: H655Y and T63N) circulating in Southern Brazil in 2020

Author

Gularte, Juliana Schons, da Silva, Mariana Soares, Filippi, Micheli, Demoliner, Meriane, Schallenberger, Karoline, Hansen, Alana Witt, de Abreu Góes Pereira, Vyctoria Malayhka, Heldt, Fágner Henrique, Girardi, Viviane, Weber, Matheus Nunes, de Almeida, Paula Rodrigues, Abbadi, Bruno Lopes, Dornelles, Maiele, Bizarro, Cristiano Valim, Machado, Pablo, Basso, Luiz Augusto, Dellagostin, Odir Antonio, Fleck, Juliane Deise, and Spilki, Fernando Rosado

Published
2022
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2. Antiviral Potential of Chiococca alba (L.) Hitchc. Plant Extracts Against Chikungunya and Mayaro Viruses.

Author

Pires, Ellen Caroline Feitoza, da Silva, Francini Pereira, Schallenberger, Karoline, Hermann, Bruna Saraiva, Mallmann, Larissa, Moura, Wellington Souza, Ascêncio, Sergio Donizeti, Barbosa, Robson dos Santos, Soares, Ilsamar Mendes, Fleck, Juliane Deise, de Oliveira, Eugênio Eduardo, Smagghe, Guy, Ribeiro, Bergmann Morais, and Aguiar, Raimundo Wagner de Souza

Subjects
CHIKUNGUNYA, HIGH performance liquid chromatography, CHIKUNGUNYA virus, VIRUS diseases, METABOLITES, NARINGIN
Abstract

Chikungunya and Mayaro fevers are viral infectious diseases characterized by fever and arthralgia, for which there are currently no effective vaccines or treatments. The urgent need for novel antiviral agents against Chikungunya virus (CHIKV) and Mayaro virus (MAYV) has led to interest in plant-based compounds that can disrupt the viral replication cycle. Chiococca alba (L.) Hitchc., a Neotropical plant traditionally used by Yucatec Maya healers as an antipyretic and antirheumatic, may hold potential as a source of antiviral agents. This study aimed to evaluate the antiviral potential of C. alba methanolic extracts (CAH21 and CAH24) against CHIKV and MAYV through preliminary in vitro and in silico analyses. The cytotoxicity of two methanolic extracts from C. alba roots was assessed in Vero cells using the neutral red assay, and their viral activity was determined via plaque assay post-treatment. Given the observed antiviral effects, we used computational predictions to explore interactions between the multifunctional nsP2 proteases and secondary metabolites identified in C. alba extracts. The metabolites were identified using high-performance liquid chromatography (HPLC) and gas chromatography–mass spectrometry (GC-MS). Phytochemical analysis revealed the presence of flavonoids, coumarins, and phenolic acids in the C. alba extracts. In vitro assays demonstrated that both extracts inhibited over 70% of activity against CHIKV and MAYV at a concentration of 60 µg/mL. In silico predictions suggested that the flavonoids naringin and vitexin had the highest affinity for the nsP2 proteases of CHIKV and MAYV, indicating their potential as viral inhibitors. Our findings revealed that C. alba extract represents a promising source of novel antiviral compounds. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Preliminary analysis of a neotropical plant extract antiviral potential against Chikungunya and Mayaro viruses

Author

Feitoza Pires, Ellen Caroline, primary, da Silva, Francini Pereira, additional, Schallenberger, Karoline, additional, Hermann, Bruna Saraiva, additional, Mallmann, Larissa, additional, dos Santos, Alini Godinho, additional, Moura, Wellington S., additional, de Oliveira, Eugênio E., additional, Smagghe, Guy, additional, Ascêncio, Sergio Donizeti, additional, Santos Barbosa, Robson dos, additional, Mendes, Ilsamar, additional, Fleck, Juliane Deise, additional, Ribeiro, Bergmann Morais, additional, and de Souza Aguiar, Raimundo Wagner, additional

Published
2021
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4. Pervasive transmission of E484K and emergence of VUI-NP13L with evidence of SARS-CoV-2 co-infection events by two different lineages in Rio Grande do Sul, Brazil

Author

Francisco Jr, Ronaldo da Silva, primary, Benites, L. Felipe, additional, Lamarca, Alessandra P., additional, de Almeida, Luiz G.P., additional, Hansen, Alana Witt, additional, Gularte, Juliana Schons, additional, Demoliner, Meriane, additional, Gerber, Alexandra L., additional, de C Guimarães, Ana Paula, additional, Antunes, Ana Karolina Eisen, additional, Heldt, Fagner Henrique, additional, Mallmann, Larissa, additional, Hermann, Bruna, additional, Ziulkoski, Ana Luiza, additional, Goes, Vyctoria, additional, Schallenberger, Karoline, additional, Fillipi, Micheli, additional, Pereira, Francini, additional, Weber, Matheus Nunes, additional, de Almeida, Paula Rodrigues, additional, Fleck, Juliane Deise, additional, Vasconcelos, Ana Tereza R., additional, and Spilki, Fernando Rosado, additional

Published
2021
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5. Screening for antiviral activity of two purified saponin fractions of Quillaja spp. against Yellow Fever Virus and Chikungunya Virus

Author

Troian, Eduardo Artur, Schallenberger, Karoline, da Silva, Francini Pereira, Dietrich, Gabriela Klein, Ferreira Chiesa, Fernando, Olivaro, Cristina, Wallace, Federico, Fleck, Juliane, Verza, Simone, Troian, Eduardo Artur, Schallenberger, Karoline, da Silva, Francini Pereira, Dietrich, Gabriela Klein, Ferreira Chiesa, Fernando, Olivaro, Cristina, Wallace, Federico, Fleck, Juliane, and Verza, Simone

Abstract

Yellow Fever Virus (YFV) and Chikungunya Virus (CHIV) are neglected reemerging pathogens that cause comorbidities worldwide. Since no antiviral drug is prescribed for those infections, there is a demand on researching compounds that inhibit viral replication. Saponins are amphiphilic compounds that already demonstrated in vitro activity against enveloped virus. Therefore, two purified saponin fractions from Quillaja spp. were evaluated regarding their antiviral potential against YFV and CHIKV. The cell line used in this study was VERO (African green monkey kidney cells) since it is permissive to the replication of both viruses. The antiviral activity of both saponins fractions was screened using the plaque reduction assay protocol. Although saponins did not inhibited YFV replication, they strongly inhibited CHIKV. To confirm the absence of antiviral activity of Quillaja saponins against YFV, the cytopathic effect inhibition assay was performed also. Further studies are required to determine the antiviral mechanisms involved in the CHIKV inhibition.

Published
2020

6. Pervasive transmission of E484K and emergence of VUI-NP13L with evidence of SARS-CoV-2 co-infection events by two different lineages in Rio Grande do Sul, Brazil

Author

da Silva Francisco, Ronaldo, primary, Benites, L. Felipe, additional, Lamarca, Alessandra P, additional, de Almeida, Luiz G P, additional, Hansen, Alana Witt, additional, Gularte, Juliana Schons, additional, Demoliner, Meriane, additional, Gerber, Alexandra L, additional, de C Guimarães, Ana Paula, additional, Antunes, Ana Karolina Eisen, additional, Heldt, Fagner Henrique, additional, Mallmann, Larissa, additional, Hermann, Bruna, additional, Ziulkoski, Ana Luiza, additional, Goes, Vyctoria, additional, Schallenberger, Karoline, additional, Fillipi, Micheli, additional, Pereira, Francini, additional, Weber, Matheus Nunes, additional, de Almeida, Paula Rodrigues, additional, Fleck, Juliane Deise, additional, Vasconcelos, Ana Tereza R, additional, and Spilki, Fernando Rosado, additional

Published
2021
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9. Comparison of Different Kits for SARS-CoV-2 RNA Extraction Marketed in Brazil

Author

Eisen, Ana Karolina Antunes, primary, Demoliner, Meriane, additional, Gularte, Juliana Schons, additional, Hansen, Alana Witt, additional, Schallenberger, Karoline, additional, Mallmann, Larissa, additional, Hermann, Bruna Saraiva, additional, Heldt, Fágner Henrique, additional, de Almeida, Paula Rodrigues, additional, Fleck, Juliane Deise, additional, and Spilki, Fernando Rosado, additional

Published
2020
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