15 results on '"Schaack T"'
Search Results
2. Central American biomass burning smoke can increase tornado severity in the U.S.
- Author
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Saide, P. E., primary, Spak, S. N., additional, Pierce, R. B., additional, Otkin, J. A., additional, Schaack, T. K., additional, Heidinger, A. K., additional, da Silva, A. M., additional, Kacenelenbogen, M., additional, Redemann, J., additional, and Carmichael, G. R., additional
- Published
- 2015
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3. Attribution and evolution of ozone from Asian wild fires using satellite and aircraft measurements during the ARCTAS campaign
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Dupont, R., primary, Pierce, B., additional, Worden, J., additional, Hair, J., additional, Fenn, M., additional, Hamer, P., additional, Natarajan, M., additional, Schaack, T., additional, Lenzen, A., additional, Apel, E., additional, Dibb, J., additional, Diskin, G., additional, Huey, G., additional, Weinheimer, A., additional, Kondo, Y., additional, and Knapp, D., additional
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- 2012
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4. Reconstructing ozone chemistry from Asian wild fires using models, satellite and aircraft measurements during the ARCTAS campaign
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Dupont, R., primary, Pierce, B., additional, Worden, J., additional, Hair, J., additional, Fenn, M., additional, Hamer, P., additional, Natarajan, M., additional, Schaack, T., additional, Lenzen, A., additional, Apel, E., additional, Dibb, J., additional, Diskin, G., additional, Huey, G., additional, Weinheimer, A., additional, and Knapp, D., additional
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- 2010
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5. Downscale linkage of global model output for regional chemical transport modeling: Method and general performance
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Song, C.‐K., primary, Byun, D. W., additional, Pierce, R. B., additional, Alsaadi, J. A., additional, Schaack, T. K., additional, and Vukovich, F., additional
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- 2008
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6. Regional Air Quality Modeling System (RAQMS) predictions of the tropospheric ozone budget over east Asia
- Author
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Pierce, R. B., primary, Al-Saadi, J. A., additional, Schaack, T., additional, Lenzen, A., additional, Zapotocny, T., additional, Johnson, D., additional, Kittaka, C., additional, Buker, M., additional, Hitchman, M. H., additional, Tripoli, G., additional, Fairlie, T. D., additional, Olson, J. R., additional, Natarajan, M., additional, Crawford, J., additional, Fishman, J., additional, Avery, M., additional, Browell, E. V., additional, Creilson, J., additional, Kondo, Y., additional, and Sandholm, S. T., additional
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- 2003
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7. SPECIFIC REMOVAL OF ANTI-A AND ANTI-B ANTIBODIES USING MODIFIED DIALYSIS AND PLASMAPHERESIS FILTERS
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Hout, M S, primary, LeJeune, K E, additional, Schaack, T, additional, Bristow, D, additional, and Federspiel, W J, additional
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- 1999
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8. Relationship between body mass index and cardiometabolic health in a multi-ethnic population: A project baseline health study.
- Author
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Shah NP, Lu R, Haddad F, Shore S, Schaack T, Mega J, Pagidipati NJ, Palaniappan L, Mahaffey K, Shah SH, and Rodriguez F
- Abstract
Objective: Obesity is associated with a higher risk of cardiovascular disease. Understanding the associations between comprehensive health parameters and body mass index (BMI) may lead to targeted prevention efforts., Methods: Project Baseline Health Study (PBHS) participants were divided into six BMI categories: underweight (BMI <18.5 kg/m
2 ), normal weight (BMI 18.5-24.9 kg/m2 ), overweight (BMI 25-29.9 kg/m2 ), class I obesity (30-34.9 kg/m2 ), class II obesity (35-39.9 kg/m2 ), and class III obesity (BMI ≥40 kg/m2 ). Demographic, cardiometabolic, mental health, and physical health parameters were compared across BMI categories, and multivariable logistic regression models were fit to evaluate associations., Results: A total of 2,493 PBHS participants were evaluated. The mean age was 50±17.2 years; 55 % were female, 12 % Hispanic, 16 % Black, and 10 % Asian. The average BMI was 28.4 kg/m2 ±6.9. The distribution of BMI by age group was comparable to the 2017-2018 National Health and Nutrition Examination Survey (NHANES) dataset. The obesity categories had higher proportions of participants with CAC scores >0, hypertension, diabetes, lower HDL-C, lower vitamin D, higher triglycerides, higher hsCRP, lower mean step counts, higher mean PHQ-9 scores, and higher mean GAD-7 scores., Conclusion: We identified associations of cardiometabolic and mental health characteristics with BMI, thereby providing a deeper understanding of cardiovascular health across BMI., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: All authors acknowledge institutional research grants from Verily Life Sciences. NPS received research grants from Amgen, Janssen, and the National Institutes of Health (NIH) and served as a consultant/advisor for Esperion, Amgen, and Novartis. FH received an institutional research grant from Actelion Ltd. within the last 2 years and an institutional research grant from Precordior Ltd. KM reports grants from Verily, Afferent, the American Heart Association (AHA), Cardiva Medical Inc, Gilead, Luitpold, Medtronic, Merck, Eidos, Ferring, Apple Inc, Sanifit, and St. Jude; grants and personal fees from Amgen, AstraZeneca, Bayer, CSL Behring, Johnson & Johnson, Novartis, and Sanofi; and personal fees from Anthos, Applied Therapeutics, Elsevier, Inova, Intermountain Health, Medscape, Mount Sinai, Mundi Pharma, Myokardia, Novo Nordisk, Otsuka, Portola, SmartMedics, and Theravance outside the submitted work. The other authors have no conflicts of interest to disclose., (© 2024 The Author(s).)- Published
- 2024
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9. Accelerated Epigenetic Aging Is Associated With Multiple Cardiometabolic, Hematologic, and Renal Abnormalities: A Project Baseline Health Substudy.
- Author
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Uchehara B, Coulter Kwee L, Regan J, Chatterjee R, Eckstrand J, Swope S, Gold G, Schaack T, Douglas P, Mettu P, Haddad F, Shore S, Hernandez A, Mahaffey KW, Pagidipati N, and Shah SH
- Subjects
- Humans, Child, Preschool, DNA Methylation, Aging genetics, Epigenomics, Epigenesis, Genetic, Cardiovascular Diseases
- Abstract
Background: Epigenetic clocks estimate chronologic age using methylation levels at specific loci. We tested the hypothesis that accelerated epigenetic aging is associated with abnormal values in a range of clinical, imaging, and laboratory characteristics., Methods: The Project Baseline Health Study recruited 2502 participants, including 1661 with epigenetic age estimates from the Horvath pan-tissue clock. We classified individuals with extreme values as having epigenetic age acceleration (EAA) or epigenetic age deceleration. A subset of participants with longitudinal methylation profiling was categorized as accelerated versus nonaccelerated. Using principal components analysis, we created phenoclusters using 122 phenotypic variables and compared individuals with EAA versus epigenetic age deceleration, and at one year of follow-up, using logistic regression models adjusted for sex (false discovery rate [ Q ] <0.10); in secondary exploratory analyses, we tested individual clinical variables., Results: The EAA (n=188) and epigenetic age deceleration (n=195) groups were identified as having EAA estimates ≥5 years or ≤-5 years, respectively. In primary analyses, individuals with EAA had higher values for phenoclusters summarizing lung function and lipids, and lower values for a phenocluster representing physical function. In secondary analyses of individual variables, neutrophils, body mass index, and waist circumference were significantly higher in individuals with EAA ( Q <0.10). No phenoclusters were significantly different between participants with accelerated (n=148) versus nonaccelerated (n=112) longitudinal aging., Conclusions: We report multiple cardiometabolic, hematologic, and physical function features characterizing individuals with EAA. These highlight factors that may mediate the adverse effects of aging and identify potential targets for study of mitigation of these effects., Registration: URL: https://www., Clinicaltrials: gov; Unique identifier: NCT03154346., Competing Interests: Disclosures All authors acknowledge institutional research grants from Verily Life Sciences. Dr Haddad received an institutional research grant from Actelion Ltd within the last 2 years and an institutional research grant from Precordior Ltd. Dr Mahaffey reports grants from Verily, Afferent, the American Heart Association (AHA), Cardiva Medical Inc, Gilead, Luitpold, Medtronic, Merck, Eidos, Ferring, Apple Inc, Sanifit, and St. Jude; grants and personal fees from Amgen, AstraZeneca, Bayer, CSL Behring, Johnson & Johnson, Novartis, and Sanofi; and personal fees from Anthos, Applied Therapeutics, Elsevier, Inova, Intermountain Health, Medscape, Mount Sinai, Mundi Pharma, Myokardia, Novo Nordisk, Otsuka, Portola, SmartMedics, and Theravance outside the submitted work. Dr Hernandez reports grants from Verily; grants and personal fees from AstraZeneca, Amgen, Bayer, Merck, and Novartis; and personal fees from Boston Scientific outside the submitted work. The other authors report no conflicts.
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- 2023
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10. The Project Baseline Health Study: a step towards a broader mission to map human health.
- Author
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Arges K, Assimes T, Bajaj V, Balu S, Bashir MR, Beskow L, Blanco R, Califf R, Campbell P, Carin L, Christian V, Cousins S, Das M, Dockery M, Douglas PS, Dunham A, Eckstrand J, Fleischmann D, Ford E, Fraulo E, French J, Gambhir SS, Ginsburg GS, Green RC, Haddad F, Hernandez A, Hernandez J, Huang ES, Jaffe G, King D, Koweek LH, Langlotz C, Liao YJ, Mahaffey KW, Marcom K, Marks WJ Jr, Maron D, McCabe R, McCall S, McCue R, Mega J, Miller D, Muhlbaier LH, Munshi R, Newby LK, Pak-Harvey E, Patrick-Lake B, Pencina M, Peterson ED, Rodriguez F, Shore S, Shah S, Shipes S, Sledge G, Spielman S, Spitler R, Schaack T, Swamy G, Willemink MJ, and Wong CA
- Abstract
The Project Baseline Health Study (PBHS) was launched to map human health through a comprehensive understanding of both the health of an individual and how it relates to the broader population. The study will contribute to the creation of a biomedical information system that accounts for the highly complex interplay of biological, behavioral, environmental, and social systems. The PBHS is a prospective, multicenter, longitudinal cohort study that aims to enroll thousands of participants with diverse backgrounds who are representative of the entire health spectrum. Enrolled participants will be evaluated serially using clinical, molecular, imaging, sensor, self-reported, behavioral, psychological, environmental, and other health-related measurements. An initial deeply phenotyped cohort will inform the development of a large, expanded virtual cohort. The PBHS will contribute to precision health and medicine by integrating state of the art testing, longitudinal monitoring and participant engagement, and by contributing to the development of an improved platform for data sharing and analysis., Competing Interests: Competing interestsK.A. received research funding from Verily Inc. for work at Duke Clinical and Translational Science Institute. R.C. and J.H. are employed or have a leadership role at at Google Health. R.C. is also a Board member, Cytokinetics. M.D. receives research funding from Celgene, Abbvie, United Therapeutics, Varian, Genzyme, Novartis, Verily Inc., and consults or receives honoraria from Astra Zeneca, Bristol Myer Squibb. A.H. receives research funding from American Regent, AstraZeneca, Merck, Novartis, Verily Inc., and consults for Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Boston Scientific, Merck, Novartis, and Sanofi. C.L. has the following engagements Shareholder and Advisory Board, whiterabbit.ai; Shareholder, Nines.ai; Advisory Board, Nines.ai; Shareholder, GalileoCDS, Inc.; Advisory Board, GalileoCDS, Inc; Shareholder and Board of Directors Bunker Hill, Inc.; Research Grant, GE Healthcare; Departmental Research Grant, Koninklijke Philips NV; Departmental Research Grant, Siemens AG; School of Medicine Research Grant, Google, Inc.; Travel Grant, Canon Medical Systems Corp; Travel Grant, Siemens Healthineers. S.S.G. is a consultant or receives funding from several companies that work in the healthcare space although none of these companies are directly involved in the current work. K.W.M.’s financial disclosure can be viewed at http://med.stanford.edu/profiles/kenneth-mahaffey. W.J.M., J.M., D.M., and S.S. are employed, have a leadership role, or receive equity from Verily Inc. J.M. is also a Board Member, Danaher. L.K.N. received research grant support from Verily Inc., (© The Author(s) 2020.)
- Published
- 2020
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11. Specific removal of anti-A and anti-B antibodies by using modified dialysis filters.
- Author
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Hout MS, LeJeune KE, Schaack TM, Bristow DK, and Federspiel WJ
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- Dialysis instrumentation, Filtration instrumentation, Filtration methods, Humans, Immunosorbent Techniques, In Vitro Techniques, Kidney Transplantation immunology, Plasmapheresis, ABO Blood-Group System immunology, Dialysis methods, Isoantibodies blood, Isoantibodies isolation & purification
- Abstract
Removal of anti-A and anti-B blood group antibodies from human blood has been shown to facilitate cross-matched kidney transplantation by preventing hyperacute rejection. Patients in these studies had anti-A and anti-B antibodies removed by using plasmapheresis, followed by immunoadsorption onto packed bead columns. We conducted a study to assess the feasibility of selectively removing anti-A and anti-B antibodies directly from blood by using modified dialysis filters. An anti-A and anti-B specific antigen was covalently attached to the lumenal surfaces of hollow fibers within selected commercial dialysis modules. The filters were able to reduce the anti-A and anti-B titers of 300 ml of blood to 2 or below. A low molecular weight fraction of our antigen system was found to have no antibody binding capacity. The standard antigen was purified by removal of the low molecular weight fraction and a dialysis filter was modified by using the purified antigen. This filter displayed a six-fold higher capacity than a dialysis filter modified with the same mass of standard antigen. We conclude that selective blood group antibody removal by antigen modified dialysis filters is feasible and may be a simpler system than plasmapheresis followed by immunoadsorption.
- Published
- 2000
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12. Molecular mimicry in HLA-B27-related arthritis.
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Yu DT, Choo SY, and Schaack T
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- Alleles, Arthritis etiology, Bacteria immunology, Bacterial Infections complications, Cross Reactions, Disease Susceptibility immunology, HLA-B Antigens genetics, HLA-B Antigens immunology, HLA-B27 Antigen, Humans, Spondylitis, Ankylosing immunology, Arthritis immunology, HLA-B Antigens analysis
- Abstract
A unique feature of patients with ankylosing spondylitis and reactive arthritis is that almost all share the HLA type B27. The primary structures of the HLA-B27 antigens have been determined. At least six variants exist. However, disease predisposition does not appear to be restricted to a particular variant. One hypothesis about the pathogenesis of arthritis is that the bacteria that cause the arthritis carry components that are cross-reactive with HLA-B27 antigens. Several reactive bacterial components have indeed been identified using monoclonal anti-HLA-B27 antibodies. Even more striking is the identification, through a computerized search, of a Klebsiella protein. This protein carries a stretch of six amino acids identical to residues 72 to 77 of two of the HLA-B27 variants. A synthetic peptide carrying these six amino acids of HLA-B27 protein is reactive with serum antibodies in some patients with arthritis. With this knowledge, investigators will be able to formulate new approaches for examining the pathogenesis of HLA-B27-associated arthritis.
- Published
- 1989
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13. Chemotaxis under agarose: dependence upon polymorphonuclear leukocyte density.
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Schaack TM and Persellin RH
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- Cell Count, Cytological Techniques, Humans, Neutrophils drug effects, Chemotaxis, Leukocyte, Neutrophils cytology, Polysaccharides, Sepharose
- Abstract
Since the number of polymorphonuclear leukocytes (PMN) responding to a chemotactic stimulus in the Boyden chamber is influenced by the cell density, we studied whether this variable was important in determining chemotaxis under agarose. The chemotactic index was determined by summing the product of each cell that had migrated from the chemotactic well by its distance and correcting this sum for random migration. Cell density (number of PMN per mm2 surface area of the agarose plate well) influenced the number of cells responding to the chemotactic stimulus. Only when more than 1.8 x 10(2) PMN/mm2 were used was chemotaxis then detected. For cell densities greater than this number, there was a highly positive correlation between cell density and chemotactic index (P less than 0.001). These findings are consistent with previous reports and indicate that PMN density is a critical variable when using the agarose method. In addition, these studies provide further evidence for cellular cooperation in the initial phases of the chemotactic response.
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- 1981
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14. Alteration of polymorphonuclear leukocyte surface charge by endogenous and exogenous chemotactic factors.
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Schaack TM, Takeuchi A, Spilberg I, and Persellin RH
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- Endotoxins pharmacology, Escherichia coli, Humans, Chemotactic Factors pharmacology, Erythrocytes analysis, Granulocytes analysis, Membrane Potentials, Neutrophils metabolism
- Abstract
We investigated the effects of chemotaxins on the surface charge of isolated human PMN. Chemotaxis was ascertained using Boyden chambers. Surface charge was calculated using data derived from cell mobility as measured in a cytophorometer. The electrophoretic mobility of cells exposed to all chemotactic agents studied was altered. Endotoxin-activated serum containing C5a, PMN lysosomal extracts from "resting" and from crystal-stimulated cells, and Gly-His-Gly, a synthetic tripeptide, all significantly reduced the net negative surface charge of isolated neutrophils. Only chemotactically active substances effected this change; controls including heat-inactivated serum, other subcellular fractions, and an inert tripeptide, Gly-Gly-Gly, did not alter cell mobility in an electric field. These findings are consistent with studies by others on the effects of chemotactic factors on cation fluxes and cell aggregation and suggest a possible mechanism by which PMN directional migration is regulated.
- Published
- 1980
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15. A monoclonal anti-HLA-B27 antibody which is reactive with a linear sequence of the HLA-B27 protein is useful for the study of molecular mimicry.
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Yong Z, Zhang JJ, Schaack T, Chen S, Nakayama A, and Yu DT
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- Amino Acid Sequence, Animals, Blotting, Western, Cross Reactions immunology, Electrophoresis, Polyacrylamide Gel, Enzyme-Linked Immunosorbent Assay, Mice, Molecular Sequence Data, Peptide Fragments immunology, Peptide Mapping, Antibodies, Monoclonal immunology, Carbonic Anhydrases immunology, HLA-B27 Antigen immunology
- Abstract
In the search for cross-reactivity between bacteria and HLA-B27, three groups of investigators have identified several bacterial envelope proteins which are reactive with the monoclonal anti-HLA-B27 antibodies B27.M1 and B27.M2. Since these two antibodies react poorly with HLA-B27-derived synthetic peptides, it is not possible to locate the reactive epitopes on the HLA-B27 using synthetic peptides. Here, we introduce Ye-2, a monoclonal anti-HLA-B27 antibody which, unlike B27.M1 and B27.M2, is reactive with a synthetic peptide derived from residues 63-84 of HLA-B27.1. Analysis with a cross-reactive peptide derived from residues 226-244 of bovine carbonic anhydrase suggests that only a few of the amino acid residues in the HLA-B27-derived peptide are responsible for the reactivity. This antibody should be a useful adjunct in a preliminary assessment of whether a bacterial protein mimics HLA-B27 in primary structure.
- Published
- 1989
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