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4. Key Learning Outcomes for Clinical Pharmacology and Therapeutics Education in Europe: A Modified Delphi Study

Author

Brinkman, D, Tichelaar, J, Mokkink, L, Christiaens, T, Likic, R, Maciulaitis, R, Costa, J, Sanz, E, Maxwell, S, Richir, M, Van, A, Michiel A., L, Kostadinova, I, Ganeva, M, Atanasova, I, Gatchev, E, Stavreva, G, Vitezic, D, Matanovic, S, Wozniak, G, Nicolaou, P, Urbanek, K, Slanar, O, Kmonickova, E, Demlova, R, Bergmann, T, Damkier, P, Kalda, A, Huupponen, R, Backman, J, Drici, M, Deplanque, D, Molimard, M, Toussirot, E, Pers, Y, Bertin, P, Laviolle, B, Jeunne, C, Saulnier, P, Chamontin, B, Roustit, M, Orlikowski, D, Simon, N, Dequin, P, Angoulvant, T, Bolbrinker, J, Wojnowski, L, Cascorbi, I, Müller, F, Müller, S, Schwaninger, M, Neumann, J, Stümpel, F, Regenthal, R, Fuhr, U, Thürmann, P, Eirini, A, Papaioannidou, P, Kouvelas, D, Kolios, G, Riba, P, Kerins, D, Williams, D, Harnett, A, Spina, E, Fumagalli, G, Filippelli, A, Benemei, S, De Ponti, F, Cosentino, M, Locatelli, V, De Montis, M, Memo, M, Raschi, E, Purvina, S, Gulbinovic, J, Mifsud, J, Keijsers, K, Rissmann, R, Dumont, G, van Rosse, F, Spigset, O, Opdal, M, Braszko, J, Mirowska-Guzel, D, Broncel, M, Kocic, I, Sousa, M, Monteiro, E, Dima, L, Magyar, I, Conea, S, Buzoianu, A, Glasova, H, Tisonova, J, Glasa, J, Krzan, M, Saez-Penataro, J, de Abajo Iglesias, F, Capella, D, Figuerola, F, Sansuan, A, Lopez-Rico, M, Manso, G, Benitez, J, Lucena, M, Bernal, M, Cladellas, X, Hernandez, R, Pontes, C, Panagiotidis, G, Böttiger, Y, Wallerstedt, S, Eriksson, A, Desmeules, J, Krähenbühl, S, Plumb, R, Okorie, M, Wilson, K, Mckay, G, Sofat, R, Kapil, V, Whitfield, J, Thanacoody, R, Mir, F, Loke, Y, Schachter, M, O'Brien, L, Heep, A, Brinkman, David J, Tichelaar, Jelle, Mokkink, Lidwine B, Christiaens, Thierry, Likic, Robert, Maciulaitis, Romaldas, Costa, Joao, Sanz, Emilio J, Maxwell, Simon R, Richir, Milan C, van Agtmael, Michiel A. Lefebvre R, Kostadinova I, Ganeva M, Atanasova I, Gatchev E, Stavreva G, Vitezic D, Matanovic S, Wozniak G, Nicolaou P, Urbanek K, Slanar O, Kmonickova E, Demlova R, Bergmann T, Damkier P, Kalda A, Huupponen R, Backman J, Drici MD, Deplanque D, Molimard M, Toussirot E, Pers YM, Bertin P, Laviolle B, Jeunne CL, Saulnier PJ, Chamontin B, Roustit M, Orlikowski D, Simon N, Dequin PF, Angoulvant T, Bolbrinker J, Wojnowski L, Cascorbi I, Müller F, Müller S, Schwaninger M, Neumann J, Stümpel F, Regenthal R, Fuhr U, Thürmann P, Eirini A, Papaioannidou P, Kouvelas D, Kolios G, Riba P, Kerins D, Williams D, Harnett A, Spina E, Fumagalli G, Filippelli A, Benemei S, De Ponti F, Cosentino M, Locatelli V, De Montis MG, Memo M, Raschi E, Purvina S, Gulbinovic J, Mifsud J, Keijsers K, Rissmann R, Dumont G, van Rosse F, Spigset O, Opdal MS, Braszko J, Mirowska-Guzel D, Broncel M, Kocic I, Sousa MC, Monteiro E, Dima L, Magyar I, Conea S, Buzoianu A, Glasova H, Tisonova J, Glasa J, Krzan M, Saez-Penataro J, de Abajo Iglesias FJ, Capella D, Figuerola FAH, Sansuan AJC, Lopez-Rico M, Manso G, Benitez J, Lucena MI, Bernal ML, Cladellas XC, Hernandez RA, Pontes C, Panagiotidis G, Böttiger Y, Wallerstedt S, Eriksson A, Desmeules J, Krähenbühl S, Plumb R, Okorie M, Wilson K, McKay G, Sofat R, Kapil V, Whitfield J, Thanacoody R, Mir F, Loke Y, Schachter M, O'Brien L, Heep A, Brinkman, D, Tichelaar, J, Mokkink, L, Christiaens, T, Likic, R, Maciulaitis, R, Costa, J, Sanz, E, Maxwell, S, Richir, M, Van, A, Michiel A., L, Kostadinova, I, Ganeva, M, Atanasova, I, Gatchev, E, Stavreva, G, Vitezic, D, Matanovic, S, Wozniak, G, Nicolaou, P, Urbanek, K, Slanar, O, Kmonickova, E, Demlova, R, Bergmann, T, Damkier, P, Kalda, A, Huupponen, R, Backman, J, Drici, M, Deplanque, D, Molimard, M, Toussirot, E, Pers, Y, Bertin, P, Laviolle, B, Jeunne, C, Saulnier, P, Chamontin, B, Roustit, M, Orlikowski, D, Simon, N, Dequin, P, Angoulvant, T, Bolbrinker, J, Wojnowski, L, Cascorbi, I, Müller, F, Müller, S, Schwaninger, M, Neumann, J, Stümpel, F, Regenthal, R, Fuhr, U, Thürmann, P, Eirini, A, Papaioannidou, P, Kouvelas, D, Kolios, G, Riba, P, Kerins, D, Williams, D, Harnett, A, Spina, E, Fumagalli, G, Filippelli, A, Benemei, S, De Ponti, F, Cosentino, M, Locatelli, V, De Montis, M, Memo, M, Raschi, E, Purvina, S, Gulbinovic, J, Mifsud, J, Keijsers, K, Rissmann, R, Dumont, G, van Rosse, F, Spigset, O, Opdal, M, Braszko, J, Mirowska-Guzel, D, Broncel, M, Kocic, I, Sousa, M, Monteiro, E, Dima, L, Magyar, I, Conea, S, Buzoianu, A, Glasova, H, Tisonova, J, Glasa, J, Krzan, M, Saez-Penataro, J, de Abajo Iglesias, F, Capella, D, Figuerola, F, Sansuan, A, Lopez-Rico, M, Manso, G, Benitez, J, Lucena, M, Bernal, M, Cladellas, X, Hernandez, R, Pontes, C, Panagiotidis, G, Böttiger, Y, Wallerstedt, S, Eriksson, A, Desmeules, J, Krähenbühl, S, Plumb, R, Okorie, M, Wilson, K, Mckay, G, Sofat, R, Kapil, V, Whitfield, J, Thanacoody, R, Mir, F, Loke, Y, Schachter, M, O'Brien, L, Heep, A, Brinkman, David J, Tichelaar, Jelle, Mokkink, Lidwine B, Christiaens, Thierry, Likic, Robert, Maciulaitis, Romaldas, Costa, Joao, Sanz, Emilio J, Maxwell, Simon R, Richir, Milan C, van Agtmael, Michiel A. Lefebvre R, Kostadinova I, Ganeva M, Atanasova I, Gatchev E, Stavreva G, Vitezic D, Matanovic S, Wozniak G, Nicolaou P, Urbanek K, Slanar O, Kmonickova E, Demlova R, Bergmann T, Damkier P, Kalda A, Huupponen R, Backman J, Drici MD, Deplanque D, Molimard M, Toussirot E, Pers YM, Bertin P, Laviolle B, Jeunne CL, Saulnier PJ, Chamontin B, Roustit M, Orlikowski D, Simon N, Dequin PF, Angoulvant T, Bolbrinker J, Wojnowski L, Cascorbi I, Müller F, Müller S, Schwaninger M, Neumann J, Stümpel F, Regenthal R, Fuhr U, Thürmann P, Eirini A, Papaioannidou P, Kouvelas D, Kolios G, Riba P, Kerins D, Williams D, Harnett A, Spina E, Fumagalli G, Filippelli A, Benemei S, De Ponti F, Cosentino M, Locatelli V, De Montis MG, Memo M, Raschi E, Purvina S, Gulbinovic J, Mifsud J, Keijsers K, Rissmann R, Dumont G, van Rosse F, Spigset O, Opdal MS, Braszko J, Mirowska-Guzel D, Broncel M, Kocic I, Sousa MC, Monteiro E, Dima L, Magyar I, Conea S, Buzoianu A, Glasova H, Tisonova J, Glasa J, Krzan M, Saez-Penataro J, de Abajo Iglesias FJ, Capella D, Figuerola FAH, Sansuan AJC, Lopez-Rico M, Manso G, Benitez J, Lucena MI, Bernal ML, Cladellas XC, Hernandez RA, Pontes C, Panagiotidis G, Böttiger Y, Wallerstedt S, Eriksson A, Desmeules J, Krähenbühl S, Plumb R, Okorie M, Wilson K, McKay G, Sofat R, Kapil V, Whitfield J, Thanacoody R, Mir F, Loke Y, Schachter M, O'Brien L, and Heep A

Abstract

Harmonizing clinical pharmacology and therapeutics (CPT) education in Europe is necessary to ensure that the prescribing competency of future doctors is of a uniform high standard. As there are currently no uniform requirements, our aim was to achieve consensus on key learning outcomes for undergraduate CPT education in Europe. We used a modified Delphi method consisting of three questionnaire rounds and a panel meeting. A total of 129 experts from 27 European countries were asked to rate 307 learning outcomes. In all, 92 experts (71%) completed all three questionnaire rounds, and 33 experts (26%) attended the meeting. 232 learning outcomes from the original list, 15 newly suggested and 5 rephrased outcomes were included. These 252 learning outcomes should be included in undergraduate CPT curricula to ensure that European graduates are able to prescribe safely and effectively. We provide a blueprint of a European core curriculum describing when and how the learning outcomes might be acquired.

Published
2018

6. The Management of Azoospermia

Author

Friedler, S., primary, Raziel, A., additional, Strassburger, D., additional, Schachter, M., additional, Bern, O., additional, Kasterstein, E., additional, Komarovsky, D., additional, and Ron-El, R., additional

Published
2008
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8. Contributors

Author

ALLWOOD, M.C., primary, ARONSON, J.K., additional, AURSNES, I., additional, BALDACCHINO, A.M., additional, BEHREND, M., additional, BRAUN, F., additional, BUSER, J., additional, CARVAJAL, A., additional, CHOULIS, N.H., additional, COSTA, J., additional, COWEN, P.J., additional, CURRAN, S., additional, de WOLFF, F.A., additional, DEL FAVERO, A., additional, DALTON, H.R., additional, DAR, S., additional, DESCOTES, J., additional, DITTMANN, S., additional, DUKES, M.N.G., additional, DUNNER, D.L., additional, ERNST, E., additional, FARRÉ, M., additional, FATTINGER, K., additional, FLISBERG, P., additional, FRANKLYN, J.A., additional, FRANZOSI, M.G., additional, GHODSE, A.H., additional, GIL-NAGEL, A., additional, GROLL, A.H., additional, HARTMANN, J.T., additional, HARTMANN, K., additional, IMHOF, A., additional, JACKSON, S.A., additional, JIMENO, N., additional, JOERGER, MARKUS, additional, JOUBERT, P., additional, KEELING, DAVID M., additional, KNOWLES, SANDRA R., additional, KOLVE, H., additional, KRANS, H.M.J., additional, KUHN, MAX, additional, LATINI, R., additional, LEUWER, M., additional, LIPP, H.-P., additional, MAGEE, P., additional, MAGGIONI, A.P., additional, MARTÍN ARIAS, L.H., additional, MEYBOOM, R.H.B., additional, MIDTVEDT, T., additional, MORCOS, S.K., additional, MUSA, S., additional, O'CONNOR, D.J., additional, PAGE, R., additional, PATEL, J.K., additional, POLAK, B.C.P., additional, RALSTON, T.E., additional, REUTER, H.D., additional, SCHACHTER, M., additional, SCHMID, PATRICK, additional, SCHUG, S.A., additional, SEQUEIRA, R.P., additional, SHEAR, N.H., additional, SICA, D.A., additional, STANLEY, A., additional, STRENGERS, P.F.W., additional, SWAMINATHAN, S., additional, VAN AKEN, W.G., additional, VAN DER VOET, G.B., additional, VAN GENDEREN, P.J.J., additional, VERHAEGHE, R., additional, VERNAZZA, PIETRO L., additional, VIAL, T., additional, VOSSEBELD, P.J.M., additional, WALSH, G.M., additional, WALSH, T.J., additional, WONG, E.J., additional, WONG, GAVIN, additional, YOUNG, Y., additional, and ZUZAN, O., additional

Published
2005
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42. Aliskiren - The first of a new class of antihypertensive

Author

Price, L, Kassianos, G, Brown, M, Gaw, A, Kirby, M, Morrell, J, Schachter, M, Tamargo, J, Yawn, B, Yawn, R, Barakat, K, Brown, P, Dalrymple, J, Elward, K, Ganiats, T, Halpin, D, LeFevre, M, North, F, Price, D, Rasmussen, J, Spann, S, Stevens, R, Tallia, A, Uden, D, and Waite, M

Abstract

Aliskiren is the first of a new class of orally active, non-peptide, renin inhibitors. The enzyme renin is involved in the first step of the renin - angiotensin - aldosterone system (RAAS), which helps regulate blood pressure. Inhibition of renin activity suppresses the RAAS at an earlier point than that targeted by the angiotensin converting enzyme (ACE) inhibitors. Short-term, placebo-controlled studies in patients with mild-to-moderate hypertension show aliskiren monotherapy to be well tolerated and effective; it lowers blood pressure at least as effectively as the diuretic hydrochlorothiazide and the angiotensin II receptor antagonists (blockers: ARBs) irbesartan and losartan. In a 26-week study, aliskiren-based treatment had a greater antihypertensive effect than treatment based on the ACE inhibitor ramipril. Aliskiren in combination with an ACE inhibitor, an ARB, a calcium-channel blocker or with hydrochlorothiazide reduced blood pressure more effectively than the respective monotherapies in most instances. Whereas ACE inhibitors and ARBs increase plasma renin concentration and activity as a consequence of interrupting angiotensin II-mediated negative feedback on renin release, renin inhibitors decrease plasma renin activity. This is illustrated best in studies in which aliskiren neutralises the increase in plasma renin activity caused by an ACE inhibitor and an ARB. The net reduction in renin activity occurs despite the increase in plasma renin concentration that aliskiren causes. These increases are slightly larger with aliskiren than those occurring with other blockers of the renin pathway, consistent with inhibition at the rate-limiting step causing the greatest inhibition of the angiotensin II-mediated negative feedback. © 2008 CSF Medical Communications Ltd.

Published
2016

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