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165 results on '"Scaffidi M"'

1. Patient Position and ERCP Outcomes in Patients with Surgically Altered Foregut Anatomy

Author

Malipatil, S., additional, Khalaf, K., additional, Scaffidi, M., additional, Tham, D., additional, Chopra, D., additional, Mokhtar, A., additional, Na, C., additional, Abal, S., additional, Jugnundan, S., additional, Gupta, S., additional, Fujiyoshi, M.R. A., additional, Fujiyoshi, Y., additional, Pawlak, K. M., additional, Gimpaya, N., additional, Calo, N., additional, Mosko, J., additional, Teshima, C., additional, May, G., additional, and Grover, S., additional

Published
2024
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2. The Role of Preventative Therapies in Stricture Formation Post Esophageal Endoscopic Resection

Author

Tham, D., additional, Khalaf, K., additional, Seleq, S., additional, Mohan, B. P., additional, Spadaccini, M., additional, Gimpaya, N., additional, Fujiyoshi, Y., additional, Fujiyoshi, M.R. A., additional, Malipatil, S., additional, Pawlak, K. M., additional, Scaffidi, M., additional, Khan, R., additional, Forbes, N., additional, Bechara, R., additional, Hassan, C., additional, Repici, A., additional, Calo, N., additional, Mosko, J., additional, Teshima, C., additional, May, G., additional, and Grover, S., additional

Published
2024
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6. A143 PATIENT POSITION AND ENDOSCOPIC CHOLANGIOPANCREATOGRAPHY (ERCP) TECHNICAL SUCCESS AMONG PATIENTS WITH SURGICALLY ALTERED FOREGUT ANATOMY: A RETROSPECTIVE ANALYSIS

Author

Scaffidi, M, primary, Khalaf, K, additional, Pawlak, K, additional, Chopra, D, additional, Tham, D, additional, Malipatil, S B, additional, Gimpaya, N, additional, Chan, B, additional, Yeung, E, additional, Forbes, N, additional, Calo, N, additional, Mokhtar, A, additional, Na, C, additional, Mosko, J, additional, May, G, additional, and Grover, S, additional

Published
2024
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8. Primary biliary cholangitis: perception and expectation of illness

Author

Floreani, A, Scaffidi, M, Coco, B, Giannini, E, Labanca, S, Bonaiuto, E, De Martin, S, Invernizzi, P, Carbone, M, Alvaro, D, Bragazzi, M, Calvaruso, V, Cossiga, V, Cazzagon, N, Floreani A., Scaffidi M., Coco B., Giannini E. G., Labanca S., Bonaiuto E., De Martin S., Invernizzi P., Carbone M., Alvaro D., Bragazzi M. C., Calvaruso V., Cossiga V., Cazzagon N., Floreani, A, Scaffidi, M, Coco, B, Giannini, E, Labanca, S, Bonaiuto, E, De Martin, S, Invernizzi, P, Carbone, M, Alvaro, D, Bragazzi, M, Calvaruso, V, Cossiga, V, Cazzagon, N, Floreani A., Scaffidi M., Coco B., Giannini E. G., Labanca S., Bonaiuto E., De Martin S., Invernizzi P., Carbone M., Alvaro D., Bragazzi M. C., Calvaruso V., Cossiga V., and Cazzagon N.

Abstract

An important tool to explore personal experience of symptoms, treatment and clinical outcome is stratification of illness perception in patients affected by PBC. Aim: To assess the perception of illness in a cohort of Italian patients with PBC. Methods: Between June and December 2019, a specific questionnaire was administered to a pool of 210 patients from 7 tertiary Italian centers, in order to identify and assess the patient's past history, symptoms and their impact on the quality of life, follow-up, treatment and perceived satisfaction of patients toward the provided care. Results: Fatigue, pruritus, and abdominal discomfort and sicca syndrome were present in 50.4%, 45%, 30.4% and 28.5% of patients, fatigue having the most impacting the daily-life. After a consultation with a specialist, the diagnosis of PBC was met within 18 months for 143 patients. Patients were mostly concerned about possible health problems that occur and in 25% of cases, symptoms had a negative impact on their life. Eighty percent of patients said they were satisfied with efficacy and tolerability of treatment, while 26% requested an improvement in the relationship with the specialist. Conclusions: The results highlight the importance of both promoting timely referral to the specialist and facilitating communication between healthcare professionals and patients.

Published
2022

10. A117 VALIDITY EVIDENCE FOR ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY COMPETENCY ASSESSMENT TOOLS: A SYSTEMATIC REVIEW

Author

Khan, R, primary, Homsi, H, additional, Gimpaya, N, additional, Sabrie, N, additional, Gholami, R, additional, Bansal, R, additional, Scaffidi, M, additional, Lightfoot, D, additional, James, P, additional, Siau, K, additional, Forbes, N, additional, Wani, S, additional, Keswani, R, additional, Walsh, C, additional, and Grover, S, additional

Published
2023
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24. A77 A REUSABLE POLYCARBONATE BOX TO DECREASE DROPLET CONTAMINATION DURING UPPER ENDOSCOPY: A SIMULATION-BASED STUDY FOR THE COVID-19 PANDEMIC

Author

Gimpaya, N, primary, Khan, R, additional, Gallinger, Z R, additional, Scaffidi, M A, additional, Al Abdulqader, A K, additional, Ahmed, M, additional, Gholami, R, additional, Ramkissoon, A, additional, James, P D, additional, Mosko, J, additional, Griller, N, additional, Bansal, R, additional, and Grover, S C, additional

Published
2021
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28. A Comprehensive Assessment of Human Natural Killer Cell Phenotype and Function in Whole Blood

Author

Scaffidi M, Gayashan Tennakoon, de Souza Ct, Michael A. Kennedy, Marisa Market, Rebecca C. Auer, and Juliana Ng

Subjects
Cytokine, medicine.anatomical_structure, Chemistry, medicine.medical_treatment, Receptor expression, Extracellular, medicine, IL-2 receptor, Receptor, Peripheral blood mononuclear cell, Molecular biology, Whole blood, Natural killer cell
Abstract

The majority of data on human Natural Killer (NK) cell phenotype and function has been generated using cryopreserved peripheral blood mononuclear cells (PBMCs). However, cryopreservation can have adverse effects on PBMCs. In contrast, investigating immune cells in whole blood can reduce the time, volume of blood required, and potential artifacts associated with manipulation of the cells. Whole blood collected from healthy donors and cancer patients was processed by three separate protocols that can be used independently or in parallel to assess extracellular receptors, intracellular signaling protein phosphorylation, and intracellular and extracellular cytokine production in human NK cells. To assess extracellular receptor expression, 200 μL of whole blood was incubated with an extracellular staining (ECS) mix and cells were subsequently fixed and RBCs lysed prior to analysis. The phosphorylation status of signaling proteins was assessed in 500 μL of whole blood following co-incubation with interleukin (IL)−2/12 and the ECS mix for 20 minutes prior to cell fixation and RBC lysis and subsequent permeabilization for staining with an intracellular staining (ICS) mix. Cytokine production (IFNγ) was similarly assessed by incubating 1 mL of whole blood with PMA-ionomycin or IL−2/12 prior to incubation with ECS and subsequent ICS antibodies. In addition, plasma was collected from stimulated samples prior to ECS for quantification of secreted IFNγ by ELISA. Results were consistent, despite inherent interpatient variability. Although we did not investigate an exhaustive list of targets, this approach enabled quantification of representative ECS surface markers including activating (NKG2D and DNAM−1) and inhibitory (NKG2D, PD−1, TIGIT, and TIM−3) receptors, cytokine receptors (CD25, CD122, CD132, and CD212) and ICS markers associated with NK cell activation following stimulation, including signaling protein phosphorylation (p-STAT4, p-STAT5, p-p38 MAPK, p-S6K) and IFNγ in both healthy donors and cancer patients. In addition, we compared extracellular receptor expression using whole blood versus cryopreserved PBMCs and observed a significant difference in the expression of almost all receptors. The methods presented permit a relatively rapid parallel assessment of immune cell receptor expression, signaling protein activity, and cytokine production in a minimal volume of whole blood from both healthy donors and cancer patients.

Published
2020
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34. Perception of illness in Italian patients with Primary Biliary Cholangitis referred to tertiary care units

Author

Cazzagon, N., primary, Scaffidi, M., additional, Coco, B., additional, Giannini, E.G., additional, Cacciato, V., additional, Bonaiuto, E., additional, De Martin, S., additional, Invernizzi, P., additional, Carbone, M., additional, Alvaro, D., additional, Bragazza, M.C., additional, Calvaruso, V., additional, Morisco, F., additional, and Floreani, A., additional

Published
2020
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