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Your search keyword '"Sayem, Syed Al Jawad"' showing total 9 results
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9 results on '"Sayem, Syed Al Jawad"'

4. Comparative Assessment of Three Medicinal Plants against Diabetes and Oxidative Stress Using Experimental and Computational Approaches

Author

Shah, Md. Shahin, primary, Talukder, Md. Saddam Hossain, additional, Uddin, A. M. Kafil, additional, Hasan, Muhammad Nazmul, additional, Sayem, Syed Al Jawad, additional, Mostafa-Hedeab, Gomaa, additional, Rahman, Md. Masudur, additional, Sharma, Rohit, additional, Swelum, Ayman A., additional, Mohamed, Amany Abdel-Rahman, additional, and Emran, Talha Bin, additional

Published
2023
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6. Investigation of the Pharmacological Properties of Lepidagathis hyalina Nees through Experimental Approaches

Author

Fahad, Fowzul Islam, primary, Barua, Niloy, additional, Islam, Md. Shafiqul, additional, Sayem, Syed Al Jawad, additional, Barua, Koushik, additional, Uddin, Mohammad Jamir, additional, Chy, Md. Nazim Uddin, additional, Adnan, Md., additional, Islam, Mohammad Nazmul, additional, Sayeed, Mohammed Aktar, additional, Emran, Talha Bin, additional, Simal-Gandara, Jesus, additional, Pagano, Ester, additional, and Capasso, Raffaele, additional

Published
2021
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7. Therapeutic Potentials of Syzygium fruticosum Fruit (Seed) Reflected into an Array of Pharmacological Assays and Prospective Receptors-Mediated Pathways

Author

Moni, Jannatul Nasma Rupa, primary, Adnan, Md., additional, Tareq, Abu Montakim, additional, Kabir, Md. Imtiazul, additional, Reza, A.S.M. Ali, additional, Nasrin, Mst. Samima, additional, Chowdhury, Kamrul Hasan, additional, Sayem, Syed Al Jawad, additional, Rahman, Md Atiar, additional, Alam, AHM Khurshid, additional, Alam, Seema Binte, additional, Sakib, Mahfuz Ahmed, additional, Oh, Ki Kwang, additional, Cho, Dong Ha, additional, and Capasso, Raffaele, additional

Published
2021
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9. Investigation of Potential Antioxidant, Thrombolytic and Neuropharmacological Activities of Homalomena aromatica Leaves Using Experimental and In Silico Approaches.

Author

Ali, Md. Sekendar, Sayem, Syed Al Jawad, Habibullah, Quah, Yixian, Lee, Eon-Bee, Birhanu, Biruk Tesfaye, Suk, Kyoungho, Park, Seung-Chun, Cacciola, Francesco, and Saleh-E-In, Md. Moshfekus

Subjects
*PLASMINOGEN, *TISSUE plasminogen activator, *ANTIOXIDANTS, *SEROTONIN receptors, *GALLIC acid, *MOLECULAR docking
Abstract

The leaves of Homalomena aromatica are traditionally used in Bangladesh for the treatment of different chronic ailments. The purpose of this study was to explore in vitro antioxidant, thrombolytic activities, and in vivo neuropharmacological effects of methanolic extract of Homalomena aromatica (MEHA) leaves. Antioxidant activity of MEHA was assessed by a DPPH free radical scavenging assay and total phenolics content, total flavonoids content were also measured. The thrombolytic activity was determined by percentage of clot lysis and neuropharmacological activities by hole board, tail suspension, forced swimming and elevated plus maze tests. The results showed that the IC50 value of the extract against DPPH was 199.51 μg/mL. Quantitative analysis displayed higher contents of phenolics and flavonoids (147.71 mg gallic acid equivalent/g & 66.65 mg quercetin equivalent/g dried extract, respectively). The extract also showed a significant clot lysis (33.31%) activity. In case of anxiolytic activity, the elevate plus maze (EPM) test demonstrated an increase in time spent in open arms, and in case of hole board test, the number of head dipping was also significantly increased (p < 0.05). All the test compared with control (1% Tween in water) and standard (diazepam 1 mg/kg), significant dose (200 & 400 mg/kg) dependent anxiolytic activity was found. In antidepressant activity, there was a significant decrease in period of immobility in both test models (tail suspension and forced swimming) (p < 0.05). Moreover, 13 compounds were identified as bioactive, showed good binding affinities to xanthine oxidoreductase, tissue plasminogen activator receptor, potassium channel receptor, human serotonin receptor targets in molecular docking experiments. Furthermore, ADME/T analysis revealed their drug-likeness, likely pharmacological actions and non-toxic upon consumption. Taken together, our finding support the traditional medicinal use of this plant, which may provide a potential source for future drug discovery. [ABSTRACT FROM AUTHOR]

Published
2021
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