33 results on '"Scarcella, Alda"'
Search Results
2. Fetoneonatal alloimmune thrombocytopenia (FNAIT): Our experience
- Author
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Fratellanza, Giorgio, Fratellanza, Annagrazia, Paesano, Luigi, Scarcella, Alda, Safoian, Alexander, Misso, Saverio, Formisano, Salvatore, and Scarpato, Nicola
- Published
- 2006
- Full Text
- View/download PDF
3. Gestational Maturation of Electrical Activity of the Stomach
- Author
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Cucchiara, Salvatore, Salvia, Gennaro, Scarcella, Alda, Rapagiolo, Stefania, Borrelli, Osvaldo, Boccia, Gabriella, Riezzo, Giuseppe, and Ciccimarra, Filippo
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- 1999
- Full Text
- View/download PDF
4. Molecular epidemiology of extended-spectrum β-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit
- Author
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Bagattini, Maria, Crivaro, Valeria, Di Popolo, Anna, Gentile, Fabrizio, Scarcella, Alda, Triassi, Maria, Villari, Paolo, and Zarrilli, Raffaele
- Published
- 2006
5. Pseudomonas aeruginosa in a neonatal intensive care unit: molecular epidemiology and infection control measures
- Author
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Triassi Maria, Scarcella Alda, Borriello Tonia, Di Resta Mario, Lambiase Antonietta, Caprio Alessandro, Di Popolo Anna, Crivaro Valeria, and Zarrilli Raffaele
- Subjects
Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Pseudomonas aeruginosa, a non-fermentative, gram-negative rod, is responsible for a wide variety of clinical syndromes in NICU patients, including sepsis, pneumonia, meningitis, diarrhea, conjunctivitis and skin infections. An increased number of infections and colonisations by P. aeruginosa has been observed in the neonatal intensive care unit (NICU) of our university hospital between 2005 and 2007. Methods Hand disinfection compliance before and after an educational programme on hand hygiene was evaluated. Identification of microrganisms was performed using conventional methods. Antibiotic susceptibility was evaluated by MIC microdilution. Genotyping was performed by PFGE analysis. Results The molecular epidemiology of Pseudomonas aeruginosa in the NICU of the Federico II University hospital (Naples, Italy) and the infection control measures adopted to stop the spreading of P. aeruginosa in the ward were described. From July 2005 to June 2007, P. aeruginosa was isolated from 135 neonates and caused severe infections in 11 of them. Macrorestriction analysis of clinical isolates from 90 neonates identified 20 distinct genotypes, one major PFGE type (A) being isolated from 48 patients and responsible for 4 infections in 4 of them, four other distinct recurrent genotypes being isolated in 6 to 4 patients. Seven environmental strains were isolated from the hand of a nurse and from three sinks on two occasions, two of these showing PFGE profiles A and G identical to two clinical isolates responsible for infection. The successful control of the outbreak was achieved through implementation of active surveillance of healthcare-associated infections in the ward together with environmental microbiological sampling and an intense educational programme on hand disinfection among the staff members. Conclusion P. aeruginosa infections in the NICU were caused by the cross-transmission of an epidemic clone in 4 neonates, and by the selection of sporadic clones in 7 others. An infection control programme that included active surveillance and strict adherence to hand disinfection policies was effective in controlling NICU-acquired infections and colonisations caused by P. aeruginosa.
- Published
- 2009
- Full Text
- View/download PDF
6. Renal tubular dysgenesis without pulmonary hypoplasia
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SCARCELLA, ALDA, PECORARO C, D'AGNELLO MR, SOLE AN, Scarcella, Alda, Pecoraro, C, D'Agnello, Mr, and Sole, An
- Published
- 1994
7. Collodion baby associated with congenital auricular anomalies: Postpartum splinting of a rare congenital auricular deformity
- Author
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Schonauer, Fabrizio, primary, Scarcella, Alda, additional, Mataro, Ilaria, additional, Umbaldo, Angela, additional, and Molea, Guido, additional
- Published
- 2010
- Full Text
- View/download PDF
8. Pseudomonas aeruginosain a neonatal intensive care unit: molecular epidemiology and infection control measures
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Crivaro, Valeria, primary, Di Popolo, Anna, additional, Caprio, Alessandro, additional, Lambiase, Antonietta, additional, Di Resta, Mario, additional, Borriello, Tonia, additional, Scarcella, Alda, additional, Triassi, Maria, additional, and Zarrilli, Raffaele, additional
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- 2009
- Full Text
- View/download PDF
9. Molecular Epidemiology of an Outbreak ofSerratia marcescensin a Neonatal Intensive Care Unit
- Author
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Villari, Paolo, primary, Crispino, Margherita, additional, Salvadori, Alessandra, additional, and Scarcella, Alda, additional
- Published
- 2001
- Full Text
- View/download PDF
10. Liposomal amphotericin B treatment for neonatal fungal infections
- Author
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SCARCELLA, ALDA, primary, PASQUARIELLO, MARIA B., additional, GIUGLIANO, BRUNELLA, additional, VENDEMMIA, MARIA, additional, and DE LUCIA, AMALIA, additional
- Published
- 1998
- Full Text
- View/download PDF
11. Neonatal sporadic hyperekplexia: a rare and often unrecognized entity
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Scarcella, Alda, primary and Coppola, Giangennaro, additional
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- 1997
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12. Pseudomonas aeruginosa in a neonatal intensive care unit: molecular epidemiology and infection control measures.
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Crivaro, Valeria, Di Popolo, Anna, Caprio, Alessandro, Lambiase, Antonietta, Di Resta, Mario, Borriello, Tonia, Scarcella, Alda, Triassi, Maria, and Zarrilli, Raffaele
- Subjects
PSEUDOMONAS aeruginosa ,EPIDEMIOLOGY ,CRITICAL care medicine ,NEONATAL intensive care ,INFANT health services ,HOSPITAL care of newborn infants - Abstract
Background: Pseudomonas aeruginosa, a non-fermentative, gram-negative rod, is responsible for a wide variety of clinical syndromes in NICU patients, including sepsis, pneumonia, meningitis, diarrhea, conjunctivitis and skin infections. An increased number of infections and colonisations by P. aeruginosa has been observed in the neonatal intensive care unit (NICU) of our university hospital between 2005 and 2007. Methods: Hand disinfection compliance before and after an educational programme on hand hygiene was evaluated. Identification of microrganisms was performed using conventional methods. Antibiotic susceptibility was evaluated by MIC microdilution. Genotyping was performed by PFGE analysis. Results: The molecular epidemiology of Pseudomonas aeruginosa in the NICU of the Federico II University hospital (Naples, Italy) and the infection control measures adopted to stop the spreading of P. aeruginosa in the ward were described. From July 2005 to June 2007, P. aeruginosa was isolated from 135 neonates and caused severe infections in 11 of them. Macrorestriction analysis of clinical isolates from 90 neonates identified 20 distinct genotypes, one major PFGE type (A) being isolated from 48 patients and responsible for 4 infections in 4 of them, four other distinct recurrent genotypes being isolated in 6 to 4 patients. Seven environmental strains were isolated from the hand of a nurse and from three sinks on two occasions, two of these showing PFGE profiles A and G identical to two clinical isolates responsible for infection. The successful control of the outbreak was achieved through implementation of active surveillance of healthcare-associated infections in the ward together with environmental microbiological sampling and an intense educational programme on hand disinfection among the staff members. Conclusion: P. aeruginosa infections in the NICU were caused by the cross-transmission of an epidemic clone in 4 neonates, and by the selection of sporadic clones in 7 others. An infection control programme that included active surveillance and strict adherence to hand disinfection policies was effective in controlling NICU-acquired infections and colonisations caused by P. aeruginosa. [ABSTRACT FROM AUTHOR]
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- 2009
- Full Text
- View/download PDF
13. Passage of Gliadin into Human Breast Milk.
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TRONCONE, RICCARDO, SCARCELLA, ALDA, DONATIELLO, ANNA, CANNATARO, IERO, TARABUSO, ANNA, and AURICCHIO, SALVATORE
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- 1987
- Full Text
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14. Molecular Epidemiology of an Outbreak of Serratia marcescensin a Neonatal Intensive Care Unit
- Author
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Villari, Paolo, Crispino, Margherita, Salvadori, Alessandra, and Scarcella, Alda
- Abstract
AbstractObjective:To investigate and control a biphasic outbreak of Serratia marcescensin a neonatal intensive care unit (NICU).Design:Epidemiological and laboratory investigation of the outbreak.Setting:The NICU of the 1,470-bed teaching hospital of the University “Federico II,” Naples, Italy.Patients:The outbreak involved 56 cases of colonization by S marcescensover a 15-month period, with two epidemic peaks of 6 and 3 months, respectively. Fourteen (25%) of the 56 colonized infants developed clinical infections, 50% of which were major (sepsis, meningitis, or pneumonia).Methods:Epidemiological and microbiological investigations, analysis of macrorestriction pattern of genomic DNA through pulsed-field gel electrophoresis (PFGE) of clinical and environmental isolates, and institution of infection control measures.Results:Analysis of macrorestriction patterns of genomic DNA by PFGE demonstrated that the vast majority of S marcescensisolates, including three environmental strains isolated from two handwashing disinfectants and the hands of a nurse, were of the same clonal type. The successful control of the outbreak was achieved through cohorting of noncolonized infants, isolation of S marcescens-infectedand -colonized infants, and an intense educational program that emphasized the need for adherence to glove use and handwashing policies. The NICU remained open to new admissions.Conclusions:Outbreaks caused by S marcescensare very difficult to eradicate. An infection control program that includes molecular typing of microorganisms and the proper dissemination among staff members of the typing results is likely to be very effective in reducing NICU-acquired infections and in controlling outbreaks caused by S marcescens,as well as other multiresistant bacteria.
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- 2001
- Full Text
- View/download PDF
15. [Neonatal thyrotoxicosis (author's transl)]
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CASCIOLI CF, CAPASSO A, PONTICELLI A, BALLETTA M., SCARCELLA, ALDA, Cascioli, Cf, Scarcella, Alda, Capasso, A, Ponticelli, A, and Balletta, M.
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- 1982
16. [Relation between severe asphyxia and birth order in twin pregnancy]
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CASCIOLI CF, BALLETTA M, DE FILIPPIS A, CACCIAPUOTI M, IERVOLINO P., SCARCELLA, ALDA, Cascioli, Cf, Scarcella, Alda, Balletta, M, DE FILIPPIS, A, Cacciapuoti, M, and Iervolino, P.
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- 1983
17. [Immunological enhancement in pregnancy: necessity of materno-fetal incompatibility for a good result of fetoplacental homograft]
- Author
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CARDONE A, TOLINO A, DIMITA U, FROLLO G, ZARCONE R, IERVOLINO P, SCARCELLA, ALDA, DE PLACIDO, GIUSEPPE, Cardone, A, Tolino, A, Dimita, U, Frollo, G, Zarcone, R, Scarcella, Alda, Iervolino, P, and DE PLACIDO, Giuseppe
- Published
- 1977
18. [The urinary hydroxyproline-creatinine ratio, in random samples, in normal children and pituitary dwarfs]
- Author
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KLAIN U, CICCHIELLO V, NOCERINO P, CHIANESE A, DE CURTIS M, DE CURTIS D., SCARCELLA, ALDA, Klain, U, Cicchiello, V, Scarcella, Alda, Nocerino, P, Chianese, A, DE CURTIS, M, and DE CURTIS, D.
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- 1980
19. [Betamethasone in the prevention of pulmonary hyaline membrane disease: the results and applicability of G.C. Liggins' protocol]
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SCARCELLA, ALDA, DE FILIPPIS A, CASCIOLI CF, BALLETTA M, ROSSI E, CICCIMARRA F., Scarcella, Alda, DE FILIPPIS, A, Cascioli, Cf, Balletta, M, Rossi, E, and Ciccimarra, F.
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- 1983
20. [Breech presentation: relation between asphyxia and the method of delivery observed in 3 academic years]
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SCARCELLA, ALDA, CASCIOLI CF, IERVOLINO P, BALLETTA M, NESPOLI G., Scarcella, Alda, Cascioli, Cf, Iervolino, P, Balletta, M, and Nespoli, G.
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- 1983
21. [Analysis and importance of levels of caffeine and theophylline in cord blood of premature newborn infants]
- Author
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SCARCELLA, ALDA, GAMBARDELLA P, DE FRANCISCIS A., Scarcella, Alda, Gambardella, P, and DE FRANCISCIS, A.
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- 1988
22. [Breech presentation: vaginal delivery or elective cesarean section?]
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CASCIOLI FC, BALLETTA M, ROSSI E, PALUDETTO R, SCARCELLA, ALDA, Cascioli, Fc, Balletta, M, Rossi, E, Paludetto, R, and Scarcella, Alda
- Published
- 1982
23. Pseudomonas aeruginosain a neonatal intensive care unit: molecular epidemiology and infection control measures
- Author
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Antonietta Lambiase, Raffaele Zarrilli, Mario Di Resta, Alessandro Caprio, Valeria Crivaro, Tonia Borriello, Maria Triassi, Alda Scarcella, Anna Di Popolo, Crivaro, V., Di Popolo, A., Caprio, A., Lambiase, Antonietta, Di Resta, M., Borriello, T., Scarcella, Alda, Triassi, Maria, and Zarrilli, Raffaele
- Subjects
DNA, Bacterial ,medicine.medical_specialty ,Neonatal intensive care unit ,Genotype ,medicine.drug_class ,Antibiotics ,Skin infection ,medicine.disease_cause ,lcsh:Infectious and parasitic diseases ,Microbiology ,Hospitals, University ,Medical microbiology ,Intensive Care Units, Neonatal ,Internal medicine ,medicine ,Humans ,Infection control ,lcsh:RC109-216 ,Pseudomonas Infections ,Cross Infection ,Infection Control ,Molecular Epidemiology ,Molecular epidemiology ,Pseudomonas aeruginosa ,business.industry ,Incidence ,Infant, Newborn ,Outbreak ,medicine.disease ,Bacterial Typing Techniques ,Electrophoresis, Gel, Pulsed-Field ,Infectious Diseases ,Italy ,business ,Hand Disinfection ,Research Article - Abstract
Background Pseudomonas aeruginosa, a non-fermentative, gram-negative rod, is responsible for a wide variety of clinical syndromes in NICU patients, including sepsis, pneumonia, meningitis, diarrhea, conjunctivitis and skin infections. An increased number of infections and colonisations by P. aeruginosa has been observed in the neonatal intensive care unit (NICU) of our university hospital between 2005 and 2007. Methods Hand disinfection compliance before and after an educational programme on hand hygiene was evaluated. Identification of microrganisms was performed using conventional methods. Antibiotic susceptibility was evaluated by MIC microdilution. Genotyping was performed by PFGE analysis. Results The molecular epidemiology of Pseudomonas aeruginosa in the NICU of the Federico II University hospital (Naples, Italy) and the infection control measures adopted to stop the spreading of P. aeruginosa in the ward were described. From July 2005 to June 2007, P. aeruginosa was isolated from 135 neonates and caused severe infections in 11 of them. Macrorestriction analysis of clinical isolates from 90 neonates identified 20 distinct genotypes, one major PFGE type (A) being isolated from 48 patients and responsible for 4 infections in 4 of them, four other distinct recurrent genotypes being isolated in 6 to 4 patients. Seven environmental strains were isolated from the hand of a nurse and from three sinks on two occasions, two of these showing PFGE profiles A and G identical to two clinical isolates responsible for infection. The successful control of the outbreak was achieved through implementation of active surveillance of healthcare-associated infections in the ward together with environmental microbiological sampling and an intense educational programme on hand disinfection among the staff members. Conclusion P. aeruginosa infections in the NICU were caused by the cross-transmission of an epidemic clone in 4 neonates, and by the selection of sporadic clones in 7 others. An infection control programme that included active surveillance and strict adherence to hand disinfection policies was effective in controlling NICU-acquired infections and colonisations caused by P. aeruginosa.
- Published
- 2009
24. Liposomal amphotericin B treatment for neonatal fungal infections
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A. Scarcella, M. Vendemmia, M.B. Pasquariello, B. Giugliano, A. De Lucia, Scarcella, Alda, Pasquariello, Mb, Giugliano, B, Vendemmia, M, and DE LUCIA, A.
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Microbiology (medical) ,Antifungal ,medicine.medical_specialty ,Antifungal Agents ,medicine.drug_class ,medicine.medical_treatment ,Amfotericina B ,Infant, Premature, Diseases ,Gastroenterology ,Amphotericin B ,Internal medicine ,medicine ,Humans ,Candida albicans ,Mycosis ,Chemotherapy ,biology ,business.industry ,Infant, Newborn ,biology.organism_classification ,medicine.disease ,Amphotéricine B ,Infectious Diseases ,Mycoses ,Liposomes ,Pediatrics, Perinatology and Child Health ,Immunology ,Liposomal amphotericin ,business ,Infant, Premature ,medicine.drug - Abstract
Disseminated fungal infections are a major problem in high risk neonates. Conventional antifungal agents are often unsatisfactory and have a high incidence of severe adverse effects.We administered liposomal encapsulated amphotericin B (AmBisome), which is an alternative to conventional amphotericin B, to 40 preterm (mean birth weight, 1090 +/- 313.6 g; mean gestational age, 28.35 +/- 2.13 weeks) and 4 full term (mean birth weight, 3080 +/- 118 g; mean gestational age, 39 +/- 0.7 weeks) newborn infants with a severe fungal infection.Candida albicans was the most frequent fungus isolated (70%). The duration of intravenous AmBisome therapy ranged from 7 to 49 days; the cumulative dose ranged from 7 to 138.8 mg/kg (median, 45.2 mg/kg). Administration of AmBisome was effective in 72.7% of patients; 5 of 6 cases of meningitis also recovered; 63.6% of 33 very low birth weight infants survived. No side effects were observed.To our knowledge this is the largest study of the treatment of neonates with liposomal amphotericin B, and the results confirm its effectiveness and safety. However, randomized clinical trials are required to establish the most effective administration protocol for AmBisome, i.e. the starting dosage, the maximum effective dosage and the cumulative dosage, and to verify whether the preparation should be associated with another antifungal agent.
- Published
- 1998
25. Molecular epidemiology of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit
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Fabrizio Gentile, Alda Scarcella, Maria Bagattini, Valeria Crivaro, Anna Di Popolo, Raffaele Zarrilli, Paolo Villari, Maria Triassi, Bagattini, M, Crivaro, V, DI POPOLO, A, Gentile, F, Scarcella, Alda, Triassi, Maria, Villari, P, and Zarrilli, Raffaele
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Microbiology (medical) ,Genotyping ,Klebsiella pneumoniae ,Microbial Sensitivity Tests ,Biology ,Antimicrobial resistance ,beta-Lactamases ,Microbiology ,Hospitals, University ,Plasmid ,Bacterial Proteins ,Drug Resistance, Multiple, Bacterial ,Intensive Care Units, Neonatal ,Nosocomial infections ,polycyclic compounds ,Pulsed-field gel electrophoresis ,Humans ,Pharmacology (medical) ,Typing ,Etest ,Pharmacology ,Molecular Epidemiology ,Molecular epidemiology ,Incidence ,Genetic transfer ,Infant, Newborn ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,biology.organism_classification ,nosocomial infections, antimicrobial resistance, genotyping, horizontal gene transfer ,Anti-Bacterial Agents ,Klebsiella Infections ,Infectious Diseases ,Italy ,Genes, Bacterial ,horizontal gene transfer ,Isoelectric Focusing - Abstract
OBJECTIVES: To investigate the molecular epidemiology of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae in the neonatal intensive care unit of a university hospital in Italy. METHODS: Antibiotic susceptibility was evaluated by disc diffusion and Etest. ESBLs were identified by isoelectric focusing, PCR and DNA sequencing analysis. Genotyping was performed by PFGE analysis. Conjugation was performed by broth mating. RESULTS: Molecular typing of K. pneumoniae isolates identified three distinct PFGE patterns. Isolates of PFGE profile A were isolated during an epidemic in 1996, while isolates of PFGE profiles B and C were sequentially isolated from September 2002 to December 2004, when 233 colonizations and 19 infections by K. pneumoniae occurred. All K. pneumoniae strains of different PFGE types were identified as ESBL producers. DNA sequencing of amplified beta-lactamase genes identified a novel bla(TEM) ESBL (bla(TEM-136)) along with bla(SHV-1) in chromosomal and plasmid DNA from K. pneumoniae of PFGE type A, respectively, and bla(TEM-1) and bla(SHV-12) in plasmid DNA from K. pneumoniae of PFGE types B and C. Conjugation experiments demonstrated that resistance to third-generation cephalosporins, along with an approximately 80 kb plasmid containing bla(SHV-12) and bla(TEM-1), was transferred from K. pneumoniae epidemic strains of PFGE types B and C to a susceptible Escherichia coli host at a frequency of 4 x 10(-6) and 1 x 10(-6) cfu/recipient cell, respectively. CONCLUSIONS: The selection of ESBL-producing clones and the transfer of the bla(SHV-12) ESBL gene between different clones were responsible for the spread of K. pneumoniae in the neonatal intensive care unit.
- Published
- 2006
26. Molecular epidemiology of an outbreak of Serratia marcescens in a neonatal intensive care unit
- Author
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Alessandra Salvadori, Paolo Villari, Alda Scarcella, M. Crispino, Villari, P, Crispino, M, Salvadori, A, and Scarcella, Alda
- Subjects
DNA, Bacterial ,Microbiology (medical) ,medicine.medical_specialty ,Neonatal intensive care unit ,Epidemiology ,Microbial Sensitivity Tests ,Disease Outbreaks ,Serratia Infections ,law.invention ,law ,Intensive Care Units, Neonatal ,Internal medicine ,Pulsed-field gel electrophoresis ,medicine ,Humans ,Infection control ,Deoxyribonucleases, Type II Site-Specific ,Intensive care medicine ,Serratia marcescens ,Cross Infection ,Molecular Epidemiology ,Molecular epidemiology ,biology ,business.industry ,Infant, Newborn ,Outbreak ,biology.organism_classification ,medicine.disease ,Intensive care unit ,Electrophoresis, Gel, Pulsed-Field ,Infectious Diseases ,Italy ,Bacteremia ,business - Abstract
Objective:To investigate and control a biphasic outbreak ofSerratia marcescensin a neonatal intensive care unit (NICU).Design:Epidemiological and laboratory investigation of the outbreak.Setting:The NICU of the 1,470-bed teaching hospital of the University “Federico II,” Naples, Italy.Patients:The outbreak involved 56 cases of colonization by Smarcescensover a 15-month period, with two epidemic peaks of 6 and 3 months, respectively. Fourteen (25%) of the 56 colonized infants developed clinical infections, 50% of which were major (sepsis, meningitis, or pneumonia).Methods:Epidemiological and microbiological investigations, analysis of macrorestriction pattern of genomic DNA through pulsed-field gel electrophoresis (PFGE) of clinical and environmental isolates, and institution of infection control measures.Results:Analysis of macrorestriction patterns of genomic DNA by PFGE demonstrated that the vast majority of Smarcescensisolates, including three environmental strains isolated from two handwashing disinfectants and the hands of a nurse, were of the same clonal type. The successful control of the outbreak was achieved through cohorting of noncolonized infants, isolation of Smarcescens-infectedand -colonized infants, and an intense educational program that emphasized the need for adherence to glove use and handwashing policies. The NICU remained open to new admissions.Conclusions:Outbreaks caused by Smarcescensare very difficult to eradicate. An infection control program that includes molecular typing of microorganisms and the proper dissemination among staff members of the typing results is likely to be very effective in reducing NICU-acquired infections and in controlling outbreaks caused by Smarcescens,as well as other multiresistant bacteria.
- Published
- 2001
27. Early death in two sisters with Hennekam syndrome
- Author
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A. Scarcella, M.B. Pasquariello, P. Gambardella, A. De Lucia, Scarcella, Alda, DE LUCIA, A, Pasquariello, Mb, and Gambardella, P.
- Subjects
medicine.medical_specialty ,Pediatrics ,business.industry ,Protein losing enteropathy ,Primary hypothyroidism ,medicine.disease ,Pylorus ,Hennekam syndrome ,Stenosis ,medicine.anatomical_structure ,Endocrinology ,Intestinal lymphangiectasia ,Internal medicine ,medicine ,Enteropathy ,business ,Genetics (clinical) ,Hypertrophic Pyloric Stenosis - Abstract
We report on two sisters with facial anomalies, protein-losing enteropathy, and intestinal lymphangiectasia consistent with the diagnosis of Hennekam syndrome. Both patients had a number of other anomalies not previously described in this autosomal recessive disorder, i.e., primary hypothyroidism, hypertrophic pyloric stenosis, and an early fatal outcome. These cases support the autosomal recessive transmission and the expansion of the phenotype of the Hennekam syndrome.
- Published
- 2000
28. Molecular epidemiology as an effective tool in the surveillance of infections in the neonatal intensive care unit
- Author
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I. Torre, L. Iacuzio, Paolo Villari, Alda Scarcella, P., Villari, L., Iacuzio, Torre, Ida, A., Scarcella, Villari, P, Iacuzio, L, and Scarcella, Alda
- Subjects
Male ,Neonatal intensive care unit ,Antibiotics ,medicine.disease_cause ,Disease Outbreaks ,law.invention ,Risk Factors ,law ,Staphylococcus epidermidis ,geographic spread ,Prospective Studies ,methicillin ,field gel-electrophoresis ,french hospitals ,klebsiella-pneumoniae ,nosocomial infections ,outbreak ,resistant ,shv-5 beta-lactamase ,staphylococcus-aureus clone ,Cross Infection ,Molecular Epidemiology ,biology ,Bacterial Infections ,Intensive care unit ,Electrophoresis, Gel, Pulsed-Field ,Intensive Care Units ,Klebsiella pneumoniae ,Infectious Diseases ,Staphylococcus aureus ,Population Surveillance ,Female ,DNA, Bacterial ,Microbiology (medical) ,medicine.medical_specialty ,medicine.drug_class ,Microbial Sensitivity Tests ,Penicillins ,Intensive care ,medicine ,Humans ,Intensive care medicine ,Molecular epidemiology ,business.industry ,Infant, Newborn ,Outbreak ,biology.organism_classification ,Methicillin Resistance ,business - Abstract
Objectives nosocomial infections result in considerable morbidity and mortality in Neonatal Intensive Care Units (NICUs). The aim of this study was to investigate the usefulness of the molecular epidemiology approach in the surveillance and control of infections in the NICU. Methods a 1-year prospective surveillance of nosocomial infections in a NICU was performed using traditional epidemiological methods as well as molecular typing of micro-organisms. Results the nosocomial infection rate among the 343 newborns was 24.8%. The risk of infection was associated with low birth weight, prolonged length of stay, empiric antibiotic treatment and nasopharyngeal colonization. Four pathogens ( Klebsiella pneumoniae , methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE) and methicillin-sensitive Staphylococcus aureus (MSSA) were responsible for more than 80% of the infections. Extended-spectrum β-lactamase-producing (ESBL) K. pneumoniae and MRSA infections constituted outbreaks caused by a single clone, whereas MRSE and MSSA infections did not represent outbreaks but rather a series of sporadic infections caused by different strains. Conclusions molecular epidemiology techniques are powerful tools that can elucidate modes of spread and reservoirs of infection in the NICU and identify effective measures to control epidemic or endemic situations.
- Published
- 1998
29. Partial exchange transfusion using peripheral vessels in polycythaemic newborn infants
- Author
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P. Gambardella, A. Scarcella, Scarcella, Alda, and Gambardella, P.
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Umbilical Veins ,Polycythaemia ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Exchange Transfusion, Whole Blood ,Infant, Newborn ,Exchange transfusion ,Gestational Age ,Polycythemia ,medicine.disease ,Surgery ,Hematocrit ,Anesthesia ,Recien nacido ,medicine.artery ,Infant, Small for Gestational Age ,Pediatrics, Perinatology and Child Health ,medicine ,Humans ,Peripheral vessels ,Radial artery ,business - Abstract
The authors detail their experience with partial exchange transfusion performed through peripheral vessels in 35 polycythaemic newborn infants. They suggest that this alternative procedure might be the method of choice for short term exchanges, since it is easy to apply and avoids the risks associated with umbilical vein catheterisation.
- Published
- 1986
30. [Incidence of osteomyelitis and septic arthritis in a neonatal pathology unit]
- Author
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Scarcella, A, Cascioli, C. F, DE CURTIS, Mario, Bartolomeo De Iuri, A, Tamburrini, O., Scarcella, Alda, Cascioli, Cf, DE CURTIS, M, BARTOLOMEO DE IURI, A, and Tamburrini, O.
- Subjects
Male ,Arthritis, Infectious ,Cross Infection ,Arthritis ,Infectious ,Infant, Newborn ,Infant ,Osteomyelitis ,Staphylococcal Infections ,Newborn ,Radiography ,Intensive Care Units ,Female ,Humans ,Intensive Care Units, Neonatal ,Retrospective Studies ,Neonatal - Abstract
During a five years period 8 newborns on 2035 admissions developed septic arthritis representing a very low incidence of 4%. Umbilical catheters were used in 3 patients. Staphylococcus aureus was the most frequent etiologic agent and in 6/8 cases blood cultures were positive for the same pathogen agent. Because of the paucity of clinical signs in the first period in the sick neonate, detection of the disorder by the radiologist assumes great importance in the neonatal intensive care unit, as early recognition and therapy may prevent residual deformity.
- Published
- 1982
31. Epidemiological and bacteriological investigation of Serratia marcescens epidemic in a nursery and in a neonatal intensive care unit
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I Annino, A. Scarcella, F. Schioppa, N. de Ruggiero, D. Montanaro, G. M. Grasso, Montanaro, D, Grasso, Gm, Annino, I, DE RUGGIERO, N, Scarcella, Alda, and Schioppa, F.
- Subjects
Pediatrics ,medicine.medical_specialty ,Neonatal intensive care unit ,health care facilities, manpower, and services ,Immunology ,Attack rate ,Microbial Sensitivity Tests ,Serratia ,Disease Outbreaks ,Feces ,Throat ,Intensive Care Units, Neonatal ,Case fatality rate ,Epidemiology ,medicine ,Humans ,Serratia marcescens ,Skin ,Cross Infection ,biology ,business.industry ,Public Health, Environmental and Occupational Health ,Enterobacteriaceae Infections ,Infant, Newborn ,Overcrowding ,biology.organism_classification ,Anti-Bacterial Agents ,Personnel, Hospital ,medicine.anatomical_structure ,Nurseries, Hospital ,Italy ,Pharynx ,business ,Infant, Premature ,Research Article - Abstract
SUMMARYAn epidemic caused bySerratia marcescensthat involved 26 infants admitted to the Neonatal Intensive Care Unit (NICU) and 82 infants admitted to the Nursery of the 2nd Medical School of Naples is reported. Two different biotypes ofS. marcescenswith two completely different epidemiological patterns were identified. The prevalent biotype (A8b trigonelline –) was isolated in the delivery room, in the operating room, in the Nursery and in the NICU from items, healthy infant excreters and affected infants; the second biotype (A3a) was isolated only in the NICU from staff, two healthy infant excreters and two affected infants. Colonization of the throat and the gastrointestinal tract was frequent. Infected and colonized infants were the most important reservoir for serratia in the Nursery and in the NICU particularly for the type strain A3a. A mucus aspiration apparatus contaminated in the delivery room and the contamination of several instruments and items probably had a major role in the initiation and maintenance of the spread of the A8b strain. Mass contamination of the nursery has been related to overcrowding and a lack of the control measures; the transfer of high-risk colonized infants caused spread in the NICU.In the NICU the attack rate was 26%; 69% of infants became ill; the case fatality ratio was 19%. Epidemiological investigation of the infants at risk showed some factors predisposing to infection with serratia. The hygienic measures failed to control the spread of serratia and it was necessary to refuse new admissions to pregnant women in order to decontaminate and re-organize the wards.
- Published
- 1984
32. PASSAGE OF GLIADIN INTO HUMAN BREAST MILK
- Author
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Salvatore Auricchio, P Cannataro, A Tarabuso, A Donatiello, Riccardo Troncone, A Scarcella, Troncone, R, Scarcella, Alda, Donatiello, A, Cannataro, P, Tarabuso, A, Auricchio, S., Troncone, Riccardo, and Scarcella, A
- Subjects
medicine.medical_specialty ,Allergy ,Administration, Oral ,Physiology ,Enzyme-Linked Immunosorbent Assay ,Breast milk ,digestive system ,Coeliac disease ,Gliadin ,Andrology ,Immunoenzyme Techniques ,Internal medicine ,Lactation ,medicine ,Humans ,Ingestion ,Food science ,Human breast milk ,Plant Proteins ,chemistry.chemical_classification ,Milk, Human ,biology ,business.industry ,nutritional and metabolic diseases ,food and beverages ,General Medicine ,medicine.disease ,Gluten ,digestive system diseases ,Ovalbumin ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Plant protein ,Pediatrics, Perinatology and Child Health ,biology.protein ,Female ,business - Abstract
Cow's milk proteins and ovalbumin have been recently identified in human breast milk(1). The aim of this investigation was to determine whether wheat gliadin is also present in human milk. Following the ingestion of a test meal of 20 g gluten, samples of breast milk were collected from 53 women at various stage of lactation. Gliadin was assessed by a double-antibody sandwich ELISA and 5 ng/ml or more could be measured in this way. Despite the presence of specific antibodies, prechallenge milk did not inhibit significantly the ELISA. After ingestion, gliadin was detected in breast milk from 41/53 women at 1 week after delivery, 8/17 at 6 weeks, 3/6 at 3 months and 2/4 at 5 months. The gliadin concentration ranged from 5 to 95ng/ml. Maximum levels in breast milk were found 2-4 hours after ingestion; however, gliadin could not be detected simultaneously in serum. The transfer of gliadin from mother to child early in his life might be critical for the development in later life of an appropriate specific immune response. 1)Kilshaw P.J.:Int.Archs Allergy appl.Immun. 75, 8-15,1984.
- Published
- 1986
33. Molecular epidemiology of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit.
- Author
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Bagattini M, Crivaro V, Di Popolo A, Gentile F, Scarcella A, Triassi M, Villari P, and Zarrilli R
- Subjects
- Anti-Bacterial Agents pharmacology, Bacterial Proteins genetics, Genes, Bacterial, Hospitals, University, Humans, Incidence, Infant, Newborn, Isoelectric Focusing, Italy, Klebsiella Infections epidemiology, Klebsiella pneumoniae drug effects, Klebsiella pneumoniae enzymology, Klebsiella pneumoniae growth & development, Microbial Sensitivity Tests, Molecular Epidemiology, beta-Lactamases genetics, Bacterial Proteins biosynthesis, Drug Resistance, Multiple, Bacterial genetics, Intensive Care Units, Neonatal, Klebsiella Infections microbiology, Klebsiella pneumoniae genetics, beta-Lactamases biosynthesis
- Abstract
Objectives: To investigate the molecular epidemiology of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae in the neonatal intensive care unit of a university hospital in Italy., Methods: Antibiotic susceptibility was evaluated by disc diffusion and Etest. ESBLs were identified by isoelectric focusing, PCR and DNA sequencing analysis. Genotyping was performed by PFGE analysis. Conjugation was performed by broth mating., Results: Molecular typing of K. pneumoniae isolates identified three distinct PFGE patterns. Isolates of PFGE profile A were isolated during an epidemic in 1996, while isolates of PFGE profiles B and C were sequentially isolated from September 2002 to December 2004, when 233 colonizations and 19 infections by K. pneumoniae occurred. All K. pneumoniae strains of different PFGE types were identified as ESBL producers. DNA sequencing of amplified beta-lactamase genes identified a novel bla(TEM) ESBL (bla(TEM-136)) along with bla(SHV-1) in chromosomal and plasmid DNA from K. pneumoniae of PFGE type A, respectively, and bla(TEM-1) and bla(SHV-12) in plasmid DNA from K. pneumoniae of PFGE types B and C. Conjugation experiments demonstrated that resistance to third-generation cephalosporins, along with an approximately 80 kb plasmid containing bla(SHV-12) and bla(TEM-1), was transferred from K. pneumoniae epidemic strains of PFGE types B and C to a susceptible Escherichia coli host at a frequency of 4 x 10(-6) and 1 x 10(-6) cfu/recipient cell, respectively., Conclusions: The selection of ESBL-producing clones and the transfer of the bla(SHV-12) ESBL gene between different clones were responsible for the spread of K. pneumoniae in the neonatal intensive care unit.
- Published
- 2006
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