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1. Oxytocin ameliorates KCC2 decrease induced by oral bacteria-derived LPS that affect rat primary cultured cells and PC-12 cells

Author

Kazuo Tomita, Sayuri Yamanishi-Taira, Kento Igarashi, Yuichi Oogai, Yoshikazu Kuwahara, Mehryar Habibi Roudkenar, Amaneh Mohammadi Roushandeh, Shouichi Miyawaki, Akihiro Kurimasa, and Tomoaki Sato

Subjects
Lipopolysaccharides, Brain Diseases, Glycogen Synthase Kinase 3 beta, Symporters, Physiology, Oxytocin, PC12 Cells, Biochemistry, Rats, Cellular and Molecular Neuroscience, Endocrinology, Escherichia coli, Animals, Humans, Cells, Cultured, gamma-Aminobutyric Acid
Abstract

Inflammation, especially neuroinflammation, which is caused by stress, leads to central nervous system (CNS) dysfunction. Because lipopolysaccharides (LPSs) cause neuroinflammation, we investigated the effect of LPSs to CNS. In PC-12 cells, LPSs derived from oral bacteria reduced the expression of KCC2, a Cl

Published
2022
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