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We tested whether a brief self-affirmation writing intervention protected against identity-threats (i.e., stereotyping and discrimination) for adolescents' school-related adjustment. The longitudinal study followed 639 adolescents in Germany (65% of immigrant descent, 50% female, M[subscript age] = 12.35 years, SD[subscript age] = 0.69) from 7th grade (pre-intervention at T1, five to six months post-intervention at T2) to the end of 8th grade (one-year follow-up at T3). We tested for direct and moderated (by heritage group, discrimination, classroom cultural diversity climate) effects using regression and latent change models. The self-affirmation intervention did not promote grades or math competence. However, in the short-term and for adolescents of immigrant descent, the intervention prevented a downward trajectory in mastery reactions to academic challenges for those experiencing greater discrimination. Further, it protected against a decline in behavioral school engagement for those in positive classroom cultural diversity climates. In the long-term and for all adolescents, the intervention lessened an upward trajectory in disruptive behavior. Overall, the self-affirmation intervention benefited some aspects of school-related adjustment for adolescents of immigrant and non-immigrant descent. The intervention context is important, with classroom cultural diversity climate acting as a psychological affordance enhancing affirmation effects. Our study supports the ongoing call for theorizing and empirically testing student and context heterogeneity to better understand for whom and under which conditions this intervention may work.

The ability to infer others' prosocial vs. antisocial behavioral tendencies from minimal information is core to social reasoning. Aesthetic motivation (the value or appreciation of aesthetic beauty) is linked with prosocial tendencies, raising the question of whether this factor is used in interpersonal reasoning and in the attribution of mental capacities. We propose and test a model of this reasoning, predicting that evidence of others' aesthetic motivations should impact judgments of others' prosocial (and antisocial) tendencies by signaling a heightened capacity for emotional experience. In a series of four pre-registered experiments (total N = 1440), participants saw pairs of characters (as photos/vignettes), and judged which in each pair showed more of a mental capacity of interest. Distractor items prevented participants from guessing the hypothesis. For one critical pair of characters, both characters performed the same activity (music listening, painting, cooking, exercising, being in nature, doing math), but one was motivated by the activities' aesthetic value, and the other by its functional value. Across all activities, participants robustly chose aesthetically-motivated characters as more likely to behave compassionately (Exp. 1; 3), less likely to behave selfishly/manipulatively (Exp. 1; 3), and as more emotionally sensitive, but not more intelligent (Exp. 2; 3; 4). Emotional sensitivity best predicted compassionate behavior judgements (Exp. 3). Aesthetically-motivated characters were not reliably chosen as more helpful; intelligence best predicted helpfulness judgements (Exp. 4). Evidence of aesthetic motivation conveys important social information about others, impacting fundamental interpersonal judgments about others' mental life and social behavior.

Abstract GeoMx Digital Spatial Profiling (Nanostring) is a commercial spatial transcriptomics method to selectively analyze regions of interest within intact tissue sections. We show that decalcification with ethylene-diamine-tetra-acetic (EDTA) variably attenuates probe counts, while probes that are more resistant to this effect consequently appear overexpressed after quantile normalization. By determining the undisclosed full-length target sequences of probes used in the human whole transcriptome panel, hereby updating target transcripts and genes, we find that the gene-promiscuity of probes is an important factor that determines sensitivity to EDTA incubation.

Abstract Neurons rely heavily on high mitochondrial metabolism to provide sufficient energy for proper development. However, it remains unclear how neurons maintain high oxidative phosphorylation (OXPHOS) during development. Mitophagy plays a pivotal role in maintaining mitochondrial quality and quantity. We herein describe that G protein-coupled receptor 50 (GPR50) is a novel mitophagy receptor, which harbors the LC3-interacting region (LIR) and is required in mitophagy under stress conditions. Although it does not localize in mitochondria under normal culturing conditions, GPR50 is recruited to the depolarized mitochondrial membrane upon mitophagy stress, which marks the mitochondrial portion and recruits the assembling autophagosomes, eventually facilitating the mitochondrial fragments to be engulfed by the autophagosomes. Mutations Δ502-505 and T532A attenuate GPR50-mediated mitophagy by disrupting the binding of GPR50 to LC3 and the mitochondrial recruitment of GPR50. Deficiency of GPR50 causes the accumulation of damaged mitochondria and disrupts OXPHOS, resulting in insufficient ATP production and excessive ROS generation, eventually impairing neuronal development. GPR50-deficient mice exhibit impaired social recognition, which is rescued by prenatal treatment with mitoQ, a mitochondrially antioxidant. The present study identifies GPR50 as a novel mitophagy receptor that is required to maintain mitochondrial OXPHOS in developing neurons.

Drawing on recent syntheses of the emerging science of learning and development and its implications for school practice, this article examines the kinds of preparation teachers need to enact such practices. We synthesize research on how children learn and develop and research on how effective preparation programs support teachers in developing the knowledge, skills, and dispositions associated with developing the whole child. This includes the "what" of teacher preparation -- the content educators need to learn about children and their and learning -- and the "how" of preparation -- the strategies for educator learning that can produce deep understanding, critical skills and dispositions, and the capacity to reflect, learn, and continue to improve. Preparing educators to acquire and use these insights holds promise for generating the kinds of education that enable children ultimately to learn independently and thrive.

Due to rising Islamophobia in Europe today, Muslim ethnic minority adolescents are at great risk of experiencing identity-based harassment at school. We extend previous research on ethnic discrimination by focusing on religious discrimination of Muslim adolescents and its effect on their psychological (i.e., depressive symptoms and self-esteem) and behavioural adjustment (i.e., disruptive behaviour at school). Further, we consider Muslim adolescents' ethnic and religious identification as two factors that may promote adolescents' adjustment and protect them from the negative consequences of discrimination. We used data from N = 105 Muslim ethnic minority adolescents (M[subscript age]= 13.30, SD = 0.75, 45% female). Factor analysis revealed that adolescents did not differentiate between ethnic and religious discrimination. Results show that higher perceived ethno-religious discrimination (PERD) was related to more depressive symptoms. While higher ethnic identification was associated with greater self-esteem, higher religious identification was related to fewer depressive symptoms. Contrary to our expectation, Muslim adolescents who were highly identified with their ethnic group reported more depressive symptoms when experiencing more PERD. Their self-esteem was negatively affected by higher PERD when possessing high religious identification, while for low religious identification a positive effect of higher PERD on self-esteem emerged. Results highlight the importance of developing evidence-based intervention programmes for schools to tackle identity-based harassment.

Abstract Background The surgical evaluation and management of non-A non-B aortic dissections, in the absence of ascending aortic involvement, remains a grey area. It is in these scenarios when thorough evaluation of patient/family history, clinical presentation, but also overall lifestyle, is of immense importance when determining an optimal intervention. Case presentation We present a 38-year-old patient with a physically demanding lifestyle as a professional wrestler, uncontrolled hypertension due to history of medical non-adherence, and family history of aortic dissection who presented with acute non-A non-B aortic dissection. He was spared a total arch replacement by undergoing a hybrid approach of complete aortic debranching with antegrade Thoracic Endovascular Aortic Repair (TEVAR). The patient was able to benefit from reduced cardiopulmonary bypass (CPB) time, avoidance of aortic cross clamp, circulatory arrest, and hypothermic circulation. Conclusions This patient’s unique composition of a physically demanding lifestyle, personal history of medical non-adherence, family history of aortic dissection, and clinical presentation required a holistic approach to understanding an ideal intervention that would be best suited long-term. Due to this contextualization, the patient was able to be spared a total arch replacement, or suboptimal medical management, by instead undergoing a hybrid-approach with total aortic arch debranching with antegrade TEVAR.

Without conscious thought, listeners link events in the world to sounds they hear. We study one surprising example: Adults can judge the temperature of water simply from hearing it being poured. We test the development of the ability to hear water temperature, with the goal of informing developmental theories regarding the origins and cognitive bases of nuanced sound source judgments. We first confirmed that adults accurately distinguished the sounds of hot and cold water (pre-registered Experiments. 1, 2; total N = 384), even though many were unaware or uncertain of this ability. By contrast, children showed protracted development of this skill over the course of middle childhood (Experiments. 2, 3; total N = 178). In spite of accurately identifying other sounds and hot/cold images, older children (7-11 years) but not younger children (3-6 years) reliably distinguished the sounds of hot and cold water. Accuracy increased with age; 11-year old's performance was similar to adults. Adults also showed individual differences in accuracy that were predicted by their amount of prior relevant experience (Experiment 1). Experience may similarly play a role in children's performance; differences in auditory sensitivity and multimodal integration may also contribute to young children's failures. The ability to hear water temperature develops slowly over childhood, such that nuanced auditory information that is easily and quickly accessible to adults is not available to guide young children's behavior. HIGHLIGHTS: Adults can make nuanced judgments from sound, including accurately judging the temperature of water from the sound of it being poured. Children showed protracted development of this skill over the course of middle childhood, such that 7-11-year-olds reliably succeeded while 3-6-year-olds performed at chance. Developmental changes may be due to experience (adults with greater relevant experience showed higher accuracy) and the development of multimodal integration and auditory sensitivity. Young children may not detect subtle auditory information that adults easily perceive.

In this note, we explore the distribution of vacuum expectation values of the superpotential W0 in explicit Type IIB flux compactifications. We show that the distribution can be approximated universally across geometries by a two-dimensional Gaussian with a model-dependent standard deviation. We identify this behaviour in 20 Calabi-Yau orientifold compactifications with between two and five complex structure moduli by constructing a total of O(107) flux vacua. We observe a characteristic scaling behaviour of the width σ of our distributions with respect to the D3-charge contributions Nflux from fluxes which can be approximated by σ∼Nflux. This W0 distribution implies that locating small values of |W0| as a preferred regime associated with classes of string theory solutions typically featuring hierarchies, simplifies to the basic statement of finding small Euclidean norms of normally distributed values. We also identify small modifications to this Gaussian behaviour in our samples, which might be seen as indications for the breakdown of the continuous flux approximation commonly used in the context of statistical analyses of the flux landscape.

Dance is a universal human behavior and a crucial component of human musicality. When and how does the motivation and tendency to move to music develop? How does this behavior change as a process of maturation and learning? We characterize infants' earliest dance behavior, leveraging parents' extensive at-home observations of their children. Parents of infants aged 0-24 months (N = 278, 82.7% White, 84.5% in the United States, 46.0% of household incomes ≥ $100,000) were surveyed regarding their child's current and earliest dance behavior (movement by the child, during music, that the parent considered dance), motor development, and their own infant-directed dance. We found that dance begins early: 90% of infants produced recognizable dance by 12.8 months, and the age of onset was not solely a function of motor development. Infants who produced dance did so often, on average almost every day. We also found that dance shows qualitative developmental change over the first 2 years, rather than remaining stable. With motor development, age, and more time dancing, infants used a greater variety of movements in dance, and began to incorporate learned, imitated gestures (80% of infants by 17.9 months). 99.8% of parents reported dancing for or with their infants, raising questions about the role of infant-directed dance. These findings provide evidence that the motivation and tendency to move to music appears extremely early and that both learning and maturation lead to qualitative change in dance behavior during the first 2 years, informing broad questions about the origins of human musicality. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Similarity of behaviors or attributes is often used to infer social affiliation and prosociality. Does this reflect reasoning using a simple expectation of homophily, or more complex reasoning about shared utility? We addressed this question by examining the inferences children make from similar choices when this similarity does or does not cause competition over a zero-sum resource. Four- to six-year-olds (N = 204) saw two vignettes, each featuring three characters (a target plus two others) choosing between two types of resources. In all stories, each character expressed a preference: one 'other' chose the same resource as the target, while a second 'other' chose the different resource. In one condition there were enough resources for all the characters; in the other condition, one type of resource was limited, with only one available (inducing potential competition between the target and the similar-choice other). Children then judged which of the two 'other' characters was being nicer (prosocial judgment) and which of the two was more preferred by the target (affiliative inference). When resources were limited (vs. unlimited), children were less likely to select the similar other as being nice. Children's initial tendency to report that the target preferred the similar other was also eliminated in the limited resource scenario. These findings show that children's reasoning about similarity is not wholly based on homophily. Instead, by reasoning about shared utility - how each person values the goals of others - children engage in flexible inferences regarding whether others' similar preferences and behaviors have positive or negative social meaning.

How do people detect lies from the content of messages, and design lies that go undetected? Lying requires strategic reasoning about how others think and respond. We propose a unified framework underlying lie design and detection, formalized as recursive social reasoning. Senders design lies by inferring the likelihood the receiver detects potential lies; receivers detect lies by inferring if and how the sender would lie. Under this framework, we can predict the rate and content of lies people produce, and which lies are detected. In Experiment 1, we show that people calibrate the extremeness of their lies and what lies they detect to beliefs about goals and the statistics of the world. In Experiment 2, we present stronger diagnostic evidence for the function of social reasoning in lying: people cater their lies to their audience, even when their audience's beliefs differ from their own. We conclude that recursive and rational social reasoning is a key cognitive process underlying how people communicate in adversarial settings. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Abstract The heterogeneity inherent in today’s biotherapeutics, especially as a result of heavy glycosylation, can affect a molecule’s safety and efficacy. Characterizing this heterogeneity is crucial for drug development and quality assessment, but existing methods are limited in their ability to analyze intact glycoproteins or other heterogeneous biotherapeutics. Here, we present an approach to the molecular assessment of biotherapeutics that uses proton-transfer charge-reduction with gas-phase fractionation to analyze intact heterogeneous and/or glycosylated proteins by mass spectrometry. The method provides a detailed landscape of the intact molecular weights present in biotherapeutic protein preparations in a single experiment. For glycoproteins in particular, the method may offer insights into glycan composition when coupled with a suitable bioinformatic strategy. We tested the approach on various biotherapeutic molecules, including Fc-fusion, VHH-fusion, and peptide-bound MHC class II complexes to demonstrate efficacy in measuring the proteoform-level diversity of biotherapeutics. Notably, we inferred the glycoform distribution for hundreds of molecular weights for the eight-times glycosylated fusion drug IL22-Fc, enabling correlations between glycoform sub-populations and the drug’s pharmacological properties. Our method is broadly applicable and provides a powerful tool to assess the molecular heterogeneity of emerging biotherapeutics.

A growing literature shows that music increases prosocial behavior. Why does this occur? We propose a novel hypothesis, informed by moral psychology: evidence of others’ musicality may promote prosociality by leading us to judge musical individuals as having enhanced moral standing. This effect may be largely indirect, by increasing perceptions of how intelligent and emotionally sensitive musical individuals are. If so, simply knowing about others’ musicality should affect moral evaluations, such as wrongness to harm. Across four experiments (total N = 550), we found supportive evidence. Information that an animal or person had the capacity and motivation to engage with music led participants to judge these entities as more wrong to harm than matched neutral or non-musical counterparts. Similarly, knowing that a person was not musical made people judge them as less wrong to harm than neutral or musical counterparts. As predicted, musicality was positively associated with perceptions of capacities for emotionality and intelligence, and these broader factors partially mediated the relationship between musicality and wrongness to harm. These effects were not influenced by participants’ own musicality. Thus, non-moral attributes like musicality can impact moral consideration, carrying implications for social behavior and for interventions to promote prosociality.

Many studies argue that synchronized movement increases prosocial attitudes and behavior. We reviewed meta-analytic evidence that reported effects of synchrony may be driven by experimenter expectancy, leading to experimenter bias; and participant expectancy, otherwise known as placebo effects. We found that a majority of published studies do not adequately control for experimenter bias and that multiple independent replication attempts with added controls have failed to find the original effects. In a preregistered experiment, we measured participant expectancy directly, asking whether participants have a priori expectations about synchrony and prosociality that match the findings in published literature. Expectations about the effects of synchrony on prosocial attitudes directly mirrored previous experimental findings (including both positive and null effects)-despite the participants not actually engaging in synchrony. On the basis of this evidence, we propose an alternative account of the reported bottom-up effects of synchrony on prosociality: the effects of synchrony on prosociality may be explicable as the result of top-down expectations invoked by placebo and experimenter effects.

When interacting with infants, humans often alter their speech and song in ways thought to support communication. Theories of human child-rearing, informed by data on vocal signalling across species, predict that such alterations should appear globally. Here, we show acoustic differences between infant-directed and adult-directed vocalizations across cultures. We collected 1,615 recordings of infant- and adult-directed speech and song produced by 410 people in 21 urban, rural and small-scale societies. Infant-directedness was reliably classified from acoustic features only, with acoustic profiles of infant-directedness differing across language and music but in consistent fashions. We then studied listener sensitivity to these acoustic features. We played the recordings to 51,065 people from 187 countries, recruited via an English-language website, who guessed whether each vocalization was infant-directed. Their intuitions were more accurate than chance, predictable in part by common sets of acoustic features and robust to the effects of linguistic relatedness between vocalizer and listener. These findings inform hypotheses of the psychological functions and evolution of human communication.

Dance is a universal human behavior and a crucial component of human musicality. When and how does the motivation and tendency to move to music develop? How does this behavior change as a process of maturation and learning? We characterize infants' earliest dance behavior, leveraging parents' extensive at-home observations of their children. Parents of infants aged 0-24 months (N = 278, 82.7% White, 84.5% in the United States, 46.0% of household incomes [greater than or equal to]$100,000) were surveyed regarding their child's current and earliest dance behavior (movement by the child, during music, that the parent considered dance), motor development, and their own infant-directed dance. We found that dance begins early: 90% of infants produced recognizable dance by 12.8 months, and the age of onset was not solely a function of motor development. Infants who produced dance did so often, on average almost every day. We also found that dance shows qualitative developmental change over the first 2 years, rather than remaining stable. With motor development, age, and more time dancing, infants used a greater variety of movements in dance, and began to incorporate learned, imitated gestures (80% of infants by 17.9 months). 99.8% of parents reported dancing for or with their infants, raising questions about the role of infant-directed dance. These findings provide evidence that the motivation and tendency to move to music appears extremely early and that both learning and maturation lead to qualitative change in dance behavior during the first 2 years, informing broad questions about the origins of human musicality.

ObjectivesAlthough the Perceval sutureless aortic valve bioprosthesis presents a feasible alternative to conventional aortic valve prostheses, the extent of its applicability with respect to technical considerations for a real-world patient collective is still under debate.MethodsOne hundred patients received the Perceval prosthesis [males: 59; age: 72.5 (7.3–79) years] between December 2015 and February 2023 [EuroSCORE II: 2.8 (1.7–5.4)] for an aortic valve replacement (AVR), with additional concomitant procedures, for underlying severe aortic valve stenosis [n = 93 (93)], endocarditis [n = 5 (5)], and redo AVR [n = 7 (7)] including a prior surgical AVR [n = 4 (4)] and a failed transcatheter aortic valve implantation [n = 3 (3)]. Surgery was conducted primarily by median sternotomy [n = 71 (71)] and, alternatively, by the upper hemisternotomy approach [n = 29 (29)].ResultsOver a median follow-up time of 36.5 (16.5–53) months, eight patients (8%) underwent postoperative pacemaker implantation, with five (5%) due to high-grade atrioventricular block, while nine patients experienced a stroke (9%). The median values of maximum and mean gradients across all valve sizes were 22 (18–27.5) mmHg and 10 (13–18) mmHg, respectively. Two patients (2%) had moderate and one (1%) had severe paravalvular leakage, with the latter presenting the only case of underlying valve migration and induced redo AVR with valve explantation 2 days following initial surgery. Thirty-day mortality (and overall mortality) was 5% and 26%, respectively.ConclusionThe implantation of the Perceval bioprosthesis is feasible for a variety of indications, with excellent hemodynamic results and low complication rates in a real-world high-risk patient collective.