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501 results on '"Schain, Martin A."'

5. The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases

Author

Smith, Ruben, Capotosti, Francesca, Schain, Martin, Ohlsson, Tomas, Vokali, Efthymia, Molette, Jerome, Touilloux, Tanja, Hliva, Valerie, Dimitrakopoulos, Ioannis K., Puschmann, Andreas, Jögi, Jonas, Svenningsson, Per, Andréasson, Mattias, Sandiego, Christine, Russell, David S., Miranda-Azpiazu, Patricia, Halldin, Christer, Stomrud, Erik, Hall, Sara, Bratteby, Klas, Tampio L’Estrade, Elina, Luthi-Carter, Ruth, Pfeifer, Andrea, Kosco-Vilbois, Marie, Streffer, Johannes, and Hansson, Oskar

Published
2023
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10. Preprocessing, Prediction and Significance: Framework and Application to Brain Imaging

Author

Nørgaard, Martin, Ozenne, Brice, Svarer, Claus, Frokjaer, Vibe G., Schain, Martin, Strother, Stephen C., Ganz, Melanie, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Shen, Dinggang, editor, Liu, Tianming, editor, Peters, Terry M., editor, Staib, Lawrence H., editor, Essert, Caroline, editor, Zhou, Sean, editor, Yap, Pew-Thian, editor, and Khan, Ali, editor

Published
2019
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11. Update on [18F]ACI‐12589: a novel and promising PET tracer for a‐synuclein

Author

Capotosti, Francesca, primary, Smith, Ruben, additional, Vokali, Efthymia, additional, Molette, Jerome, additional, Ohlsson, Tomas, additional, Schain, Martin, additional, Ravache, Myriam, additional, Dimitrakopoulos, Ioannis K, additional, Delgado, Christophe, additional, Kocher, Jacqueline, additional, Pittet, Laure, additional, Vallet, Coralie, additional, Luthi‐Carter, Ruth, additional, Hliva, Valerie, additional, Pfeifer, Andrea, additional, Kosco‐Vilbois, Marie, additional, Streffer, Johannes, additional, and Hansson, Oskar, additional

Published
2023
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22. Patterns of age related changes for phosphodiesterase type-10A in comparison with dopamine D2/3 receptors and sub-cortical volumes in the human basal ganglia: A PET study with 18F-MNI-659 and 11C-raclopride with correction for partial volume effect

Author

Fazio, Patrik, Schain, Martin, Mrzljak, Ladislav, Amini, Nahid, Nag, Sangram, Al-Tawil, Nabil, Fitzer-Attas, Cheryl J., Bronzova, Juliana, Landwehrmeyer, Bernhard, Sampaio, Cristina, Halldin, Christer, and Varrone, Andrea

Published
2017
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34. Guidelines for the content and format of PET brain data in publications and archives: A consensus paper

Author

Knudsen, Gitte M, Ganz, Melanie, Appelhoff, Stefan, Boellaard, Ronald, Bormans, Guy, Carson, Richard E, Catana, Ciprian, Doudet, Doris, Gee, Antony D, Greve, Douglas N, Gunn, Roger N, Halldin, Christer, Herscovitch, Peter, Huang, Henry, Keller, Sune H, Lammertsma, Adriaan A, Lanzenberger, Rupert, Liow, Jeih-San, Lohith, Talakad G, Lubberink, Mark, Lyoo, Chul H, Mann, J John, Matheson, Granville J, Nichols, Thomas E, Nørgaard, Martin, Ogden, Todd, Parsey, Ramin, Pike, Victor W, Price, Julie, Rizzo, Gaia, Rosa-Neto, Pedro, Schain, Martin, Scott, Peter JH, Searle, Graham, Slifstein, Mark, Suhara, Tetsuya, Talbot, Peter S, Thomas, Adam, Veronese, Mattia, Wong, Dean F, Yaqub, Maqsood, Zanderigo, Francesca, Zoghbi, Sami, and Innis, Robert B

Published
2020
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39. Kinetic models for estimating occupancy from single-scan PET displacement studies

Author

Laurell, Gjertrud Louise, primary, Plavén-Sigray, Pontus, additional, Johansen, Annette, additional, Raval, Nakul Ravi, additional, Nasser, Arafat, additional, Aabye Madsen, Clara, additional, Madsen, Jacob, additional, Hansen, Hanne Demant, additional, Donovan, Lene Lundgaard, additional, Knudsen, Gitte Moos, additional, Lammertsma, Adriaan A, additional, Ogden, R Todd, additional, Svarer, Claus, additional, and Schain, Martin, additional

Published
2023
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41. Kinetic models for estimating occupancy from single-scan PET displacement studies

Author

Laurell, Gjertrud Louise, Plavén-Sigray, Pontus, Johansen, Annette, Raval, Nakul Ravi, Nasser, Arafat, Aabye Madsen, Clara, Madsen, Jacob, Hansen, Hanne Demant, Donovan, Lene Lundgaard, Knudsen, Gitte Moos, Lammertsma, Adriaan A., Ogden, R. Todd, Svarer, Claus, Schain, Martin, Laurell, Gjertrud Louise, Plavén-Sigray, Pontus, Johansen, Annette, Raval, Nakul Ravi, Nasser, Arafat, Aabye Madsen, Clara, Madsen, Jacob, Hansen, Hanne Demant, Donovan, Lene Lundgaard, Knudsen, Gitte Moos, Lammertsma, Adriaan A., Ogden, R. Todd, Svarer, Claus, and Schain, Martin

Abstract

The traditional design of PET target engagement studies is based on a baseline scan and one or more scans after drug administration. We here evaluate an alternative design in which the drug is administered during an on-going scan (i.e., a displacement study). This approach results both in lower radiation exposure and lower costs. Existing kinetic models assume steady state. This condition is not present during a drug displacement and consequently, our aim here was to develop kinetic models for analysing PET displacement data. We modified existing compartment models to accommodate a time-variant increase in occupancy following the pharmacological in-scan intervention. Since this implies the use of differential equations that cannot be solved analytically, we developed instead one approximate and one numerical solution. Through simulations, we show that if the occupancy is relatively high, it can be estimated without bias and with good accuracy. The models were applied to PET data from six pigs where [11C]UCB-J was displaced by intravenous brivaracetam. The dose-occupancy relationship estimated from these scans showed good agreement with occupancies calculated with Lassen plot applied to baseline-block scans of two pigs. In summary, the proposed models provide a framework to determine target occupancy from a single displacement scan., The traditional design of PET target engagement studies is based on a baseline scan and one or more scans after drug administration. We here evaluate an alternative design in which the drug is administered during an on-going scan (i.e., a displacement study). This approach results both in lower radiation exposure and lower costs. Existing kinetic models assume steady state. This condition is not present during a drug displacement and consequently, our aim here was to develop kinetic models for analysing PET displacement data. We modified existing compartment models to accommodate a time-variant increase in occupancy following the pharmacological in-scan intervention. Since this implies the use of differential equations that cannot be solved analytically, we developed instead one approximate and one numerical solution. Through simulations, we show that if the occupancy is relatively high, it can be estimated without bias and with good accuracy. The models were applied to PET data from six pigs where [11C]UCB-J was displaced by intravenous brivaracetam. The dose-occupancy relationship estimated from these scans showed good agreement with occupancies calculated with Lassen plot applied to baseline-block scans of two pigs. In summary, the proposed models provide a framework to determine target occupancy from a single displacement scan.

Published
2023

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