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4. Noncanonical atherosclerosis as the driving force in tricuspid aortic valve associated aneurysms - A trace collection

Author

Doppler, Christian, primary, Messner, Barbara, additional, Mimler, Teresa, additional, Schachner, Bruno, additional, Rezk, Marlene, additional, Ganhör, Clara, additional, Wechselberger, Christian, additional, Müller, Marina, additional, Puh, Spela, additional, Pröll, Johannes, additional, Arbeithuber, Barbara, additional, Müller, Thomas, additional, Zierer, Andreas, additional, and Bernhard, David, additional

Published
2023
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5. Journal of Lipid Research / Noncanonical atherosclerosis as the driving force in tricuspid aortic valve associated aneurysms : a trace collection

Author

Doppler, Christian, Messner, Barbara, Mimler, Teresa, Schachner, Bruno, Rezk, Marlene, Ganhör, Clara, Wechselberger, Christian, Müller, Marina, Puh, Spela, Pröll, Johannes, Arbeithuber, Barbara, Müller, Thomas, Zirer, Andreas, and Bernhard, David

Subjects
lysophosphatidylcholine, lipidomics, cholesterol, matrix-assisted laser desorption ionization mass spectrometry, smooth muscle cells
Abstract

Pathogenic mechanisms in degenerative thoracic aortic aneurysms (TAA) are still unclear. There is an ongoing debate about whether TAAs are caused by uniform or distinct processes, which would obviously have a major impact on future treatment strategies. Clearly, the ultimate outcome of TAA subgroups associated with a tricuspid aortic valve (TAV) or a bicuspid aortic valve (BAV) is the same, namely a TAA. Based on results from our own and others' studies, we decided to compare the different TAAs (TAV and BAV) and controls using a broad array of analyses, i.e., metabolomic analyses, gene expression profiling, protein expression analyses, histological characterization, and matrix-assisted laser desorption ionization imaging. Central findings of the present study are the presence of noncanonical atherosclerosis, pathological accumulation of macrophages, and disturbances of lipid metabolism in the aortic media. Moreover, we have also found that lipid metabolism is impaired systemically. Importantly, all of the above-described phenotypes are characteristic for TAV-TAA only, and not for BAV-TAA. In summary, our results suggest different modes of pathogenesis in TAV- and BAV-associated aneurysms. Intimal atherosclerotic changes play a more central role in TAV-TAA formation than previously thought, particularly as the observed alterations do not follow classical patterns. Atherosclerotic alterations are not limited to the intima but also affect and alter the TAV-TAA media. Further studies are needed to i) clarify patho-relevant intima-media interconnections, ii) define the origin of the systemic alteration of lipid metabolism, and iii) to define valid biomarkers for early diagnosis, disease progression, and successful treatments in TAV-TAAs. Version of record

Published
2023

7. Aortic Arch Surgery Under Warm Conditions (Moderate to Mild Hypothermia)

Author

Schachner Bruno, Zierer Andreas, Ratschiller Thomas, Gottsberger Jessica, Mair Roland, Benedikt Peter, and Huber Florian

Subjects
Mild hypothermia, business.industry, 030204 cardiovascular system & hematology, Aortic arch surgery, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, Cerebral blood flow, Anesthesia, Surgical skills, Deep hypothermic circulatory arrest, Medicine, Neurological dysfunction, Autoregulation, business
Abstract

Since the beginnings of cardiovascular surgery, aortic arch surgery has been the most challenging aspiration. Not only requiring the finest surgical skills but also demanding sound knowledge in neurophysiology since adequate cerebral and visceral protection is essential for achieving a successful outcome.

Published
2019

10. Impact of the coronavirus disease 2019 (COVID-19) pandemic on the care of patients with acute and chronic aortic conditions

Author

Alessandro Della Corte, Vitali A Sorokin, Mario D Oria, Arminder S. Jassar, Sandro Lepidi, Claudio Muneretto, Andreas Voetsch, Luca Di Marco, Claudio Corazzari, Chiara Lomazzi, Marwan Hamiko, Sven Peterss, J. Sirch, Andreas Zierer, Christian Hagl, K. Meisenbacher, Rodolfo Citro, Eric L.G. Verhoeven, Ernst Weigang, Maria Hugas-Mallorqui, Piotr Szopinski, C Probst, Athanasios Katsargyris, Maciej Kolowca, Xun Yuan, Michael Petrich, Antonio Micari, Severino Iesu, Alexander Hyhlik-Duerr, Massimiliano M. Marrocco-Trischitta, Frieda-Maria Kainz, Tim Walter, Corinna Walter, Bruno Schachner, Paul Puiu, Miriam Rychla, Jos C. van den Berg, Mariusz Kusmierczyk, Gabriele Ianelli, Thomas Schachner, Dittmar Böckler, Oyvind Jacobsen, Francesco Baldascino, Ivana Iesu, Philipp Discher, Martin Czerny, Jürg Schmidli, Kenji Minatoya, Martina Fink, Benedikt Reutersberg, Christopher De Troia, Christoph A. Nienaber, Koki Yokawa, Matthias Siepe, Thomas R Wyss, Filippo Gorgatti, Kay-Hyun Park, Ferdinand Vogt, Denise Galbiati, Oliver Y Bernecker, Luigi Di Tommaso, Peter L. Haldenwang, Ilenia D Alessio, Jai Ajitchandra Sule, Filippo Benedetto, Gabriele Piffaretti, Julia Dumfarth, Davide Pacini, Gabriel Weiss, Zoltán Szeberin, Andrzej Juraszek, Stephan Koter, Kazuhisa Sakamoto, Roman Gottardi, Fabrizio Rosati, Takayuki Shijo, Justus Strauch, Eduardo Bossone, Joon-Chui Jung, Yvonne Gosslau, Piotr Kołsut, Robin H. Heijmen, Antonio De Bellis, Santi Trimarchi, Giulio Accarino, Thomas Nolte, Eliza Pleban, Bartosz Rylski, Giovanni Nava, Florian Huber, Eva-Luca Tobler, Hector W.L. de Beaufort, Hitoshi Matsuda, Balazs Lengyel, Czerny, Martin, Gottardi, Roman, Puiu, Paul, Bernecker, Oliver Y, Citro, Rodolfo, Della Corte, Alessandro, di Marco, Luca, Fink, Martina, Gosslau, Yvonne, Haldenwang, Peter Luka, Heijmen, Robin H, Hugas-Mallorqui, Maria, Iesu, Severino, Jacobsen, Oyvind, Jassar, Arminder S, Juraszek, Andrzej, Kolowca, Maciej, Lepidi, Sandro, Marrocco-Trischitta, Massimiliano M, Matsuda, Hitoshi, Meisenbacher, Katrin, Micari, Antonio, Minatoya, Kenji, Park, Kay-Hyun, Peterss, Sven, Petrich, Michael, Piffaretti, Gabriele, Probst, Chri, Reutersberg, Benedikt, Rosati, Fabrizio, Schachner, Bruno, Schachner, Thoma, Sorokin, Vitali A, Szeberin, Zoltan, Szopinski, Piotr, Di Tommaso, Luigi, Trimarchi, Santi, Verhoeven, Eric L G, Vogt, Ferdinand, Voetsch, Andrea, Walter, Tim, Weiss, Gabriel, Yuan, Xun, Benedetto, Filippo, De Bellis, Antonio, D Oria, Mario, Discher, Philipp, Zierer, Andrea, Rylski, Bartosz, van den Berg, Jos C, Wyss, Thomas R, Bossone, Eduardo, Schmidli, Jürg, Nienaber, Christoph, Accarino, Giulio, Baldascino, Francesco, Böckler, Dittmar, Corazzari, Claudio, D Alessio, Ilenia, de Beaufort, Hector, De Troia, Christopher, Dumfarth, Julia, Galbiati, Denise, Gorgatti, Filippo, Hagl, Christian, Hamiko, Marwan, Huber, Florian, Hyhlik-Duerr, Alexander, Ianelli, Gabriele, Iesu, Ivana, Jung, Joon-Chui, Kainz, Frieda-Maria, Katsargyris, Athanasio, Koter, Stephan, Kusmierczyk, Mariusz, Kolsut, Piotr, Lengyel, Balaz, Lomazzi, Chiara, Muneretto, Claudio, Nava, Giovanni, Nolte, Thoma, Pacini, Davide, Pleban, Eliza, Rychla, Miriam, Sakamoto, Kazuhisa, Shijo, Takayuki, Yokawa, Koki, Siepe, Matthia, Sirch, Joachim, Strauch, Justu, Sule, Jai Ajitchandra, Tobler, Eva-Luca, Walter, Corinna, Weigang, Ernst, Y Bernecker, Oliver, Lukas Haldenwang, Peter, H Heijmen, Robin, S Jassar, Arminder, M Marrocco-Trischitta, Massimiliano, A Sorokin, Vitaly, G Verhoeven, Eric L, D'Oria, Mario, C van den Berg, Jo, R Wyss, Thoma, D´ Alessio, Ilenia, and Ajitchandra Sule, Jai

Subjects
Coronavirus disease 2019 pandemic, Surgical volume, Acute and elective thoracic and abdominal aortic procedures, 030204 cardiovascular system & hematology, Acute and elective thoracic and abdominal aortic procedure, 0302 clinical medicine, Pandemic, 030212 general & internal medicine, 610 Medicine & health, Acute aortic syndrome, AcademicSubjects/MED00920, General Medicine, Coronavirus disease, Europe, medicine.anatomical_structure, Italy, Elective Surgical Procedures, Original Article, Cardiology and Cardiovascular Medicine, Aortic surgery, Switzerland, Human, Pulmonary and Respiratory Medicine, medicine.medical_specialty, 2019 pandemic, Asia, Coronavirus disease 2019 (COVID-19), Referral, Thoracic aorta, 03 medical and health sciences, Acute onset, medicine.artery, Internal medicine, medicine, Humans, ddc:610, Pandemics, Aorta, Elective Surgical Procedure, business.industry, SARS-CoV-2, COVID-19, The Netherlands, medicine.disease, Confidence interval, Abdomen, Surgery, business
Abstract

OBJECTIVES The aim of this study was to evaluate the effects of the coronavirus 2019 pandemic on elective and acute thoracic aortic surgery in the Netherlands. METHODS The Netherlands Heart Registration database was used to compare the volume of elective and acute surgery on the thoracic aorta in 2019 and 2020, starting from week 11 in both years. A sub-analysis was done to assess the impact of the pandemic on high-volume and low-volume aortic centres. RESULTS During the pandemic, the number of elective thoracic aortic operations declined by 18% [incidence rate ratio (IRR) 0.82 [0.73–0.91]; P < 0.01]. The decline in volume of elective surgery was significant in both high-volume (IRR 0.82 [0.71–0.94]; P < 0.01) and low-volume aortic centres (IRR 0.81 [0.68–0.98]; P = 0.03). The overall number of acute aortic operations during the pandemic remained similar to that in 2019 (505 vs 499; P = 0.85), but an increased share of these operations occurred at high-volume centres. The number of acute operations performed in high-volume centres increased by 20% (IRR 1.20 [1.01–1.42]; P = 0.04), while the number of acute operations performed in low-volume centres decreased by 17% (IRR 0.83 [0.69–1.00]; P = 0.04). CONCLUSIONS The coronavirus 2019 pandemic led to a significant decrease in elective thoracic aortic surgery but did not cause a change in the volume of acute thoracic aortic surgery in the Netherlands. Moreover, the pandemic led to a centralization of care for acute thoracic aortic surgery., The coronavirus disease 19 (COVID-19) pandemic has impacted the delivery of health care around the world.

Published
2021

11. Corrigendum to 'Impact of the coronavirus disease 2019 (COVID-19) pandemic on the care of patients with acute and chronic aortic conditions'.

Author

Czerny M, Gottardi R, Puiu P, Bernecker OY, Citro R, Corte AD, di Marco L, Fink M, Gosslau Y, Haldenwang PL, Heijmen RH, Hugas-Mallorqui M, Iesu S, Jacobsen O, Jassar AS, Juraszek A, Kolowca M, Lepidi S, Marrocco-Trischitta MM, Matsuda H, Meisenbacher K, Micari A, Minatoya K, Park KH, Peterss S, Petrich M, Piffaretti G, Probst C, Reutersberg B, Rosati F, Schachner B, Schachner T, Sorokin VA, Szeberin Z, Szopinski P, Di Tommaso L, Trimarchi S, Verhoeven ELG, Vogt F, Voetsch A, Walter T, Weiss G, Yuan X, Benedetto F, De Bellis A, D'Oria M, Discher P, Zierer A, Rylski B, van den Berg JC, Wyss TR, Bossone E, Schmidli J, Nienaber C, Accarino G, Baldascino F, Böckler D, Corazzari C, D'Alessio I, de Beaufort H, De Troia C, Dumfarth J, Galbiati D, Gorgatti F, Hagl C, Hamiko M, Huber F, Hyhlik-Duerr A, Ianelli G, Iesu I, Jung JC, Kainz FM, Katsargyris A, Koter S, Kusmierczyk M, Kolsut P, Lengyel B, Lomazzi C, Muneretto C, Nava G, Nolte T, Pacini D, Pleban E, Rychla M, Sakamoto K, Shijo T, Yokawa K, Siepe M, Sirch J, Strauch J, Sule JA, Tobler EL, Walter C, and Weigang E

Published
2021
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12. Impact of the coronavirus disease 2019 (COVID-19) pandemic on the care of patients with acute and chronic aortic conditions.

Author

Czerny M, Gottardi R, Puiu P, Bernecker OY, Citro R, Della Corte A, di Marco L, Fink M, Gosslau Y, Haldenwang PL, Heijmen RH, Hugas-Mallorqui M, Iesu S, Jacobsen O, Jassar AS, Juraszek A, Kolowca M, Lepidi S, Marrocco-Trischitta MM, Matsuda H, Meisenbacher K, Micari A, Minatoya K, Park KH, Peterss S, Petrich M, Piffaretti G, Probst C, Reutersberg B, Rosati F, Schachner B, Schachner T, Sorokin VA, Szeberin Z, Szopinski P, Di Tommaso L, Trimarchi S, Verhoeven ELG, Vogt F, Voetsch A, Walter T, Weiss G, Yuan X, Benedetto F, De Bellis A, D Oria M, Discher P, Zierer A, Rylski B, van den Berg JC, Wyss TR, Bossone E, Schmidli J, Nienaber C, Accarino G, Baldascino F, Böckler D, Corazzari C, D Alessio I, de Beaufort H, De Troia C, Dumfarth J, Galbiati D, Gorgatti F, Hagl C, Hamiko M, Huber F, Hyhlik-Duerr A, Ianelli G, Iesu I, Jung JC, Kainz FM, Katsargyris A, Koter S, Kusmierczyk M, Kolsut P, Lengyel B, Lomazzi C, Muneretto C, Nava G, Nolte T, Pacini D, Pleban E, Rychla M, Sakamoto K, Shijo T, Yokawa K, Siepe M, Sirch J, Strauch J, Sule JA, Tobler EL, Walter C, and Weigang E

Subjects
Asia, Elective Surgical Procedures, Europe, Humans, Italy, SARS-CoV-2, Switzerland, COVID-19, Pandemics
Abstract

Objectives: To evaluate the impact of the coronavirus disease 2019 (COVID-19) pandemic on acute and elective thoracic and abdominal aortic procedures., Methods: Forty departments shared their data on acute and elective thoracic and abdominal aortic procedures between January and May 2020 and January and May 2019 in Europe, Asia and the USA. Admission rates as well as delay from onset of symptoms to referral were compared., Results: No differences in the number of acute thoracic and abdominal aortic procedures were observed between 2020 and the reference period in 2019 [incidence rates ratio (IRR): 0.96, confidence interval (CI) 0.89-1.04; P = 0.39]. Also, no difference in the time interval from acute onset of symptoms to referral was recorded (<12 h 32% vs > 12 h 68% in 2020, < 12 h 34% vs > 12 h 66% in 2019 P = 0.29). Conversely, a decline of 35% in elective procedures was seen (IRR: 0.81, CI 0.76-0.87; P < 0.001) with substantial differences between countries and the most pronounced decline in Italy (-40%, P < 0.001). Interestingly, in Switzerland, an increase in the number of elective cases was observed (+35%, P = 0.02)., Conclusions: There was no change in the number of acute thoracic and abdominal aortic cases and procedures during the initial wave of the COVID-19 pandemic, whereas the case load of elective operations and procedures decreased significantly. Patients with acute aortic syndromes presented despite COVID-19 and were managed according to current guidelines. Further analysis is required to prove that deferral of elective cases had no impact on premature mortality., (© The Author(s) 2021. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.)

Published
2021
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