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5. Ganzkörper‐Blaulichtbestrahlung zur Behandlung der atopischen Dermatitis: eine randomisierte, placebokontrollierte klinische Studie (AD‐Blue)

Author

Buhl, Timo, primary, Santibanez Santana, Marisol, additional, Forkel, Susann, additional, Kromer, Christian, additional, Seidel, Julia, additional, Möbs, Christian, additional, Pfützner, Wolfgang, additional, Pfeiffer, Sebastian, additional, Laubach, Hans‐Joachim, additional, Boehncke, Wolf‐Henning, additional, Liebmann, Joerg, additional, Born, Matthias, additional, and Schön, Michael Peter, additional

Published
2023
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6. Full‐body blue light irradiation as treatment for atopic dermatitis: a randomized sham‐controlled clinical trial (AD‐Blue).

Author

Buhl, Timo, Santibanez Santana, Marisol, Forkel, Susann, Kromer, Christian, Seidel, Julia, Möbs, Christian, Pfützner, Wolfgang, Pfeiffer, Sebastian, Laubach, Hans‐Joachim, Boehncke, Wolf‐Henning, Liebmann, Joerg, Born, Matthias, and Schön, Michael Peter

Abstract

Summary: Background: Visible blue light (wavelength 400–495 nm) is a promising new treatment option for both psoriasis and atopic dermatitis (AD). Whilst previous clinical trials featured various devices and blue light at a variety of wavelengths, none of these interventions were challenged in objective clinical criteria. Patients and Methods: Eighty‐seven patients diagnosed with AD were enrolled in AD‐Blue, an international, prospective, double‐blinded, three‐armed (415 nm vs. 450 nm vs. sham control), randomized trial designed to investigate the safety and efficacy of prototype full‐body blue light devices. Results: Full‐body irradiation with 450 nm blue light but not 415 nm had a significant impact on itch (Itch‐VAS, –1.6 ± 2.3; p = 0.023 vs. sham irradiation). PO‐SCORAD values also decreased significantly in response to irradiation at 415 nm (–11.5 ± 18.4; p = 0.028 vs. sham irradiation). None of the other outcome measures (EASI, SCORAD, IGA, DLQI) changed significantly. No safety signals were observed. Evaluation of skin transcriptomes, cytokine levels in serum, and ELISpots from peripheral blood mononuclear cells isolated from a subset of patients revealed moderate decreases in IL‐31 in response to irradiation with blue light. Conclusions: Despite its favorable safety profile and moderate reductions in itch and IL‐31 levels, full‐body blue light irradiation did not lead to an amelioration of any of the objective measures of AD. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Neue Erkenntnisse zu Fumarsäureestern (Fumaderm®): Ergebnisse des 2. Experten-Workshops

Author

Mrowietz, Ulrich, Altmeyer, Peter, Augustin, Matthias, Boehncke, Wolf-Henning, Bonnekoh, Bernd, Frambach, Yvonne, Gambichler, Thilo, Ghoreschi, Kamran, Hertl, Michael, Hund, Anna-Carina, Jacobi, Arnd, Kuhn, Annegret, Ludwig, Ralf J, Luger, Thomas, Martin, Stefan F, Merk, Hans, Norgauer, Johannes, Reich, Kristian, Rostami-Yazdi, Martin, Sabat1, Robert, Schäkel, Knut, Scharffetter-Kochanek1, Karin, Schön, Michael Peter, Scola, Nina, Sticherling1, Michael, Thaci, Diamant, Wilsmann-Theis, Dagmar, Viehweg, Antje, Wozel, Gottfried, Zouboulis, Christos C., and Neureither, Marcus

Published
2012
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21. Nodal Basin Recurrence After Sentinel Lymph Node Biopsy for Melanoma

Author

Kretschmer, Lutz, Bertsch, Hans Peter, Zapf, Antonia, Mitteldorf, Christina, Satzger, Imke, Thoms, Kai-Martin, Völker, Bernward, Schön, Michael Peter, Gutzmer, Ralf, and Starz, Hans

Subjects
Adult, Male, Sentinel Lymph Node Biopsy, Observational Study, Kaplan-Meier Estimate, Middle Aged, Prognosis, Risk Assessment, Germany, Lymphatic Metastasis, Humans, Lymph Node Excision, Female, Lymph Nodes, Neoplasm Recurrence, Local, Melanoma, Research Article, Aged, Neoplasm Staging, Retrospective Studies
Abstract

The objective of this study was to analyze different types of nodal basin recurrence after sentinel lymph node biopsy (SLNB) for melanoma. Patients and Methods: Kaplan–Meier estimates and the Cox proportional hazards model were used to study 2653 patients from 3 German melanoma centers retrospectively. The estimated 5-year negative predictive value of SLNB was 96.4%. The estimated false-negative (FN) rates after 1, 2, 3, 5, and 10 years were 2.5%, 4.6%, 6.4%, 8.7%, and 12.6%, respectively. Independent factors associated with false negativity were older age, fewer SLNs excised, and head or neck location of the primary tumor. Compared with SLN-positive patients, the FNs had a significantly lower survival. In SLN-positive patients undergoing completion lymphadenectomy (CLND), the 5-year nodal basin recurrence rate was 18.3%. The recurrence rates for axilla, groin, and neck were 17.2%, 15.5%, and 44.1%, respectively. Significant factors predicting local relapse after CLND were older age, head, or neck location of the primary tumor, ulceration, deeper penetration of the metastasis into the SLN, tumor-positive CLND, and >2 lymph node metastases. All kinds of nodal relapse were associated with a higher prevalence of in-transit metastases. The FN rate after SLNB steadily increases over the observation period and should, therefore, be estimated by the Kaplan–Meier method. False-negativity is associated with fewer SLNs excised. The beneficial effect of CLND on nodal basin disease control varies considerably across different risk groups. This should be kept in mind about SLN-positive patients when individual decisions on prophylactic CLND are taken.

Published
2015

25. Solitary Cutaneous Nodule of Blastic Plasmacytoid Dendritic Cell Neoplasm Progressing to Overt Leukemia Cutis After Chemotherapy: Immunohistology and FISH Analysis Confirmed the Diagnosis

Author

Kaune, Kjell Matthias, primary, Baumgart, Mario, additional, Bertsch, Hans Peter, additional, Mitteldorf, Christina, additional, Müller-Hermelink, Hans Konrad, additional, Haase, Detlef, additional, Ghadimi, B Michael, additional, Schön, Michael Peter, additional, and Neumann, Christine, additional

Published
2009
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31. Hautkrebs

Author

Frick, Stephanie, Skudlik, Christoph, editor, Schön, Michael Peter, editor, and John, Swen Malte, editor

Published
2023
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35. Fußekzem

Author

Brans, Richard, Voß, Heike, Hübner, Anja, Skudlik, Christoph, editor, Schön, Michael Peter, editor, and John, Swen Malte, editor

Published
2023
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38. Schutzhandschuhe

Author

Wilke, Annika, Sonsmann, Flora K., Skudlik, Christoph, editor, Schön, Michael Peter, editor, and John, Swen Malte, editor

Published
2023
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41. Hautarztverfahren

Author

Skudlik, Christoph, Skudlik, Christoph, editor, Schön, Michael Peter, editor, and John, Swen Malte, editor

Published
2023
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44. Berufliches Schuhwerk

Author

Hübner, Anja, Brans, Richard, Skudlik, Christoph, editor, Schön, Michael Peter, editor, and John, Swen Malte, editor

Published
2023
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48. Histologische Diagnostik

Author

Möckel, Sigrid M. C., Lippert, Undine, Schön, Michael P., Skudlik, Christoph, editor, Schön, Michael Peter, editor, and John, Swen Malte, editor

Published
2023
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