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1. Mental health sequelae in survivors of cardiogenic shock complicating myocardial infarction. A population-based cohort study

Author

Fernando, Shannon M., Qureshi, Danial, Talarico, Robert, Vigod, Simone N., McIsaac, Daniel I., Sterling, Lee H., van Diepen, Sean, Price, Susanna, Di Santo, Pietro, Kyeremanteng, Kwadwo, Fan, Eddy, Needham, Dale M., Brodie, Daniel, Bienvenu, Oscar Joseph, Combes, Alain, Slutsky, Arthur S., Scales, Damon C., Herridge, Margaret S., Thiele, Holger, Hibbert, Benjamin, Tanuseputro, Peter, and Mathew, Rebecca

Published
2024
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3. Resource Utilization and Costs Associated With Cardiogenic Shock Complicating Myocardial Infarction: A Population-Based Cohort Study

Author

Parlow, Simon, Fernando, Shannon M., Pugliese, Michael, Qureshi, Danial, Talarico, Robert, Sterling, Lee H., van Diepen, Sean, Herridge, Margaret S., Price, Susanna, Brodie, Daniel, Fan, Eddy, McIsaac, Daniel I., Di Santo, Pietro, Jung, Richard G., Slutsky, Arthur S., Scales, Damon C., Combes, Alain, Hibbert, Benjamin, Thiele, Holger, Tanuseputro, Peter, and Mathew, Rebecca

Published
2024
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9. ICU Staffing in the United States

Author

Gershengorn, Hayley B., Garland, Allan, Costa, Deena K., Dzierba, Amy L., Fowler, Robert, Kramer, Andrew A., Liu, Vincent X., Lizano, Danny, Scales, Damon C., and Wunsch, Hannah

Published
2024
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11. Prognostic factors associated with favourable functional outcome among adult patients requiring extracorporeal cardiopulmonary resuscitation for out-of-hospital cardiac arrest: A systematic review and meta-analysis

Author

Tran, Alexandre, Rochwerg, Bram, Fan, Eddy, Belohlavek, Jan, Suverein, Martje M., Poll, Marcel C.G. van de, Lorusso, Roberto, Price, Susanna, Yannopoulos, Demetris, MacLaren, Graeme, Ramanathan, Kollengode, Ling, Ryan Ruiyang, Thiara, Sonny, Tonna, Joseph E., Shekar, Kiran, Hodgson, Carol L., Scales, Damon C., Sandroni, Claudio, Nolan, Jerry P., Slutsky, Arthur S., Combes, Alain, Brodie, Daniel, and Fernando, Shannon M.

Published
2023
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14. The authors reply

Author

Angriman, Federico, Muttalib, Fiona, Lamontagne, François, Adhikari, Neill K. J., Chassé, Michaël, Aslanian, Pierre, Bélisle, Sylvain, Cailhier, Jean-François, Martin Carrier, François, Charbonney, Emmanuel, Denault, André, Girard, Martin, Guimond, Jean-Gilles, Halwagi, Antoine, Hébert, Paul, Kolan, Christophe, Ouellet, Caroline, Robillard, Nicholas, Benettaib, Fatna, Boumahni, Dounia, Lebrasseur, Martine, Salamé, Maya, Cantin, Marie-Ève, Archambault, Patrick, Drouin, Christine, Duquet-Deblois, Estel, Noël-Hunter, Monia, Dubé, Jean-Nicolas, Bériault, Marie-Josée, Chacon, Marco, Claveau, David, Naud, Jean-François, Rodrigue, Élise, Tapss, Danielle, Toupin, Guylaine, Ting Wang, Han, Brosseau, Marc, Laufer, Brian, Marquis, François, Toupin, Francis, Tassy, Danaë, Cheung, Vincent, Toun, Sam-Ang, Lamontagne, François, D’Aragon, Frédérick, Bérard, Dominique, Grondin-Beaudoin, Brian, Leclair, Marc-André, Lesur, Olivier, Mayette, Michaël, Poulin, Yannick, Quiroz Martinez, Hector, St-Arnaud, Charles, Carbonneau, Elaine, Bélisle, Julie, Bouchard, Marie-Pier, Côté, Line, Ladouceur, Marylène, Marchand, Joannie, Naisby, Alexandra, Robert-Petit, Louise, Thibault, Marie-Ève, Charbonney, Emmanuel, Albert, Martin, Bernard, Francis, Cavayas, Alexandros, Serri, Karim, Williamson, David, Williams, Virginie, Lainer Palacios, Julia, Lauzier, François, Francoeur, Charles, Leblanc, Guillaume, St-Onge, Maude, Turgeon, Alexis, Bellemare, David, Boulanger, Marie-Claude, Cloutier, Eve, Guilbault, Gabrielle, Thibeault, Frédérique, Belley-Côté, Emilie, Fox-Robichaud, Alison, Meade, Maureen, Whitlock, Richard, Hand, Lori, Hayward, Leah, Mullen, Courtney, Savija, Nevena, Lellouche, François, Simon, Mathieu, Tung Sia, Ying, Lizotte, Patricia, Rochwerg, Bram, Millen, Tina, Maslove, David, Gordon Boyd, J., Drover, John, Muscedere, John, Sibley, Stephanie, Boyd, Tracy, Hunt, Miranda, Mele, Tina, Bentall, Tracey, ElKhatib, Chadia, Shahin, Jason, Khwaja, Kosar, Campisi, Josie, Alam, Norine, Rahgoshai, Raham, Mehta, Sangeeta, Detsky, Michael, Shah, Sumesh, Kohli, Sonny, Cui, Fulan, Khera, Vikas, McConachie, David, Rehsia, Sachdeep, Bharti, Dalisha, Perez, Adic, James Kutsogiannis, Demetrios, Chowdhury, Raiyan, Davidow, Jon, Johnston, Curtis, Kim, Michael, Macala, Kimberley, Marcushamer, Sam, Markland, Darren, Matheson, Doug, Parker, Arabesque, Paton-Gay, Damian, Hewer, Tayne, Thompson, Patrica, Cook, Deborah, Al-Hazzani, Waleed, Duan, Erick, Ligori, Tania, Soth, Mark, Clarke, France, Copland, Mary, Matic, Karlo, Adhikari, Neill KJ, Amaral, Andre, Cuthbertson, Brian H, Fowler, Robert A, Piquette, Dominique, Scales, Damon C, Tillmann, Bourke, Wunsch, Hannah, Marinoff, Nicole, Kamra, Maneesha, Kaur, Navjot, Murali, Deeptha, Sabananthan, Thivya, Sugumaran, Thuva, Seely, Andrew, English, Shane, Meggison, Hilary, Microys, Sherissa, Millington, Scott, Sarti, Aimee, Haines, Jessica, Miezitis, Sydney, Porteous, Rebecca, Watpool, Irene, Del Sorbo, Lorenzo, Fan, Eddy, Granton, John, Abdelhady, Hesham, Romagnuolo, Tina, Rewa, Oleksa, Bagshaw, Sean, Meier, Michael, Sligl, Wendy, Baig, Nadia, Wood, Gordon, Ovakim, Daniel, Auld, Fiona, Carney, Gayle, Parfett, Deborah, Leblanc, Rémi, Poirier, Matthieu, Theriault, Theophile, Williston, Maryse, Caissie Collette, Jackie, Carriere, Melanie, Daigle, Melissa, Gaudet, Bernise, Morin, Karine, Ouellette-Bernier, Lola, Poitras, Julie, Robichaud, Melanie, Rockburn, Joanne, Mekontso Dessap, Armand, Arrestier, Romain, Bagate, François, Bendib, Ines, Benelli, Brice, Berti, Enora, Bertier, Astrid, Cavaleiro, Pedro, de Prost, Nicolas, Gendreau, Segolene, Hartman, Otto, Haudebourg, Anne-Fleur, Lopinto, Julien, Masi, Paul, Michaud, Gaël, Razazi, Keyvan, Tuffet, Samuel, Alves, Aline, Nait Chabane, Luiza, Ouali, Fariza, Ouedraogo, Rachida, Annane, Djillali, Abdeladim, Lilia, Bounab, Rania, Heming, Nicholas, Maxime, Virginie, Moine, Pierre, Bossard, Isabelle, Jourdier, Segolene, Mahiou, Siline, Tessa, Hayette, McGuinness, Shay, Ball, Jonathan, Hennessy, Immanuel, Hogan, Maurice, Butler, Magdalena, Cowdrey, Keri-Anne, Gilder, Eileen, Parke, Rachael, Ryan, Samantha, Woollett, Melissa, Van Der Poll, Andrew, Benson-Cooper, Kerry, Chen, Jonathan, Freeman, Kirk, Harley, David, Harvey, Dave, Hourigan, Craig, Julian, Kylie, Lo, Stephen, McArthur, Colin, Miller, Stuart, Pointer, Chris, Anthony Smith, Rex, Tincknell, Laura, McConnochie, Rachael, Simmonds, Catherine, Shaw, Geoffrey, Betteridge, Toby, Burke, Brandon, Closey, David, Crombie, Rosalind, Davidson, Neil, Henderson, Louise, Henderson, Seton, Hitchings, Louise, Knight, David, Quigley, Christine, Ritzema Carter, Jay, Roberts, Jessica, Townend, Katherine, Doyle, Tara, Mehrtens, Jan, Morgan, Stacey, Morris, Anna, Van Der Heyden, Kymbalee, Twardowski, Pawel, Dvoracek, Martin, Renner, Markus, Silverman, David, Smith, Myles, Monica Stephens, Katherine, Albert Waibel, Hansjörg, Wiebe, Stefan, Woolley, Mark, Eden, Amie, France, Dawn, Buehner, Ulrike, Erin Williams, Katallah Kramer, Browne, Troy, Callender, Owen, Chen, Jonathan, Farrell, Susanne, Higson, Vicky, Jackson, David, Keet, Owen, Goodson, Jennifer, Martynoga, Robert, Byrne, Kelly, Butler, Amelia, Trask, Kara, Mans, Gay, Termaat, Jonathan, Young, Paul, Barnes, Colin, Barry, Ben, Grayson, Kim, Moore, James, Psirides, Alex, Sturland, Shawn, Tietjens, Kate, Ure, Bob, Walker, Laurence, Wright, Jason, Aguilar-Dano, April, Delaney, Kirsha, Lawrence, Cassie, Lesona, Mildred, Millington, Alexandra, Navarra, Leanlove, Olatunji, Shaanti, Sol Cruz, Raulle, Sol Cruz, Rhoze, Young, Chelsea, Day, Andrew, Cook, Deborah J, Guyatt, Gordon H, Sprague, Sheila, Cohen, Dian, Heyland, Daren K, Lamontagne, François, Masse, Marie-Hélène, Ménard, Julie, Adhikari, Neill KJ, Pinto, Ruxandra, Kanji, Salmaan, Battista, Marie-Claude, Annane, Djillali, Tirupakuzhi Vijayaraghavan, Bharath Kumar, McGuinness, Shay, Parke, Rachael, and Arabi, Yaseen

Published
2023
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15. Epinephrine in Out-of-Hospital Cardiac Arrest: A Network Meta-analysis and Subgroup Analyses of Shockable and Nonshockable Rhythms

Author

Fernando, Shannon M., Mathew, Rebecca, Sadeghirad, Behnam, Rochwerg, Bram, Hibbert, Benjamin, Munshi, Laveena, Fan, Eddy, Brodie, Daniel, Di Santo, Pietro, Tran, Alexandre, McLeod, Shelley L., Vaillancourt, Christian, Cheskes, Sheldon, Ferguson, Niall D., Scales, Damon C., Lin, Steve, Sandroni, Claudio, Soar, Jasmeet, Dorian, Paul, Perkins, Gavin D., and Nolan, Jerry P.

Published
2023
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19. Neuroprognostication in the Post Cardiac Arrest Patient: A Canadian Cardiovascular Society Position Statement

Author

Fordyce, Christopher B., Kramer, Andreas H., Ainsworth, Craig, Christenson, Jim, Hunter, Gary, Kromm, Julie, Lopez Soto, Carmen, Scales, Damon C., Sekhon, Mypinder, van Diepen, Sean, Dragoi, Laura, Josephson, Colin, Kutsogiannis, Jim, Le May, Michel R., Overgaard, Christopher B., Savard, Martin, Schnell, Gregory, Wong, Graham C., Belley-Côté, Emilie, Fantaneanu, Tadeu A., Granger, Christopher B., Luk, Adriana, Mathew, Rebecca, McCredie, Victoria, Murphy, Laurel, and Teitelbaum, Jeanne

Published
2023
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20. Outpatient Mental Health Follow-up and Recurrent Self-harm and Suicide Among Patients Admitted to the ICU for Self-harm: A Population-based Cohort Study

Author

Fernando, Shannon M., Pugliese, Michael, McIsaac, Daniel I., Qureshi, Danial, Talarico, Robert, Sood, Manish M., Myran, Daniel T., Herridge, Margaret S., Needham, Dale M., Munshi, Laveena, Rochwerg, Bram, Fiest, Kirsten M., Milani, Christina, Kisilewicz, Magdalena, Bienvenu, O. Joseph, Brodie, Daniel, Fan, Eddy, Fowler, Robert A., Ferguson, Niall D., Scales, Damon C., Wunsch, Hannah, Tanuseputro, Peter, and Kyeremanteng, Kwadwo

Published
2023
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22. IV Vitamin C in Adults With Sepsis: A Bayesian Reanalysis of a Randomized Controlled Trial*

Author

Angriman, Federico, Muttalib, Fiona, Lamontagne, François, Adhikari, Neill K. J., Chassé, Michaël, Aslanian, Pierre, Bélisle, Sylvain, Cailhier, Jean-François, Carrier, François Martin, Charbonney, Emmanuel, Denault, André, Girard, Martin, Guimond, Jean-Gilles, Halwagi, Antoine, Hébert, Paul, Kolan, Christophe, Ouellet, Caroline, Robillard, Nicholas, Benettaib, Fatna, Boumahni, Dounia, Lebrasseur, Martine, Salamé, Maya, Cantin, Marie-Ève, Archambault, Patrick, Drouin, Christine, Dubé, Jean-Nicolas, Bériault, Marie-Josée, Chacon, Marco, Claveau, David, Naud, Jean-François, Rodrigue, Élise, Ting Wang, Han, Brosseau, Marc, Laufer, Brian, Marquis, François, Toupin, Francis, Lamontagne, François, D’Aragon, Frédérick, Bérard, Dominique, Grondin-Beaudoin, Brian, Leclair, Marc-André, Lesur, Olivier, Mayette, Michaël, Poulin, Yannick, Quiroz Martinez, Hector, St-Arnaud, Charles, Charbonney, Emmanuel, Albert, Martin, Bernard, Francis, Cavayas, Alexandros, Serri, Karim, Williamson, David, Duquet-Deblois, Estel, Noël-Hunter, Monia, Tapss, Danielle, Toupin, Guylaine, Tassy, Danaë, Cheung, Vincent, Toun, Sam-Ang, Carbonneau, Elaine, Bélisle, Julie, Bouchard, Marie-Pier, Côté, Line, Ladouceur, Marylène, Marchand, Joannie, Naisby, Alexandra, Robert-Petit, Louise, Thibault, Marie-Ève, Williams, Virginie, Lainer Palacios, Julia, Charbonney, Emmanuel, Albert, Martin, Bernard, Francis, Cavayas, Alexandros, Serri, Karim, Williamson, David, Lauzier, François, Francoeur, Charles, Leblanc, Guillaume, St-Onge, Maude, Turgeon, Alexis, Belley-Côté, Emilie, Fox-Robichaud, Alison, Meade, Maureen, Whitlock, Richard, Lellouche, François, Simon, Mathieu, Tung Sia, Ying, Rochwerg, Bram, Maslove, David, Gordon Boyd, J., Drover, John, Muscedere, John, Sibley, Stephanie, Mele, Tina, Shahin, Jason, Khwaja, Kosar, Mehta, Sangeeta, Detsky, Michael, Kohli, Sonny, Cui, Fulan, Khera, Vikas, McConachie, David, Rehsia, Sachdeep, James Kutsogiannis, Demetrios, Chowdhury, Raiyan, Davidow, Jon, Johnston, Curtis, Kim, Michael, Macala, Kimberley, Marcushamer, Sam, Markland, Darren, Matheson, Doug, Parker, Arabesque, Paton-Gay, Damian, Cook, Deborah, Al-Hazzani, Waleed, Duan, Erick, Ligori, Tania, Soth, Mark, Adhikari, Neill KJ, Amaral, Andre, Cuthbertson, Brian H, Fowler, Robert A, Piquette, Dominique, Scales, Damon C, Tillmann, Bourke, Wunsch, Hannah, Seely, Andrew, English, Shane, Meggison, Hilary, Microys, Sherissa, Millington, Scott, Sarti, Aimee, Del Sorbo, Lorenzo, Fan, Eddy, Granton, John, Rewa, Oleksa, Bagshaw, Sean, Meier, Michael, Sligl, Wendy, Wood, Gordon, Ovakim, Daniel, Leblanc, Rémi, Poirier, Matthieu, Theriault, Theophile, Williston, Maryse, Bellemare, David, Boulanger, Marie-Claude, Cloutier, Eve, Guilbault, Gabrielle, Thibeault, Frédérique, Hand, Lori, Hayward, Leah, Mullen, Courtney, Savija, Nevena, Lizotte, Patricia, Millen, Tina, Boyd, Tracy, Hunt, Miranda, Bentall, Tracey, ElKhatib, Chadia, Campisi, Josie, Alam, Norine, Rahgoshai, Raham, Shah, Sumesh, Bharti, Dalisha, Perez, Adic, Hewer, Tayne, Thompson, Patrica, Clarke, France, Copland, Mary, Matic, Karlo, Marinoff, Nicole, Kamra, Maneesha, Kaur, Navjot, Murali, Deeptha, Sabananthan, Thivya, Sugumaran, Thuva, Haines, Jessica, Miezitis, Sydney, Porteous, Rebecca, Watpool, Irene, Abdelhady, Hesham, Romagnuolo, Tina, Baig, Nadia, Auld, Fiona, Carney, Gayle, Parfett, Deborah, Caissie Collette, Jackie, Carriere, Melanie, Daigle, Melissa, Gaudet, Bernise, Morin, Karine, Ouellette-Bernier, Lola, Poitras, Julie, Robichaud, Melanie, Rockburn, Joanne, Mekontso Dessap, Armand, Arrestier, Romain, Bagate, François, Bendib, Ines, Benelli, Brice, Berti, Enora, Bertier, Astrid, Cavaleiro, Pedro, de Prost, Nicolas, Gendreau, Segolene, Hartman, Otto, Haudebourg, Anne-Fleur, Lopinto, Julien, Masi, Paul, Michaud, Gaël, Razazi, Keyvan, Tuffet, Samuel, Annane, Djillali, Abdeladim, Lilia, Bounab, Rania, Heming, Nicholas, Maxime, Virginie, Moine, Pierre, Alves, Aline, Nait Chabane, Luiza, Ouali, Fariza, Ouedraogo, Rachida, Bossard, Isabelle, Jourdier, Segolene, Mahiou, Siline, Tessa, Hayette, McGuinness, Shay, Ball, Jonathan, Hennessy, Immanuel, Hogan, Maurice, Van Der Poll, Andrew, Benson-Cooper, Kerry, Chen, Jonathan, Freeman, Kirk, Harley, David, Harvey, Dave, Hourigan, Craig, Julian, Kylie, Lo, Stephen, McArthur, Colin, Miller, Stuart, Pointer, Chris, Anthony Smith, Rex, Tincknell, Laura, Shaw, Geoffrey, Betteridge, Toby, Burke, Brandon, Closey, David, Crombie, Rosalind, Davidson, Neil, Henderson, Louise, Henderson, Seton, Hitchings, Louise, Knight, David, Quigley, Christine, Ritzema Carter, Jay, Roberts, Jessica, Townend, Katherine, Twardowski, Pawel, Dvoracek, Martin, Renner, Markus, Silverman, David, Smith, Myles, Monica Stephens, Katherine, Albert Waibel, Hansjörg, Wiebe, Stefan, Woolley, Mark, Buehner, Ulrike, Kramer, Katallah, Browne, Troy, Callender, Owen, Chen, Jonathan, Farrell, Susanne, Higson, Vicky, Jackson, David, Keet, Owen, Martynoga, Robert, Byrne, Kelly, Young, Paul, Barnes, Colin, Barry, Ben, Grayson, Kim, Moore, James, Psirides, Alex, Sturland, Shawn, Tietjens, Kate, Ure, Bob, Walker, Laurence, Wright, Jason, Butler, Magdalena, Cowdrey, Keri-Anne, Gilder, Eileen, Parke, Rachael, Ryan, Samantha, Woollett, Melissa, McConnochie, Rachael, Simmonds, Catherine, Doyle, Tara, Mehrtens, Jan, Morgan, Stacey, Morris, Anna, Van Der Heyden, Kymbalee, Eden, Amie, France, Dawn, Williams, Erin, Goodson, Jennifer, Butler, Amelia, Trask, Kara, Mans, Gay, Termaat, Jonathan, Aguilar-Dano, April, Delaney, Kirsha, Lawrence, Cassie, Lesona, Mildred, Millington, Alexandra, Navarra, Leanlove, Olatunji, Shaanti, Cruz, Raulle Sol, Cruz, Rhoze Sol, Young, Chelsea, Day, Andrew, Cook, Deborah J, Guyatt, Gordon H, Sprague, Sheila, Cohen, Dian, Heyland, Daren K, Lamontagne, François, Masse, Marie-Hélène, Ménard, Julie, Adhikari, Neill KJ, Pinto, Ruxandra, Kanji, Salmaan, Battista, Marie-Claude, Annane, Djillali, Vijayaraghavan, Bharath Kumar Tirupakuzhi, McGuinness, Shay, Parke, Rachael, and Arabi, Yaseen

Published
2023
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23. Sepsis hospitalization and risk of subsequent cardiovascular events in adults: a population-based matched cohort study

Author

Angriman, Federico, Rosella, Laura C., Lawler, Patrick R., Ko, Dennis T., Wunsch, Hannah, and Scales, Damon C.

Subjects
Ontario. Ministry of Health and Long-Term Care, Heart attack -- Complications and side effects -- Risk factors, Thromboembolism -- Risk factors -- Complications and side effects, Infection -- Risk factors -- Complications and side effects, Adults, Cardiovascular diseases -- Risk factors -- Complications and side effects, Health care industry
Abstract

Purpose To determine whether surviving a first sepsis hospitalization is associated with long-term cardiovascular events. Methods Population-based matched cohort study conducted in Ontario, Canada (2008-2017). Adult survivors (older than 18 years) of a first sepsis hospitalization were matched to adult survivors of a non-sepsis hospitalization using hard-matching and propensity score methods. Patients with pre-existing cardiovascular disease were excluded. The primary composite outcome was myocardial infarction, stroke, or cardiovascular death up to 5 years of follow-up. Secondary outcomes included venous thromboembolism and all-cause death. Cox proportional hazards models with robust standard errors were used to estimate the association of sepsis with all outcomes of interest; hazard ratios (HR) and 95% confidence intervals (CI) were calculated. Sensitivity analyses included Fine and Gray models to account for the competing risk of all-cause death and probabilistic bias analyses. Results 254,241 adult sepsis survivors were matched to adult survivors of non-sepsis hospitalization episodes. Sepsis survivors experienced an increased hazard of major cardiovascular events compared to non-sepsis survivors (HR 1.30; 95% CI 1.27-1.32), which was more pronounced in younger patients (HR 1.66; 95% CI 1.36-2.02 for patients aged 40 or younger; HR 1.21; 95% CI 1.18-1.24 for patients older than 80 years). Sepsis survivors also faced an increased hazard of venous thromboembolism (HR 1.61; 95% CI 1.55-1.67) and all-cause death (HR 1.26; 95% CI 1.25-1.27). Sensitivity analyses yielded consistent results. Conclusions Adult sepsis survivors experience an increased hazard of major cardiovascular events compared to survivors of a non-sepsis hospitalization., Author(s): Federico Angriman [sup.1] [sup.2] [sup.3], Laura C. Rosella [sup.4] [sup.5] [sup.8] [sup.9], Patrick R. Lawler [sup.2] [sup.6], Dennis T. Ko [sup.5] [sup.7], Hannah Wunsch [sup.1] [sup.2] [sup.3] [sup.5], Damon [...]

Published
2022
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25. Intensive Care Unit Staffing in the United States

Author

Gershengorn, Hayley B., primary, Garland, Allan, additional, Costa, Deena K., additional, Dzierba, Amy L., additional, Fowler, Robert, additional, Kramer, Andrew A., additional, Liu, Vincent X., additional, Lizano, Danny, additional, Scales, Damon C., additional, and Wunsch, Hannah, additional

Published
2024
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26. Impact of cardiopulmonary bypass duration on efficacy of fibrinogen replacement with cryoprecipitate compared with fibrinogen concentrate: a post hoc analysis of the Fibrinogen Replenishment in Surgery (FIBRES) randomised controlled trial

Author

Farouh, Michael E., Scales, Damon C., Heddle, Nancy M., Crowther, Mark, Rao, Vivek, Hucke, Hans-Peter, Carroll, Jo, Grewal, Deep, Brar, Sukhpal, Brussières, Jean, Grocott, Hilary, Harle, Christopher, Pavenski, Katerina, Rochon, Antoine, Saha, Tarit, Shepherd, Lois, Syed, Summer, Tran, Diem, Wong, Daniel, Zeller, Michelle, Bartoszko, Justyna, Martinez-Perez, Selene, Callum, Jeannie, and Karkouti, Keyvan

Published
2022
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28. Critical illness in patients with hematologic malignancy: a population-based cohort study

Author

Ferreyro, Bruno L., Scales, Damon C., Wunsch, Hannah, Cheung, Matthew C., Gupta, Vikas, Saskin, Refik, and Thyagu, Santhosh

Subjects
Leukemia -- Care and treatment -- Analysis, Lymphomas -- Care and treatment -- Analysis, Lung diseases, Obstructive -- Care and treatment -- Analysis, Hospital patients -- Care and treatment -- Analysis, Health care industry
Abstract

Purpose To describe the modern incidence and predictors of ICU admission for adult patients newly diagnosed with a hematologic malignancy. Methods We conducted a population-based cohort study of adults with a new diagnosis of hematologic malignancy (April 1, 2006-March 31, 2017) in Ontario, Canada. We described the baseline demographic, clinical and laboratory predictors of ICU admission and subsequent mortality. The primary outcome was the incidence of ICU admission within 1 year of hematologic malignancy diagnosis. We assessed the predictors of ICU admission using Cox-proportional models that accounted for the competing risk of death and reported as subdistribution hazard ratios (sHR) with 95% confidence intervals (CI). Results A total of 87,965 patients (mean [SD] age, 67.8 (15.7) years) were included. The 1-year incidence of ICU admission was 13.9% (median time 35 days), ranging from 7.3% (indolent lymphoma) to 22.5% (acute myeloid leukemia). After multivariable adjustment, compared to indolent lymphoma, acute myeloid leukemia (sHR, 3.09; 95% CI 2.84-3.35), aggressive non-Hodgkin lymphoma (sHR, 2.47; 95% CI 2.31-2.65) and acute lymphoblastic leukemia (sHR, 2.46; 95% CI 2.15-2.80) had the highest risk of ICU admission. Comorbidities such as cardiovascular disease (sHR, 2.09; 95% CI 2.01-2.19), chronic obstructive pulmonary disease (sHR, 1.33; 95% CI 1.26-1.39) and baseline laboratory abnormalities (anemia, thrombocytopenia and high creatinine) were also associated with ICU admission. Among ICU patients, 36.7% required invasive mechanical ventilation and in-hospital mortality was 31%. Conclusion Critical illness in patients with a newly diagnosed hematologic malignancy is frequent, occurring early after diagnosis. Certain baseline characteristics can help identify those patients at the highest risk., Author(s): Bruno L. Ferreyro [sup.1] [sup.2] [sup.3] [sup.10], Damon C. Scales [sup.1] [sup.2] [sup.4] [sup.5] [sup.6], Hannah Wunsch [sup.1] [sup.2] [sup.4] [sup.5], Matthew C. Cheung [sup.5] [sup.7] [sup.8], Vikas Gupta [...]

Published
2021
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29. Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Author

Bégin, Philippe, Callum, Jeannie, Jamula, Erin, Cook, Richard, Heddle, Nancy M., Tinmouth, Alan, Zeller, Michelle P., Beaudoin-Bussières, Guillaume, Amorim, Luiz, Bazin, Renée, Loftsgard, Kent Cadogan, Carl, Richard, Chassé, Michaël, Cushing, Melissa M., Daneman, Nick, Devine, Dana V., Dumaresq, Jeannot, Fergusson, Dean A., Gabe, Caroline, Glesby, Marshall J., Li, Na, Liu, Yang, McGeer, Allison, Robitaille, Nancy, Sachais, Bruce S., Scales, Damon C., Schwartz, Lisa, Shehata, Nadine, Turgeon, Alexis F., Wood, Heidi, Zarychanski, Ryan, Finzi, Andrés, and Arnold, Donald M.

Published
2021
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31. Targeted temperature management following out-of-hospital cardiac arrest: a systematic review and network meta-analysis of temperature targets

Author

Fernando, Shannon M., Di Santo, Pietro, Sadeghirad, Behnam, Lascarrou, Jean-Baptiste, Rochwerg, Bram, Mathew, Rebecca, Sekhon, Mypinder S., Munshi, Laveena, Fan, Eddy, Brodie, Daniel, Rowan, Kathryn M., Hough, Catherine L., McLeod, Shelley L., Vaillancourt, Christian, Cheskes, Sheldon, Ferguson, Niall D., Scales, Damon C., Sandroni, Claudio, Nolan, Jerry P., and Hibbert, Benjamin

Published
2021
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32. Association between sepsis survivorship and long-term cardiovascular outcomes in adults: a systematic review and meta-analysis

Author

Kosyakovsky, Leah B., Angriman, Federico, Katz, Emma, Adhikari, Neill K., Godoy, Lucas C., Marshall, John C., Ferreyro, Bruno L., Lee, Douglas S., Rosenson, Robert S., Sattar, Naveed, Verma, Subodh, Toma, Augustin, Englesakis, Marina, Burstein, Barry, Farkouh, Michael E., Herridge, Margaret, Ko, Dennis T., Scales, Damon C., Detsky, Michael E., Bibas, Lior, and Lawler, Patrick R.

Published
2021
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34. Venous Thromboembolism Prophylaxis in Critically Ill Adults: A Systematic Review and Network Meta-analysis

Author

Fernando, Shannon M., Tran, Alexandre, Cheng, Wei, Sadeghirad, Behnam, Arabi, Yaseen M., Cook, Deborah J., Møller, Morten Hylander, Mehta, Sangeeta, Fowler, Robert A., Burns, Karen E.A., Wells, Philip S., Carrier, Marc, Crowther, Mark A., Scales, Damon C., English, Shane W., Kyeremanteng, Kwadwo, Kanji, Salmaan, Kho, Michelle E., and Rochwerg, Bram

Published
2021
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40. Impact of Centre of Admission on Receipt of ECMO among Patients with Hypoxemic Respiratory Failure: A Secondary Analysis of the LUNG SAFE and REVA Influenza A(H1N1) Studies

Author

Tillmann, Bourke W., primary, Pham, Tai, additional, Scales, Damon C., additional, Fan, Eddy, additional, Pinto, Ruxandra, additional, Rubenfeld, Gordon, additional, Rios, Fernando, additional, Van Haren, Frank, additional, T, Sottiaux, additional, P, Depuydt, additional, Lora, Fredy S., additional, Azevedo, Luciano Cesar, additional, Bugedo, Guillermo, additional, Qiu, Haibo, additional, Gonzalez, Marcos, additional, Silesky, Juan, additional, Cerny, Vladimir, additional, Nielsen, Jonas, additional, Jibaja, Manuel, additional, Pham, Tài, additional, Wrigge, Hermann, additional, Matamis, Dimitrios, additional, Ranero, Jorge Luis, additional, Amin, Pravin, additional, Hashemian, S.M., additional, Clarkson, Kevin, additional, Bellani, Giacomo, additional, Kurahashi, Kiyoyasu, additional, Villagomez, Asisclo, additional, Zeggwagh, Amine Ali, additional, Heunks, Leo M., additional, Laake, Jon Henrik, additional, Palo, Jose Emmanuel, additional, Fernandes, Antero do Vale, additional, Sandesc, Dorel, additional, Arabi, Yaasen, additional, Bumbasierevic, Vesna, additional, Nin, Nicolas, additional, Lorente, Jose A., additional, Larsson, Anders, additional, Piquilloud, Lise, additional, Abroug, Fekri, additional, McAuley, Daniel F., additional, McNamee, Lia, additional, Hurtado, Javier, additional, Bajwa, Ed, additional, Démpaire, Gabriel, additional, Zogheib, E., additional, Dupont, H., additional, Mercat, A., additional, Pierrot, M., additional, Capellier, G., additional, Verdiere, B., additional, Bastien, O., additional, Lehot, J.-J., additional, Tonnelier, J.M., additional, Guelon, D., additional, du Cheyron, D., additional, Thille, A., additional, Pham, T., additional, Brun-Buisson, C., additional, Quenot, J.-P., additional, Arasomoano, C., additional, Minet, C., additional, Timsit, J.-F., additional, Dessertaine, G., additional, Robriquet, L., additional, Jaillette, E., additional, Castanier, M., additional, Roch, A., additional, Papazian, L., additional, Eliet, J., additional, Gaudard, P., additional, Machado, S., additional, Kuteifan, K., additional, Kimmoun, A., additional, Levy, B., additional, Bizouarn, P., additional, Villiers, D., additional, Guitton, C., additional, Dellamonica, J., additional, Boulain, T., additional, Mourvillier, B., additional, Salin, J. Bailly, additional, Wolff, M., additional, Charpentier, J., additional, Chiche, J.-D., additional, Ricome, S., additional, Megarbane, B., additional, Combes, A., additional, Schmidt, M., additional, Bréchot, N., additional, Chastre, J., additional, Rozé, H., additional, Ouattara, A., additional, Robert, R., additional, Carise, E., additional, Reignier, J., additional, Beduneau, G., additional, Richard, J.-C.M., additional, Le Tulzo, Y., additional, Zeni, F., additional, Jospe, R., additional, Kummerlen, C., additional, Gouello, J.P., additional, Cerf, C., additional, Devaquet, J., additional, Riu-Poulenc, B., additional, Luzi, A., additional, Georges, B., additional, Mayeur, N., additional, Mercier, E., additional, Guillon, A., additional, and Eustache, M.L., additional

Published
2023
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43. Convalescent plasma for adults with acute COVID-19 respiratory illness (CONCOR-1): study protocol for an international, multicentre, randomized, open-label trial

Author

Bégin, Philippe, Callum, Jeannie, Heddle, Nancy M., Cook, Richard, Zeller, Michelle P., Tinmouth, Alan, Fergusson, Dean A., Cushing, Melissa M., Glesby, Marshall J., Chassé, Michaël, Devine, Dana V., Robitalle, Nancy, Bazin, Renée, Shehata, Nadine, Finzi, Andrés, McGeer, Allison, Scales, Damon C., Schwartz, Lisa, Turgeon, Alexis F., Zarychanski, Ryan, Daneman, Nick, Carl, Richard, Amorim, Luiz, Gabe, Caroline, Ellis, Martin, Sachais, Bruce S., Loftsgard, Kent Cadogan, Jamula, Erin, Carruthers, Julie, Duncan, Joanne, Lucier, Kayla, Li, Na, Liu, Yang, Armali, Chantal, Kron, Amie, Modi, Dimpy, Auclair, Marie-Christine, Cerro, Sabrina, Avram, Meda, and Arnold, Donald M.

Published
2021
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44. Mental illness after admission to an intensive care unit

Author

Sivanathan, Lavarnan, Wunsch, Hannah, Vigod, Simone, Hill, Andrea, Pinto, Ruxandra, and Scales, Damon C.

Subjects
Ontario. Ministry of Health and Long-Term Care -- Analysis, Hospital patients -- Analysis, Health care industry
Abstract

Purpose Survivors of critical illness may be at higher risk of developing subsequent mental illness. We sought to determine the risk of new mental illness diagnoses across a large population of intensive care unit (ICU) survivors compared with hospitalized patients. Methods Population-based study (2005-2015) conducted in adults hospitalized in Ontario, Canada. The primary exposure was ICU admission for [greater than or equal to] 48 h; secondary exposures were ICU procedures including mechanical ventilation and duration of ICU. The primary outcome was mental illness diagnosed during the year after hospital discharge. To account for case mix differences between ICU and other hospitalized patients, sensitivity analyses were conducted restricting to six pre-specified diagnoses that can lead to hospitalization with or without ICU. Results 1,847,462 patients survived hospitalization, of whom 121,101 were admitted to ICU for [greater than or equal to] 48 h. ICU patients had a higher rate of new mental illness diagnoses in the year after discharge compared to hospitalized patients (17 vs. 15%, adjusted hazard ratio (aHR) 1.08, 95% CI 1.07-1.10). In analyses restricted to pre-specified most responsible diagnoses, the increased risk associated with ICU was only significant for patients with pneumonia. Among ICU survivors, exposure to mechanical ventilation (aHR: 1.08; 95% CI 1.05-1.12) or longer ICU stays (aHR: 1.004 per day; 95% CI 1.003-1.005) increased the risk of new mental illness diagnosis. Conclusions ICU was associated with a marginally increased risk of mental illness diagnosis after hospitalization that was often no longer apparent when reason for admission was considered. Patients exposed to mechanical ventilation or longer ICU stays may be at higher risk of subsequent mental illnesses., Author(s): Lavarnan Sivanathan [sup.1] [sup.2], Hannah Wunsch [sup.1] [sup.2] [sup.3] [sup.4] [sup.5], Simone Vigod [sup.1] [sup.3] [sup.6] [sup.7], Andrea Hill [sup.5], Ruxandra Pinto [sup.5], Damon C. Scales [sup.1] [sup.3] [sup.4] [...]

Published
2019
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48. Determinants of Depressive Symptoms at 1 Year Following ICU Discharge in Survivors of ≥ 7 Days of Mechanical Ventilation: Results From the RECOVER Program, a Secondary Analysis of a Prospective Multicenter Cohort Study

Author

Herridge, Margaret S., Chu, Leslie M., Matte, Andrea, Tomlinson, George, Chan, Linda, Thomas, Claire, Friedrich, Jan O., Mehta, Sangeeta, Lamontagne, Francois, Levasseur, Melanie, Ferguson, Niall D., Adhikari, Neill K.J., Rudkowski, Jill C., Meggison, Hilary, Skrobik, Yoanna, Flannery, John, Bayley, Mark, Batt, Jane, Santos, Claudia dos, Abbey, Susan E., Tan, Adrienne, Lo, Vincent, Mathur, Sunita, Parotto, Matteo, Morris, Denise, Flockhart, Linda, Fan, Eddy, Lee, Christie M., Wilcox, M. Elizabeth, Ayas, Najib, Choong, Karen, Fowler, Robert, Scales, Damon C., Sinuff, Tasnim, Cuthbertson, Brian H., Rose, Louise, Robles, Priscila, Burns, Stacey, Cypel, Marcelo, Singer, Lianne, Chaparro, Cecelia, Chow, Chung-Wai, Keshavjee, Shaf, Brochard, Laurent, Hebert, Paul, Slutsky, Arthur S., Marshall, John C., Cook, Deborah, Cameron, Jill I., Hamilton, Mika, Chu, Leslie, Ferguson, Niall, Cameron, Jill, and Herridge, Margaret

Published
2019
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