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1. Comparison between the EKFC-equation and machine learning models to predict Glomerular Filtration Rate

Author

Nakano, Felipe Kenji, Åkesson, Anna, de Boer, Jasper, Dedja, Klest, D’hondt, Robbe, Haredasht, Fateme Nateghi, Björk, Jonas, Courbebaisse, Marie, Couzi, Lionel, Ebert, Natalie, Eriksen, Björn O., Dalton, R. Neil, Derain-Dubourg, Laurence, Gaillard, Francois, Garrouste, Cyril, Grubb, Anders, Jacquemont, Lola, Hansson, Magnus, Kamar, Nassim, Legendre, Christophe, Littmann, Karin, Mariat, Christophe, Melsom, Toralf, Rostaing, Lionel, Rule, Andrew D., Schaeffner, Elke, Sundin, Per-Ola, Bökenkamp, Arend, Berg, Ulla, Åsling-Monemi, Kajsa, Selistre, Luciano, Larsson, Anders, Nyman, Ulf, Lanot, Antoine, Pottel, Hans, Delanaye, Pierre, and Vens, Celine

Published
2024
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5. Including measures of chronic kidney disease to improve cardiovascular risk prediction by SCORE2 and SCORE2-OP.

Author

Matsushita, Kunihiro, Kaptoge, Stephen, Hageman, Steven, Sang, Yingying, Ballew, Shoshana, Grams, Morgan, Surapaneni, Aditya, Sun, Luanluan, Arnlov, Johan, Bozic, Milica, Brenner, Hermann, Brunskill, Nigel, Chang, Alex, Chinnadurai, Rajkumar, Cirillo, Massimo, Correa, Adolfo, Ebert, Natalie, Eckardt, Kai-Uwe, Gansevoort, Ron, Gutierrez, Orlando, Hadaegh, Farzad, He, Jiang, Hwang, Shih-Jen, Jafar, Tazeen, Jassal, Simerjot, Kayama, Takamasa, Kovesdy, Csaba, Landman, Gijs, Levey, Andrew, Lloyd-Jones, Donald, Major, Rupert, Miura, Katsuyuki, Muntner, Paul, Nadkarni, Girish, Nowak, Christoph, Ohkubo, Takayoshi, Pena, Michelle, Polkinghorne, Kevan, Sairenchi, Toshimi, Schaeffner, Elke, Schneider, Markus, Shalev, Varda, Shlipak, Michael, Solbu, Marit, Stempniewicz, Nikita, Tollitt, James, Valdivielso, José, van der Leeuw, Joep, Wang, Angela, Wen, Chi-Pang, Woodward, Mark, Yamagishi, Kazumasa, Yatsuya, Hiroshi, Zhang, Luxia, Dorresteijn, Jannick, Di Angelantonio, Emanuele, Visseren, Frank, Pennells, Lisa, and Coresh, Josef

Subjects
Cardiovascular disease, Chronic kidney disease, Meta-analysis, Risk prediction, Humans, Aged, Aged, 80 and over, Cardiovascular Diseases, Risk Factors, Creatinine, Renal Insufficiency, Chronic, Albuminuria, Glomerular Filtration Rate, Heart Disease Risk Factors
Abstract

AIMS: The 2021 European Society of Cardiology (ESC) guideline on cardiovascular disease (CVD) prevention categorizes moderate and severe chronic kidney disease (CKD) as high and very-high CVD risk status regardless of other factors like age and does not include estimated glomerular filtration rate (eGFR) and albuminuria in its algorithms, systemic coronary risk estimation 2 (SCORE2) and systemic coronary risk estimation 2 in older persons (SCORE2-OP), to predict CVD risk. We developed and validated an Add-on to incorporate CKD measures into these algorithms, using a validated approach. METHODS: In 3,054 840 participants from 34 datasets, we developed three Add-ons [eGFR only, eGFR + urinary albumin-to-creatinine ratio (ACR) (the primary Add-on), and eGFR + dipstick proteinuria] for SCORE2 and SCORE2-OP. We validated C-statistics and net reclassification improvement (NRI), accounting for competing risk of non-CVD death, in 5,997 719 participants from 34 different datasets. RESULTS: In the target population of SCORE2 and SCORE2-OP without diabetes, the CKD Add-on (eGFR only) and CKD Add-on (eGFR + ACR) improved C-statistic by 0.006 (95%CI 0.004-0.008) and 0.016 (0.010-0.023), respectively, for SCORE2 and 0.012 (0.009-0.015) and 0.024 (0.014-0.035), respectively, for SCORE2-OP. Similar results were seen when we included individuals with diabetes and tested the CKD Add-on (eGFR + dipstick). In 57 485 European participants with CKD, SCORE2 or SCORE2-OP with a CKD Add-on showed a significant NRI [e.g. 0.100 (0.062-0.138) for SCORE2] compared to the qualitative approach in the ESC guideline. CONCLUSION: Our Add-ons with CKD measures improved CVD risk prediction beyond SCORE2 and SCORE2-OP. This approach will help clinicians and patients with CKD refine risk prediction and further personalize preventive therapies for CVD.

Published
2023

8. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease

Author

Stevens, Paul E., Ahmed, Sofia B., Carrero, Juan Jesus, Foster, Bethany, Francis, Anna, Hall, Rasheeda K., Herrington, Will G., Hill, Guy, Inker, Lesley A., Kazancıoğlu, Rümeyza, Lamb, Edmund, Lin, Peter, Madero, Magdalena, McIntyre, Natasha, Morrow, Kelly, Roberts, Glenda, Sabanayagam, Dharshana, Schaeffner, Elke, Shlipak, Michael, Shroff, Rukshana, Tangri, Navdeep, Thanachayanont, Teerawat, Ulasi, Ifeoma, Wong, Germaine, Yang, Chih-Wei, Zhang, Luxia, and Levin, Adeera

Published
2024
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9. Executive summary of the KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease: known knowns and known unknowns

Author

Levin, Adeera, Ahmed, Sofia B., Carrero, Juan Jesus, Foster, Bethany, Francis, Anna, Hall, Rasheeda K., Herrington, Will G., Hill, Guy, Inker, Lesley A., Kazancıoğlu, Rümeyza, Lamb, Edmund, Lin, Peter, Madero, Magdalena, McIntyre, Natasha, Morrow, Kelly, Roberts, Glenda, Sabanayagam, Dharshana, Schaeffner, Elke, Shlipak, Michael, Shroff, Rukshana, Tangri, Navdeep, Thanachayanont, Teerawat, Ulasi, Ifeoma, Wong, Germaine, Yang, Chih-Wei, Zhang, Luxia, Robinson, Karen A., Wilson, Lisa, Wilson, Renee F., Kasiske, Bertram L., Cheung, Michael, Earley, Amy, and Stevens, Paul E.

Published
2024
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12. Explaining International Trends in Mortality on Hemodialysis Through Changes in Hemodialysis Practices in the Dialysis Outcomes and Practice Patterns Study (DOPPS)

Author

Dr. Ali Al-Aradi, Jadoul, Michel, Evenepoel, Pieter, Sood, Manish, Suri, Rita, Zuo, Li, Chen, Yuqing, Ni, Zhaohui, Chen, Xiaonong, Hou, Fanfan, Liang, Xinling, Combe, Christian, Guebre-Egziabher, Fitsum, Antonio Ureña Torres, Pablo, Kleophas, Werner, Schaeffner, Elke, Weinreich, Thomas, Brunori, Giuliano, Messa, Piergiorio, Nitta, Kosaku, Inaba, Masaaki, Fukagawa, Masafumi, Sakai, Ken, Tsuruya, Kazuhiko, Hamano, Takayuki, Honda, Hirokazu, Hoshino, Junichi, Komaba, Hirotaka, Nakano, Toshiaki, Al Helal, Bassam, Alkandari, Naser, AlRajab, Heba, Alyousef, Anas, Al Maimani, Yacoub, Alsalmi, Issa, Al Ali, Fadwa, Hamad, Abdulla, Al-Ghamdi, Saeed, Al Ghonaim, Mohammed, Al Wakeel, Jamal, Hejaili, Fayez, Karkar, Ayman, Shaheen, Faissal, Jacobson, Stefan, Christensson, Anders, Cases, Aleix, Vega Martínez, Almudena, Abdulkarim Al Obaidli, Ali, Al Rukhaimi, Mona, Hassan, Mohamed, Kareem Saleh, Abdul, Asgari, Elham, Dasgupta, Indranil, McCullough, Keith P., Morgenstern, Hal, Rayner, Hugh C., Port, Friedrich K., Jadoul, Michel Y., Akizawa, Tadao, Pisoni, Ronald L., Herman, William H., and Robinson, Bruce M.

Published
2024
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14. Iohexol plasma clearance measurement protocol standardization for adults: a consensus paper of the European Kidney Function Consortium

Author

Ebert, Natalie, Schaeffner, Elke, Seegmiller, Jesse C., van Londen, Marco, Bökenkamp, Arend, Cavalier, Etienne, Delanaye, Pierre, Derain-Dubourg, Laurence, Eriksen, Bjørn O., Indridason, Olafur S., Palsson, Runolfur, Shafi, Tariq, Christensson, Anders, Bevc, Sebastjan, Carrara, Fabiola, Courbebaisse, Marie, Dalton, R. Neil, van der Giet, Markus, Melsom, Toralf, Methven, Shona, Nordin, Gunnar, Pottel, Hans, Rule, Andrew D., Trillini, Matias, and White, Christine A.

Published
2024
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15. Copeptin, Natriuretic Peptides, and Cardiovascular Outcomes in Patients With CKD: The German Chronic Kidney Disease (GCKD) Study

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Reis, André, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer, Schneider, Markus P., Schultheiss, Ulla T., Friedrich, Nele, and Nauck, Matthias

Published
2023
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16. Trends and perspectives for improving quality of chronic kidney disease care: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Author

Al-Aly, Ziyad, Ashuntantang, Gloria E., Boor, Peter, Calice da Silva, Viviane, Coleman, Jill, Coresh, Josef, Delanaye, Pierre, Ebert, Natalie, Enghard, Philipp, Feldman, Harold I., Fisher, Lori, Flythe, Jennifer E., Fukui, Akira, Grams, Morgan E., Ix, Joseph H., Jardine, Meg J., Jha, Vivek, Ju, Wenjun, Jurish, Robert, Kalyesubula, Robert, Kashihara, Naoki, Levey, Andrew S., Levin, Adeera, Luyckx, Valerie, Małyszko, Jolanta, Manski-Nankervis, Jo-Anne, Navaneethan, Sankar D., Obrador, Greg, Ortiz, Alberto, Ortiz, John, Cardoso Dos Santos, Bento Fortunato, Sarnak, Mark J., Schaeffner, Elke, Selby, Nick M., Simpson, David M., Solá, Laura, St. Peter, Wendy L., Stevens, Paul E., Tangri, Navdeep, Tannor, Elliot Koranteng, Tchokhonelidze, Irma, Wilck, Nicola, Wong, Michelle M.Y., Eckardt, Kai-Uwe, Delgado, Cynthia, Heerspink, Hiddo J.L., Pecoits-Filho, Roberto, Ricardo, Ana C., Stengel, Bénédicte, Tonelli, Marcello, Cheung, Michael, Jadoul, Michel, Winkelmayer, Wolfgang C., and Kramer, Holly

Published
2023
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17. Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts

Author

Ahn, Curie, Berger, Stefan P., Caskey, Fergus J., Cho, Min Hyun, Cho, Heeyeon, Dekker, Friedo W., Diwan, Vishal, Drechsler, Christiane, Eckardt, Kai-Uwe, Evans, Marie, Ferreiro, Alejandro, Floege, Jürgen, Gadola, Liliana, Haller, Hermann, Han, Kyung Hee, Healy, Helen G., Heerspink, Hiddo Lambers, Hemmelder, Marc, Hiemstra, Thomas, Hilbrands, Luuk, Kim, Seong Heon, Klyprayong, Pinkaew, Köttgen, Anna, Kronenberg, Florian, Lamadrid, Veronica, Lee, Joo Hoo, Mark, Patrick, Matheson, Matt, Mi, Eun, Noppakun, Kajohnsak, Oefner, Peter, Panaput, Thanachai, Park, Young Seo, Prokosch, Hans-Ulrich, Reis, André, Rios, Pablo, Rosivall, Laszlo, Rotmans, Joris I., Sackeyfio, Alfred, Sangthawan, Pornpen, Schmid, Matthias, Shin, Jae Il, Silavarino, Ricardo, Sitter, Thomas, Sommerer, Claudia, Szymczak, Maciej, Torino, Claudia, Toth, Janos, van Ittersum, Frans J., Venuthurupalli, Sree Krishna, Verhaar, Marianne C., Wang, Zaimin, Wanner, Christoph, Wiecek, Andrzej, Wolf, Gunter, de Zeeuw, Dick, Zhang, Luxia, Zheng, Yuyan, Zhao, Ming-Hui, Zietse, Robert, Canney, Mark, Induruwage, Dilshani, Tang, Mila, Alencar de Pinho, Natalia, Er, Lee, Zhao, Yinshan, Djurdjev, Ognjenka, Ahn, Yo Han, Behnisch, Rouven, Calice-Silva, Viviane, Chesnaye, Nicholas C., de Borst, Martin H., Dember, Laura M., Dionne, Janis, Ebert, Natalie, Eder, Susanne, Fenton, Anthony, Fukagawa, Masafumi, Furth, Susan L., Hoy, Wendy E., Imaizumi, Takahiro, Jager, Kitty J., Jha, Vivekanand, Kang, Hee Gyung, Kitiyakara, Chagriya, Mayer, Gert, Oh, Kook-Hwan, Onu, Ugochi, Pecoits-Filho, Roberto, Reichel, Helmut, Richards, Anna, Schaefer, Franz, Schaeffner, Elke, Scheppach, Johannes B., Sola, Laura, Ulasi, Ifeoma, Wang, Jinwei, Yadav, Ashok K., Zhang, Jianzhen, Feldman, Harold I., Taal, Maarten W., Stengel, Bénédicte, and Levin, Adeera

Published
2023
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18. Differential Prognostic Utility of Adiposity Measures in Chronic Kidney Disease

Author

Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Reis, André, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Paul, Rainer, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Cejka, Vladimir, Störk, Stefan, Nadal, Jennifer, Sitter, Thomas, Meiselbach, Heike, Busch, Martin, Schneider, Markus P., Saritas, Turgay, Schultheiss, Ulla T., Kotsis, Fruzsina, Wanner, Christoph, Eckardt, Kai-Uwe, and Krane, Vera

Published
2023
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21. Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus P., Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Kraska, Detlef, Reis, André, Ekici, Arif B., Becker, Susanne, Alberth-Schmidt, Ulrike, Marschall, Sabine, Schefler, Eugenia, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Schmidt-Ott, Kai, Zeier, Martin, Sommerer, Claudia, Aykac, Mehtap, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer, Müller-Krebs, Sandra, Schultheiss, Ulla T., Friedrich, Nele, Nauck, Matthias, Nußhag, Christian, Reiser, Jochen, and Hayek, Salim S.

Published
2023
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22. Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium

Author

Inker, Lesley A, Grams, Morgan E, Levey, Andrew S, Coresh, Josef, Cirillo, Massimo, Collins, John F, Gansevoort, Ron T, Gutierrez, Orlando M, Hamano, Takayuki, Heine, Gunnar H, Ishikawa, Shizukiyo, Jee, Sun Ha, Kronenberg, Florian, Landray, Martin J, Miura, Katsuyuki, Nadkarni, Girish N, Peralta, Carmen A, Rothenbacher, Dietrich, Schaeffner, Elke, Sedaghat, Sanaz, Shlipak, Michael G, Zhang, Luxia, van Zuilen, Arjan D, Hallan, Stein I, Kovesdy, Csaba P, Woodward, Mark, Levin, Adeera, Astor, Brad, Appel, Larry, Greene, Tom, Chen, Teresa, Chalmers, John, Arima, Hisatomi, Perkovic, Vlado, Yatsuya, Hiroshi, Tamakoshi, Koji, Li, Yuanying, Hirakawa, Yoshihisa, Matsushita, Kunihiro, Grams, Morgan, Sang, Yingying, Polkinghorne, Kevan, Chadban, Steven, Atkins, Robert, Djurdjev, Ognjenka, Liu, Lisheng, Zhao, Minghui, Wang, Fang, Wang, Jinwei, Ebert, Natalie, Martus, Peter, Tang, Mila, Heine, Gunnar, Emrich, Insa, Seiler, Sarah, Zawada, Adam, Nally, Joseph, Navaneethan, Sankar, Schold, Jesse, Shlipak, Michael, Sarnak, Mark, Katz, Ronit, Hiramoto, Jade, Iso, Hiroyasu, Yamagishi, Kazumasa, Umesawa, Mitsumasa, Muraki, Isao, Fukagawa, Masafumi, Maruyama, Shoichi, Hasegawa, Takeshi, Fujii, Naohiko, Wheeler, David, Emberson, John, Townend, John, Landray, Martin, Brenner, Hermann, Schöttker, Ben, Saum, Kai-Uwe, Fox, Caroline, Hwang, Shih-Jen, Köttgen, Anna, Schneider, Markus P, Eckardt, Kai-Uwe, Green, Jamie, Kirchner, H Lester, and Chang, Alex R

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Women's Health, Clinical Research, Kidney Disease, Renal and urogenital, Good Health and Well Being, Aged, Albuminuria, Blood Chemical Analysis, Creatinine, Cross-Sectional Studies, Disease Progression, Female, Global Health, Glomerular Filtration Rate, Humans, Hypertension, Renal, Internationality, Kidney Function Tests, Male, Middle Aged, Predictive Value of Tests, Renal Insufficiency, Chronic, Retrospective Studies, Sensitivity and Specificity, Severity of Illness Index, Urinalysis, CKD Prognosis Consortium, CKD stage, Chronic kidney disease, albuminuria, anemia, diabetes, glomerular filtration rate, hematocrit, hemoglobin, hyperparathyroidism, hypertension, individual-level meta-analysis, kidney function, laboratory abnormality, laboratory tests, meta-analysis, serum bicarbonate, serum calcium, serum intact parathyroid hormone, serum phosphorus, serum potassium, staging system, Public Health and Health Services, Urology & Nephrology, Clinical sciences
Abstract

Rationale & objectiveChronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework.Study designCross-sectional individual participant-level analyses in a global consortium.Setting & study populations17 CKD and 38 general population and high-risk cohorts.Selection criteria for studiesCohorts in the CKD Prognosis Consortium with data for eGFR and albuminuria, as well as a measurement of hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, or calcium, or hypertension.Data extractionData were obtained and analyzed between July 2015 and January 2018.Analytical approachWe modeled the association of eGFR and albuminuria with hemoglobin, bicarbonate, phosphorus, parathyroid hormone, potassium, and calcium values using linear regression and with hypertension and categorical definitions of each abnormality using logistic regression. Results were pooled using random-effects meta-analyses.ResultsThe CKD cohorts (n=254,666 participants) were 27% women and 10% black, with a mean age of 69 (SD, 12) years. The general population/high-risk cohorts (n=1,758,334) were 50% women and 2% black, with a mean age of 50 (16) years. There was a strong graded association between lower eGFR and all laboratory result abnormalities (ORs ranging from 3.27 [95% CI, 2.68-3.97] to 8.91 [95% CI, 7.22-10.99] comparing eGFRs of 15 to 29 with eGFRs of 45 to 59mL/min/1.73m2), whereas albuminuria had equivocal or weak associations with abnormalities (ORs ranging from 0.77 [95% CI, 0.60-0.99] to 1.92 [95% CI, 1.65-2.24] comparing urinary albumin-creatinine ratio > 300 vs < 30mg/g).LimitationsVariations in study era, health care delivery system, typical diet, and laboratory assays.ConclusionsLower eGFR was strongly associated with higher odds of multiple laboratory result abnormalities. Knowledge of risk associations might help guide management in the heterogeneous group of patients with CKD.

Published
2019

24. Educational Attainment Is Associated With Kidney and Cardiovascular Outcomes in the German CKD (GCKD) Cohort

Author

Winitzki, Doris, Zacharias, Helena U., Nadal, Jennifer, Baid-Agrawal, Seema, Schaeffner, Elke, Schmid, Matthias, Busch, Martin, Bergmann, Manuela M., Schultheiss, Ulla, Kotsis, Fruzsina, Stockmann, Helena, Meiselbach, Heike, Wolf, Gunter, Krane, Vera, Sommerer, Claudia, Eckardt, Kai-Uwe, Schneider, Markus P., Schlieper, Georg, Floege, Jürgen, and Saritas, Turgay

Published
2022
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25. #2422 Iohexol plasma clearance measurement protocol standardization—a consensus of the European Kidney Function Consortium

Author

Ebert, Natalie, primary, Schaeffner, Elke, additional, Seegmiller, Jesse C, additional, van Londen, Marco, additional, Bökenkamp, Arend, additional, Cavalier, Etienne, additional, Delanaye, Pierre, additional, Derain-Dubourg, Laurence, additional, Eriksen, Bjørn O, additional, Pálsson, Runólfur, additional, Shafi, Tariq, additional, and White, Christine A, additional

Published
2024
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28. Frequent LPA KIV-2 Variants Lower Lipoprotein(a) Concentrations and Protect Against Coronary Artery Disease

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus P., Schiffer, Mario, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Reis, André, Ekici, Arif B., Becker, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Saritas, Turgay, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Theilinger, Johanna, Wolf, Gunter, Busch, Martin, Paul, Rainer, Sitter, Thomas, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Schmid, Matthias, Nadal, Jennifer, Schachtl-Riess, Johanna F., Kheirkhah, Azin, Grüneis, Rebecca, Di Maio, Silvia, Schoenherr, Sebastian, Streiter, Gertraud, Losso, Jamie Lee, Paulweber, Bernhard, Lamina, Claudia, and Coassin, Stefan

Published
2021
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29. Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data

Author

Matsushita, Kunihiro, Ballew, Shoshana H, Coresh, Josef, Arima, Hisatomi, Ärnlöv, Johan, Cirillo, Massimo, Ebert, Natalie, Hiramoto, Jade S, Kimm, Heejin, Shlipak, Michael G, Visseren, Frank LJ, Gansevoort, Ron T, Kovesdy, Csaba P, Shalev, Varda, Woodward, Mark, Kronenberg, Florian, Chalmers, John, Perkovic, Vlado, Grams, Morgan E, Sang, Yingying, Schaeffner, Elke, Martus, Peter, Levin, Adeera, Djurdjev, Ognjenka, Tang, Mila, Heine, Gunnar, Seiler, Sarah, Zawada, Adam, Emrich, Insa, Sarnak, Mark, Katz, Ronit, Brenner, Hermann, Schöttker, Ben, Rothenbacher, Dietrich, Saum, Kai-Uwe, Köttgen, Anna, Schneider, Markus, Eckardt, Kai-Uwe, Green, Jamie, Kirchner, H Lester, Chang, Alex R, Black, Corri, Marks, Angharad, Prescott, Gordon, Clark, Laura, Fluck, Nick, Jee, Sun Ha, Mok, Yejin, Chodick, Gabriel, Wetzels, Jack FM, Blankestijn, Peter J, van Zuilen, Arjan D, Bots, M, Peralta, Carmen, Hiromoto, Jade, Bottinger, Erwin, Nadkarni, Girish N, Ellis, Stephen B, Nadukuru, Rajiv, Kenealy, Timothy, Elley, C Raina, Collins, John F, Drury, Paul L, Bakker, Stephan JL, Heerspink, Hiddo J Lambers, Jassal, Simerjot K, Bergstrom, Jaclyn, Ix, Joachim H, Barrett-Connor, Elizabeth, Kalantar-Zadeh, Kamyar, Carrero, Juan J, Gasparini, Alessandro, Qureshi, Abdul Rashid, Barany, Peter, Algra, Ale, van der Graaf, Yolanda, Evans, Marie, Segelmark, Mårten, Stendahl, Maria, Schön, Staffan, Tangri, Navdeep, Sud, Maneesh, Naimark, David, Lannfelt, Lars, Larsson, Anders, Hallan, Stein, Levey, Andrew S, Chen, Jingsha, and Kwak, Lucia

Subjects
Clinical Research, Kidney Disease, Prevention, Renal and urogenital, Good Health and Well Being, Adult, Aged, Albuminuria, Creatinine, Databases, Factual, Female, Glomerular Filtration Rate, Humans, Incidence, Male, Middle Aged, Peripheral Arterial Disease, Renal Insufficiency, Chronic, Risk Factors, Chronic Kidney Disease Prognosis Consortium, Medical Biochemistry and Metabolomics, Clinical Sciences, Public Health and Health Services
Abstract

BackgroundSome evidence suggests that chronic kidney disease is a risk factor for lower-extremity peripheral artery disease. We aimed to quantify the independent and joint associations of two measures of chronic kidney disease (estimated glomerular filtration rate [eGFR] and albuminuria) with the incidence of peripheral artery disease.MethodsIn this collaborative meta-analysis of international cohorts included in the Chronic Kidney Disease Prognosis Consortium (baseline measurements obtained between 1972 and 2014) with baseline measurements of eGFR and albuminuria, at least 1000 participants (this criterion not applied to cohorts exclusively enrolling patients with chronic kidney disease), and at least 50 peripheral artery disease events, we analysed adult participants without peripheral artery disease at baseline at the individual patient level with Cox proportional hazards models to quantify associations of creatinine-based eGFR, urine albumin-to-creatinine ratio (ACR), and dipstick proteinuria with the incidence of peripheral artery disease (including hospitalisation with a diagnosis of peripheral artery disease, intermittent claudication, leg revascularisation, and leg amputation). We assessed discrimination improvement through c-statistics.FindingsWe analysed 817 084 individuals without a history of peripheral artery disease at baseline from 21 cohorts. 18 261 cases of peripheral artery disease were recorded during follow-up across cohorts (median follow-up was 7·4 years [IQR 5·7-8·9], range 2·0-15·8 years across cohorts). Both chronic kidney disease measures were independently associated with the incidence of peripheral artery disease. Compared with an eGFR of 95 mL/min per 1·73 m2, adjusted hazard ratios (HRs) for incident study-specific peripheral artery disease was 1·22 (95% CI 1·14-1·30) at an eGFR of 45 mL/min per 1·73 m2 and 2·06 (1·70-2·48) at an eGFR of 15 mL/min per 1·73 m2. Compared with an ACR of 5 mg/g, the adjusted HR for incident study-specific peripheral artery disease was 1·50 (1·41-1·59) at an ACR of 30 mg/g and 2·28 (2·12-2·44) at an ACR of 300 mg/g. The adjusted HR at an ACR of 300 mg/g versus 5 mg/g was 3·68 (95% CI 3·00-4·52) for leg amputation. eGFR and albuminuria contributed multiplicatively (eg, adjusted HR 5·76 [4·90-6·77] for incident peripheral artery disease and 10·61 [5·70-19·77] for amputation in eGFR

Published
2017

30. Social support and frailty progression in community-dwelling older adults

Author

Barghouth, Muhammad Helmi, Klein, Jessica, Bothe, Tim, Ebert, Natalie, Schaeffner, Elke, Mielke, Nina, Barghouth, Muhammad Helmi, Klein, Jessica, Bothe, Tim, Ebert, Natalie, Schaeffner, Elke, and Mielke, Nina

Abstract

Objectives: Despite the growing evidence regarding the influence of social factors on frailty in older adults, the effect of social support remains unclear. This study aims to assess the association between social support and frailty progression (transition and incidence) in a sample of community-dwelling older adults. Methods: Using a cohort study design, 1,059 older adults from the Berlin Initiative Study were followed up for 2.1 years. Multinomial and logistic regression analyses were performed to assess the association of social support using Oslo Social Support Scale-3 with frailty transition and incidence, respectively. Gender differences were explored using stratified analyses. Results: At baseline, frailty prevalence in the study population [mean (SD) age 84.3 (5.6) years; 55.8% women] reached 33.1% with 47.0, 29.4 and 23.6% of the participants reporting moderate, strong and poor social support, respectively. Over the follow-up period, social support was not significantly associated with the frailty transition categories in the adjusted model. Conversely, the adjusted logistic regression analysis showed that participants with poor social support had twice the odds of becoming frail compared to those with strong social support (OR 2.07; 95% CI 1.08–3.95). Gender-stratified analyses showed comparable estimates to the main analysis but were statistically non-significant. Discussion: Our study results underpin the role of social factors in frailty incidence and highlight social support as a potential target for frailty-preventing interventions in older adults. Therefore, it is important to adopt a biopsychosocial model rather than a purely biomedical model to understand and holistically improve the health of community-dwelling older adults.

Published
2024

31. Diagnostic Validity of Chronic Kidney Disease in Health Claims Data Over Time: Results from a Cohort of Community-Dwelling Older Adults in Germany

Author

Bothe,Tim, Fietz,Anne-Katrin, Schaeffner,Elke, Douros,Antonios, Pöhlmann,Anna, Mielke,Nina, Villain,Cédric, Barghouth,Muhammad, Wenning,Volker, Ebert,Natalie, Bothe,Tim, Fietz,Anne-Katrin, Schaeffner,Elke, Douros,Antonios, Pöhlmann,Anna, Mielke,Nina, Villain,Cédric, Barghouth,Muhammad, Wenning,Volker, and Ebert,Natalie

Abstract

Tim Bothe,1 Anne-Katrin Fietz,2 Elke Schaeffner,1 Antonios Douros,3– 5 Anna Pöhlmann,2 Nina Mielke,1 Cédric Villain,1,6 Muhammad Helmi Barghouth,1 Volker Wenning,7 Natalie Ebert1 1Institute of Public Health, Charité – Universitätsmedizin Berlin, Berlin, Germany; 2Institute of Biometry and Clinical Epidemiology, Charité – Universitätsmedizin Berlin, Berlin, Germany; 3Departments of Medicine and of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, QC, Canada; 4Institute of Clinical Pharmacology and Toxicology, Charité – Universitätsmedizin Berlin, Berlin, Germany; 5Center for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital, Montreal, QC, Canada; 6Normandie Univ UNICAEN, INSERM U1075 COMETE, service de Gériatrie, CHU de Caen, Caen, France; 7AOK Nordost – Die Gesundheitskasse, Potsdam, GermanyCorrespondence: Tim Bothe, Charité – Universitätsmedizin Berlin, Institute of Public Health, Charitéplatz 1, Berlin, DE-10117, Germany, Tel +49 30 450 570054, Email tim.bothe@charite.dePurpose: The validity of ICD-10 diagnostic codes for chronic kidney disease (CKD) in health claims data has not been sufficiently studied in the general population and over time.Patients and Methods: We used data from the Berlin Initiative Study (BIS), a prospective longitudinal cohort of community-dwelling individuals aged ≥ 70 years in Berlin, Germany. With estimated glomerular filtration rate (eGFR) as reference, we assessed the diagnostic validity (sensitivity, specificity, positive [PPV], and negative predictive values [NPV]) of different claims-based ICD-10 codes for CKD stages G3-5 (eGFR < 60mL/min/1.73m²: ICD-10 N18.x-N19), G3 (eGFR 30–< 60mL/min/1.73m²: N18.3), and G4-5 (eGFR < 30mL/min/1.73m²: N18.4– 5). We analysed trends over five study visits (2009– 2019).Results: We included data of 2068 participants at baseline (2009– 2011) and 870 at follow-up 4 (2018– 2019), of whom 784 (38.9%) and 4

Published
2024

32. Diuretic prescriptions in the first year of haemodialysis: international practice patterns and associations with outcomes.

Author

Tabibzadeh, Nahid, Wang, Dongyu, Karaboyas, Angelo, Schaeffner, Elke, Jacobson, Stefan H, Vega, Almudena, Nitta, Kosaku, Bieber, Brian, Pecoits-Filho, Roberto, and Torres, Pablo Antonio Ureña

Subjects
HEMODIALYSIS patients, DIURETICS, TREATMENT effectiveness, MORTALITY, PARATHYROID hormone
Abstract

Background The use of diuretics in patients on haemodialysis (HD) is thought to maintain diuresis. However, this assumption and the optimal dose are based on little scientific evidence, and associations with clinical outcomes are unclear. Methods We reported international variations in diuretic use and loop diuretic dose across 27 759 HD patients with dialysis vintage <1 year in the Dialysis Outcomes and Practice Patterns Study phases 2–5 (2002–2015), a prospective cohort study. Doses of torsemide (4:1) and bumetanide (80:1) were converted to oral furosemide-equivalent doses. Adjusted Cox, logistic and linear regressions were used to investigate the association of diuretic use and dose with outcomes. Results Diuretic utilization varied widely by country at vintage <3 months, ranging from >80% in Germany and Sweden to <35% in the USA, at a median dose ranging from 400–500 mg/day in Germany and Sweden to <100 mg/day in Japan and the USA. Neither diuretic use nor higher doses were associated with a lower risk of all-cause mortality, a higher risk of hospitalization for fracture or elevated parathyroid hormone levels, but the prescription of higher doses (>200 mg/day) was associated with a higher risk of all-cause hospitalization. Conclusions Substantial international differences exist in diuretic prescriptions, with use and doses much higher in some European countries than the USA. The prescription and higher doses of loop diuretics was not associated with improved outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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33. Incorporating kidney disease measures into cardiovascular risk prediction: Development and validation in 9 million adults from 72 datasets

Author

Matsushita, Kunihiro, Jassal, Simerjot K, Sang, Yingying, Ballew, Shoshana H, Grams, Morgan E, Surapaneni, Aditya, Arnlov, Johan, Bansal, Nisha, Bozic, Milica, Brenner, Hermann, Brunskill, Nigel J, Chang, Alex R, Chinnadurai, Rajkumar, Cirillo, Massimo, Correa, Adolfo, Ebert, Natalie, Eckardt, Kai-Uwe, Gansevoort, Ron T, Gutierrez, Orlando, Hadaegh, Farzad, He, Jiang, Hwang, Shih-Jen, Jafar, Tazeen H, Kayama, Takamasa, Kovesdy, Csaba P, Landman, Gijs W, Levey, Andrew S, Lloyd-Jones, Donald M, Major, Rupert W., Miura, Katsuyuki, Muntner, Paul, Nadkarni, Girish N, Naimark, David MJ, Nowak, Christoph, Ohkubo, Takayoshi, Pena, Michelle J, Polkinghorne, Kevan R, Sabanayagam, Charumathi, Sairenchi, Toshimi, Schneider, Markus P, Shalev, Varda, Shlipak, Michael, Solbu, Marit D, Stempniewicz, Nikita, Tollitt, James, Valdivielso, José M, van der Leeuw, Joep, Wang, Angela Yee-Moon, Wen, Chi-Pang, Woodward, Mark, Yamagishi, Kazumasa, Yatsuya, Hiroshi, Zhang, Luxia, Schaeffner, Elke, and Coresh, Josef

Published
2020
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34. Results from the German Chronic Kidney Disease (GCKD) study support association of relative telomere length with mortality in a large cohort of patients with moderate chronic kidney disease

Author

Eckardt, Kai-Uwe, Meiselbach, Heike, Schneider, Markus, Dienemann, Thomas, Prokosch, Hans-Ulrich, Bärthlein, Barbara, Beck, Andreas, Ganslandt, Thomas, Reis, André, Ekici, Arif B., Avendaño, Susanne, Becker-Grosspitsch, Dinah, Alberth-Schmidt, Ulrike, Hausknecht, Birgit, Zitzmann, Rita, Weigel, Anke, Walz, Gerd, Köttgen, Anna, Schultheiß, Ulla T., Kotsis, Fruzsina, Meder, Simone, Mitsch, Erna, Reinhard, Ursula, Floege, Jürgen, Schlieper, Georg, Saritas, Turgay, Ernst, Sabine, Beaujean, Nicole, Schaeffner, Elke, Baid-Agrawal, Seema, Theisen, Kerstin, Haller, Hermann, Menne, Jan, Zeier, Martin, Sommerer, Claudia, Woitke, Rebecca, Wolf, Gunter, Busch, Martin, Fuß, Rainer, Sitter, Thomas, Blank, Claudia, Wanner, Christoph, Krane, Vera, Börner-Klein, Antje, Bauer, Britta, Kronenberg, Florian, Raschenberger, Julia, Kollerits, Barbara, Forer, Lukas, Schönherr, Sebastian, Weissensteiner, Hansi, Oefner, Peter, Gronwald, Wolfram, Zacharias, Helena, Schmid, Matthias, Nadal, Jennifer, Fazzini, Federica, Lamina, Claudia, Schultheiss, Ulla T., and Steinbrenner, Inga

Published
2020
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35. Association Between Dietary Patterns and Kidney Function in Patients With Chronic Kidney Disease: A Cross-Sectional Analysis of the German Chronic Kidney Disease Study

Author

Heindel, Judith, Baid-Agrawal, Seema, Rebholz, Casey M., Nadal, Jennifer, Schmid, Matthias, Schaeffner, Elke, Schneider, Markus P., Meiselbach, Heike, Kaesler, Nadine, Bergmann, Manuela, Ernst, Sabine, Krane, Vera, Eckardt, Kai-Uwe, Floege, Jürgen, Schlieper, Georg, and Saritas, Turgay

Published
2020
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40. Trends and perspectives for improving quality of chronic kidney disease care: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Author

Eckardt, Kai-Uwe, primary, Delgado, Cynthia, additional, Heerspink, Hiddo J.L., additional, Pecoits-Filho, Roberto, additional, Ricardo, Ana C., additional, Stengel, Bénédicte, additional, Tonelli, Marcello, additional, Cheung, Michael, additional, Jadoul, Michel, additional, Winkelmayer, Wolfgang C., additional, Kramer, Holly, additional, Al-Aly, Ziyad, additional, Ashuntantang, Gloria E., additional, Boor, Peter, additional, Calice da Silva, Viviane, additional, Coleman, Jill, additional, Coresh, Josef, additional, Delanaye, Pierre, additional, Ebert, Natalie, additional, Enghard, Philipp, additional, Feldman, Harold I., additional, Fisher, Lori, additional, Flythe, Jennifer E., additional, Fukui, Akira, additional, Grams, Morgan E., additional, Ix, Joseph H., additional, Jardine, Meg J., additional, Jha, Vivek, additional, Ju, Wenjun, additional, Jurish, Robert, additional, Kalyesubula, Robert, additional, Kashihara, Naoki, additional, Levey, Andrew S., additional, Levin, Adeera, additional, Luyckx, Valerie, additional, Małyszko, Jolanta, additional, Manski-Nankervis, Jo-Anne, additional, Navaneethan, Sankar D., additional, Obrador, Greg, additional, Ortiz, Alberto, additional, Ortiz, John, additional, Cardoso Dos Santos, Bento Fortunato, additional, Sarnak, Mark J., additional, Schaeffner, Elke, additional, Selby, Nick M., additional, Simpson, David M., additional, Solá, Laura, additional, St. Peter, Wendy L., additional, Stevens, Paul E., additional, Tangri, Navdeep, additional, Tannor, Elliot Koranteng, additional, Tchokhonelidze, Irma, additional, Wilck, Nicola, additional, and Wong, Michelle M.Y., additional

Published
2023
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41. Copeptin, Natriuretic Peptides, and Cardiovascular Outcomes in Patients With CKD: The German Chronic Kidney Disease (GCKD) Study

Author

Schneider, Markus P., primary, Schmid, Matthias, additional, Nadal, Jennifer, additional, Krane, Vera, additional, Saritas, Turgay, additional, Busch, Martin, additional, Schultheiss, Ulla T., additional, Meiselbach, Heike, additional, Friedrich, Nele, additional, Nauck, Matthias, additional, Floege, Jürgen, additional, Kronenberg, Florian, additional, Wanner, Christoph, additional, Eckardt, Kai-Uwe, additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Becker-Grosspitsch, Dinah, additional, Alberth-Schmidt, Ulrike, additional, Hausknecht, Birgit, additional, Weigel, Anke, additional, Walz, Gerd, additional, Köttgen, Anna, additional, Schultheiß, Ulla T., additional, Kotsis, Fruzsina, additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Haller, Hermann, additional, Menne, Jan, additional, Zeier, Martin, additional, Sommerer, Claudia, additional, Theilinger, Johanna, additional, Wolf, Gunter, additional, Paul, Rainer, additional, Sitter, Thomas, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, and Gronwald, Wolfram, additional

Published
2023
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43. Prospective Cohort Study of Soluble Urokinase Plasminogen Activation Receptor and Cardiovascular Events in Patients With CKD

Author

Sommerer, Claudia, primary, Müller-Krebs, Sandra, additional, Nadal, Jennifer, additional, Schultheiss, Ulla T., additional, Friedrich, Nele, additional, Nauck, Matthias, additional, Schmid, Matthias, additional, Nußhag, Christian, additional, Reiser, Jochen, additional, Eckardt, Kai-Uwe, additional, Zeier, Martin, additional, Hayek, Salim S., additional, Meiselbach, Heike, additional, Schneider, Markus P., additional, Schiffer, Mario, additional, Prokosch, Hans-Ulrich, additional, Bärthlein, Barbara, additional, Beck, Andreas, additional, Kraska, Detlef, additional, Reis, André, additional, Ekici, Arif B., additional, Becker, Susanne, additional, Alberth-Schmidt, Ulrike, additional, Marschall, Sabine, additional, Schefler, Eugenia, additional, Weigel, Anke, additional, Walz, Gerd, additional, Köttgen, Anna, additional, Schultheiß, Ulla T., additional, Kotsis, Fruzsina, additional, Meder, Simone, additional, Mitsch, Erna, additional, Reinhard, Ursula, additional, Floege, Jürgen, additional, Saritas, Turgay, additional, Schaeffner, Elke, additional, Baid-Agrawal, Seema, additional, Theisen, Kerstin, additional, Schmidt-Ott, Kai, additional, Sommerer, Claudia, additional, Aykac, Mehtap, additional, Wolf, Gunter, additional, Busch, Martin, additional, Paul, Rainer, additional, Sitter, Thomas, additional, Wanner, Christoph, additional, Krane, Vera, additional, Börner-Klein, Antje, additional, Bauer, Britta, additional, Kronenberg, Florian, additional, Raschenberger, Julia, additional, Kollerits, Barbara, additional, Forer, Lukas, additional, Schönherr, Sebastian, additional, Weissensteiner, Hansi, additional, Oefner, Peter, additional, and Gronwald, Wolfram, additional

Published
2023
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44. Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts

Author

Canney, Mark, primary, Induruwage, Dilshani, additional, Tang, Mila, additional, Alencar de Pinho, Natalia, additional, Er, Lee, additional, Zhao, Yinshan, additional, Djurdjev, Ognjenka, additional, Ahn, Yo Han, additional, Behnisch, Rouven, additional, Calice-Silva, Viviane, additional, Chesnaye, Nicholas C., additional, de Borst, Martin H., additional, Dember, Laura M., additional, Dionne, Janis, additional, Ebert, Natalie, additional, Eder, Susanne, additional, Fenton, Anthony, additional, Fukagawa, Masafumi, additional, Furth, Susan L., additional, Hoy, Wendy E., additional, Imaizumi, Takahiro, additional, Jager, Kitty J., additional, Jha, Vivekanand, additional, Kang, Hee Gyung, additional, Kitiyakara, Chagriya, additional, Mayer, Gert, additional, Oh, Kook-Hwan, additional, Onu, Ugochi, additional, Pecoits-Filho, Roberto, additional, Reichel, Helmut, additional, Richards, Anna, additional, Schaefer, Franz, additional, Schaeffner, Elke, additional, Scheppach, Johannes B., additional, Sola, Laura, additional, Ulasi, Ifeoma, additional, Wang, Jinwei, additional, Yadav, Ashok K., additional, Zhang, Jianzhen, additional, Feldman, Harold I., additional, Taal, Maarten W., additional, Stengel, Bénédicte, additional, Levin, Adeera, additional, Ahn, Curie, additional, Berger, Stefan P., additional, Caskey, Fergus J., additional, Cho, Min Hyun, additional, Cho, Heeyeon, additional, Dekker, Friedo W., additional, Diwan, Vishal, additional, Drechsler, Christiane, additional, Eckardt, Kai-Uwe, additional, Evans, Marie, additional, Ferreiro, Alejandro, additional, Floege, Jürgen, additional, Gadola, Liliana, additional, Haller, Hermann, additional, Han, Kyung Hee, additional, Healy, Helen G., additional, Heerspink, Hiddo Lambers, additional, Hemmelder, Marc, additional, Hiemstra, Thomas, additional, Hilbrands, Luuk, additional, Kim, Seong Heon, additional, Klyprayong, Pinkaew, additional, Köttgen, Anna, additional, Kronenberg, Florian, additional, Lamadrid, Veronica, additional, Lee, Joo Hoo, additional, Mark, Patrick, additional, Matheson, Matt, additional, Mi, Eun, additional, Noppakun, Kajohnsak, additional, Oefner, Peter, additional, Panaput, Thanachai, additional, Park, Young Seo, additional, Prokosch, Hans-Ulrich, additional, Reis, André, additional, Rios, Pablo, additional, Rosivall, Laszlo, additional, Rotmans, Joris I., additional, Sackeyfio, Alfred, additional, Sangthawan, Pornpen, additional, Schmid, Matthias, additional, Shin, Jae Il, additional, Silavarino, Ricardo, additional, Sitter, Thomas, additional, Sommerer, Claudia, additional, Szymczak, Maciej, additional, Torino, Claudia, additional, Toth, Janos, additional, van Ittersum, Frans J., additional, Venuthurupalli, Sree Krishna, additional, Verhaar, Marianne C., additional, Wang, Zaimin, additional, Wanner, Christoph, additional, Wiecek, Andrzej, additional, Wolf, Gunter, additional, de Zeeuw, Dick, additional, Zhang, Luxia, additional, Zheng, Yuyan, additional, Zhao, Ming-Hui, additional, and Zietse, Robert, additional

Published
2023
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45. #5529 RED BLOOD CELL TRANSFUSION RATES IN THE INTERNATIONAL DOPPS PROGRAM (2012–2022): HEMODIALYSIS, PERITONEAL DIALYSIS, AND NON-DIALYSIS CKD POPULATIONS

Author

Karaboyas, Angelo, primary, Tu, Charlotte, additional, Hunnicutt, Jake, additional, Richards, Anna, additional, Pham, Timothy, additional, Asgari, Elham, additional, Guebre-Egziabher, Fitsum, additional, Schaeffner, Elke, additional, Lopes, Antonio Alberto, additional, Perl, Jeffrey, additional, and Pecoits-Filho, Roberto, additional

Published
2023
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47. Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data

Author

Chalmers, John, Arima, Hisatomi, Perkovic, Vlado, Grams, Morgan E., Sang, Yingying, Schaeffner, Elke, Martus, Peter, Levin, Adeera, Djurdjev, Ognjenka, Tang, Mila, Heine, Gunnar, Seiler, Sarah, Zawada, Adam, Emrich, Insa, Sarnak, Mark, Katz, Ronit, Brenner, Hermann, Schöttker, Ben, Rothenbacher, Dietrich, Saum, Kai-Uwe, Köttgen, Anna, Schneider, Markus, Eckardt, Kai-Uwe, Green, Jamie, Kirchner, H Lester, Chang, Alex R, Black, Corri, Marks, Angharad, Prescott, Gordon, Clark, Laura, Fluck, Nick, Jee, Sun Ha, Mok, Yejin, Chodick, Gabriel, Shalev, Varda, Wetzels, Jack F.M., Blankestijn, Peter J, van Zuilen, Arjan D, Bots, M, Peralta, Carmen, Hiromoto, Jade, Bottinger, Erwin, Nadkarni, Girish N, Ellis, Stephen B, Nadukuru, Rajiv, Kenealy, Timothy, Elley, C Raina, Collins, John F, Drury, Paul L, Bakker, Stephan JL, Heerspink, Hiddo J Lambers, Jassal, Simerjot K, Bergstrom, Jaclyn, Ix, Joachim H, Barrett-Connor, Elizabeth, Kalantar-Zadeh, Kamyar, Carrero, Juan J, Gasparini, Alessandro, Qureshi, Abdul Rashid, Barany, Peter, Algra, Ale, van der Graaf, Yolanda, Evans, Marie, Segelmark, Mårten, Stendahl, Maria, Schön, Staffan, Tangri, Navdeep, Sud, Maneesh, Naimark, David, Lannfelt, Lars, Larsson, Anders, Hallan, Stein, Levey, Andrew S, Chen, Jingsha, Kwak, Lucia, Matsushita, Kunihiro, Ballew, Shoshana H, Coresh, Josef, Ärnlöv, Johan, Cirillo, Massimo, Ebert, Natalie, Hiramoto, Jade S, Kimm, Heejin, Shlipak, Michael G, Visseren, Frank L J, Gansevoort, Ron T, Kovesdy, Csaba P, Woodward, Mark, and Kronenberg, Florian

Published
2017
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49. Diagnostic Validity of Chronic Kidney Disease in Health Claims Data Over Time: Results from a Cohort of Community-Dwelling Older Adults in Germany.

Author

Bothe, Tim, Fietz, Anne-Katrin, Schaeffner, Elke, Douros, Antonios, Pöhlmann, Anna, Mielke, Nina, Villain, Cédric, Barghouth, Muhammad Helmi, Wenning, Volker, and Ebert, Natalie

Subjects
CHRONIC kidney failure, OLDER patients, FRAIL elderly, GLOMERULAR filtration rate, ADULTS, OLDER people
Abstract

Purpose: The validity of ICD-10 diagnostic codes for chronic kidney disease (CKD) in health claims data has not been sufficiently studied in the general population and over time. Patients and Methods: We used data from the Berlin Initiative Study (BIS), a prospective longitudinal cohort of community-dwelling individuals aged ≥ 70 years in Berlin, Germany. With estimated glomerular filtration rate (eGFR) as reference, we assessed the diagnostic validity (sensitivity, specificity, positive [PPV], and negative predictive values [NPV]) of different claims-based ICD-10 codes for CKD stages G3-5 (eGFR < 60mL/min/1.73m²: ICD-10 N18.x-N19), G3 (eGFR 30–< 60mL/min/1.73m²: N18.3), and G4-5 (eGFR < 30mL/min/1.73m²: N18.4– 5). We analysed trends over five study visits (2009– 2019). Results: We included data of 2068 participants at baseline (2009– 2011) and 870 at follow-up 4 (2018– 2019), of whom 784 (38.9%) and 440 (50.6%) had CKD G3-5, respectively. At baseline, sensitivity for CKD in claims data ranged from 0.25 (95%-confidence interval [CI] 0.22– 0.28) to 0.51 (95%-CI 0.48– 0.55) for G3-5, depending on the included ICD-10 codes, 0.20 (95%-CI 0.18– 0.24) for G3, and 0.36 (95%-CI 0.25– 0.49) for G4-5. Over the course of 10 years, sensitivity increased by 0.17 to 0.29 in all groups. Specificity, PPVs, and NPVs remained mostly stable over time and ranged from 0.82– 0.99, 0.47– 0.89, and 0.66– 0.98 across all study visits, respectively. Conclusion: German claims data showed overall agreeable performance in identifying older adults with CKD, while differentiation between stages was limited. Our results suggest increasing sensitivity over time possibly attributable to improved CKD diagnosis and awareness. [ABSTRACT FROM AUTHOR]

Published
2024
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