426 results on '"Scanlon, Martin J."'
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2. Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9
3. Fluoromethylketone‐Fragment Conjugates Designed as Covalent Modifiers of EcDsbA are Atypical Substrates.
4. Multiplexed Native Mass Spectrometry Determination of Ligand Selectivity for Fatty Acid-Binding Proteins.
5. NMR fragment screening reveals a novel small molecule binding site near the catalytic surface of the disulfide–dithiol oxidoreductase enzyme DsbA from Burkholderia pseudomallei
6. Applications of NMR Spectroscopy in FBDD
7. Fatty Acid–Binding Protein 5 Mediates the Uptake of Fatty Acids, but not Drugs, Into Human Brain Endothelial Cells
8. Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra-Terminal Domain
9. Structural studies of MUC1 core related peptides
10. Design of a Fragment-Screening Library
11. Fragment screening libraries for the identification of protein hot spots and their minimal binding pharmacophores
12. HN, N, Cα and Cβ assignments of the two periplasmic domains of Neisseria meningitidis DsbD
13. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
14. Reduced blood‐brain barrier expression of fatty acid‐binding protein 5 is associated with increased vulnerability of APP/PS1 mice to cognitive deficits from low omega‐3 fatty acid diets
15. Assembly of Fragment Screening Libraries
16. Applications of NMR Spectroscopy in FBDD
17. Determination of ligand binding modes in weak protein–ligand complexes using sparse NMR data
18. Novel small molecules that increase the susceptibility of Neisseria gonorrhoeae to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase
19. Parallel Screening of Low Molecular Weight Fragment Libraries: Do Differences in Methodology Affect Hit Identification?
20. Fatty Acid Binding Proteins Expressed at the Human Blood–Brain Barrier Bind Drugs in an Isoform-Specific Manner
21. Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation
22. Selective Binding of Small Molecules to Vibrio cholerae DsbA Offers a Starting Point for the Design of Novel Antibacterials
23. Identification and characterization of two drug-like fragments that bind to the same cryptic binding pocket of Burkholderia pseudomallei DsbA
24. Assignments of human integrin α1I domain in the apo and Mg2+ bound states
25. Elaboration of a benzofuran scaffold and evaluation of binding affinity and inhibition of Escherichia coli DsbA: A fragment-based drug design approach to novel antivirulence compounds
26. Targeting virulence not viability in the search for future antibacterials
27. Fatty acid binding proteins shape the cellular response to activation of the glucocorticoid receptor
28. Elaboration of a benzofuran scaffold and evaluation of binding affinity and inhibition of Escherichia coli DsbA: A fragment-based drug design approach to novel antivirulence compounds
29. Fatty Acid Binding Proteins: Potential Chaperones of Cytosolic Drug Transport in the Enterocyte?
30. Backbone and side chain 1H, 15N and 13C assignments for the oxidised and reduced forms of the oxidoreductase protein DsbA from Staphylococcus aureus
31. Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein
32. Fragment screening libraries for the identification of protein hot spots and their minimal binding pharmacophoresElectronic supplementary information (ESI) available: Organic solvent and MicroFrag library SMILES, library design details, affinity characterisation, and crystallography statistics. See DOI: https://doi.org/10.1039/d2md00253a
33. Backbone assignments of the 34 kDa ketopantoate reductase from E. coli
34. Identification and characterization of two drug-like fragments that bind to the same cryptic binding pocket of Burkholderia pseudomallei DsbA
35. Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX)
36. Self-Micellization of Gemfibrozil 1-O-β Acyl Glucuronide in Aqueous Solution
37. Colloidal characteristics and formulation of pure protein particulate vaccines
38. Solution structure of BSTI: a new trypsin inhibitor from skin secretions of Bombina bombina
39. Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX)
40. Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra Terminal Domain
41. Pharmaceutical applications of NMR
42. NMR solution structure of the RNA-binding peptide from human immunodeficiency virus (type 1) Rev
43. Three-dimensional structure of a cysteine-rich repeat from the low-density lipoprotein receptor
44. Three-dimensional structure in solution of the polypeptide cardiac stimulant anthopleurin-A
45. The Fragment-Based Development of a Benzofuran Hit as a New Class of Escherichia coli DsbA Inhibitors
46. A ligand-induced structural change in fatty acid–binding protein 1 is associated with potentiation of peroxisome proliferator–activated receptor α agonists
47. Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe
48. Controlled Construction of Cyclic d/ l Peptide Nanorods
49. Fragment-based discovery of inhibitors of the bacterial DnaG-SSB interaction
50. Backbone and side chain 1H, 15N and 13C assignments for the reduced form of the oxidoreductase protein DsbA from Vibrio cholerae
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