Search

Your search keyword '"Schüller, Vitalia"' showing total 17 results
Start Over Author "Schüller, Vitalia"

Refine your results

more »

more »

more »

more »
17 results on '"Schüller, Vitalia"'

1. Dissecting the genetic heterogeneity of gastric cancer

Author

Hess, Timo, Maj, Carlo, Gehlen, Jan, Borisov, Oleg, Haas, Stephan L., Gockel, Ines, Vieth, Michael, Piessen, Guillaume, Alakus, Hakan, Vashist, Yogesh, Pereira, Carina, Knapp, Michael, Schüller, Vitalia, Quaas, Alexander, Grabsch, Heike I., Trautmann, Jessica, Malecka-Wojciesko, Ewa, Mokrowiecka, Anna, Speller, Jan, Mayr, Andreas, Schröder, Julia, Hillmer, Axel M., Heider, Dominik, Lordick, Florian, Pérez-Aísa, Ángeles, Campo, Rafael, Espinel, Jesús, Geijo, Fernando, Thomson, Concha, Bujanda, Luis, Sopeña, Federico, Lanas, Ángel, Pellisé, María, Pauligk, Claudia, Goetze, Thorsten Oliver, Zelck, Carolin, Reingruber, Julian, Hassanin, Emadeldin, Elbe, Peter, Alsabeah, Sandra, Lindblad, Mats, Nilsson, Magnus, Kreuser, Nicole, Thieme, René, Tavano, Francesca, Pastorino, Roberta, Arzani, Dario, Persiani, Roberto, Jung, Jin-On, Nienhüser, Henrik, Ott, Katja, Schumann, Ralf R., Kumpf, Oliver, Burock, Susen, Arndt, Volker, Jakubowska, Anna, Ławniczak, Małgorzta, Moreno, Victor, Martín, Vicente, Kogevinas, Manolis, Pollán, Marina, Dąbrowska, Justyna, Salas, Antonio, Cussenot, Olivier, Boland-Auge, Anne, Daian, Delphine, Deleuze, Jean-Francois, Salvi, Erika, Teder-Laving, Maris, Tomasello, Gianluca, Ratti, Margherita, Senti, Chiara, De Re, Valli, Steffan, Agostino, Hölscher, Arnulf H., Messerle, Katharina, Bruns, Christiane Josephine, Sīviņš, Armands, Bogdanova, Inga, Skieceviciene, Jurgita, Arstikyte, Justina, Moehler, Markus, Lang, Hauke, Grimminger, Peter P., Kruschewski, Martin, Vassos, Nikolaos, Schildberg, Claus, Lingohr, Philipp, Ridwelski, Karsten, Lippert, Hans, Fricker, Nadine, Krawitz, Peter, Hoffmann, Per, Nöthen, Markus M., Veits, Lothar, Izbicki, Jakob R., Mostowska, Adrianna, Martinón-Torres, Federico, Cusi, Daniele, Adolfsson, Rolf, Cancel-Tassin, Geraldine, Höblinger, Aksana, Rodermann, Ernst, Ludwig, Monika, Keller, Gisela, Metspalu, Andres, Brenner, Hermann, Heller, Joerg, Neef, Markus, Schepke, Michael, Dumoulin, Franz Ludwig, Hamann, Lutz, Cannizzaro, Renato, Ghidini, Michele, Plaßmann, Dominik, Geppert, Michael, Malfertheiner, Peter, Gehlen, Olivier, Skoczylas, Tomasz, Majewski, Marek, Lubiński, Jan, Palmieri, Orazio, Boccia, Stefania, Latiano, Anna, Aragones, Nuria, Schmidt, Thomas, Dinis-Ribeiro, Mário, Medeiros, Rui, Al-Batran, Salah-Eddin, Leja, Mārcis, Kupcinskas, Juozas, García-González, María A., Venerito, Marino, and Schumacher, Johannes

Published
2023
Full Text
View/download PDF

4. Corrigendum to “Dissecting the genetic heterogeneity of gastric cancer”

Author

Hess, Timo, primary, Maj, Carlo, additional, Gehlen, Jan, additional, Borisov, Oleg, additional, Haas, Stephan L., additional, Gockel, Ines, additional, Vieth, Michael, additional, Piessen, Guillaume, additional, Alakus, Hakan, additional, Vashist, Yogesh, additional, Pereira, Carina, additional, Knapp, Michael, additional, Schüller, Vitalia, additional, Quaas, Alexander, additional, Grabsch, Heike I., additional, Trautmann, Jessica, additional, Malecka-Wojciesko, Ewa, additional, Mokrowiecka, Anna, additional, Speller, Jan, additional, Mayr, Andreas, additional, Schröder, Julia, additional, Hillmer, Axel M., additional, Heider, Dominik, additional, Lordick, Florian, additional, Pérez-Aísa, Ángeles, additional, Campo, Rafael, additional, Espinel, Jesús, additional, Geijo, Fernando, additional, Thomson, Concha, additional, Bujanda, Luis, additional, Sopeña, Federico, additional, Lanas, Ángel, additional, Pellisé, María, additional, Pauligk, Claudia, additional, Goetze, Thorsten Oliver, additional, Zelck, Carolin, additional, Reingruber, Julian, additional, Hassanin, Emadeldin, additional, Elbe, Peter, additional, Alsabeah, Sandra, additional, Lindblad, Mats, additional, Nilsson, Magnus, additional, Kreuser, Nicole, additional, Thieme, René, additional, Tavano, Francesca, additional, Pastorino, Roberta, additional, Arzani, Dario, additional, Persiani, Roberto, additional, Jung, Jin-On, additional, Nienhüser, Henrik, additional, Ott, Katja, additional, Schumann, Ralf R., additional, Kumpf, Oliver, additional, Burock, Susen, additional, Arndt, Volker, additional, Jakubowska, Anna, additional, Ławniczak, Małgorzta, additional, Moreno, Victor, additional, Martín, Vicente, additional, Kogevinas, Manolis, additional, Pollán, Marina, additional, Dąbrowska, Justyna, additional, Salas, Antonio, additional, Cussenot, Olivier, additional, Boland-Auge, Anne, additional, Daian, Delphine, additional, Deleuze, Jean-Francois, additional, Salvi, Erika, additional, Teder-Laving, Maris, additional, Tomasello, Gianluca, additional, Ratti, Margherita, additional, Senti, Chiara, additional, De Re, Valli, additional, Steffan, Agostino, additional, Hölscher, Arnulf H., additional, Messerle, Katharina, additional, Bruns, Christiane Josephine, additional, Sīviņš, Armands, additional, Bogdanova, Inga, additional, Skieceviciene, Jurgita, additional, Arstikyte, Justina, additional, Moehler, Markus, additional, Lang, Hauke, additional, Grimminger, Peter P., additional, Kruschewski, Martin, additional, Vassos, Nikolaos, additional, Schildberg, Claus, additional, Lingohr, Philipp, additional, Ridwelski, Karsten, additional, Lippert, Hans, additional, Fricker, Nadine, additional, Krawitz, Peter, additional, Hoffmann, Per, additional, Nöthen, Markus M., additional, Veits, Lothar, additional, Izbicki, Jakob R., additional, Mostowska, Adrianna, additional, Martinón-Torres, Federico, additional, Cusi, Daniele, additional, Adolfsson, Rolf, additional, Cancel-Tassin, Geraldine, additional, Höblinger, Aksana, additional, Rodermann, Ernst, additional, Ludwig, Monika, additional, Keller, Gisela, additional, Metspalu, Andres, additional, Brenner, Hermann, additional, Heller, Joerg, additional, Neef, Markus, additional, Schepke, Michael, additional, Dumoulin, Franz Ludwig, additional, Hamann, Lutz, additional, Cannizzaro, Renato, additional, Ghidini, Michele, additional, Plaßmann, Dominik, additional, Geppert, Michael, additional, Malfertheiner, Peter, additional, Glehen, Olivier, additional, Skoczylas, Tomasz, additional, Majewski, Marek, additional, Lubiński, Jan, additional, Palmieri, Orazio, additional, Boccia, Stefania, additional, Latiano, Anna, additional, Aragones, Nuria, additional, Schmidt, Thomas, additional, Dinis-Ribeiro, Mário, additional, Medeiros, Rui, additional, Al-Batran, Salah-Eddin, additional, Leja, Mārcis, additional, Kupcinskas, Juozas, additional, García-González, María A., additional, Venerito, Marino, additional, and Schumacher, Johannes, additional

Published
2023
Full Text
View/download PDF

5. Pathogen-specific innate immune response patterns are distinctly affected by genetic diversity

Author

Häder, Antje, primary, Schäuble, Sascha, additional, Gehlen, Jan, additional, Thielemann, Nadja, additional, Buerfent, Benedikt C., additional, Schüller, Vitalia, additional, Hess, Timo, additional, Wolf, Thomas, additional, Schröder, Julia, additional, Weber, Michael, additional, Hünniger, Kerstin, additional, Löffler, Jürgen, additional, Vylkova, Slavena, additional, Panagiotou, Gianni, additional, Schumacher, Johannes, additional, and Kurzai, Oliver, additional

Published
2023
Full Text
View/download PDF

8. Identification of loci of functional relevance to Barrett’s esophagus and esophageal adenocarcinoma: Cross-referencing of expression quantitative trait loci data from disease-relevant tissues with genetic association data

Author

Schröder, Julia, primary, Schüller, Vitalia, additional, May, Andrea, additional, Gerges, Christian, additional, Anders, Mario, additional, Becker, Jessica, additional, Hess, Timo, additional, Kreuser, Nicole, additional, Thieme, René, additional, Ludwig, Kerstin U., additional, Noder, Tania, additional, Venerito, Marino, additional, Veits, Lothar, additional, Schmidt, Thomas, additional, Fuchs, Claudia, additional, Izbicki, Jakob R., additional, Hölscher, Arnulf H., additional, Dakkak, Dani, additional, Jansen-Winkeln, Boris, additional, Moulla, Yusef, additional, Lyros, Orestis, additional, Niebisch, Stefan, additional, Mehdorn, Matthias, additional, Lang, Hauke, additional, Lorenz, Dietmar, additional, Schumacher, Brigitte, additional, Mayershofer, Rupert, additional, Vashist, Yogesh, additional, Ott, Katja, additional, Vieth, Michael, additional, Weismüller, Josef, additional, Mangold, Elisabeth, additional, Nöthen, Markus M., additional, Moebus, Susanne, additional, Knapp, Michael, additional, Neuhaus, Horst, additional, Rösch, Thomas, additional, Ell, Christian, additional, Gockel, Ines, additional, Schumacher, Johannes, additional, and Böhmer, Anne C., additional

Published
2019
Full Text
View/download PDF

9. First genotype‐phenotype study reveals HLA‐DQβ1 insertion heterogeneity in high‐resolution manometry achalasia subtypes

Author

Vackova, Zuzana, primary, Niebisch, Stefan, additional, Triantafyllou, Tania, additional, Becker, Jessica, additional, Hess, Timo, additional, Kreuser, Nicole, additional, Kanoni, Stavroula, additional, Deloukas, Panos, additional, Schüller, Vitalia, additional, Heinrichs, Sophie KM, additional, Thieme, René, additional, Nöthen, Markus M, additional, Knapp, Michael, additional, Spicak, Julius, additional, Gockel, Ines, additional, Schumacher, Johannes, additional, Theodorou, Dimitris, additional, and Martinek, Jan, additional

Published
2019
Full Text
View/download PDF

10. Evidence for PTGER4 ,PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level

Author

Heinrichs, Sophie K. M., primary, Hess, Timo, additional, Becker, Jessica, additional, Hamann, Lutz, additional, Vashist, Yogesh K., additional, Butterbach, Katja, additional, Schmidt, Thomas, additional, Alakus, Hakan, additional, Krasniuk, Iurii, additional, Höblinger, Aksana, additional, Lingohr, Philipp, additional, Ludwig, Monika, additional, Hagel, Alexander F., additional, Schildberg, Claus W., additional, Veits, Lothar, additional, Gyvyte, Ugne, additional, Weise, Katharina, additional, Schüller, Vitalia, additional, Böhmer, Anne C., additional, Schröder, Julia, additional, Gehlen, Jan, additional, Kreuser, Nicole, additional, Hofer, Sebastian, additional, Lang, Hauke, additional, Lordick, Florian, additional, Malfertheiner, Peter, additional, Moehler, Markus, additional, Pech, Oliver, additional, Vassos, Nikolaos, additional, Rodermann, Ernst, additional, Izbicki, Jakob R., additional, Kruschewski, Martin, additional, Ott, Katja, additional, Schumann, Ralf R., additional, Vieth, Michael, additional, Mangold, Elisabeth, additional, Gasenko, Evita, additional, Kupcinskas, Limas, additional, Brenner, Hermann, additional, Grimminger, Peter, additional, Bujanda, Luis, additional, Sopeña, Federico, additional, Espinel, Jesús, additional, Thomson, Concha, additional, Pérez-Aísa, Ángeles, additional, Campo, Rafael, additional, Geijo, Fernando, additional, Collette, Daniela, additional, Bruns, Christiane, additional, Messerle, Katharina, additional, Gockel, Ines, additional, Nöthen, Markus M., additional, Lippert, Hans, additional, Ridwelski, Karsten, additional, Lanas, Angel, additional, Keller, Gisela, additional, Knapp, Michael, additional, Leja, Marcis, additional, Kupcinskas, Juozas, additional, García-González, Maria A., additional, Venerito, Marino, additional, and Schumacher, Johannes, additional

Published
2018
Full Text
View/download PDF

11. First Genotype-Phenotype Study in Achalasia Implies that the HLA-DQB1-Insertion Affects Different High-Resolution Manometry (HRM) Manifestation of the Disease

Author

Vackova, Zuzana, primary, Niebisch, Stefan, additional, Triantafilou, Tania, additional, Becker, Jessica, additional, Kosiol, Nils, additional, Kreuser, Nicole, additional, Schüller, Vitalia, additional, Heinrichs, Sophie, additional, Hess, Timo, additional, Nöthen, Markus, additional, Knapp, Michael, additional, Spicak, Julius, additional, Gockel, Ines, additional, Schumacher, Johannes, additional, Theodorou, Dimitris, additional, and Martinek, Jan, additional

Published
2017
Full Text
View/download PDF

12. Rare Variant Collapsing Test with Variable Binning

Author

Drichel, Dmitriy, Lacour, Andre, Herold, Christine, Schüller, Vitalia, Vaitsiakhovich, Tatsiana, and Becker, Tim

Abstract

Methodology of rare variant analysis underwent a rapid devel-opment since the application of collapsing tests to predefined bins was proposed (Li and Leal, 2008). The basic collapsing test is the 1 d.f. χ² test dichotomizing carriers and non-carriers of rare variants. An individual is considered a carrier if at least one minor allele is present in the analysis unit (bin).Although a multitude of statistical tests exist by now, the major-ity relies on a twofold parameterization of the dataset: the choice of the threshold minor allele frequency (MAFT) to define ‘rare’ and ‘common’ variants, and the definition of analysis bins (‘bin-ning’). The choice of parameters is an educated guess at best and implies a certain Type II error rate due to uncertain signal-no-noise ratio in predefined analysis units.The Variable-Threshold (VT) method (Price et al., 2010) elim-inates the choice of a specific MAFT by analyzing the space of all possible thresholds in each bin, finding the optimal MAFT and using permutations for multiple testing correction. The COLL VT method is computationally feasible even for large genome-wide datasets with ~20,000–100,000 bins (Drichel et al., 2014).We investigated the possibility of elimination of a priori bin-ning in an analogous fashion. In this scenario, all possible contigu-ous bins, i.e. bins with all possible combinations of start and end positions are tested for association. Although the number of com-binations is very large (n(n+1)/2 per chromosome with n rare vari-ants), in the case of COLL, the number of bins with distinct sets of carriers is much smaller due to the characteristic ‘individual-wise’ collapsing condition.We applied the Variable-Binning method (VB) implemented in INTERSNP-RARE to an imputed case-control dataset contain-ing 9832 controls and 3332 late-onset Alzheimer’s disease (AD) cases, with 2,279,783 rare variants (MAF

Published
2015

13. A38 Extension of the One-Degree-of-Freedom Test for Supra-Multiplicativity of SNP Effects in Logistic Regression Models

Author

Schüller, Vitalia, Drichel, Dmitriy, Lacour, Andre, Vaitsiakhovich, Tatsiana, Becker, Tim, and Herold, Christine

Subjects
ddc:610
Abstract

A possible reason for the phenomenon of missing heritability encountered in the genetics of complex diseases is the omission of interaction effects in genome-wide association studies (GWAS). Even pairwise SNP-SNP-interaction may be a too simple assump-tion in the presence of polygenic influences. In order to address multi marker models, we recently devel-oped the test for supra-multiplicativity (SMT) that is applicable to SNP sets of up to 1,000. The SMT requires only one degree of free-dom and is designed to detect amplifying interaction as implied by liability threshold models. In general, the SMT allows deviation from multiplicativity. A drawback of the original approach is the need to use a Bonferroni-correction to adjustment for multiple testing.Here, we present an extended SMT (ESMT), an improved ver-sion of the original SMT. By implementation of a generalized re-gression equation, the ESMT avoids multiple testing and provides more sophisticated modeling of amplifying interaction. In a simu-lation study, we show that the ESMT uniformly has higher power than its predecessor. In addition, computing time is improved sub-stantially. The ESMT is implemented in the interaction analysis tool INTERSNP.

Published
2015

14. 241 Association of the HLA-DQB1-insertion in Idiopathic Achalasia and First Genotype-Phenotype (GxP) Study Using High-Resolution Manometry Data

Author

Vackova, Zuzana, primary, Niebisch, Stefan, additional, Becker, Jessica, additional, Kosiol, Nils, additional, Kreuser, Nicole, additional, Schüller, Vitalia, additional, Heinrichs, Sophie, additional, Hess, Timo, additional, Nöthen, Markus M., additional, Gockel, Ines, additional, Spicak, Julius, additional, Schumacher, Johannes, additional, and Martinek, Jan, additional

Published
2016
Full Text
View/download PDF

15. Evidence for PTGER4,PSCA, and MBOAT7 as risk genes for gastric cancer on the genome and transcriptome level.

Author

Heinrichs, Sophie K. M., Hess, Timo, Becker, Jessica, Hamann, Lutz, Vashist, Yogesh K., Butterbach, Katja, Schmidt, Thomas, Alakus, Hakan, Krasniuk, Iurii, Höblinger, Aksana, Lingohr, Philipp, Ludwig, Monika, Hagel, Alexander F., Schildberg, Claus W., Veits, Lothar, Gyvyte, Ugne, Weise, Katharina, Schüller, Vitalia, Böhmer, Anne C., and Schröder, Julia

Subjects
STOMACH cancer risk factors, TRANSCRIPTOMES, GENE expression, GENE mapping, DOWNREGULATION
Abstract

Genetic associations between variants on chromosome 5p13 and 8q24 and gastric cancer (GC) have been previously reported in the Asian population. We aimed to replicate these findings and to characterize the associations at the genome and transcriptome level. We performed a fine‐mapping association study in 1926 GC patients and 2012 controls of European descent using high dense SNP marker sets on both chromosomal regions. Next, we performed expression quantitative trait locus (eQTL) analyses using gastric transcriptome data from 143 individuals focusing on the GC associated variants. On chromosome 5p13 the strongest association was observed at rs6872282 (P = 2.53 × 10−04) and on chromosome 8q24 at rs2585176 (P = 1.09 × 10−09). On chromosome 5p13 we found cis‐eQTL effects with an upregulation of PTGER4 expression in GC risk allele carrier (P = 9.27 × 10−11). On chromosome 8q24 we observed cis‐eQTL effects with an upregulation of PSCA expression in GC risk allele carrier (P = 2.17 × 10−47). In addition, we found trans‐eQTL effects for the same variants on 8q24 with a downregulation of MBOAT7 expression in GC risk allele carrier (P = 3.11 × 10−09). In summary, we confirmed and refined the previously reported GC associations at both chromosomal regions. Our data point to shared etiological factors between Asians and Europeans. Furthermore, our data imply an upregulated expression of PTGER4 and PSCA as well as a downregulated expression of MBOAT7 in gastric tissue as risk‐conferring GC pathomechanisms. Genetic variants at chromosome 5p13 and 8q24 contribute to gastric cancer (GC) risk. Expression quantitative trait loci (eQTLs) involving PTGER4 (5p13), PSCA (8q24), and MBOAT7 may act as underlying pathomechanisms. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results