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2. Golimumab improves health-related quality of life of patients with moderate-to-severe ulcerative colitis: Results of the go-care study

Author

Saibeni, S., Bezzio, C., Bossa, F., Privitera, A.C., Marchi, S., Roselli, J., Mazzuoli, S., Geccherle, A., Soriano, A., Principi, M.B., Viola, A., Sarpi, L., Cappello, M., D'Incà, R., Mastronardi, M., Bodini, G., Guerra, M., Benedetti, A., Romano, M., Cicala, M., Di Sabatino, A., Scaldaferri, F., De Rosa, T., Giardino, A.M., Germano, V., Orlando, A., and Armuzzi, A.

Published
2024
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3. OC.07.9: ENDOSCOPIC BALLOON DILATION ASSOCIATED WITH BIOLOGICAL THERAPY IN CROHN'S DISEASE STRICTURES: A SINGLE CENTER EXPERIENCE

Author

Lopetuso, L.R., primary, Coppola, G., additional, Alfieri, N., additional, Morretta, C., additional, Di Vincenzo, F., additional, Puca, P., additional, Parisio, L., additional, Marmo, C., additional, Settanni, C.R., additional, Laterza, L., additional, Pugliese, D., additional, Riccioni, M.E., additional, Cammarota, G., additional, Papa, A., additional, Gasbarrini, A., additional, and Scaldaferri, F., additional

Published
2024
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5. T.05.4: RENAL LITHOGENIC RISK IN PATIENTS WITH INFLAMMATORY BOWEL DISEASES CORRELATES WITH MICROBIOTA COMPOSITION, URINARY PROFILE AND DIETARY INTAKE

Author

Mignini, I., primary, Blasi, V., additional, Masucci, L., additional, De Maio, F., additional, Agrillo, C., additional, Monzo, F.R., additional, Laterza, L., additional, Settanni, C.R., additional, Scaldaferri, F., additional, Napolitano, D., additional, Schiavoni, E., additional, D'Amato, D., additional, De Ninno, G., additional, Baroni, S., additional, Garcovich, M., additional, Riccardi, L., additional, Grassi, F., additional, Cintoni, M., additional, Mele, M.C., additional, Gasbarrini, A., additional, Ferraro, P.M., additional, and Papa, A., additional

Published
2024
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6. OC.07.2: ASSESSMENT OF VEDOLIZUMAB AND USTEKINUMAB IN ELDERLY (AVENUE) PATIENTS WITH CROHN'S DISEASE (CD): AN IG-IBD STUDY

Author

Viola, A., primary, Ventimiglia, M., additional, Sparacino, A., additional, D'Antonio, E., additional, Orlando, A., additional, De Vivo, S., additional, Pugliese, D., additional, Varca, S., additional, Scaldaferri, F., additional, Ribaldone, D.G., additional, Armandi, A., additional, Balestrieri, P., additional, Castiglione, F., additional, Savarino, E.V., additional, Cappello, M., additional, Viganò, C., additional, Mocci, G., additional, Allocca, M., additional, Principi, M.B., additional, Soriano, A., additional, Onali, S., additional, Bodini, G., additional, Riguccio, G., additional, Festa, S., additional, Bertani, L., additional, Checchin, D., additional, Caprioli, F., additional, and Fries, W., additional

Published
2024
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8. OC.07.8: THE POCER INDEX: APPLICATION OF A NOVEL ENDOSCOPIC SCORE IN A REAL-LIFE COHORT OF PATIENTS WITH CROHN'S DISEASE AFTER SURGERY

Author

Del Gaudio, A., primary, Parisio, L., additional, Cuccia, G., additional, Privitera, G., additional, Laterza, L., additional, Lopetuso, L.R., additional, Rumi, G., additional, De Biasio, F., additional, Mignini, I., additional, Coppola, G., additional, Gasbarrini, A., additional, Scaldaferri, F., additional, and Pugliese, D., additional

Published
2024
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9. T.08.9: SPECIFIC GUT MICROBIOTA SIGNATURES ARE ASSOCIATED WITH SYMPTOMATIC LACTOSE MALABSORPTION

Author

Capobianco, I., primary, Graziani, C., additional, Del Chierico, F., additional, Puca, P., additional, Di Vincenzo, F., additional, Wlderk, G., additional, Pirro, M.A., additional, Putignani, L., additional, Laterza, L., additional, Bibbò, S., additional, Petito, V., additional, Lopetuso, L.R., additional, Gasbarrini, A., additional, and Scaldaferri, F., additional

Published
2024
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10. The first international Rome consensus conference on gut microbiota and faecal microbiota transplantation in inflammatory bowel disease

Author

Lopetuso, L, Deleu, S, Godny, L, Petito, V, Puca, P, Facciotti, F, Sokol, H, Ianiro, G, Masucci, L, Abreu, M, Dotan, I, Costello, S, Hart, A, Iqbal, T, Paramsothy, S, Sanguinetti, M, Danese, S, Tilg, H, Cominelli, F, Pizarro, T, Armuzzi, A, Cammarota, G, Gasbarrini, A, Vermeire, S, Scaldaferri, F, Lopetuso L. R., Deleu S., Godny L., Petito V., Puca P., Facciotti F., Sokol H., Ianiro G., Masucci L., Abreu M., Dotan I., Costello S. P., Hart A., Iqbal T. H., Paramsothy S., Sanguinetti M., Danese S., Tilg H., Cominelli F., Pizarro T. T., Armuzzi A., Cammarota G., Gasbarrini A., Vermeire S., Scaldaferri F., Lopetuso, L, Deleu, S, Godny, L, Petito, V, Puca, P, Facciotti, F, Sokol, H, Ianiro, G, Masucci, L, Abreu, M, Dotan, I, Costello, S, Hart, A, Iqbal, T, Paramsothy, S, Sanguinetti, M, Danese, S, Tilg, H, Cominelli, F, Pizarro, T, Armuzzi, A, Cammarota, G, Gasbarrini, A, Vermeire, S, Scaldaferri, F, Lopetuso L. R., Deleu S., Godny L., Petito V., Puca P., Facciotti F., Sokol H., Ianiro G., Masucci L., Abreu M., Dotan I., Costello S. P., Hart A., Iqbal T. H., Paramsothy S., Sanguinetti M., Danese S., Tilg H., Cominelli F., Pizarro T. T., Armuzzi A., Cammarota G., Gasbarrini A., Vermeire S., and Scaldaferri F.

Abstract

Background Several randomised clinical trials (RCTs) performing faecal microbiota transplantation (FMT) for the management of inflammatory bowel disease (IBD), particularly for ulcerative colitis, have recently been published, but with major variations in study design. These include differences in administered dose, route and frequency of delivery, type of placebo and evaluated endpoints. Although the overall outcomes appear to be promising, they are highly dependent on both donor and recipient factors. Objective To develop concensus-based statements and recommendations for the evaluation, management and potential treatment of IBD using FMT in order to move towards standardised practices. Design An international panel of experts convened several times to generate evidence-based guidelines by performing a deep evaluation of currently available and/or published data. Twenty-five experts in IBD, immunology and microbiology collaborated in different working groups to provide statements on the following key issues related to FMT in IBD: (A) pathogenesis and rationale, (B) donor selection and biobanking, (C) FMT practices and (D) consideration of future studies and perspectives. Statements were evaluated and voted on by all members using an electronic Delphi process, culminating in a plenary consensus conference and generation of proposed guidelines. Results and conclusions Our group has provided specific statements and recommendations, based on best available evidence, with the end goal of providing guidance and general criteria required to promote FMT as a recognised strategy for the treatment of IBD.

Published
2023

11. P715 Multiparametric assessment of IBD and SpA-IBD patients to explore disease biomarkers and response predictors

Author

Privitera, G, primary, Parisio, L, additional, Perniola, S, additional, Varca, S, additional, Alivernini, S, additional, Tolusso, B, additional, Petito, V, additional, Napolitano, D, additional, Schiavoni, E, additional, Scaldaferri, F, additional, Gasbarrini, A, additional, Armuzzi, A, additional, Gremese, E, additional, Guidi, L, additional, and Pugliese, D, additional

Published
2024
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12. P363 Multimodal dynamic ultrasound approach as predictor of response in patients with Crohn’s disease treated with ustekinumab

Author

Mignini, I, primary, Maresca, R, additional, Esposto, G, additional, Ainora, M E, additional, Liguori, A, additional, Cintoni, M, additional, Galasso, L, additional, Laterza, L, additional, Lopetuso, L R, additional, Garcovich, M, additional, Riccardi, L, additional, Gasbarrini, A, additional, Scaldaferri, F, additional, and Zocco, M A, additional

Published
2024
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14. P109 Organic Cation Transporter (OCTN)-1 variants shape innate immunity and predict individual response to vedolizumab In ulcerative colitis patients

Author

Capobianco, I, primary, Puca, P, additional, Masi, L, additional, Petito, V, additional, Pafundi, P C, additional, De Felice, M, additional, Fidaleo, M, additional, Di Vincenzo, F, additional, Del Chierico, F, additional, Delogu, G, additional, Palucci, I, additional, Laterza, L, additional, Pizzoferrato, M, additional, Schiavoni, E, additional, Napolitano, D, additional, Turchini, L, additional, Amatucci, V, additional, Strazzeri, M, additional, Pugliese, D, additional, Putignani, L, additional, Armuzzi, A, additional, Lopetuso, L R, additional, Gasbarrini, A, additional, Pani, G, additional, and Scaldaferri, F, additional

Published
2024
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16. P881 Real-life vs trial access to biologic therapy differences: a 2019-2020 experience in an Italian tertiary IBD center

Author

DI VINCENZO, F, primary, Maresca, R, additional, Mora, V, additional, Petito, V, additional, Turchini, L, additional, Amatucci, V, additional, Napolitano, D, additional, Schiavoni, E, additional, Lopetuso, L R, additional, Parisio, L, additional, Settanni, C R, additional, Pizzoferrato, M, additional, Armuzzi, A, additional, Pugliese, D, additional, Laterza, L, additional, Gasbarrini, A, additional, and Scaldaferri, F, additional

Published
2024
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17. P750 Endoscopic balloon dilation associated with biological therapy in Crohn's Disease strictures: a single center experience

Author

Lopetuso, L R, primary, Coppola, G, additional, Alfieri, N, additional, Morretta, C, additional, Di Vincenzo, F, additional, Puca, P, additional, Parisio, L, additional, Marmo, C, additional, Settanni, C R, additional, Laterza, L, additional, Pugliese, D, additional, Riccioni, M E, additional, Cammarota, G, additional, Papa, A, additional, Gasbarrini, A, additional, and Scaldaferri, F, additional

Published
2024
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18. N06 Self-care in patients affected by inflammatory bowel disease: SELF-IBD observational study in a single center

Author

Napolitano, D, primary, Schiavoni, E, additional, Amatucci, V, additional, Monaci, A, additional, Martella, P, additional, Orgiana, N, additional, Benini, V, additional, Di Massimo, A, additional, Turchini, L, additional, Giordano, L N, additional, Conticelli, C, additional, Pettinari, V, additional, De Vito, A, additional, Virone, C, additional, Lorusso, A, additional, Fanali, C, additional, Ribaudi, E, additional, Bernabei, T, additional, Gasbarrini, A, additional, Scaldaferri, F, additional, and Cocchieri, A, additional

Published
2024
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19. P460 The POCER index: application of a novel endoscopic score in a real-life cohort of patients with Crohn's disease after surgery

Author

Parisio, L, primary, Del Gaudio, A, additional, Privitera, G, additional, Cuccia, G, additional, Lopetuso, L R, additional, Laterza, L, additional, Rumi, G, additional, De Biasio, F, additional, Mignini, I, additional, Calvez, V, additional, Coppola, G, additional, Gasbarrini, A, additional, Scaldaferri, F, additional, and Pugliese, D, additional

Published
2024
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20. P1203 Fecal transplantation for Ulcerative Colitis from diet conditioned donors followed by dietary intervention results in favorable gut microbial profile and decreased gut inflammation compared to fecal transplantation alone

Author

Leibovitzh, H, primary, Sarbagili Shabat, C, additional, Hirsch, A, additional, Zittan, E, additional, Mentella, M C, additional, Petito, V, additional, Cohen, N A, additional, Ron, Y, additional, Fliss Isakov, N, additional, Pfeffer, J, additional, Yaakov, M, additional, Fanali, C, additional, Turchini, L, additional, Masucci, L, additional, Quaranta, G, additional, Kolonimos, N, additional, Godneva, A, additional, Weinberger, A, additional, Scaldaferri, F, additional, and Maharshak, N, additional

Published
2024
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21. P544 Ustekinumab safety and effectiveness in ulcerative colitis patients: results from a large real-life study

Author

Mocci, G, primary, Scaldaferri, F, additional, Pugliese, D, additional, Savarino, E, additional, Bodini, G, additional, Cuomo, A, additional, Donnarumma, L, additional, Maconi, G, additional, Cataletti, G, additional, Rodino, S, additional, Sebkova, L, additional, Ferronato, A, additional, Gaiani, F, additional, Marzo, M, additional, Luppino, I, additional, Paese, P, additional, Elisei, W, additional, Monterubbianesi, R, additional, Faggiani, R, additional, Napolitano, D, additional, Grossi, L, additional, Serio, M, additional, Scarcelli, A, additional, Lorenzetti, R, additional, Allegretta, L, additional, Rocco, G, additional, Zampaletta, C, additional, Bolognini, L, additional, Meucci, C, additional, Colucci, R, additional, Tonti, P, additional, Della Valle, N, additional, Piga, R, additional, Forti, G, additional, Onidi, F M, additional, Usai Satta, P, additional, Picchio, M, additional, Papa, A, additional, and Tursi, A, additional

Published
2024
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22. P442 Renal lithogenic risk in patients with Inflammatory Bowel Diseases correlates with microbiota composition, urinary profile and dietary intake

Author

Mignini, I, primary, Blasi, V, additional, Masucci, L, additional, De Maio, F, additional, Agrillo, C, additional, Monzo, F R, additional, Laterza, L, additional, Scaldaferri, F, additional, Napolitano, D, additional, Schiavoni, E, additional, D' Amato, D, additional, De Ninno, G, additional, Baroni, S, additional, Mele, M C, additional, Grassi, F, additional, Cintoni, M, additional, Garcovich, M, additional, Riccardi, L, additional, Gasbarrini, A, additional, Ferraro, P M, additional, and Papa, A, additional

Published
2024
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23. P1213 The effects of Escherichia coli Nissle 1917 on the gut microbiota composition in ulcerative colitis patients

Author

Puca, P, primary, Del Chierico, F, additional, Graziani, C, additional, Masi, L, additional, Coppola, G, additional, Di Vincenz, F, additional, Capobianco, I, additional, Lopetuso, L R, additional, Barbaro, M R, additional, Masucci, L, additional, Putignani, L, additional, Petito, V, additional, Marasco, G, additional, Sanguinetti, M, additional, Barbara, G, additional, Gasbarrini, A, additional, and Scaldaferri, F, additional

Published
2024
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24. P908 Real-life effectiveness and safety of tofacitinib and vedolizumab as a second-line therapy in anti-TNFs experienced patients ulcerative colitis: preliminary results of an IGIBD study (VE2TO-UC)

Author

Noviello, D, primary, Savarino, E, additional, Fries, W, additional, Fantini, M C, additional, Conforti, F, additional, Orlando, A, additional, Ribaldone, D G, additional, Mocci, G, additional, Viganò, C, additional, Festa, S, additional, Spagnuolo, R, additional, Campigotto, M, additional, Grossi, L, additional, Gravina, A G, additional, Principi, M, additional, Imperatore, N, additional, Carvalhas, A, additional, Scardino, G, additional, Scaldaferri, F, additional, Ceccarelli, L, additional, Biancone, L, additional, Di Sario, A, additional, De Barba, C, additional, De Francesco, C, additional, Calderone, S, additional, Onali, S, additional, Vecchi, M, additional, Ventimiglia, M, additional, and Caprioli, F, additional

Published
2024
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25. P096 Human extrachromosomal circular DNA is an emerging biomarker in Inflammatory Bowel Disease

Author

Petito, V, primary, DI VINCENZO, F, additional, Gerovska, D, additional, Piazzesi, A, additional, Russo, A, additional, Turchini, L, additional, Masi, L, additional, Lopetuso, L R, additional, Abreu, M T, additional, Regenberg, B, additional, Gasbarrini, A, additional, Putignani, L, additional, Bravo Araúzo, M J, additional, and Scaldaferri, F, additional

Published
2024
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26. P831 Acute infusion reactions due to different biologic agents in a large cohort of patients with Inflammatory Bowel Disease

Author

Colantuono, S, primary, Caruso, C, additional, Rumi, G, additional, Capobianco, I, additional, Blasi, V, additional, Termite, F, additional, Coppola, G, additional, Laterza, L, additional, Lopetuso, L R, additional, Mignini, I, additional, Napolitano, D, additional, Parisio, L, additional, Pugliese, D, additional, Scaldaferri, F, additional, Gasbarrini, A, additional, and Papa, A, additional

Published
2024
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28. Golimumab improves health-related quality of life of patients with moderate-to-severe ulcerative colitis: Results of the go-care study

Author

Saibeni, S., primary, Bezzio, C., additional, Bossa, F., additional, Privitera, A.C., additional, Marchi, S., additional, Roselli, J., additional, Mazzuoli, S., additional, Geccherle, A., additional, Soriano, A., additional, Principi, M.B., additional, Viola, A., additional, Sarpi, L., additional, Cappello, M., additional, D'Incà, R., additional, Mastronardi, M., additional, Bodini, G., additional, Guerra, M., additional, Benedetti, A., additional, Romano, M., additional, Cicala, M., additional, Sabatino, A. Di, additional, Scaldaferri, F., additional, De Rosa, T., additional, Giardino, A.M., additional, Germano, V., additional, Orlando, A., additional, and Armuzzi, A., additional

Published
2023
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31. Case report: Dupilumab treatment improved type 2 disorders in a patient with IPEX syndrome diagnosis

Author

Caruso, Cristiano, Laterza, Lucrezia, Settanni, Carlo Romano, Colantuono, S., Di Mario, Clara, Tolusso, Barbara, Castri, Federica, Gremese, Elisa, Scaldaferri, Franco, Armuzzi, Alessandro, De Simone, Clara, Peris, Ketty, Chiricozzi, Andrea, Gasbarrini, Antonio, Caruso C., Laterza L., Settanni C. R., Di Mario C., Tolusso B. (ORCID:0000-0002-9108-6609), Castri F., Gremese E. (ORCID:0000-0002-2248-1058), Scaldaferri F. (ORCID:0000-0001-8334-7541), Armuzzi A. (ORCID:0000-0003-1572-0118), De Simone C. (ORCID:0000-0002-0898-0045), Peris K. (ORCID:0000-0002-5237-0463), Chiricozzi A. (ORCID:0000-0002-6739-0387), Gasbarrini A. (ORCID:0000-0002-7278-4823), Caruso, Cristiano, Laterza, Lucrezia, Settanni, Carlo Romano, Colantuono, S., Di Mario, Clara, Tolusso, Barbara, Castri, Federica, Gremese, Elisa, Scaldaferri, Franco, Armuzzi, Alessandro, De Simone, Clara, Peris, Ketty, Chiricozzi, Andrea, Gasbarrini, Antonio, Caruso C., Laterza L., Settanni C. R., Di Mario C., Tolusso B. (ORCID:0000-0002-9108-6609), Castri F., Gremese E. (ORCID:0000-0002-2248-1058), Scaldaferri F. (ORCID:0000-0001-8334-7541), Armuzzi A. (ORCID:0000-0003-1572-0118), De Simone C. (ORCID:0000-0002-0898-0045), Peris K. (ORCID:0000-0002-5237-0463), Chiricozzi A. (ORCID:0000-0002-6739-0387), and Gasbarrini A. (ORCID:0000-0002-7278-4823)

Abstract

We described a case of IPEX syndrome successfully controlled with dupilumab, an anti-IL4 receptor alpha subunit inhibitor. IPEX syndrome is a rare and generally fatal genetic disorder characterized by immune dysregulation, polyendocrinopathy and enteropathy, mostly diagnosed in early childhood. Nonetheless, cases reported in the last 20 years demonstrated that IPEX clinical spectrum encompasses more than the classical triad of early-onset intractable diarrhea, type 1 diabetes and eczema. Atypical cases of IPEX include patients with late-onset of symptoms, single-organ involvement, mild disease phenotypes or rare clinical features. A 21-year-old caucasian man presented with immune dysregulation (hypereosinophilia and elevated IgE), protein-losing enteropathy, polyendocrinopathy (thyroiditis, osteoporosis, delayed puberty), weight loss, eczema manifestations and celiac disease. IPEX syndrome was diagnosed because of the presence of a hemizygous mutation in FOXP3 gene (c.543C>T (p.S181S) in the exon 5). During the course of the disease, the patient developed erosive proctitis, pyoderma gangrenosum, and erythema nodosum. Symptoms improved only after enteral and parenteral corticosteroid therapy and the patient soon developed steroid-dependence. Notwithstanding various therapies including azathioprine, sirolimus, tacrolimus, adalimumab, vedolizumab, the patient failed to achieve a good control of symptoms without steroids. Almost exclusive enteral nutrition with a hypoallergenic, milk-protein free, amino acid-based food for special medical purposes. He continued to lose weight (BMI 14.5 kg/m2) with a consequent high limitation of physical activity and a progressive worsening of the quality of life. In consideration of the poor response to conventional immunosuppressants and the presence of type 2 inflammatory manifestations, treatment with dupilumab at an initial dose of 600 mg, followed by a maintenance dose of 300 mg every other week, according to atopic dermatitis

Published
2023

34. OC.04.3 REAL-LIFE VS TRIAL ACCESS TO BIOLOGIC THERAPY DIFFERENCES: A 2019-2020 EXPERIENCE IN AN ITALIAN TERTIARY IBD CENTER

Author

Laterza, L., primary, Di Vincenzo, F., additional, Maresca, R., additional, Russo, M.C., additional, Mora, V., additional, Petito, V., additional, Turchini, L., additional, Amatucci, V., additional, Napolitano, D., additional, Schiavoni, E., additional, Settanni, C., additional, Parisio, L., additional, Pizzoferrato, M., additional, Lopetuso, L., additional, Armuzzi, A., additional, Gasbarrini, A., additional, Pugliese, D., additional, and Scaldaferri, F., additional

Published
2023
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35. T.06.8 REAL WORD LONG-TERM EFFICACY AND SAFETY OF VEDOLIZUMAB IN MANAGING ULCERATIVE COLITIS VERSUS CROHN'S DISEASE: RESULTS FROM “LONG VEDO” ITALIAN MULTICENTER STUDY

Author

Mocci, G., primary, Maconi, G., additional, Cataletti, G., additional, Mantia, B., additional, Serio, M., additional, Scarcelli, A., additional, Onidi, F.M., additional, Pagnini, C., additional, Graziani, M., additional, Di Paolo, M., additional, Pranzo, G., additional, Luppino, I., additional, Paese, P., additional, Monterubbianesi, R., additional, Faggiani, R., additional, Ferronato, A., additional, Perini, B., additional, Savarino, E., additional, Binaghi, L., additional, Schiavoni, E., additional, Napolitano, D., additional, Scaldaferri, F., additional, Papa, A., additional, Lorenzetti, R., additional, Pica, R., additional, Cocco, A., additional, Rodino, S., additional, Sebkova, L., additional, Zampaletta, C., additional, Gaiani, F., additional, Fanigliulo, L., additional, Allegretta, L., additional, Cuomo, A., additional, Donnarumma, L., additional, Della Valle, N., additional, Forti, G., additional, Dore, M., additional, Antonelli, E., additional, Bassotti, G., additional, Iannelli, C., additional, Aragona, G., additional, Lauria, A., additional, Piergallini, S., additional, Colucci, R., additional, Meucci, C., additional, Usai Satta, P., additional, Elisai, W., additional, and Tursi, A., additional

Published
2023
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39. P828 Incidence and predictors of arterial and venous thromboembolic events in hospitalized patients with inflammatory bowel disease compared to patients with acute infective gastroenteritis and colitis: a propensity score-matched study

Author

Papa, A, primary, Lopetuso, L R, additional, Mignini, I, additional, Settanni, C R, additional, Scaldaferri, F, additional, Pugliese, D, additional, Laterza, L, additional, Covino, M, additional, Franceschi, F, additional, and Gasbarrini, A, additional

Published
2023
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41. P505 Real word long-term efficacy and safety of vedolizumab in managing ulcerative colitis versus crohn’s disease: results from “long vedo” italian multicenter study

Author

Mocci, G, primary, Maconi, G, additional, Onidi, F M, additional, Cataletti, G, additional, Elisei, W, additional, Scaldaferri, F, additional, Lorenzetti, R, additional, Pagnini, C, additional, Scarcelli, A, additional, Graziani, M G, additional, Di Paolo, M C, additional, Pranzo, G, additional, Luppino, I, additional, Monterubbianesi, R, additional, Faggiani, R, additional, Ferronato, A, additional, Savarino, E, additional, Pica, R, additional, Cocco, A, additional, Rodino, S, additional, Sebkova, L, additional, Zampaletta, C, additional, Gaiani, F, additional, Fanigliulo, L, additional, Allegretta, L, additional, Cuomo, A, additional, Donnarumma, L, additional, Della Valle, N, additional, Forti, G, additional, Antonelli, E, additional, Bassotti, G, additional, Iannelli, C, additional, Aragona, G, additional, Lauria, A, additional, Piergallini, S, additional, Colucci, R, additional, Binaghi, L, additional, Meucci, C, additional, Papa, A, additional, and Tursi, A, additional

Published
2023
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42. N14 The satisfaction of IBD patients’ nursing care in biological therapy. Observational study

Author

Napolitano, D, primary, Cocchieri, A, additional, Orgiana, N, additional, Fanali, C, additional, Poscia, A, additional, Schiavoni, E, additional, Bernabei, T, additional, Amatucci, V, additional, Turchini, L, additional, Durini, E, additional, Strazzeri, M, additional, Laterza, L, additional, Lopetuso, L R, additional, Mora, V, additional, Papa, A, additional, Pugliese, D, additional, Gasbarrini, A, additional, and Scaldaferri, F, additional

Published
2023
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43. N04 How to manage the concerns of patients with inflammatory bowel disease due to the transition from in-hospital to home management with oral or subcutaneous therapies: results of a survey of a cohort of patients in intravenous biologic treatment

Author

Napolitano, D, primary, Settanni, C R, additional, Parisio, L, additional, Schiavoni, E, additional, Pugliese, D, additional, Scaldaferri, F, additional, Gasbarrini, A, additional, and Papa, A, additional

Published
2023
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44. Case report: Dupilumab treatment improved type 2 disorders in a patient with IPEX syndrome diagnosis

Author

Caruso, C., primary, Laterza, L., additional, Settanni, C. R., additional, Colantuono, S., additional, Di Mario, C., additional, Tolusso, B., additional, Castrì, F., additional, Gremese, E., additional, Scaldaferri, F., additional, Armuzzi, A., additional, De Simone, C., additional, Peris, K., additional, Chiricozzi, A., additional, and Gasbarrini, A., additional

Published
2023
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49. Effectiveness and safety of vedolizumab in a matched cohort of elderly and nonelderly patients with inflammatory bowel disease: the IG-IBD LIVE study

Author

Pugliese, D., Privitera, G., Crispino, F., Mezzina, N., Castiglione, F., Fiorino, G., Laterza, L., Viola, A., Bertani, L., Caprioli, F., Cappello, M., Barberio, B., Ricci, C., Balestrieri, P., Daperno, M., Pluchino, D., Rizzello, F., Scribano, M. L., Sablich, R., Pastorelli, L., Manguso, F., Variola, A., Di Sario, A., Grossi, L., Armuzzi, A., Ribaldone, D. G., Biscaglia, G., Buda, A., Mocci, G., Viscido, A., Di Paolo, M. C., Onali, S., Rodino, S., Coletta, M., Principi, M., Miranda, A., Amato, A., Bezzio, C., Petruzzellis, C., Mazzuoli, S., Festa, S., Sartini, A., Checchin, D., Fanigliulo, L., Gallina, S., Cesarini, M., Bodini, G., Stradella, D., Spagnuolo, R., Guidi, L., Savarino, E., Scrivo, B., Soru, P., Costa, F., Fries, W., Scaldaferri, F., Allocca, M., Pellegrini, L., Massari, A., Orlando, A., Pugliese D., Privitera G., Crispino F., Mezzina N., Castiglione F., Fiorino G., Laterza L., Viola A., Bertani L., Caprioli F., Cappello M., Barberio B., Ricci C., Balestrieri P., Daperno M., Pluchino D., Rizzello F., Scribano M.L., Sablich R., Pastorelli L., Manguso F., Variola A., Di Sario A., Grossi L., Armuzzi A., Ribaldone D.G., Biscaglia G., Buda A., Mocci G., Viscido A., Di Paolo M.C., Onali S., Rodino S., Coletta M., Principi M., Miranda A., Amato A., Bezzio C., Petruzzellis C., Mazzuoli S., Festa S., Sartini A., Checchin D., Fanigliulo L., Gallina S., Cesarini M., Bodini G., Stradella D., Spagnuolo R., Guidi L., Savarino E., Scrivo B., Soru P., Costa F., Fries W., Scaldaferri F., Allocca M., Pellegrini L., Massari A., and Orlando A.

Subjects
Crohn’s disease, Ulcerative, Antibodies, Monoclonal, Humanized, biologics (IBD), immunosuppression, ulcerative colitis, Aged, Chronic Disease, Colitis, Ulcerative, Crohn Disease, Humans, Prospective Studies, Retrospective Studies, Treatment Outcome, Tumor Necrosis Factor Inhibitors, Gastrointestinal Agents, Inflammatory Bowel Diseases, Antibodies, Monoclonal, Pharmacology (medical), Humanized, Settore MED/12 - Gastroenterologia, Hepatology, Gastroenterology, Colitis
Abstract

Background: Vedolizumab registration trials were the first to include elderly patients with moderate-to-severe ulcerative colitis (UC) or Crohn’s disease (CD), but few real-life data have been reported in this population. Aims: We investigated the effectiveness and safety of vedolizumab in matched cohorts of elderly and nonelderly UC and CD patients. Methods: The Long-term Italian Vedolizumab Effectiveness (LIVE) study is a retrospective-prospective study including UC and CD patients who started vedolizumab from April 2016 to June 2017. Elderly patients (≥65 years) were matched clinically 1:2 to nonelderly patients (18–64 years); the 2 groups were followed until drug discontinuation or June 2019. Results: The study included 198 elderly (108 UC, 90 CD) and 396 matched nonelderly patients (205 UC, 191 CD). Nonelderly UC patients had a significantly higher persistence on vedolizumab compared to elderly patients (67.6% vs. 51.4%, p=0.02). No significant difference in effectiveness was observed between elderly and nonelderly CD patients (59.4% vs. 52.4%, p=0.32). Age ≥65 years was associated with lower persistence in UC; for CD, previous exposure to anti-TNF-α agents, Charlson comorbidity index >2 and moderate-to-severe clinical activity at baseline were associated with lower persistence. There were recorded 130 adverse events, with comparable rates between the two groups. A Charlson comorbidity index >2 was associated with an increased risk of adverse events. Conclusion: Vedolizumab can be considered a safe option in elderly IBD patients. Its effectiveness in elderly UC patients may be reduced, while no age-dependent effect on effectiveness was observed in CD.

Published
2022

50. Therapies for inflammatory bowel disease do not pose additional risks for adverse outcomes of SARS-CoV-2 infection: an IG-IBD study

Author

Bezzio, C., Armuzzi, A., Furfaro, F., Ardizzone, S., Milla, M., Carparelli, S., Orlando, A., Caprioli, F. A., Castiglione, F., Vigano, C., Ribaldone, D. G., Zingone, F., Monterubbianesi, R., Imperatore, N., Festa, S., Daperno, M., Scucchi, L., Ferronato, A., Pastorelli, L., Balestrieri, P., Ricci, C., Cappello, M., Felice, C., Fiorino, G., Saibeni, S., Coppini, F., Alvisi, P., Gerardi, V., Variola, A., Mazzuoli, S., Lenti, M. V., Pugliese, D., Allocca, M., Ferretti, F., Roselli, J., Bossa, F., Giuliano, A., Piazza, N., Manes, G., Sartini, A., Buda, A., Micheli, F., Ciardo, V., Casella, G., Viscido, A., Bodini, G., Casini, V., Soriano, A., Amato, A., Grossi, L., Onali, S., Rottoli, M., Spagnuolo, R., Baroni, S., Cortelezzi, C. C., Baldoni, M., Vernero, M., Scaldaferri, F., Maconi, G., Guarino, A. D., Palermo, A., D'Inca, R., Scribano, M. L., Biancone, L., Carrozza, L., Ascolani, M., Costa, F., Di Sabatino, A., Zammarchi, I., Gottin, M., Conforti, F. S., Armuzzi A. (ORCID:0000-0003-1572-0118), Orlando A., Felice C., Pugliese D., Allocca M., Ferretti F., Giuliano A., Buda A., Casella G., Onali S., Spagnuolo R., Baldoni M., Scaldaferri F. (ORCID:0000-0001-8334-7541), Bezzio, C., Armuzzi, A., Furfaro, F., Ardizzone, S., Milla, M., Carparelli, S., Orlando, A., Caprioli, F. A., Castiglione, F., Vigano, C., Ribaldone, D. G., Zingone, F., Monterubbianesi, R., Imperatore, N., Festa, S., Daperno, M., Scucchi, L., Ferronato, A., Pastorelli, L., Balestrieri, P., Ricci, C., Cappello, M., Felice, C., Fiorino, G., Saibeni, S., Coppini, F., Alvisi, P., Gerardi, V., Variola, A., Mazzuoli, S., Lenti, M. V., Pugliese, D., Allocca, M., Ferretti, F., Roselli, J., Bossa, F., Giuliano, A., Piazza, N., Manes, G., Sartini, A., Buda, A., Micheli, F., Ciardo, V., Casella, G., Viscido, A., Bodini, G., Casini, V., Soriano, A., Amato, A., Grossi, L., Onali, S., Rottoli, M., Spagnuolo, R., Baroni, S., Cortelezzi, C. C., Baldoni, M., Vernero, M., Scaldaferri, F., Maconi, G., Guarino, A. D., Palermo, A., D'Inca, R., Scribano, M. L., Biancone, L., Carrozza, L., Ascolani, M., Costa, F., Di Sabatino, A., Zammarchi, I., Gottin, M., Conforti, F. S., Armuzzi A. (ORCID:0000-0003-1572-0118), Orlando A., Felice C., Pugliese D., Allocca M., Ferretti F., Giuliano A., Buda A., Casella G., Onali S., Spagnuolo R., Baldoni M., and Scaldaferri F. (ORCID:0000-0001-8334-7541)

Abstract

Background: Older age and comorbidities are the main risk factors for adverse COVID-19 outcomes in patients with inflammatory bowel disease (IBD). The impact of IBD medications is still under investigation. Aims: To assess risk factors for adverse outcomes of COVID-19 in IBD patients and use the identified risk factors to build risk indices. Methods: Observational cohort study. Univariable and multivariable logistic regression was used to identify risk factors associated with pneumonia, hospitalisation, need for ventilatory support, and death. Results: Of the 937 patients (446 with ulcerative colitis [UC]) evaluated, 128 (13.7%) had asymptomatic SARS-CoV-2 infection, 664 (70.8%) had a favourable course, and 135 (15.5%) had moderate or severe COVID-19. In UC patients, obesity, active disease and comorbidities were significantly associated with adverse outcomes. In patients with Crohn's disease (CD), age, obesity, comorbidities and an additional immune-mediated inflammatory disease were identified as risk factors. These risk factors were incorporated into two indices to identify patients with UC or CD with a higher risk of adverse COVID-19 outcomes. In multivariable analyses, no single IBD medication was associated with poor COVID-19 outcomes, but anti-TNF agents were associated with a lower risk of pneumonia in UC, and lower risks of hospitalisation and severe COVID-19 in CD. Conclusion: The course of COVID-19 in patients with IBD is similar to that in the general population. IBD patients with active disease and comorbidities are at greater risk of adverse COVID-19 outcomes. IBD medications do not pose additional risks. The risk indices may help to identify patients who should be prioritised for COVID-19 re-vaccination or for therapies for SARS-CoV-2 infection.

Published
2021

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