Search

Your search keyword '"Sazgary, Lorraine"' showing total 30 results
Start Over Author "Sazgary, Lorraine"
30 results on '"Sazgary, Lorraine"'

1. Dose escalation for stereotactic arrhythmia radioablation of recurrent ventricular tachyarrhythmia - a phase II clinical trial

Author

Kovacs, Boldizsar, Mayinger, Michael, Ehrbar, Stefanie, Fesslmeier, Debra, Ahmadsei, Maiwand, Sazgary, Lorraine, Manka, Robert, Alkadhi, Hatem, Ruschitzka, Frank, Duru, Firat, Papachristofilou, Alexandros, Sticherling, Christian, Blamek, Slawomir, Gołba, Krzysztof S., Guckenberger, Matthias, Saguner, Ardan M., and Andratschke, Nicolaus

Published
2023
Full Text
View/download PDF

2. The Impact of Clinical Radiation Audits on Patient Radiation Exposure in Cardiac Implantable Electronic Device Procedures

Author

Sazgary, Lorraine, primary, Samara, Eleni Theano, additional, Stüssi, Anja, additional, Saltybaeva, Natalia, additional, Guckenberger, Matthias, additional, Ruschitzka, Frank, additional, Wolber, Thomas, additional, Molitor, Nadine, additional, Hofer, Daniel, additional, Guan, Fu, additional, Suna, Gonca, additional, Hermes-Laufer, Julia, additional, Breitenstein, Alexander, additional, Brunckhorst, Corinna B., additional, Duru, Firat, additional, and Saguner, Ardan M., additional

Published
2024
Full Text
View/download PDF

3. Comparison of fourteen rule-out strategies for acute myocardial infarction

Author

Mueller, Deborah, Sazgary, Lorraine, Marbot, Stella, Sabti, Zaid, Flores, Dayana, Meissner, Kathrin, Kulangara, Caroline, Freese, Michael, Osswald, Stefan, Stelzig, Claudia, Bingisser, Roland, López, Beatriz, Agüero, María Martínez, Nowalany-Kozielska, Ewa, Kawecki, Damian, Parenica, Jiri, Ganovská, Eva, Lohrmann, Jens, Buser, Andreas, Grimm, Karin, Hartmann, Beate, Muzyk, Piotr, Rentsch, Katharina, von Eckardstein, Arnold, Wildi, Karin, Boeddinghaus, Jasper, Nestelberger, Thomas, Twerenbold, Raphael, Badertscher, Patrick, Wussler, Desiree, Giménez, Maria Rubini, Puelacher, Christian, du Fay de Lavallaz, Jeanne, Dietsche, Sebastian, Walter, Joan, Kozhuharov, Nikola, Morawiec, Beata, Miró, Òscar, Javier Martin-Sanchez, F., Subramaniam, Sinthuri, Geigy, Nicolas, Keller, Dagmar I., Reichlin, Tobias, and Mueller, Christian

Published
2019
Full Text
View/download PDF

4. Incremental diagnostic and prognostic value of the QRS-T angle, a 12-lead ECG marker quantifying heterogeneity of depolarization and repolarization, in patients with suspected non-ST-elevation myocardial infarction

Author

Strebel, Ivo, Twerenbold, Raphael, Wussler, Desiree, Boeddinghaus, Jasper, Nestelberger, Thomas, du Fay de Lavallaz, Jeanne, Abächerli, Roger, Maechler, Patrick, Mannhart, Diego, Kozhuharov, Nikola, Rubini Giménez, Maria, Wildi, Karin, Sazgary, Lorraine, Sabti, Zaid, Puelacher, Christian, Badertscher, Patrick, Keller, Dagmar I., Miró, Òscar, Fuenzalida, Carolina, Calderón, Sofia, Martin-Sanchez, F. Javier, Iglesias, Sergio Lopez, Osswald, Stefan, Mueller, Christian, and Reichlin, Tobias

Published
2019
Full Text
View/download PDF

5. Prospective validation of prognostic and diagnostic syncope scores in the emergency department

Author

du Fay de Lavallaz, Jeanne, Badertscher, Patrick, Nestelberger, Thomas, Isenrich, Rahel, Miró, Òscar, Salgado, Emilio, Geigy, Nicolas, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F. Javier, Bustamante Mandrión, José, Di Somma, Salvatore, Peacock, W. Frank, Kawecki, Damian, Boeddinghaus, Jasper, Twerenbold, Raphael, Puelacher, Christian, Wussler, Desiree, Strebel, Ivo, Keller, Dagmar I., Poepping, Imke, Kühne, Michael, Mueller, Christian, Reichlin, Tobias, Giménez, Maria Rubini, Walter, Joan, Kozhuharov, Nikola, Shrestha, Samyut, Mueller, Deborah, Sazgary, Lorraine, Morawiec, Beata, Muzyk, Piotr, Nowalany-Kozielska, Ewa, Freese, Michael, Stelzig, Claudia, Meissner, Kathrin, Kulangara, Caroline, Hartmann, Beate, Ferel, Ina, Sabti, Zaid, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, von Eckardstein, Arnold, Buser, Andreas, Kloos, Wanda, Lohrmann, Jens, and Osswald, Stefan

Published
2018
Full Text
View/download PDF

6. Comparison of high-sensitivity cardiac troponin I and T for the prediction of cardiac complications after non-cardiac surgery

Author

Gualandro, Danielle M, Puelacher, Christian, LuratiBuse, Giovanna, Lampart, Andreas, Strunz, Celia, Cardozo, Francisco A, Yu, Pai C, Jaffe, Allan S, Barac, Sanela, Bock, Lukas, Badertscher, Patrick, du Fay de Lavallaz, Jeanne, Marbot, Stella, Sazgary, Lorraine, Bolliger, Daniel, Rentsch, Katharina, Twerenbold, Raphael, Hammerer-Lercher, Angelika, Melo, Edielle S, Calderaro, Daniela, Duarte, Alberto JS, de Luccia, Nelson, Caramelli, Bruno, and Mueller, Christian

Published
2018
Full Text
View/download PDF

7. Combining high-sensitivity cardiac troponin and B-type natriuretic peptide in the detection of inducible myocardial ischemia

Author

Puelacher, Christian, Wagener, Max, Honegger, Ursina, Assadian, Mustafa, Schaerli, Nicolas, Mueller, Deborah, Strebel, Ivo, Twerenbold, Raphael, Boeddinghaus, Jasper, Nestelberger, Thomas, Wildi, Karin, Sabti, Zaid, Sazgary, Lorraine, Badertscher, Patrick, du Fay de Lavallaz, Jeanne, Marbot, Stella, Kaiser, Christoph, Wild, Damian, Zellweger, Michael J., Reichlin, Tobias, and Mueller, Christian

Published
2018
Full Text
View/download PDF

8. Automatically computed ECG algorithm for the quantification of myocardial scar and the prediction of mortality

Author

Badertscher, Patrick, Strebel, Ivo, Honegger, Ursina, Schaerli, Nicolas, Mueller, Deborah, Puelacher, Christian, Wagener, Max, Abächerli, Roger, Walter, Joan, Sabti, Zaid, Sazgary, Lorraine, Marbot, Stella, du Fay de Lavallaz, Jeanne, Twerenbold, Raphael, Boeddinghaus, Jasper, Nestelberger, Thomas, Kozhuharov, Nikola, Breidthardt, Tobias, Shrestha, Samyut, Flores, Dayana, Schumacher, Carmela, Wild, Damian, Osswald, Stefan, Zellweger, Michael J., Mueller, Christian, and Reichlin, Tobias

Published
2018
Full Text
View/download PDF

9. Dose escalation for stereotactic arrhythmia radioablation of recurrent ventricular tachyarrhythmia - a phase II clinical trial

Author

Kovacs, Boldizsar; https://orcid.org/0000-0002-7972-5199, Mayinger, Michael; https://orcid.org/0000-0003-4433-2552, Ehrbar, Stefanie; https://orcid.org/0000-0002-2471-1259, Fesslmeier, Debra, Ahmadsei, Maiwand, Sazgary, Lorraine, Manka, Robert; https://orcid.org/0000-0002-3383-4998, Alkadhi, Hatem; https://orcid.org/0000-0002-2581-2166, Ruschitzka, Frank; https://orcid.org/0000-0001-5972-0596, Duru, Firat; https://orcid.org/0000-0002-4748-0158, Papachristofilou, Alexandros, Sticherling, Christian; https://orcid.org/0000-0001-8428-7050, Blamek, Slawomir, Gołba, Krzysztof S, Guckenberger, Matthias; https://orcid.org/0000-0002-7146-9071, Saguner, Ardan M; https://orcid.org/0000-0003-1896-0803, Andratschke, Nicolaus; https://orcid.org/0000-0003-3647-5916, Kovacs, Boldizsar; https://orcid.org/0000-0002-7972-5199, Mayinger, Michael; https://orcid.org/0000-0003-4433-2552, Ehrbar, Stefanie; https://orcid.org/0000-0002-2471-1259, Fesslmeier, Debra, Ahmadsei, Maiwand, Sazgary, Lorraine, Manka, Robert; https://orcid.org/0000-0002-3383-4998, Alkadhi, Hatem; https://orcid.org/0000-0002-2581-2166, Ruschitzka, Frank; https://orcid.org/0000-0001-5972-0596, Duru, Firat; https://orcid.org/0000-0002-4748-0158, Papachristofilou, Alexandros, Sticherling, Christian; https://orcid.org/0000-0001-8428-7050, Blamek, Slawomir, Gołba, Krzysztof S, Guckenberger, Matthias; https://orcid.org/0000-0002-7146-9071, Saguner, Ardan M; https://orcid.org/0000-0003-1896-0803, and Andratschke, Nicolaus; https://orcid.org/0000-0003-3647-5916

Abstract

BACKGROUND: Stereotactic arrhythmia radioablation (STAR) is delivered with a planning target volume (PTV) prescription dose of 25 Gy, mostly to the surrounding 75-85% isodose line. This means that the average and maximum dose received by the target is less than 35 Gy, which is the minimum threshold required to create a homogenous transmural fibrosis. Similar to catheter ablation, the primary objective of STAR should be transmural fibrosis to prevent heterogenous intracardiac conduction velocities and the occurrence of sustained ventricular arrhythmias (sVA) caused by reentry. We hypothesize that the current dose prescription used in STAR is inadequate for the long-term prevention of sVA and that a significant increase in dose is necessary to induce transmural scar formation. OBJECTIVE: A single arm, multi-center, phase II, dose escalation prospective clinical trial employing the i3 + 3 design is being conducted to examine the safety of a radiation dose-escalation strategy aimed at inducing transmural scar formation. The ultimate objective of this trial is to decrease the likelihood of sVA recurrence in patients at risk. METHODS: Patients with ischemic or non-ischemic cardiomyopathy and recurrent sVA, with an ICD and history of ≥ 1 catheter ablation for sVA will be included. This is a prospective, multicenter, one-arm, dose-escalation trial utilizing the i3 + 3 design, a modified 3 + 3 specifically created to overcome limitations in traditional dose-finding studies. A total of 15 patients will be recruited. The trial aims to escalate the ITV dose from 27.0 Gy to an ITV prescription dose-equivalent level of maximum 35.1 Gy by keeping the PTV prescription dose constant at 25 Gy while increasing the dose to the target (i.e. the VT substrate without PTV margin) by step-wise reduction of the prescribing isodose line (85% down to 65%). The primary outcome of this trial is safety measured by registered radiation associated adverse events (AE) up to 90 days after study inter

Published
2023

10. Direct Comparison of the 0/1h and 0/3h Algorithms for Early Rule-Out of Acute Myocardial Infarction

Author

Badertscher, Patrick, Boeddinghaus, Jasper, Twerenbold, Raphael, Nestelberger, Thomas, Wildi, Karin, Wussler, Desiree, Schwarz, Jonas, Puelacher, Christian, Rubini Giménez, Maria, Kozhuharov, Nikola, du Fay de Lavallaz, Jeanne, Cerminara, Sara Elisa, Potlukova, Eliska, Rentsch, Katharina, Miró, Òscar, López, Beatriz, Martin-Sanchez, F. Javier, Morawiec, Beata, Muzyk, Piotr, Keller, Dagmar I., Reichlin, Tobias, Mueller, Christian, Sabti, Zaid, Strebel, Ivo, Shrestha, Samyut, Flores, Dayana, Freese, Michael, Stelzig, Claudia, Kulangara, Caroline, Meissner, Kathrin, Schaerli, Nicolas, Mueller, Deborah, Yufera Sanchez, Ana, Sazgary, Lorraine, Marbot, Stella, Fuenzalida, Carolina, Calderón, Sofia, Rodriguez Adrada, Esther, Kawecki, Damian, Nowalany-Kozielska, Ewa, Parenica, Jiri, Ganovská, Eva, von Eckardstein, Arnold, Lohrmann, Jens, Kloos, Wanda, Osswald, Stefan, Buser, Andreas, Bingisser, Roland, and Geigy, Nicolas

Published
2018
Full Text
View/download PDF

11. Perioperative Myocardial Injury After Noncardiac Surgery: Incidence, Mortality, and Characterization

Author

Puelacher, Christian, Lurati Buse, Giovanna, Seeberger, Daniela, Sazgary, Lorraine, Marbot, Stella, Lampart, Andreas, Espinola, Jaqueline, Kindler, Christoph, Hammerer, Angelika, Seeberger, Esther, Strebel, Ivo, Wildi, Karin, Twerenbold, Raphael, du Fay de Lavallaz, Jeanne, Steiner, Luzius, Gurke, Lorenz, Breidthardt, Tobias, Rentsch, Katharina, Buser, Andreas, Gualandro, Danielle M., Osswald, Stefan, Mueller, Christian, Seeberger, Manfred, Christ-Crain, Mirjam, Cuculi, Florim, Badertscher, Patrick, Nestelberger, Thomas, Wussler, Desiree, Flores, Dayana, Boeddinghaus, Jasper, Sabti, Zaid, Giménez, Maria Rubini, Kozhuharov, Nikola, Shrestha, Samyut, Kloos, Wanda, Lohrmann, Jens, Reichlin, Tobias, Freese, Michael, Meissner, Kathrin, Kaiser, Christoph, and Buser, Andreas

Published
2018
Full Text
View/download PDF

13. 0/1-Hour Triage Algorithm for Myocardial Infarction in Patients With Renal Dysfunction

Author

Twerenbold, Raphael, Badertscher, Patrick, Boeddinghaus, Jasper, Nestelberger, Thomas, Wildi, Karin, Puelacher, Christian, Sabti, Zaid, Rubini Gimenez, Maria, Tschirky, Sandra, du Fay de Lavallaz, Jeanne, Kozhuharov, Nikola, Sazgary, Lorraine, Mueller, Deborah, Breidthardt, Tobias, Strebel, Ivo, Flores Widmer, Dayana, Shrestha, Samyut, Miró, Òscar, Martín-Sánchez, F. Javier, Morawiec, Beata, Parenica, Jiri, Geigy, Nicolas, Keller, Dagmar I., Rentsch, Katharina, von Eckardstein, Arnold, Osswald, Stefan, Reichlin, Tobias, and Mueller, Christian

Published
2018
Full Text
View/download PDF

15. Daytime variation of perioperative myocardial injury in non-cardiac surgery and effect on outcome

Author

du Fay de Lavallaz, Jeanne, Puelacher, Christian, Lurati Buse, Giovanna, Bolliger, Daniel, Germanier, Dominic, Hidvegi, Reka, Walter, Joan Elias, Twerenbold, Raphael, Strebel, Ivo, Badertscher, Patrick, Sazgary, Lorraine, Lampart, Andreas, Espinola, Jaqueline, Kindler, Christoph, Hammerer-Lercher, Angelika, Thambipillai, Saranya, Guerke, Lorenz, Rentsch, Katharina, Buser, Andreas, Gualandro, Danielle, Jakob, Marcel, Mueller, Christian, and Basel-PMI Investigators

Subjects
Male, medicine.medical_specialty, Myocardial Infarction, 030204 cardiovascular system & hematology, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Troponin T, medicine, Humans, Prospective Studies, 030212 general & internal medicine, Myocardial infarction, Propensity Score, Aged, Morning, business.industry, Incidence, Incidence (epidemiology), Perioperative, Prognosis, medicine.disease, Circadian Rhythm, Cardiac surgery, C-Reactive Protein, Surgical Procedures, Operative, Anesthesia, Preoperative Period, Cohort, Propensity score matching, Female, Cardiology and Cardiovascular Medicine, business, Biomarkers, Switzerland, Follow-Up Studies
Abstract

ObjectiveRecently, daytime variation in perioperative myocardial injury (PMI) has been observed in patients undergoing cardiac surgery. We aim at investigating whether daytime variation also occurs in patients undergoing non-cardiac surgery.MethodsIn a prospective diagnostic study, we evaluated the presence of daytime variation in PMI in patients at increased cardiovascular risk undergoing non-cardiac surgery, as well as its possible impact on the incidence of acute myocardial infarction (AMI), and death during 1-year follow-up in a propensity score–matched cohort. PMI was defined as an absolute increase in high-sensitivity cardiac troponin T (hs-cTnT) concentration of ≥14 ng/L from preoperative to postoperative measurements.ResultsOf 1641 patients, propensity score matching defined 630 with similar baseline characteristics, half undergoing non-cardiac surgery in the morning (starting from 8:00 to 11:00) and half in the afternoon (starting from 14:00 to 17:00). There was no difference in PMI incidence between both groups (morning: 50, 15.8% (95% CI 12.3 to 20.3); afternoon: 52, 16.4% (95% CI 12.7 to 20.9), p=0.94), nor if analysing hs-cTnT release as a quantitative variable (median morning group: 3 ng/L (95% CI 1 to 7 ng/L); median afternoon group: 2 ng/L (95% CI 0 to 7 ng/L; p=0.16). During 1-year follow-up, the incidence of AMI was 1.2% (95% CI 0.4% to 3.2%) among morning surgeries versus 4.1% (95% CI 2.3% to 6.9%) among the afternoon surgeries (corrected HR for afternoon surgery 3.44, bootstrapped 95% CI 1.33 to 10.49, p log-rank=0.03), whereas no difference in mortality emerged (p=0.70).ConclusionsAlthough there is no daytime variation in PMI in patients undergoing non-cardiac surgery, the incidence of AMI during follow-up is increased in afternoon surgeries and requires further study.Clinical trial registrationNCT02573532;Results.

Published
2019
Full Text
View/download PDF

16. Prevalence of Pulmonary Embolism in Patients With Syncope

Author

Badertscher, Patrick, primary, du Fay de Lavallaz, Jeanne, additional, Hammerer-Lercher, Angelika, additional, Nestelberger, Thomas, additional, Zimmermann, Tobias, additional, Geiger, Marc, additional, Imahorn, Orell, additional, Miró, Òscar, additional, Salgado, Emilio, additional, Christ, Michael, additional, Cullen, Louise, additional, Than, Martin, additional, Martin-Sanchez, F. Javier, additional, Di Somma, Salvatore, additional, Peacock, W. Frank, additional, Keller, Dagmar I., additional, Costabel, Juan Pablo, additional, Walter, Joan, additional, Boeddinghaus, Jasper, additional, Twerenbold, Raphael, additional, Méndez, Adriana, additional, Gospodinov, Boris, additional, Puelacher, Christian, additional, Wussler, Desiree, additional, Koechlin, Luca, additional, Kawecki, Damian, additional, Geigy, Nicolas, additional, Strebel, Ivo, additional, Lohrmann, Jens, additional, Kühne, Michael, additional, Reichlin, Tobias, additional, Mueller, Christian, additional, Rubini Giménez, Maria, additional, Kozhuharov, Nikola, additional, Shrestha, Samyut, additional, Sazgary, Lorraine, additional, Morawiec, Beata, additional, Muzyk, Piotr, additional, Nowalany-Kozielska, Ewa, additional, Bustamante Mandrión, José, additional, Poepping, Imke, additional, Freese, Michael, additional, Meissner, Kathrin, additional, Kulangara, Caroline, additional, Fuenzalida Inostroza, Carolina Isabel, additional, Greenslade, Jaimi, additional, Hawkins, Tracey, additional, Rentsch, Katharina, additional, von Eckardstein, Arnold, additional, Buser, Andreas, additional, Kloos, Wanda, additional, Steude, Jana, additional, and Osswald, Stefan, additional

Published
2019
Full Text
View/download PDF

17. Comparison of fourteen rule-out strategies for acute myocardial infarction

Author

Wildi, Karin, primary, Boeddinghaus, Jasper, additional, Nestelberger, Thomas, additional, Twerenbold, Raphael, additional, Badertscher, Patrick, additional, Wussler, Desiree, additional, Giménez, Maria Rubini, additional, Puelacher, Christian, additional, du Fay de Lavallaz, Jeanne, additional, Dietsche, Sebastian, additional, Walter, Joan, additional, Kozhuharov, Nikola, additional, Morawiec, Beata, additional, Miró, Òscar, additional, Javier Martin-Sanchez, F., additional, Subramaniam, Sinthuri, additional, Geigy, Nicolas, additional, Keller, Dagmar I., additional, Reichlin, Tobias, additional, Mueller, Christian, additional, Mueller, Deborah, additional, Sazgary, Lorraine, additional, Marbot, Stella, additional, Sabti, Zaid, additional, Flores, Dayana, additional, Meissner, Kathrin, additional, Kulangara, Caroline, additional, Freese, Michael, additional, Osswald, Stefan, additional, Stelzig, Claudia, additional, Bingisser, Roland, additional, López, Beatriz, additional, Agüero, María Martínez, additional, Nowalany-Kozielska, Ewa, additional, Kawecki, Damian, additional, Parenica, Jiri, additional, Ganovská, Eva, additional, Lohrmann, Jens, additional, Buser, Andreas, additional, Grimm, Karin, additional, Hartmann, Beate, additional, Muzyk, Piotr, additional, Rentsch, Katharina, additional, and von Eckardstein, Arnold, additional

Published
2019
Full Text
View/download PDF

18. Incidence and outcomes of unstable angina compared with non-ST-elevation myocardial infarction

Author

Puelacher, Christian, primary, Gugala, Mathias, additional, Adamson, Philip D, additional, Shah, Anoop, additional, Chapman, Andrew R, additional, Anand, Atul, additional, Sabti, Zaid, additional, Boeddinghaus, Jasper, additional, Nestelberger, Thomas, additional, Twerenbold, Raphael, additional, Wildi, Karin, additional, Badertscher, Patrick, additional, Rubini Gimenez, Maria, additional, Shrestha, Samyut, additional, Sazgary, Lorraine, additional, Mueller, Deborah, additional, Schumacher, Lukas, additional, Kozhuharov, Nikola, additional, Flores, Dayana, additional, du Fay de Lavallaz, Jeanne, additional, Miro, Oscar, additional, Martín-Sánchez, Francisco Javier, additional, Morawiec, Beata, additional, Fahrni, Gregor, additional, Osswald, Stefan, additional, Reichlin, Tobias, additional, Mills, Nicholas L, additional, and Mueller, Christian, additional

Published
2019
Full Text
View/download PDF

19. Circadian, weekly, seasonal, and temperature-dependent patterns of syncope aetiology in patients at increased risk of cardiac syncope

Author

Du Fay De Lavallaz, Jeanne, Badertscher, Patrick, Nestelberger, Thomas, Flores, Dayana, Miró, Òscar, Salgado, Emilio, Geigy, Nicolas, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F. Javier, Rodriguez-Adrada, Esther, Di Somma, Salvatore, Peacock, W. Frank, Kawecki, Damian, Boeddinghaus, Jasper, Twerenbold, Raphael, Puelacher, Christian, Wussler, Desiree, Strebel, Ivo, Keller, Dagmar I., Poepping, Imke, Kühne, Michael, Reichlin, Tobias, Mueller, Christian, Giménez, Maria Rubini, Walter, Joan, Kozhuharov, Nikola, Shrestha, Samyut, Mueller, Deborah, Sazgary, Lorraine, Morawiec, Beata, Muzyk, Piotr, Nowalany-Kozielska, Ewa, Freese, Michael, Stelzig, Claudia, Meissner, Kathrin, Kulangara, Caroline, Hartmann, Beate, Ferel, Ina, Sabti, Zaid, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, Von Eckardstein, Arnold, Buser, Andreas, Kloos, Wanda, Lohrmann, Jens, Osswald, Stefan, Du Fay De Lavallaz, Jeanne, Badertscher, Patrick, Nestelberger, Thomas, Flores, Dayana, Miró, Òscar, Salgado, Emilio, Geigy, Nicolas, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F. Javier, Rodriguez-Adrada, Esther, Di Somma, Salvatore, Peacock, W. Frank, Kawecki, Damian, Boeddinghaus, Jasper, Twerenbold, Raphael, Puelacher, Christian, Wussler, Desiree, Strebel, Ivo, Keller, Dagmar I., Poepping, Imke, Kühne, Michael, Reichlin, Tobias, Mueller, Christian, Giménez, Maria Rubini, Walter, Joan, Kozhuharov, Nikola, Shrestha, Samyut, Mueller, Deborah, Sazgary, Lorraine, Morawiec, Beata, Muzyk, Piotr, Nowalany-Kozielska, Ewa, Freese, Michael, Stelzig, Claudia, Meissner, Kathrin, Kulangara, Caroline, Hartmann, Beate, Ferel, Ina, Sabti, Zaid, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, Von Eckardstein, Arnold, Buser, Andreas, Kloos, Wanda, Lohrmann, Jens, and Osswald, Stefan

Abstract

Aims It is unknown whether cardiac syncope, and possibly also other syncope aetiologies exhibit circadian, weekly, seasonal, and temperature-dependent patterns. Methods and results We prospectively recorded the exact time, date, and outside temperature of syncope of patients >40 years old presenting with syncope to the emergency department in a diagnostic multicentre study. Two independent cardiologists/emergency physicians adjudicated the final diagnosis based on all information becoming available during clinical work-up including 1-year follow-up. Among 1230 patients, the adjudicated aetiology was cardiac in 14.6%, reflex in 39.2%, orthostatic in 25.7%, other non-cardiac in 9.7%, and unknown in 10.8% of patients. All syncope aetiologies occurred much more frequently during the day when compared with the night (P < 0.01). While reflex and orthostatic syncope showed a broad peak of prevalence with 80.9% of these events occurring between 4 am and 4 pm, cardiac syncope showed a narrow peak of prevalence with 70.1% of all events occurring between 8 am and 2 pm. A weekly pattern was present for most syncope aetiologies, with events occurring mainly from Monday to Friday (P < 0.01). Reflex syncope displayed a seasonal rhythm and was more common in winter (P < 0.01), while cardiac syncope stayed constant over the year. Syncope occurred most often when the outside temperature was coldest. Overall the patterns observed for cardiac syncope were similar to the patterns observed for its differential diagnosis. Conclusion Syncope aetiologies in patients >40 years old display circadian, weekly, seasonal, and temperature-dependent patterns. Unfortunately, these patterns do not allow to reliably differentiate cardiac syncope from other aetiologies.

Published
2019

20. Prevalence of pulmonary embolism in patients with syncope

Author

Badertscher, Patrick, du Fay de Lavallaz, Jeanne, Hammerer-Lercher, Angelika, Nestelberger, Thomas, Zimmermann, Tobias, Geiger, Marc, Imahorn, O., Miró, Òscar, Salgado, Emilio, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F. Javier, Di Somma, Salvatore, Peacock, W. Frank, Keller, Dagmar I., Costabel, Juan Pablo, Walter, Joan, Boeddinghaus, Jasper, Twerenbold, Raphael, Méndez, Adriana, Gospodinov, B., Puelacher, Christian, Wussler, Desiree, Koechlin, Luca, Kawecki, Damian, Geigy, Nicolas, Strebel, Ivo, Lohrmann, Jens, Kühne, Michael, Reichlin, Tobias, Mueller, Christian, Rubini Giménez, M., Kozhuharov, Nikola, Shrestha, Samyut, Sazgary, Lorraine, Morawiec, B., Muzyk, P., Nowalany-Kozielska, Ewa, Bustamante Mandrión, José, Poepping, Imke, Freese, Michael, Meissner, Kathrin, Kulangara, Caroline, Fuenzalida Inostroza, Carolina Isabel, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, von Eckardstein, Arnold, Buser, Andreas, Kloos, W., Steude, Jana, Osswald, Stefan, Badertscher, Patrick, du Fay de Lavallaz, Jeanne, Hammerer-Lercher, Angelika, Nestelberger, Thomas, Zimmermann, Tobias, Geiger, Marc, Imahorn, O., Miró, Òscar, Salgado, Emilio, Christ, Michael, Cullen, Louise, Than, Martin, Martin-Sanchez, F. Javier, Di Somma, Salvatore, Peacock, W. Frank, Keller, Dagmar I., Costabel, Juan Pablo, Walter, Joan, Boeddinghaus, Jasper, Twerenbold, Raphael, Méndez, Adriana, Gospodinov, B., Puelacher, Christian, Wussler, Desiree, Koechlin, Luca, Kawecki, Damian, Geigy, Nicolas, Strebel, Ivo, Lohrmann, Jens, Kühne, Michael, Reichlin, Tobias, Mueller, Christian, Rubini Giménez, M., Kozhuharov, Nikola, Shrestha, Samyut, Sazgary, Lorraine, Morawiec, B., Muzyk, P., Nowalany-Kozielska, Ewa, Bustamante Mandrión, José, Poepping, Imke, Freese, Michael, Meissner, Kathrin, Kulangara, Caroline, Fuenzalida Inostroza, Carolina Isabel, Greenslade, Jaimi, Hawkins, Tracey, Rentsch, Katharina, von Eckardstein, Arnold, Buser, Andreas, Kloos, W., Steude, Jana, and Osswald, Stefan

Abstract

Background: The prevalence of pulmonary embolism (PE) in patients presenting with syncope to the emergency department (ED) is largely unknown. This information, however, is necessary to balance the potential medical benefit or harm of systematic PE screening in patients presenting with syncope to the ED. Objectives: This study sought to determine the prevalence of PE in patients with syncope. Methods: Unselected patients presenting with syncope to the ED were prospectively enrolled in a diagnostic multicenter study. Pre-test clinical probability for PE was assessed using the 2-level Wells score and the results of D-dimer testing using age-adapted cutoffs. Presence of PE was evaluated by imaging modalities, when ordered as part of the clinical assessment by the treating ED physician or by long-term follow-up data. Results: Long-term follow-up was complete in 1,380 patients (99%) at 360 days and 1,156 patients (83%) at 720 days. Among 1,397 patients presenting with syncope to the ED, PE was detected at presentation in 19 patients (1.4%; 95% confidence interval [CI]: 0.87% to 2.11%). The incidence of new PEs or cardiovascular death during 2-year follow-up was 0.9% (95% CI: 0.5% to 1.5%). In the subgroup of patients hospitalized (47%), PE was detected at presentation in 15 patients (2.3%; 95% CI: 1.4% to 3.7%). The incidence of new PEs or cardiovascular death during 2-year follow-up was 0.9% (95% CI: 0.4% to 2.0%). Conclusions: PE seems to be a rather uncommon cause of syncope among patients presenting to the ED. Therefore, systematic PE-screening in all patients with syncope does not seem warranted. (BAsel Syncope EvaLuation Study [BASEL IX]; NCT01548352)

Published
2019

21. Diagnosis of acute myocardial infarction in the presence of left bundle branch block

Author

Nestelberger, Thomas, Cullen, Louise, Lindahl, Bertil, Reichlin, Tobias, Greenslade, Jaimi H., Giannitsis, Evangelos, Christ, Michael, Morawiec, Beata, Miro, Oscar, Martín-Sánchez, Francisco Javier, Wussler, Desiree Nadine, Koechlin, Luca, Twerenbold, Raphael, Parsonage, William, Boeddinghaus, Jasper, Rubini Gimenez, Maria, Puelacher, Christian, Wildi, Karin, Buerge, Tobias, Badertscher, Patrick, DuFaydeLavallaz, Jeanne, Strebel, Ivo, Croton, Lukas, Bendig, Garnet, Osswald, Stefan, Pickering, John William, Than, Martin, Mueller, Christian, Hillinger, Petra, Grimm, Karin, Honegger, Ursina, Schaerli, Nicolas, Kozhuharov, Nikola, Stelzig, Claudia, Freese, Michael, Sabti, Zaid, Walter, Joan, Sazgary, Lorraine, Kulangara, Caroline, Meissner, Kathrin, Mueller, Deborah, Lopez, Beatriz, Salgado, Emilio, Adrada, Esther Rodríguez, Kawecki, Damian, Parenica, Jiri, Ganovska, Eva, Rentsch, Katharina, Buser, Andreas, Lohrmann, Jens, Bingisser, Roland, Shrestha, Samyut, Stallone, Fabio, Abaecherli, Roger, McCord, James, Nowak, Richard, Body, Richard, DeFilippi, Christopher R., Christenson, Robert H., Panteghini, Mauro, Plebani, Mario, Verschuren, Franck, French, John, Weiser, Silvia, Dinkel, Carina, Keller, Dagmar I., Geigy, Nicolas, Nestelberger, Thomas, Cullen, Louise, Lindahl, Bertil, Reichlin, Tobias, Greenslade, Jaimi H., Giannitsis, Evangelos, Christ, Michael, Morawiec, Beata, Miro, Oscar, Martín-Sánchez, Francisco Javier, Wussler, Desiree Nadine, Koechlin, Luca, Twerenbold, Raphael, Parsonage, William, Boeddinghaus, Jasper, Rubini Gimenez, Maria, Puelacher, Christian, Wildi, Karin, Buerge, Tobias, Badertscher, Patrick, DuFaydeLavallaz, Jeanne, Strebel, Ivo, Croton, Lukas, Bendig, Garnet, Osswald, Stefan, Pickering, John William, Than, Martin, Mueller, Christian, Hillinger, Petra, Grimm, Karin, Honegger, Ursina, Schaerli, Nicolas, Kozhuharov, Nikola, Stelzig, Claudia, Freese, Michael, Sabti, Zaid, Walter, Joan, Sazgary, Lorraine, Kulangara, Caroline, Meissner, Kathrin, Mueller, Deborah, Lopez, Beatriz, Salgado, Emilio, Adrada, Esther Rodríguez, Kawecki, Damian, Parenica, Jiri, Ganovska, Eva, Rentsch, Katharina, Buser, Andreas, Lohrmann, Jens, Bingisser, Roland, Shrestha, Samyut, Stallone, Fabio, Abaecherli, Roger, McCord, James, Nowak, Richard, Body, Richard, DeFilippi, Christopher R., Christenson, Robert H., Panteghini, Mauro, Plebani, Mario, Verschuren, Franck, French, John, Weiser, Silvia, Dinkel, Carina, Keller, Dagmar I., and Geigy, Nicolas

Abstract

Objective Patients with suspected acute myocardial infarction (AMI) in the setting of left bundle branch block (LBBB) present an important diagnostic and therapeutic challenge to the clinician. Methods We prospectively evaluated the incidence of AMI and diagnostic performance of specific ECG and high-sensitivity cardiac troponin (hs-cTn) criteria in patients presenting with chest discomfort to 26 emergency departments in three international, prospective, diagnostic studies. The final diagnosis of AMI was centrally adjudicated by two independent cardiologists according to the universal definition of myocardial infarction. Results Among 8830 patients, LBBB was present in 247 (2.8%). AMI was the final diagnosis in 30% of patients with LBBB, with similar incidence in those with known LBBB versus those with presumably new LBBB (29% vs 35%, p=0.42). ECG criteria had low sensitivity (1%-12%) but high specificity (95%-100%) for AMI. The diagnostic accuracy as quantified by the receiver operating characteristics (ROC) curve of hs-cTnT and hs-cTnI concentrations at presentation (area under the ROC curve (AUC) 0.91, 95% CI 0.85 to 0.96 and AUC 0.89, 95% CI 0.83 to 0.95), as well as that of their 0/1-hour and 0/2-hour changes, was very high. A diagnostic algorithm combining ECG criteria with hs-cTnT/I concentrations and their absolute changes at 1 hour or 2 hours derived in cohort 1 (45 of 45(100%) patients with AMI correctly identified) showed high efficacy and accuracy when externally validated in cohorts 2 and 3 (28 of 29 patients, 97%). Conclusion Most patients presenting with suspected AMI and LBBB will be found to have diagnoses other than AMI. Combining ECG criteria with hs-cTnT/I testing at 0/1 hour or 0/2 hours allows early and accurate diagnosis of AMI in LBBB. Trial registration number APACE: NCT00470587; ADAPT: ACTRN12611001069943; TRAPID-AMI: RD001107;Results.

Published
2019

22. Incidence of major adverse cardiac events following non-cardiac surgery.

Author

Sazgary, Lorraine, Puelacher, Christian, Buse, Giovanna Lurati, Glarner, Noemi, Lampart, Andreas, Bolliger, Daniel, Steiner, Luzius, Gürke, Lorenz, Wolff, Thomas, Mujagic, Edin, Schaeren, Stefan, Lardinois, Didier, Espinola, Jacqueline, Kindler, Christoph, Hammerer-Lercher, Angelika, Strebel, Ivo, Wildi, Karin, Hidvegi, Reka, Gueckel, Johanna, and Hollenstein, Christina

Published
2021
Full Text
View/download PDF

23. Daytime variation of perioperative myocardial injury in non-cardiac surgery and effect on outcome

Author

du Fay de Lavallaz, Jeanne, primary, Puelacher, Christian, additional, Lurati Buse, Giovanna, additional, Bolliger, Daniel, additional, Germanier, Dominic, additional, Hidvegi, Reka, additional, Walter, Joan Elias, additional, Twerenbold, Raphael, additional, Strebel, Ivo, additional, Badertscher, Patrick, additional, Sazgary, Lorraine, additional, Lampart, Andreas, additional, Espinola, Jaqueline, additional, Kindler, Christoph, additional, Hammerer-Lercher, Angelika, additional, Thambipillai, Saranya, additional, Guerke, Lorenz, additional, Rentsch, Katharina, additional, Buser, Andreas, additional, Gualandro, Danielle, additional, Jakob, Marcel, additional, and Mueller, Christian, additional

Published
2018
Full Text
View/download PDF

24. Diagnostic and prognostic value of QRS duration and QTc interval in patients with suspected myocardial infarction

Author

Cupa, Janosch, primary, Strebel, Ivo, additional, Badertscher, Patrick, additional, Abächerli, Roger, additional, Twerenbold, Raphael, additional, Schumacher, Lukas, additional, Boeddinghaus, Jasper, additional, Nestelberger, Thomas, additional, Maechler, Patrick, additional, Kozhuharov, Nikola, additional, Giménez, Maria Rubini, additional, Wildi, Karin, additional, Du Fay de Lavallaz, Jeanne, additional, Sabti, Zaid, additional, Sazgary, Lorraine, additional, Puelacher, Christian, additional, Mueller, Deborah, additional, Bianci, Chiara, additional, Miró, Òscar, additional, Fuenzalida, Carolina, additional, Calderón, Sofia, additional, Martín-Sánchez, F. Javier, additional, Iglesias, Sergio Lopez, additional, Morawiec, Beata, additional, Kawecki, Damian, additional, Parenica, Jiri, additional, Keller, Dagmar I., additional, Geigy, Nicolas, additional, Osswald, Stefan, additional, Mueller, Christian, additional, and Reichlin, Tobias, additional

Published
2018
Full Text
View/download PDF

25. Prospective Validation of a Biomarker-Based Rule Out Strategy for Functionally Relevant Coronary Artery Disease

Author

Walter, Joan E, primary, Honegger, Ursina, primary, Puelacher, Christian, primary, Mueller, Deborah, primary, Wagener, Max, primary, Schaerli, Nicolas, primary, Strebel, Ivo, primary, Twerenbold, Raphael, primary, Boeddinghaus, Jasper, primary, Nestelberger, Thomas, primary, Sazgary, Lorraine, primary, Marbot, Stella, primary, du Fay de Lavallaz, Jeanne, primary, Kaiser, Christoph, primary, Osswald, Stefan, primary, Wild, Damian, primary, Rentsch, Katharina, primary, Zellweger, Michael, primary, Reichlin, Tobias, primary, and Mueller, Christian, primary

Published
2018
Full Text
View/download PDF

26. Effect of Definition on Incidence and Prognosis of Type 2 Myocardial Infarction

Author

Nestelberger, Thomas, primary, Boeddinghaus, Jasper, additional, Badertscher, Patrick, additional, Twerenbold, Raphael, additional, Wildi, Karin, additional, Breitenbücher, Dominik, additional, Sabti, Zaid, additional, Puelacher, Christian, additional, Rubini Giménez, Maria, additional, Kozhuharov, Nikola, additional, Strebel, Ivo, additional, Sazgary, Lorraine, additional, Schneider, Deborah, additional, Jann, Janina, additional, du Fay de Lavallaz, Jeanne, additional, Miró, Òscar, additional, Martin-Sanchez, F. Javier, additional, Morawiec, Beata, additional, Kawecki, Damian, additional, Muzyk, Piotr, additional, Keller, Dagmar I., additional, Geigy, Nicolas, additional, Osswald, Stefan, additional, Reichlin, Tobias, additional, Mueller, Christian, additional, Schumacher, Lukas, additional, Shrestha, Samyut, additional, Flores, Dayana, additional, Rentsch, Katharina, additional, López, Beatriz, additional, Yañez-Palma, M. Cecilia, additional, Parenica, Jiri, additional, Lohrmann, Jens, additional, and Buser, Andreas, additional

Published
2017
Full Text
View/download PDF

27. Daytime variation of perioperative myocardial injury in non-cardiac surgery and effect on outcome.

Author

de Lavallaz, Jeanne du Fay, Puelacher, Christian, Buse, Giovanna Lurati, Bolliger, Daniel, Germanier, Dominic, Hidvegi, Reka, Walter, Joan Elias, Twerenbold, Raphael, Strebel, Ivo, Badertscher, Patrick, Sazgary, Lorraine, Lampart, Andreas, Espinola, Jaqueline, Kindler, Christoph, Hammerer-Lercher, Angelika, Thambipillai, Saranya, Guerke, Lorenz, Rentsch, Katharina, Buser, Andreas, and Gualandro, Danielle

Subjects
ASPIRIN, TYPE 1 diabetes, SURGERY
Abstract

Objective: Recently, daytime variation in perioperative myocardial injury (PMI) has been observed in patients undergoing cardiac surgery. We aim at investigating whether daytime variation also occurs in patients undergoing non-cardiac surgery.Methods: In a prospective diagnostic study, we evaluated the presence of daytime variation in PMI in patients at increased cardiovascular risk undergoing non-cardiac surgery, as well as its possible impact on the incidence of acute myocardial infarction (AMI), and death during 1-year follow-up in a propensity score-matched cohort. PMI was defined as an absolute increase in high-sensitivity cardiac troponin T (hs-cTnT) concentration of ≥14 ng/L from preoperative to postoperative measurements.Results: Of 1641 patients, propensity score matching defined 630 with similar baseline characteristics, half undergoing non-cardiac surgery in the morning (starting from 8:00 to 11:00) and half in the afternoon (starting from 14:00 to 17:00). There was no difference in PMI incidence between both groups (morning: 50, 15.8% (95% CI 12.3 to 20.3); afternoon: 52, 16.4% (95% CI 12.7 to 20.9), p=0.94), nor if analysing hs-cTnT release as a quantitative variable (median morning group: 3 ng/L (95% CI 1 to 7 ng/L); median afternoon group: 2 ng/L (95% CI 0 to 7 ng/L; p=0.16). During 1-year follow-up, the incidence of AMI was 1.2% (95% CI 0.4% to 3.2%) among morning surgeries versus 4.1% (95% CI 2.3% to 6.9%) among the afternoon surgeries (corrected HR for afternoon surgery 3.44, bootstrapped 95% CI 1.33 to 10.49, p log-rank=0.03), whereas no difference in mortality emerged (p=0.70).Conclusions: Although there is no daytime variation in PMI in patients undergoing non-cardiac surgery, the incidence of AMI during follow-up is increased in afternoon surgeries and requires further study.Clinical Trial Registration: NCT02573532;Results. [ABSTRACT FROM AUTHOR]

Published
2019
Full Text
View/download PDF

28. 0/1-Hour Triage Algorithm for Myocardial Infarction in Patients With Renal Dysfunction

Author

Twerenbold, Raphael, Badertscher, Patrick, Boeddinghaus, Jasper, Nestelberger, Thomas, Wildi, Karin, Puelacher, Christian, Sabti, Zaid, Rubini Gimenez, Maria, Tschirky, Sandra, Du Fay De Lavallaz, Jeanne, Kozhuharov, Nikola, Sazgary, Lorraine, Mueller, Deborah, Breidthardt, Tobias, Strebel, Ivo, Flores Widmer, Dayana, Shrestha, Samyut, Miró, Òscar, Martín-Sánchez, F Javier, Morawiec, Beata, Parenica, Jiri, Geigy, Nicolas, Keller, Dagmar I, Rentsch, Katharina, Von Eckardstein, Arnold, Osswald, Stefan, Reichlin, Tobias, and Mueller, Christian

Subjects
610 Medicine & health, 3. Good health
Abstract

BACKGROUND The European Society of Cardiology recommends a 0/1-hour algorithm for rapid rule-out and rule-in of non-ST-segment elevation myocardial infarction using high-sensitivity cardiac troponin (hs-cTn) concentrations irrespective of renal function. Because patients with renal dysfunction (RD) frequently present with increased hs-cTn concentrations even in the absence of non-ST-segment elevation myocardial infarction, concern has been raised regarding the performance of the 0/1-hour algorithm in RD. METHODS In a prospective multicenter diagnostic study enrolling unselected patients presenting with suspected non-ST-segment elevation myocardial infarction to the emergency department, we assessed the diagnostic performance of the European Society of Cardiology 0/1-hour algorithm using hs-cTnT and hs-cTnI in patients with RD, defined as an estimated glomerular filtration rate

29. Perioperative Myocardial Injury After Noncardiac Surgery: Incidence, Mortality, and Characterization.

Author

Puelacher, Christian, Lurati Buse, Giovanna, Seeberger, Daniela, Sazgary, Lorraine, Marbot, Stella, Lampart, Andreas, Espinola, Jaqueline, Kindler, Christoph, Hammerer, Angelika, Seeberger, Esther, Strebel, Ivo, Wildi, Karin, Twerenbold, Raphael, du Fay de Lavallaz, Jeanne, Steiner, Luzius, Gurke, Lorenz, Breidthardt, Tobias, Rentsch, Katharina, Buser, Andreas, and Gualandro, Danielle M

Published
2017
Full Text
View/download PDF

30. Daytime variation of perioperative myocardial injury in non-cardiac surgery and effect on outcome.

Author

du Fay de Lavallaz J, Puelacher C, Lurati Buse G, Bolliger D, Germanier D, Hidvegi R, Walter JE, Twerenbold R, Strebel I, Badertscher P, Sazgary L, Lampart A, Espinola J, Kindler C, Hammerer-Lercher A, Thambipillai S, Guerke L, Rentsch K, Buser A, Gualandro D, Jakob M, and Mueller C

Subjects
Aged, Biomarkers blood, Female, Follow-Up Studies, Humans, Incidence, Male, Myocardial Infarction blood, Myocardial Infarction epidemiology, Preoperative Period, Prognosis, Prospective Studies, Switzerland epidemiology, C-Reactive Protein metabolism, Circadian Rhythm physiology, Myocardial Infarction diagnosis, Propensity Score, Surgical Procedures, Operative, Troponin T blood
Abstract

Objective: Recently, daytime variation in perioperative myocardial injury (PMI) has been observed in patients undergoing cardiac surgery. We aim at investigating whether daytime variation also occurs in patients undergoing non-cardiac surgery., Methods: In a prospective diagnostic study, we evaluated the presence of daytime variation in PMI in patients at increased cardiovascular risk undergoing non-cardiac surgery, as well as its possible impact on the incidence of acute myocardial infarction (AMI), and death during 1-year follow-up in a propensity score-matched cohort. PMI was defined as an absolute increase in high-sensitivity cardiac troponin T (hs-cTnT) concentration of ≥14 ng/L from preoperative to postoperative measurements., Results: Of 1641 patients, propensity score matching defined 630 with similar baseline characteristics, half undergoing non-cardiac surgery in the morning (starting from 8:00 to 11:00) and half in the afternoon (starting from 14:00 to 17:00). There was no difference in PMI incidence between both groups (morning: 50, 15.8% (95% CI 12.3 to 20.3); afternoon: 52, 16.4% (95% CI 12.7 to 20.9), p=0.94), nor if analysing hs-cTnT release as a quantitative variable (median morning group: 3 ng/L (95% CI 1 to 7 ng/L); median afternoon group: 2 ng/L (95% CI 0 to 7 ng/L; p=0.16). During 1-year follow-up, the incidence of AMI was 1.2% (95% CI 0.4% to 3.2%) among morning surgeries versus 4.1% (95% CI 2.3% to 6.9%) among the afternoon surgeries (corrected HR for afternoon surgery 3.44, bootstrapped 95% CI 1.33 to 10.49, p log-rank=0.03), whereas no difference in mortality emerged (p=0.70)., Conclusions: Although there is no daytime variation in PMI in patients undergoing non-cardiac surgery, the incidence of AMI during follow-up is increased in afternoon surgeries and requires further study., Clinical Trial Registration: NCT02573532;Results., Competing Interests: Competing interests: CP reports grants from PhD Educational Platform for Health Sciences and the University Hospital Basel during the conduct of the study. GLB reports grants from University of Basel during the conduct of the study. RT reports research support from the Swiss National Science Foundation (grant no. P300PB 167803), the Swiss Heart Foundation, the Cardiovascular Research Foundation Basel, the University of Basel and the University Hospital Basel; and speaker honoraria/consulting honoraria from Roche, Abbott, Siemens, Singulex and ThermoScientific BRAHMS. CM reports grants from the Swiss Heart Foundation and grants and non-financial support from several diagnostic companies during the conduct of the study, as well as grants, personal fees and non-financial support from several diagnostic companies outside the submitted work., (© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results