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3. Range Proofs with Constant Size and Trustless Setup

Author

Scala, Emanuele, Mostarda, Leonardo, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, and Barolli, Leonard, editor

Published
2023
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4. Zero-Knowledge Multi-transfer Based on Range Proofs and Homomorphic Encryption

Author

Scala, Emanuele, Dong, Changyu, Corradini, Flavio, Mostarda, Leonardo, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, and Barolli, Leonard, editor

Published
2023
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9. Robot Based Computing System: An Educational Experience

Author

Cacciagrano, Diletta, Culmone, Rosario, Mostarda, Leonardo, Navarra, Alfredo, Scala, Emanuele, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Barolli, Leonard, editor, Hussain, Farookh, editor, and Enokido, Tomoya, editor

Published
2022
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10. ZeroMT: Multi-transfer Protocol for Enabling Privacy in Off-Chain Payments

Author

Corradini, Flavio, Mostarda, Leonardo, Scala, Emanuele, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Barolli, Leonard, editor, Hussain, Farookh, editor, and Enokido, Tomoya, editor

Published
2022
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11. Dilemmas of nomenclature: Web search analysis reveals European preferences in atopic skin diseases

Author

Wecker, Hannah, primary, Ziehfreund, Stefanie, additional, Sitaru, Sebastian, additional, Johansson, Emma K., additional, Elberling, Jesper, additional, Doll, Anaïs, additional, Nicolaidou, Electra, additional, Scala, Emanuele, additional, Boffa, Michael J., additional, Schmidt, Lea, additional, Sikora, Mariusz, additional, Torres, Tiago, additional, Chernyshov, Pavel V., additional, and Zink, Alexander, additional

Published
2024
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15. Dilemmas of nomenclature:Web search analysis reveals European preferences in atopic skin diseases

Author

Wecker, Hannah, Ziehfreund, Stefanie, Sitaru, Sebastian, Johansson, Emma K., Elberling, Jesper, Doll, Anaïs, Nicolaidou, Electra, Scala, Emanuele, Boffa, Michael J., Schmidt, Lea, Sikora, Mariusz, Torres, Tiago, Chernyshov, Pavel V., Zink, Alexander, Wecker, Hannah, Ziehfreund, Stefanie, Sitaru, Sebastian, Johansson, Emma K., Elberling, Jesper, Doll, Anaïs, Nicolaidou, Electra, Scala, Emanuele, Boffa, Michael J., Schmidt, Lea, Sikora, Mariusz, Torres, Tiago, Chernyshov, Pavel V., and Zink, Alexander

Abstract

Atopic dermatitis (AD) or atopic eczema (AE) is a complex chronic inflammatory skin disease with a high prevalence and disease burden.1 The nomenclature for this condition has long been the subject of controversial debate within the medical community and even among global experts.2, 3 However, the terminology used not only affects experts, daily clinical practice, and research but especially patients and the general public in terms of their understanding and access to disease-related information.2-5 Given the potential of crowdsourced internet data,6 this study aimed to investigate the use of ‘atopic dermatitis’, ‘atopic eczema’, and their lay terms in internet searches and the content of these searches across 21 European countries in their respective main language.

Published
2024

16. Burden of atopic dermatitis in Europe: A population‐centred approach leveraging web search data in 21 European countries.

Author

Wecker, Hannah, Ziehfreund, Stefanie, Sitaru, Sebastian, Johansson, Emma K., Elberling, Jesper, Doll, Anaïs, Nicolaidou, Electra, Scala, Emanuele, Boffa, Michael J., Schmidt, Lea, Sikora, Mariusz, Torres, Tiago, Chernyshov, Pavel V., and Zink, Alexander

Subjects
INTERNET searching, ATOPIC dermatitis, MEDICAL personnel, WEATHER, GOVERNMENT information
Abstract

Background: The complexity, high prevalence, and substantial personal and socioeconomic burden collectively render atopic dermatitis (AD) a major public health concern. Using crowdsourced Internet data has the potential to provide unique insights into this concern, as demonstrated by several previous studies. However, a comprehensive comparison across European countries remains lacking. Objectives: The study aimed to investigate AD‐related web searches across Europe to assess spatiotemporal variations and associations between disease‐related and external factors. Methods: AD‐related web search data were extracted for 21 European countries between February 2019 and January 2023. Descriptive analysis and autocorrelation functions were performed to examine spatiotemporal patterns. Correlations (r) were used to evaluate the associations between web searches and disease‐related, socioeconomic and meteorological data. Results: Over 241 million AD‐related web searches were identified, with search volume varying substantially among European countries (p < 0.001) and correlating with AD prevalence and disease burden (both r = 0.51, p = 0.019). Search volume increased between 2019 and 2023 in all countries and seasonally peaked in January and March. Negative correlations with median population age (r = −0.46, p = 0.039), number of general practitioners (r = −0.29, p = 0.226) and specialists (r = −0.27, p = 0.270) were observed. Moderate to strong correlations were found between search volume and cold, humid and windy weather with fewer sunshine hours, while higher online interest typically occurred 1–3 months after such weather conditions. Conclusion: The study highlights the great potential of online crowdsourced data analysis, for example, to investigate the impact of climate change or to identify unmet needs at a population level. Furthermore, the growing online interest in AD and the corresponding seasonal peaks emphasize the necessity of adapting treatment plans, intensifying public health campaigns, and disseminating reliable online information by governments and healthcare providers, especially during these periods. [ABSTRACT FROM AUTHOR]

Published
2024
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17. The Intersection of the Pathogenic Processes Underlying Psoriasis and the Comorbid Condition of Obesity.

Author

Scala, Emanuele, Mercurio, Laura, Albanesi, Cristina, and Madonna, Stefania

Subjects
*PSORIASIS, *OBESITY, *METABOLIC disorders, *BIOTHERAPY, *COMORBIDITY
Abstract

In the past decade, our understanding of psoriasis pathogenesis has made significant steps forward, leading to the development of multiple game-changing therapies. While psoriasis primarily affects the skin, it is increasingly recognized as a systemic disease that can have effects beyond the skin. Obesity is associated with more severe forms of psoriasis and can potentially worsen the systemic inflammation and metabolic dysfunction seen in psoriatic patients. The exact mechanisms underlying the link between these two conditions are not fully understood, but it is believed that chronic inflammation and immune dysregulation play a role. In this review, we examine the existing body of knowledge regarding the intersection of pathogenic processes responsible for psoriasis and obesity. The ability of biological therapies to reduce systemic and obesity-related inflammation in patients with psoriasis will be also discussed. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Impact of asthma in Europe:A comparison of web search data in 21 European countries

Author

Wecker, Hannah, Tizek, Linda, Ziehfreund, Stefanie, Kain, Alphina, Traidl-Hoffmann, Claudia, Zimmermann, Gregor S., Scala, Emanuele, Elberling, Jesper, Doll, Anaïs, Boffa, Michael J., Schmidt, Lea, Sikora, Mariusz, Torres, Tiago, Ballardini, Natalia, Chernyshov, Pavel V., Buters, Jeroen, Biedermann, Tilo, Zink, Alexander, Wecker, Hannah, Tizek, Linda, Ziehfreund, Stefanie, Kain, Alphina, Traidl-Hoffmann, Claudia, Zimmermann, Gregor S., Scala, Emanuele, Elberling, Jesper, Doll, Anaïs, Boffa, Michael J., Schmidt, Lea, Sikora, Mariusz, Torres, Tiago, Ballardini, Natalia, Chernyshov, Pavel V., Buters, Jeroen, Biedermann, Tilo, and Zink, Alexander

Abstract

Background: Asthma is a chronic inflammatory disorder of the airways and one of the most important non-communicable diseases worldwide. Analyzing crowdsourced data can help understand public interest and unmet needs as well as potential factors influencing search behavior. Objective: The study aimed to investigate asthma-related web search data in Europe to identify possible regional and seasonal variations and to assess public interest. Methods: Google Ads Keyword Planner was used to measure search volume for search terms related to asthma, allergic asthma, and bronchial asthma in 21 European countries between January 2018 and December 2021. The top 10 keywords of each country were categorized qualitatively. Search volume per 100 000 inhabitants was descriptively assessed in terms of regional and seasonal trends. Spearman correlations between search volume and pollen concentration as well as coronavirus disease (COVID-19) cases were investigated. Results: The median search volume per 100 000 inhabitants for asthma and allergic asthma was highest in Northern and Western Europe, while the highest search volume for bronchial asthma was observed in Western and Eastern regions. A seasonal trend was identified for all search terms and in all regions. Correlations were found between search frequency and pollen load and search behavior and COVID-19 cases. Overall, Europeans were most interested in the diseases in general, their treatment options, and symptoms. Conclusion: These results highlighted the need for reliable and region-specific information about the disease and for public campaigns to improve asthma control. The study also emphasizes the importance of using crowdsourced data for a more encompassing overview beyond conventional healthcare data.

Published
2023

23. The potential role of serum polyclonal free light chains as markers of immune activation in psoriatic patients

Author

Caprio, Roberta DI, additional, Sacchelli, Lidia, additional, Spigna, Gaetano DI, additional, Ricciardone, Margherita, additional, Bardazzi, Federico, additional, Ladogana, Paolo, additional, Scala, Emanuele, additional, Fabbrocini, Gabriella, additional, Covelli, Bianca, additional, Balato, Anna, additional, and Postiglione, Loredana, additional

Published
2023
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28. Sociodemographic, clinical and therapeutic factors as predictors of life quality impairment in psoriasis: A cross-sectional study in Italy

Author

Scala, Emanuele, Kaczmarczyk, Robert, Zink, Alexander, Balato, Anna, Hansel, Katharina, Stingeni, Luca, Scala, E., Kaczmarczyk, R., Zink, A., and Balato, A.

Subjects
Cross-Sectional Studie, comorbiditie, Tumor Necrosis Factor Inhibitor, Arthritis, sociodemographic factors, Arthritis, Psoriatic, Psoriatic, Dermatology, General Medicine, psoriasis, comorbidities, Severity of Illness Index, life quality, Cross-Sectional Studies, sociodemographic factor, biological therapy, Quality of Life, Humans, Tumor Necrosis Factor Inhibitors, Psoriasis, psoriasi, Human
Abstract

Psoriasis is a chronic inflammatory skin disease showing a high burden due to its aesthetic, social, psychological, and quality of life (QoL) implications which also affect patient-physician relationship and, consequently, the adherence to treatments. Limited data on the natural history of psoriasis and factors predicting its prognosis are available. The aim of this study was to investigate patients' global characteristics, including treatments, associated with QoL impairment in psoriasis. Questionnaires evaluating sociodemographic features and Dermatology Life Quality Index (DLQI) were administered to patients. Multiple regression analysis was performed to evaluate factors associated with a large effect on patient's life (DLQI > 10), moderate effect on patient's life (DLQI ≥ 6 ≤ 10), small effect on patient's life (DLQI ≥ 2 < 6), and no effect on patient's life (DLQI < 2). Overall, 1052 consecutive patients affected by mild-to-severe psoriasis were recruited. Our logistic regression analysis showed that the influencing factors for a large effect on QoL were living in Southern Italy, depression, psoriatic arthritis, and psoriasis localization on facial, intertriginous, palmoplantar, trunk and scalp regions. For a moderate effect on patient's life, phototherapy and non-biological systemic therapies resulted to be the predictive factors. Mild psoriasis, living in social housing and the isolated involvement of scalp psoriasis had a small effect on QoL. Lastly, mild psoriasis and current biological therapies including anti-IL-12/23, anti-IL-17, and anti-TNF-α were positively associated with no life quality impairment. Perceived quality of life impairment in psoriasis not only depends on the skin disease but rather on patients' global characteristics. Therefore, the individual background of these patients should be respected in the selection of treatment options.

Published
2022

31. Hidradenitis Suppurativa: Where We Are and Where We Are Going

Author

Scala, Emanuele, primary, Cacciapuoti, Sara, additional, Garzorz-Stark, Natalie, additional, Megna, Matteo, additional, Marasca, Claudio, additional, Seiringer, Peter, additional, Volz, Thomas, additional, Eyerich, Kilian, additional, and Fabbrocini, Gabriella, additional

Published
2021
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34. Toxicity of malathion during Senegalese sole, Solea senegalensis larval development and metamorphosis: Histopathological disorders and effects on type B esterases and CYP1A enzymatic systems

Author

Anatomía Patológica, Biología Celular, Histología, Historia de la Ciencia, Medicina Legal y Forense y Toxicología, Ortiz-Delgado, Juan Bosco, Funes, Victoria, Albendín García, María Gemma, Scala, Emanuele, Sarasquete Reiriz, María del Carmen, Anatomía Patológica, Biología Celular, Histología, Historia de la Ciencia, Medicina Legal y Forense y Toxicología, Ortiz-Delgado, Juan Bosco, Funes, Victoria, Albendín García, María Gemma, Scala, Emanuele, and Sarasquete Reiriz, María del Carmen

Abstract

The toxicity of malathion to Solea senegalensis was studied in a static renewal bioassay during its first month of larval life (between 4 and 30 dph). Through the use of different biomarkers and biochemical, cellular and molecular approaches (inhibition of cholinesterases [ChEs], changes in cytochrome P450-1A [CYP1A] and the study of histopathological alterations), the effects of three concentrations of malathion (1.56, 3.12, and 6.25 mu g/L) have been analyzed. In subacute exposure, malathion inhibited cholinesterase activities (AChE, BChE, CbE) in a dose- and time-dependent manner, ranging the inhibition percentage from 20% to 90%. However, the expression levels of CYP1A and AChE transcripts or proteins were not modified. Additionally, exposure to malathion provoked histopathological alterations in several organ systems of Senegalese sole in a time- and dose dependent way, namely disruption of parenchymal architecture in the liver, epithelial desquamation, pyknotic nuclei and steatosis in the intestine, disorganization of supporting cartilage, and sings of hyperplasia and hypertrophy in the gills and degeneration of the epithelial cells from the renal tubules. Malathion exposure also provoked strong disorganization of cardiac fibers from the heart. The findings provide evidence that exposure to sublethal concentrations of malathion that provoked serious injury to the fish S. senegalensis, were below the expected environmental concentrations reported in many other ecosystems and different fish species,revealing a higher sensitivity for Solea senegalensis to malathion exposure, thus reinforcing its use as sentinel species for environmental pollution in coastal and estuarine environments.

Published
2021

35. A new TH17 cytokine in hidradenitis suppurativa: antimicrobial and pro-inflammatory role of IL-26

Author

Scala, Emanuele

Abstract

Interleukin (IL)-26 is a member of the IL-10 cytokine family which includes IL-10, IFN-λs (IL-28A/B and IL-29), and the IL-20 subfamily (IL-19, IL-20, IL-22, IL-24, and IL-26). It is mainly expressed in Th17 cells and plays a dual role. Indeed, IL-26 is a pro-inflammatory cytokine that exerts antimicrobial response producing direct bactericidal action through affecting the formation of membrane pores. IL-26 acts through IL-10R2/IL-20R1 heterodimeric receptor. While IL-10R2 is broadly expressed, IL-20R1 is mainly expressed by epithelial cell types, including keratinocytes, suggesting its possible role in the immune response of the skin. To date, IL-26 has been implicated in psoriasis and allergic contact dermatitis (ACD). In particular, IL-26 contribute to the cytotoxic mechanism, proper of ACD. This mechanism is responsible for the tissue injury of immune-mediated skin diseases, including Hidradenitis Suppurativa (HS). The latter is characterized by recurrent, painful, nodules and abscesses that break, leading to the formation of sinus tracts and scarring. Lesions usually affect apocrine gland-bearing anatomical areas of the body involving build-up of keratin within the hair follicle that plugs the follicle causing the occlusion and subsequent rupture of pilosebaceous unit. Morever, colonies of specialized bacteria (mainly, staphylococci and streptococci) bind irreversibly to sinus tract epithelium and hair follicles, further sustaining chronic inflammation. In this study, we have evaluated IL-26 in HS exploring its antimicrobial activity.

Published
2020

36. Immunocytometric analysis of COVID patients: A contribution to personalized therapy?

Author

Cacciapuoti, Sara, primary, De Rosa, Annunziata, additional, Gelzo, Monica, additional, Megna, Matteo, additional, Raia, Maddalena, additional, Pinchera, Biagio, additional, Pontarelli, Agostina, additional, Scotto, Riccardo, additional, Scala, Emanuele, additional, Scarano, Francesco, additional, Scalia, Giulia, additional, Castaldo, Giuseppe, additional, Fabbrocini, Gabriella, additional, Gentile, Ivan, additional, and Parrella, Roberto, additional

Published
2020
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39. Patients’ demographic and socioeconomic characteristics influence the therapeutic decision-making process in psoriasis

Author

Scala, Emanuele, primary, Megna, Matteo, additional, Amerio, Paolo, additional, Argenziano, Giuseppe, additional, Babino, Graziella, additional, Bardazzi, Federico, additional, Bianchi, Luca, additional, Caldarola, Giacomo, additional, Campanati, Anna, additional, Cannavò, Serafinella Patrizia, additional, Chiricozzi, Andrea, additional, Conti, Andrea, additional, Damiani, Giovanni, additional, Dapavo, Paolo, additional, De Simone, Clara, additional, Esposito, Maria, additional, Fabbrocini, Gabriella, additional, Fargnoli, Maria Concetta, additional, Ferrara, Francesca, additional, Fidanza, Rosaria, additional, Gualdi, Giulio, additional, Guarneri, Claudio, additional, Hansel, Katharina, additional, Malagoli, Piergiorgio, additional, Malara, Giovanna, additional, Micali, Giuseppe, additional, Mugheddu, Cristina, additional, Musumeci, Maria Letizia, additional, Odorici, Giulia, additional, Offidani, Annamaria, additional, Pescitelli, Leonardo, additional, Prignano, Francesca, additional, Raimondo, Annunziata, additional, Ribero, Simone, additional, Rongioletti, Franco, additional, Stingeni, Luca, additional, Trifirò, Caterina, additional, Zanframundo, Salvatore, additional, and Balato, Anna, additional

Published
2020
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43. Toxicity of malathion at early life stages of the Senegalese sole, Solea senegalensis (Kaup, 1858): notochord and somatic disruptions

Author

Ortiz Delgado, Juan B., Scala, Emanuele, Arellano, Juana M., Úbeda Manzanaro, María, and Sarasquete, Carmen

Subjects
Larvae, 6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU], Malathion, Notochord, Histopathology, Senegalese sole
Abstract

The toxicity of malathion to Solea senegalensis was studied in a static renewal bioassay for 24, 48 and 72 h, with toxicant concentrations ranging from 1.56 until 100 µgL-1. The LC50 values of malathion for 48 and 72-h was 63.5 (95% C.I: 50.83-79.34) and 22.94 (95% C.I: 17.16-30.68) µgL-1 respectively. The survival of larvae was non-affected by exposure to malathion at concentrations up to 25 µgL-1 (24 h NOEC), 6.25 µgL-1 (48 h NOEC) and

Published
2018

44. Additional file 1: of Circulating levels of IL-1 family cytokines and receptors in Alzheimer’s disease: new markers of disease progression?

Author

Italiani, Paola, Puxeddu, Ilaria, Napoletano, Sabrina, Scala, Emanuele, Melillo, Daniela, Manocchio, Simone, Angiolillo, Antonella, Migliorini, Paola, Boraschi, Diana, Vitale, Emilia, and Costanzo, Alfonso

Abstract

Results of multiple linear regression models without control for confounding variables. Values are β coefficients (95% confidence intervals) and p values. AD, Alzheimer’s disease; MCI, mild cognitive impairment; NHS, normal healthy subjects; SMC, subjective memory complaint. (PDF 78 kb)

Published
2018
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45. Additional file 2: of Circulating levels of IL-1 family cytokines and receptors in Alzheimer’s disease: new markers of disease progression?

Author

Italiani, Paola, Puxeddu, Ilaria, Napoletano, Sabrina, Scala, Emanuele, Melillo, Daniela, Manocchio, Simone, Angiolillo, Antonella, Migliorini, Paola, Boraschi, Diana, Vitale, Emilia, and Costanzo, Alfonso

Abstract

Results of multiple linear regression models with control for confounding variables. Values are β coefficients (95% confidence intervals) and p values. AD, Alzheimer’s disease; MCI, mild cognitive impairment; NHS, normal healthy subjects; SMC, subjective memory complaint. (PDF 75 kb)

Published
2018
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46. Ixekizumab Effectiveness and Safety in the Treatment of Moderate-to-Severe Plaque Psoriasis: A Multicenter, Retrospective Observational Study

Author

Chiricozzi, Andrea, primary, Burlando, Martina, additional, Caldarola, Giacomo, additional, Conti, Andrea, additional, Damiani, Giovanni, additional, De Simone, Clara, additional, Dini, Valentina, additional, Malagoli, Piergiorgio, additional, Peccerillo, Francesca, additional, Potenza, Concetta, additional, Scala, Emanuele, additional, Skroza, Nevena, additional, and Balato, Anna, additional

Published
2019
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