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202 results on '"Sayar, Kemal"'

1. The relationship of attachment styles, perceived social support, and anxiety and depressive symptoms with migraine-related disability

Author

Köroğlu Emre, Köroğlu Rukiye, Sayar Kemal, Topçuoğlu Volkan, and Tanrıdağ Tülin

Subjects
migraine, disability, attachment, perceived social support, anxiety, depression, Psychology, BF1-990
Abstract

Although social anxiety disorder (SAD) is widespread and associated with significant distress, its etiology is not yet fully explored. We aimed to examine how metacognitions and mindfulness interact with SAD symptoms. 531 college students were enrolled in this study. Participants completed the Liebowitz Social Anxiety Scale (LSAS), the Metacognition Questionnaire-30 (MCQ-30), and the Five-Facet Mindfulness Questionnaire (FFMQ). A path analysis was run to explore the associations between test variables. A positive correlation was found between metacognition and SAD symptoms, while mindfulness negatively correlated with SAD symptoms and metacognition. In the established path model, metacognition had an indirect effect on SAD symptoms, which is partially mediated by mindfulness. Our findings imply that metacognitions and mindfulness may influence SAD symptoms among young adults. Mindfulness seems to have a prominent role in regulating metacognition’s effects on SAD symptoms. Therefore, interventions that accurately target these factors may alleviate the symptoms of this debilitating psychological disturbance.

Published
2024
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3. The psychological determinants of emotional and external eating behavior in a university student sample from Turkey

Author

Ergun Serhat, Akca Erdogdu, Yanartas Omer, Akca Demirok Nur Zeynep, Ozercan Ahmet, and Sayar Kemal

Subjects
eating behavior, obesity, childhood adverse events, depression, anxiety, impulsivity, Psychology, BF1-990
Abstract

Psychological factors and adverse childhood events at an early age have been poorly investigated in relation to risky eating behavior and obesity. The importance of this relationship grows as these behaviors are becoming public health problems. The main objective of the present study was to examine the effects of interrelated psychological factors such as childhood negative life events, symptoms of depression and anxiety, and impulsivity on eating behaviors in a university student sample in Turkey. A total of 414 undergraduate students (60.4% women) in Turkey, completed the Turkish versions of the Dutch Eating Behavior Questionnaire (DEBQ) to assess emotional eating and external eating and the CDC-Kaiser Permanent Adverse Childhood Experiences (ACE), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), and Barratt Impulsivity Scale-11 (BSI-11). Structural equation models (SEM) were used to evaluate whether depressive/anxiety symptoms could be a mediator between impulsivity and emotional eating/external eating. Childhood adverse events were both weakly correlated with eating behavior and impulsivity measures (r = .18,r = .275, p

Published
2023
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4. Chronotype preference, sleep quality, and night-eating behaviors in patients with metabolic dysfunction-associated steatotic liver disease: Assessing the relationship with disease severity and fibrosis.

Author

Kani, Ayse Sakalli, Ozercan, Ahmet, Kani, Haluk Tarik, Eren, Fatih, Sayar, Kemal, and Yilmaz, Yusuf

Subjects
SLEEP quality, CHRONOTYPE, FOOD habits, LIVER diseases, FIBROSIS
Abstract

Background and Aim: Our primary objective is to examine the variance in chronotype, night-eating patterns, and sleep quality in patients with biopsy-proven metabolic dysfunction-associated steatotic liver disease. In addition, we aim to establish a correlation between these variables and the severity of the disease and fibrosis. Materials and Methods: Patients who were following up with biopsy-proven metabolic dysfunction associated steatotic liver disease (MASLD) were included in the study. Histologically severe disease is characterized by a Steatosis, Activity, and Fibrosis activity score of =3 or the presence of advanced fibrosis (=F3). Participants who met the inclusion criteria were given the Morningness and Evening Questionnaire (MEQ), the Pittsburgh Sleep Quality Index, and the Night Eating Questionnaire to complete. Results: A total of 93 patients were included in this study. According to the MEQ, 48 patients were morning type (51.6%), and 42 (45.2%) were neither type. Sleep quality was determined to be inferior in the non-morningness group (p=0.002). A significantly higher proportion of patients with nocturnal eating syndrome had a non-morningness chronotype preference (n=22, 23.7%), compared to those with a morningness chronotype (n=9, 9.7%) (p=0.001). In the multivariate analysis, both age and poor sleep quality had significant impacts on advanced fibrosis, with odds ratios of 1.11 and 3.81, respectively. Conclusion: Despite the non-morningness chronotype demonstrating poorer sleep quality and a higher prevalence of night-eating behavior, our findings revealed no statistically significant differences in terms of sleep quality, nocturnal eating habits, or chronotype preferences among patients with varying degrees of MASLD severity. On the other hand, advanced fibrosis was significantly impacted by poor sleep quality. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Predictors of Suicidal Behavior in a Sample of Turkish Suicide Attempters

Author

Sayar, Kemal, Kose, Samet, and Acar, Burcin

Abstract

In a Turkish sample, 100 suicide attempters, were compared with 60 healthy controls on measures of hopelessness, depression, and suicidal ideation. Suicide attempters were more depressive, more hopeless, and displayed greater suicidal ideation than healthy controls. Depression severity rather than hopelessness correlated with suicidal intent. Suicide lethality was independent of depression severity, hopelessness, and suicidal ideation and intent, suggesting that lethality is likely due to chance.

Published
2004

10. Functional Somatic Symptoms and Their Predictors in Patients with Major Depressive Disorder and Fibromyalgia Syndrome.

Author

TEKİNTAŞ, Nilüfer SUBAŞI, YANARTAŞ, Ömer, DURMUŞ, Fatma BENK, and SAYAR, Kemal

Subjects
SELF-evaluation, AGE distribution, SYMPTOM Checklist-90-Revised, FIBROMYALGIA, SEVERITY of illness index, COMPARATIVE studies, PSYCHOLOGICAL tests, HYPOCHONDRIA, MENTAL depression, ALEXITHYMIA, QUESTIONNAIRES, SOMATOFORM disorders, CLASSIFICATION of mental disorders, ANXIETY, COMORBIDITY, DISEASE risk factors, DISEASE complications, SYMPTOMS, EVALUATION
Abstract

Introduction: Despite being different medical conditions, functional somatic symptoms (FSSs) are common in patients with major depressive disorder (MDD) and fibromyalgia syndrome (FMS). Higher levels of depression, anxiety, somatosensory amplification, hypochondriacal worry and alexithymia may be related to the severity of somatization in patients with MDD and FMS. We aimed to investigate the typology and severity of FSSs and the association between FSSs and these psychiatric symptoms in patients with MDD and FMS. Method: 56 MDD, 33 FMS, 21 CoMF (Comorbidity of MDD and FMS) patients, and 50 healthy participants were included in the study, respectively. Diagnosis of MDD and FMS was established according to DSM-IV-TR (Diagnostic and Statistical Manual of Mental Disorders, Revised Text), and ACR (American College of Rheumatology) 2010 diagnostic criteria. All participants were evaluated with self-report questionnaires including Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Somatosensory Amplification Scale (SSAS), Toronto Alexithymia Scale-20 (TAS-20), Whiteley Index-7 (WI-7), The Symptom Checklist-90-R (SCL-90-R) somatization subscale and Bradford Somatic Inventory-44 (BSI-44). Results: The severity of somatization was statistically significantly highest in the CoMF group, and similar in the FMS and MDD groups, and lowest in the control group according to the BSI-44 and SCL-90-R results. The typology of FSSs was quite similar in patients with MDD and FMS, and weakness, tiredness and neck pain were the most common FSSs in both groups. Independent predictors of FSSs were age, the severity of anxiety and alexithymia in the MDD group, however, it was only the severity of anxiety in the FMS group. Conclusions: Our results show that the typology and severity of FSSs are similar in MDD and FMS patients. Moreover, somatization appears to be more associated with anxiety in patients with MDD and FMS. [ABSTRACT FROM AUTHOR]

Published
2022
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15. Geleceğin Yası

Author

SAYAR, Kemal

Subjects
Gelecek,Covid-19,Psikoloji, Philosophy, Felsefe
Abstract

TIR şoförü hayat felsefesini, kamyonun ardına astığı yazıda özetlemiş: ‘Yarını bilmiyoruz...İşte bu yüzden hayat güzel’. Kamyon yazıları bir çırpıda bize yaşadığımız hayatları hülâsa ediverir. Seçme şansı olsaydı, bu şoför kardeşimiz yarını iyi kötü bilmek istemez miydi? Yarının içerdiği belirsizlik,ânı yakalama arzusuyla bize bugünü daha dolu ve doya doya yaşama imtiyazı verebilir. O zaman şoför beyi ‘ânın evladı’ olduğu için kutlayabilir ve taşıdığı ‘bugün neşesi’nden bir hisse kapmak isteyebiliriz. Ama ya yarın radikal bir belirsizlikle malulse? Geleceğin bir yıkıntı gibi üzerimize geldiğini bilsek, aynı cümleyi rahatlıkla kurabilir miydik? İnsan bilinmezlikten hoşlanmıyor, evreni tahmin edebilmek istiyor. Olaylar bilinen seyrin dışına çıktığında olumsuz duygular galip gelmeye başlıyor. Gezegenimizdeki pek çok insan, bir kader ortaklığı yaptığımız şu günlerde, alttan alta birsorunun kendisini yokladığını hissediyor: “Sonunda öleceksem, bütün bu uğraş neden?”.

Published
2020

27. Depression and anxiety have unique contributions to somatic complaints in depression, irritable bowel syndrome and inflammatory bowel diseases

Author

Yanartaş, Ömer, primary, Kani, Haluk Tarik, additional, Kani, Ayşe Sakallı, additional, Akça, Zeynep Nur Demirok, additional, Akça, Erdoğdu, additional, Ergün, Serhat, additional, Tezcan, Neslihan, additional, Atug, Özlen, additional, İmeryüz, Neşe, additional, and Sayar, Kemal, additional

Published
2019
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30. Dijital Toplum

Author

SAYAR, Kemal

Subjects
Communication, İletişim
Published
2016

32. 9th International Congress on Psychopharmacology & 5th International Symposium on Child and Adolescent Psychopharmacology

Author

Baytunca, Muharrem Burak, primary, Kalyoncu, Tugba, additional, Ozel, Ismail, additional, Erermis, Serpil, additional, Kayahan, Bulent, additional, Ongur, Dost, additional, Aykut, Demet Sağlam, additional, Gül, Hasret Karabulut, additional, Elmas, Tuba Şerife, additional, Aydın, Memduha, additional, İlhan, Bilge Çetin, additional, Çokünlü, Yusuf, additional, Eren, İbrahim, additional, Ozdemir, İlker, additional, Gokcen, Onur, additional, Kuru, Erkan, additional, Demir, Erkan, additional, Ünal, Gökhan, additional, Arıcıoğlu, Feyza, additional, Nur Hazar Yavuz, Ayşe, additional, Aydın, Orkun, additional, Balıkçı, Kuzeymen, additional, Taş, Cumhur, additional, Aydın, Pınar Ünal, additional, Torun, Deniz, additional, Kayır, Hakan, additional, Danacı, Ayşen Esen, additional, Ölmez, Safiye Bahar, additional, Ataoğlu, Büşra Bahar, additional, Kocagöz, Zehra Başar, additional, Yazar, Neslihan, additional, Ataoğlu, Ahmet, additional, Özçetin, Adnan, additional, Asoğlu, Mehmet, additional, Doğan, Hatice, additional, Öztop, Didem Behice, additional, Eker, Özlem Olguner, additional, Özsoy, Saliha Demirel, additional, Ekinci, Özalp, additional, Okuyaz, Çetin, additional, Güneş, Serkan, additional, Direk, Meltem Çobanoğulları, additional, Ekinci, Nuran, additional, Teke, Halenur, additional, Kalınlı, Merve, additional, Yalvaç, Çiğdem Toklu, additional, Fidan, Tülin, additional, Sarı, Burcu Akın, additional, Özkula, Güler, additional, Karaokur, Remzi, additional, Esen, Halime Tuna Çak, additional, Uysal, Songül Atasavun, additional, Gül, Hesna, additional, Güngör, Olcay, additional, Sapmaz, Şermin Yalın, additional, Demirgören, Burcu Serim, additional, Öztürk, Masum, additional, Bilaç, Öznur, additional, Erkuran, Handan Özek, additional, Köroğlu, Ertuğrul, additional, Aydemir, Ömer, additional, Yazici, Kemal Utku, additional, Yazici, Ipek Percinel, additional, Ustundag, Bilal, additional, Altun, Hatice, additional, Şahin, Nilfer, additional, Kurutaş, Ergül Belge, additional, Belge Kurutaş, Ergül, additional, Balkan, Damla, additional, Karaş, Hakan, additional, Mutlu, Elif, additional, Birgül Baran, Selin, additional, Dayı, Ali, additional, Şükrü Gürbüz, Filiz, additional, Zinnur Kılıç, Emine, additional, Giynas Ayhan, Medine, additional, Seven, Hilal, additional, Hakan Öztürk, Ali, additional, Kırcı Ercan, Seda, additional, Demirel, Başak, additional, Selçuk, Mahmut, additional, Ibrahim Ozturk, Halil, additional, Atila Uygur, Hilal, additional, Varsak, Nalan, additional, Ozbek, Suleyman, additional, Eren, Ibrahim, additional, Erdoğan, Ali, additional, Canan, Fatih, additional, Ceren Pak, Şima, additional, Murat Kuloğlu, Mehmet, additional, Kuş, Sema, additional, Öztürk, Mehmet, additional, Özdemir, İlker, additional, Şafak, Yasir, additional, Volkan Şahiner, İsmail, additional, Şahiner, Şafak, additional, Ozturk, Mehmet, additional, Volkan Sahiner, İsmail, additional, Safak, Yasir, additional, Ekinci, Suat, additional, Uğur Kural, Hanife, additional, Varlık, Cenk, additional, Ünübol, Hüseyin, additional, İclal Balak, Züleyha, additional, Bakirhan, Abdurrahim, additional, Yalcin Sahiner, Safak, additional, Özbek, Süleyman, additional, Güler, İbrahim, additional, Yıldırım Özbek, Seda, additional, Er, Mehmet, additional, Tolu, İsmet, additional, Ugur, Cagatay, additional, Sertceli̇k, Mehmet, additional, Uneri, Ozden, additional, Senses Dinc, Gulser, additional, Sekmen, Ebru, additional, Solmaz, Esra, additional, Ünal Aydın, Pınar, additional, Esen Danacı, Ayşen, additional, Ayrıbaş, Başar, additional, Sayar, Kemal, additional, Öztürk, Pelin, additional, Zincir, Serkan, additional, Yükselir, Cihad, additional, Ersan Unal, Feyza, additional, Gıca, Şakir, additional, Gürsu Hariri, Aytül, additional, Dikeç, Gul, additional, Baysan Arabacı, Leyla, additional, Uzunoğlu, Gülçin, additional, Demet Mızrak, Selin, additional, Yektaş, Çiğdem, additional, Paşabeyoğlu, Başak, additional, Erdoğan, Ayten, additional, Mutlu, Caner, additional, Demirtaş Şahin, Tuğçe, additional, Utkan, Tijen, additional, Karson, Ayşe, additional, Selcen Gocmez, Semil, additional, Aricioglu, Feyza, additional, Tağcı, Süheyla, additional, Demirkaya, Sevcan Karakoç, additional, Aksu, Hatice, additional, Badur, İsa, additional, Çıtak, Serhat, additional, Bakar, Burcu, additional, Avcı, Selma Hilal, additional, Yüksellr, Cihad, additional, Ataoğlu, Safinaz, additional, Ankaralı, Handan, additional, Bahar Ataoğlu, Büşra, additional, Bahar Ölmez, Safiye, additional, Ulusoy Kaymak, Semra, additional, Norçin Demirtaş, Seda, additional, Uğurlu, Mustafa, additional, İlhan Atagün, Murat, additional, Karakaş Uğurlu, Görkem, additional, Süleyman Can, Serdar, additional, Koç, Zuhal, additional, Çayköylü, Ali, additional, Kaşak, Meryem, additional, Hesapçıoğlu, Selma Tural, additional, Ceylan, Mehmet Fatih, additional, Güneş, Hatice, additional, Hergüner, Sabri, additional, Tanıdır, Canan, additional, Adaletli, Hilal, additional, Önal, Zerrin, additional, Kutlu, Esra, additional, Önal, Hasan, additional, Münir, Kerim, additional, Nasıroğlu, Serhat, additional, Semerci, Bengi, additional, Saday Duman, Nagihan, additional, Sarı Gökten, Emel, additional, Nadir Rana, Hasan, additional, Özdemiroğlu, Filiz, additional, Öykü Memiş, Çağdaş, additional, Doğan, Bilge, additional, Karakuş, Kadir, additional, Sevinçok, Levent, additional, Çukurova, Merve, additional, Bağ, Sevda, additional, Karşıdağ, Çağatay, additional, Şahmelikoğlu, Özge, additional, Akay, Ömer, additional, Yalçın, Suat, additional, Kutlu, Gamze, additional, Kocagöz, Kübra, additional, Arslan, Filiz Civil, additional, Karagüzel, Evrim Özkorumak, additional, Tiryaki, Ahmet, additional, Örekeci, Gülhan, additional, Köroğlu, Emre, additional, Topçuoğlu, Volkan, additional, Ankaralı, Seyit, additional, Fındıklı, Ebru, additional, Onur, Özge Şahmelikoğlu, additional, Cesur, Ender, additional, Ünal, Gülşen Teksin, additional, Tüzer, Melike Yerebakan, additional, Şahmelikoğlu Onur, Özge, additional, Yalçın, Didem, additional, Yıldız Aydın, Filiz, additional, Aytaç, Hasan Mervan, additional, Aydın, Nazan, additional, Gül, Ahmet, additional, Ceviz Ozkal, Ummuhan, additional, Kıncır, Zeliha, additional, Gültekin, Gözde, additional, Emul, Murat, additional, Yeşil, Bahar, additional, Ünal, Süheyla, additional, Ay, Halil, additional, Civil Arslan, Filiz, additional, Özkorumak Karagüzel, Evrim, additional, Selçuk, Ezgi, additional, Uysal, Selin, additional, Çakır, Ayşe, additional, Gormez, Vahdet, additional, Cahid Örengül, Abdurrahman, additional, Han Almış, Behice, additional, Kıvrak, Yüksel, additional, Taşdelen, Yasin, additional, Yağcı, İbrahim, additional, Aydın, Fatih, additional, Emin Tan, Muhammet, additional, Baran, Selin Birgül, additional, Kocabaş, Oktay, additional, Sağlam Aykut, Demet, additional, Yıldırım, Mihriban, additional, Uysal, Emel, additional, Güven, Süleyman, additional, Sezer, Gülay, additional, Sezer, Zafer, additional, Çetin, İhsan, additional, and Faruk Demirel, Ömer, additional

Published
2017
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33. 9th International Congress on Psychopharmacology & 5th International Symposium on Child and Adolescent Psychopharmacology

Author

Bakirhan, Abdurrahim, primary, Sahiner, Safak Yalcin, additional, Sahiner, Volkan, additional, Çeti̇n, Şahabettin, additional, Balcı Şengül, Melike Ceyhan, additional, Kuş, Sema, additional, Canan, Fatih, additional, Erdoğan, Ali, additional, Murat Kuloğlu, Mehmet, additional, Şahin, Şengül, additional, Elboğa, Gülçin, additional, Zi̇ya Şahin, Ahmet, additional, Ünal, Ahmet, additional, Altındağ, Abdurrahman, additional, Tahsin Kılıç, Osman Hasan, additional, Dogan, Turkan, additional, Kaygisiz, Gonul, additional, Ezgi Bal, Zeynep, additional, Solmaz, Mustafa, additional, Adali Aker, Derya, additional, Akin, Ercan, additional, Kose, Samet, additional, Özturan, Deniz Deniz, additional, Güz, Hatice Özyıldız, additional, Naldan, Muhammet Emin, additional, Karayağmurlu, Ali, additional, Cevizci, Mehmet Nuri, additional, Kara, Duygu, additional, Ahiskalioğlu, Elif Oral, additional, Aydın, Pelin, additional, Marangoz, Yıldız, additional, Sarı, Burcu Akın, additional, Barış, Zeren, additional, Özçay, Figen, additional, Mutluer, Başak Tüzün, additional, Yener Orum, Tuna Güzide, additional, Şahan, Ebru, additional, Sertcelik, Sencan, additional, Yılmaz, Helin, additional, Özbaran, N. Burcu, additional, Palamar, Melis, additional, Biler, Elif Demirkılıç, additional, Yi̇lmaz, Ertan, additional, Tamam, Lut, additional, Altın, Murat, additional, Ozaktac, Ipek Fatma, additional, Sarıdogan, Ayse Sena, additional, Yavlal, Figen, additional, Tahincioğlu, Ceyda, additional, Karaş, Hakan, additional, Ebadi, Hüseyin, additional, Sogucak, Suna, additional, Karaca, Servet, additional, Kuloglu, Murat, additional, Öznur, Taner, additional, Bolu, Abdullah, additional, Öznur, Havva, additional, Atik, Serdar, additional, Çelik, Cemil, additional, Uzun, Özcan, additional, Bakirhan, Abdurrahim, additional, Göka, Erol, additional, Utkan, Tijen, additional, Şahin, Tuğçe Demirtaş, additional, Yazir, Yusufhan, additional, Halbutoğulları, Zehra Seda, additional, Gocmez, Semil Selcen, additional, Arıcıoğlu, Feyza, additional, Gülbahar, Övgü Sinem Buğan, additional, Mahmood, Abda, additional, Zsoldos, Enikő, additional, Allan, Charlotte L., additional, Topiwala, Anya, additional, Ebmeier, Klaus P., additional, Lee, Jung Suk, additional, Kim, Jong Hun, additional, Lee, Seon-Koo, additional, Ünal, Gökhan, additional, Dokumacı, Alim Hüseyin, additional, Yerer, Mükerrem Betül Aycan, additional, Özkartal, Ceren, additional, Altun, Hülya Kamarlı, additional, Keser, İlkay, additional, Mart, Mehmet, additional, Tezcan, Didem, additional, Tümkaya, Selim, additional, Ateşci, Figen Çulha, additional, Baygın, Cansu, additional, Memiş, Çağdaş Öykü, additional, Doğan, Bilge, additional, Sevinçok, Levent, additional, Karakuş, Gonca, additional, Özkartal, Ceren Şahin, additional, Tüzün, Erdem, additional, Keleş, Rümeysa, additional, Kandemir, Cansu, additional, Şirvancı, Serap, additional, Küçükali, Cem İsmail, additional, Can, Özgür Devrim, additional, Üçel, Umut İrfan, additional, Özkay, Ümide Demir, additional, Ulupınar, Emel, additional, Turan, Nazlı, additional, Can, Nafiz Öncü, additional, Baştaşkın, Tuğçe, additional, Yalçınkaya, Canan, additional, Arkan, Gülnaz, additional, Özkay, Yusuf, additional, Levent, Serkan, additional, Alyu, Feyza, additional, Öztürk, Yusuf, additional, Sadek, Bassem, additional, Khan, Nadia, additional, Łażewska, Dorota, additional, Kononowicz, Katarzyna Kieć, additional, Boztaş, Mehmet Hamid, additional, Arslan, Derya, additional, Koç, Ayşegül, additional, Aygün, Derya Öktem, additional, Ensari, Hülya, additional, Akın, Ercan, additional, Ceylan, Vedat, additional, Turkcapar, Mehmet Hakan, additional, Yalcin, Mehmet, additional, Turkcapar, Hakan, additional, Aker, Derya Adali, additional, Bal, Zeynep Ezgi, additional, Celikel, Feryal Cam, additional, Sevinçer, Güzin M, additional, Kaya, Aysenur, additional, Bozkurt, Suleyman, additional, Tekintas, Nilufer Subasi, additional, Durmus, Fatma Benk, additional, Sayar, Kemal, additional, Sarıoğlu, Fatma Kartal, additional, Erbay, Lale Gönenir, additional, Karlıdağ, Rıfat, additional, Sekmen, Ebru, additional, Karalök, Zeynep Selen, additional, Göker, Zeynep, additional, Çöp, Esra, additional, Dinç, Gülser, additional, Bozkurt, Özlem Hekim, additional, Üneri, Özden Şükran, additional, Ataoğlu, Safinaz, additional, Ankaralı, Handan, additional, Ankaralı, Seyit, additional, Ataoğlu, Büşra Bahar, additional, Ölmez, Safiye Bahar, additional, Çelebi, Esra, additional, Pasin, Özge, additional, Samancı, Rumeysa, additional, Ayyıldız, Didem, additional, Fiş, Neşe Perdahlı, additional, Özayhan, Hatice Yardi̇m, additional, Çalışkan, Ali Metehan, additional, İnanlı, İkbal, additional, Öztürk, Halil İbrahim, additional, Etli, Tahsin, additional, Eren, İbrahim, additional, Taner, Hande Ayraler, additional, Kilicaslan, Fethiye, additional, Ayaydin, Hamza, additional, Aytekin, Ayca Idil, additional, Saka, Melek, additional, Aydin, Sule, additional, Garip, Beyazit, additional, Kayir, Hakan, additional, Uğurlu, Görkem Karakaş, additional, Uğurlu, Mustafa, additional, Haydanlı, Ayza Mutlu, additional, Çayköylü, Ali, additional, Kaymak, Semra Ulusoy, additional, Apaydın, Zuhal Koç, additional, Can, Serdar Süleyman, additional, Bozkurt, Abdullah, additional, Akbaş, Seher, additional, Tander, Burak, additional, Kara, Cengiz, additional, Bıçakçı, Ünal, additional, Toz, Hamiyet İpek, additional, Yalçi̇n, Özhan, additional, Sapmaz, Şermin Yalın, additional, Erkuran, Handan Özek, additional, Karaarslan, Dilay, additional, Öztürk, Masum, additional, Ülker, Gülsüm Yörük, additional, Demirgören, Burcu Serim, additional, Köroğlu, Ertuğrul, additional, Aydemir, Ömer, additional, Yalın, Nefize, additional, Kavurma, Canem, additional, Öztekin, Siğnem, additional, Pilan, Birsen Şentürk, additional, Emiroğlu, Neslihan Inal, additional, Ergin, Dilek, additional, Celasin, Nesrin Şen, additional, Bilaç, Öznur, additional, Kararslan, Duygu, additional, Tarakçıoğlu, Mahmut Cem, additional, Acar, Gülşah, additional, Bademli, Kerime, additional, Lök, Neslihan, additional, Soyata, Ahmet Zihni, additional, Karaytug, Mahmut Onur, additional, Keskin, Necla, additional, Ozpoyraz, Nurgul, additional, and Demirkol, Mehmet Emin, additional

Published
2017
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34. 9th International Congress on Psychopharmacology & 5th International Symposium on Child and Adolescent Psychopharmacology

Author

Şahmelikoğlu Onur, Özge, primary, Çukurova, Merve, additional, Bağ, Sevda, additional, Yalçın, Suat, additional, Çakır Şen, Cansu, additional, Karşıdağ, Çağatay, additional, Süleyman Can, Serdar, additional, Tuğçe Akçaer, Emine, additional, Taşdelen Kul, Ayşegül, additional, İspir, Mustafa, additional, Bakkal, Osman, additional, Algül, Ayhan, additional, Ebrinç, Servet, additional, Yükselir, Cihad, additional, Zincir, Serkan, additional, Öztürk, Pelin, additional, Karaahmetoğlu, Bülent, additional, Baş, Özlem, additional, Şahmelikoğlu Onur, Özge, additional, Ulukaya, Sema, additional, Soykan, Çağlar, additional, Çayköylü, Ali, additional, Yazar, Neslihan, additional, Başar Kocagöz, Zehra, additional, Özçetin, Adnan, additional, Bahar Ölmez, Safiye, additional, Ataoğlu, Ahmet, additional, Hasan Balcioglu, Yasin, additional, Demir Berkol, Tonguc, additional, Ekim Cevik, Filiz, additional, Oncu, Fatih, additional, Ozgen, Guliz, additional, Demiröz, Dudu, additional, Yardım Özayhan, Hatice, additional, Seven, Hilal, additional, Çağrı Yıldız, Mustafa, additional, Başaran, Recep, additional, Eren, İbrahim, additional, Özlem Canazlar, Elif, additional, Sevinçok, Levent, additional, Doğan, Bilge, additional, Öykü Memiş, Çağdaş, additional, Baran Tanrikulu, Ali, additional, İnanli̇, İkbal, additional, Çağri̇ Yi̇ldi̇z, Mustafa, additional, Şerife Elmas, Tuba, additional, Eren, Ibrahim, additional, Alperen Korkmaz, Şükrü, additional, Pınar Şen, Cansu, additional, Fatih Ceylan, Mehmet, additional, Hesapçıoğlu, Selma Tural, additional, Bakar, Burcu, additional, Tuncer, Can, additional, Yeni Elbay, Rümeysa, additional, Görmez, Aynur, additional, Tokgöz, Yusuf, additional, Bolu, Abdullah, additional, Çelik, Cemil, additional, Uzun, Özcan, additional, Kirlioglu, Simge Seren, additional, Balcioglu, Yasin Hasan, additional, Aydin, Pinar Cetinay, additional, Uğurlu, Mustafa, additional, Uğurlu, Görkem Karakaş, additional, Akçaer, Emine Tuğçe, additional, Can, Serdar Süleyman, additional, Koç, Zuhal, additional, Kapubağlı, Nazlı, additional, Tuncer, Ömer Faruk, additional, Ünlü, Gülsen, additional, Şahin, Esra Kabadayı, additional, Apaydın, Zuhal Koç, additional, Kaymak, Semra Ulusoy, additional, Peker, Oğuz, additional, Özkan, Bedriye, additional, Kılıçoğlu, Ali Güven, additional, Karaçetin, Gül, additional, Yücehan, Zeynep, additional, Elmas, Tuğba Şerife, additional, Yağlı, Nafiye, additional, İlhan, Bilge Çetin, additional, Aker, Derya Adali, additional, Kıvılcım, Yiğit, additional, Solmaz, Mustafa, additional, Kutlu, Yeşim Ruhat, additional, Yeşil, Bahar, additional, Almış, Behice Han, additional, Küçük, Başak, additional, Cerit, Cem, additional, Sarici, Burcu, additional, Kaypak, Ayşe Ceren, additional, Baysak, Erensu, additional, Ergün, Serhat, additional, Yildiz, Mesut, additional, Ibiloglu, Aslihan Okan, additional, Atli, Abdullah, additional, Asoglu, Mehmet, additional, Ozkan, Mustafa, additional, Memik, Nursu Çakın, additional, Ünver, Hatice, additional, Gündoğdu, Özlem Yıldız, additional, Uzun, Necati, additional, Akça, Ömer Faruk, additional, Aral, Gizem, additional, Aykut, Demet Sağlam, additional, Maden, Özgür, additional, Gündoğmuş, İbrahim, additional, Gok, Fulya, additional, Kiraz, Seda, additional, Cipil, Arif, additional, Eroglu, Meliha Zengin, additional, Çiftçi, Elvan, additional, Aslan, Zeynep, additional, Gül, Melike Kevser, additional, Taştepe, Neslihan, additional, Demirci, Esra, additional, Özmen, Sevgi, additional, Doğru, Hicran, additional, Karayağmurlu, Elif, additional, Karayağmurlu, Ali, additional, Göksu, Muhsine, additional, Tügen, Leyla Ezgi, additional, Ayaz, Ayşe Burcu, additional, Arman, Ayşe, additional, Özayhan, Hatice Yardım, additional, Altunova, Deniz, additional, Yıldız, Mustafa Çağrı, additional, Atagün, Murat İlhan, additional, Kul, Ayşegül Taşdelen, additional, Güldaş, Ekrem, additional, Göl, Güler, additional, Savcı, Uğur, additional, Tufan, Ali Evren, additional, Özbek, Seda Yıldırım, additional, Özbek, Süleyman, additional, Uygur, Hilal, additional, Demirel, Başak, additional, Esra Çiçek, İ., additional, Kara, Hüseyin, additional, Balcı, Mehmet Murat, additional, Karaca, Servet, additional, Kuloğlu, Mehmet Murat, additional, Aytaç, Hasan Mervan, additional, Ger, Mehmet Can, additional, İbiloğlu, Aslıhan Okan, additional, Asoğlu, Mehmet, additional, Çakır, Ayşe, additional, Tiryaki, Ahmet, additional, Çelme, Gülşah Güçlü, additional, Boztaş, Mehmet Hamid, additional, Sırmatel, Fatma, additional, Erdogan, Mucahid, additional, Dayan, Cengiz, additional, Atakli, Hayrunisa Dilek, additional, Kartalcı, Gülşen, additional, Yücel, Ebru, additional, Kartalcı, Şükrü, additional, Eroğlu, Meliha Zengin, additional, Çipil, Arif, additional, Çalışkan, Mecit, additional, Çavusoglu, Emine Cengiz, additional, Özdemir, Yusuf Özay, additional, Elmas, Tuba Şerife, additional, Fındıklı, Ebru, additional, Şahin, Berkan, additional, Karabekiroğlu, Koray, additional, Kurt, Mustafa, additional, Memiş, Çağdaş Öykü, additional, Sevinçok, Doğa, additional, Sertdemir, Merve, additional, Ay, Rukiye, additional, Yılmaz, Nevzat, additional, Demirkaya, Sevcan Karakoç, additional, Aksu, Hatice, additional, Gizem Gerçek, Hacer, additional, Karakoç, Gülser, additional, Altıntoprak, Ayşe Ender, additional, Coşkunol, Hakan, additional, Yazici, Ipek Percinel, additional, Utku Yazici, Kemal, additional, Altıntaş, Kevser, additional, Gök, Fulya, additional, Yaylacı, Ferhat, additional, Erkuran, Handan Özek, additional, Eyüboğlu, Murat, additional, Göverti, Diğdem, additional, Yüksel, Rabia Nazik, additional, Bülbül, Alper, additional, Aydemir, Makbule Çiğdem, additional, Göka, Erol, additional, Kınalı, Ilgaz, additional, Hacıoğlu, Münevver Yıldırım, additional, Sarıcı, Burcu, additional, Sayar, Kemal, additional, Doğan, Hatice, additional, Akay, Ömer, additional, Kim, Heecheol, additional, Lee, Hyunjoo, additional, Karagöz, Abdulkadir, additional, Kullakçı, Hakan, additional, Duman, Yasin, additional, Çokünlü, Yusuf, additional, Aydın, Memduha, additional, Tanrıkulu, Ali Baran, additional, Eren, İbrahım, additional, Taner, Hande Ayraler, additional, Sarı, Burcu Akın, additional, Yektaş, Çiğdem, additional, Samurcu, Nuran Demir, additional, Çalışır, Saliha, additional, Ekinci, Özalp, additional, Tan, Muhammet Emin, additional, Kalınlı, Merve, additional, Kıyançiçek, Murat, additional, Küçükdağ, Meltem, additional, Gül, Hasret Karabulut, additional, Uysal, Emel, additional, Arslan, Filiz Civil, additional, Karagüzel, Evrim Özkorumak, additional, Karakök, Burak, additional, Çak, Halime Tuna, additional, Çankaya, Pınar Kızılay, additional, Altun, İlkay Keleş, additional, Abatan, Eren, additional, Çalışkan, Ali Metehan, additional, Çakı, Hatice Kübra, additional, Doğangün, Burak, additional, Kadak, Muhammed Tayyib, additional, Kefeli, Mehmet, additional, Arıcı, Asiye, additional, Altun, Hatice, additional, Acıpayam, Can, additional, Bayhan, Pelin Çon, additional, Sungur, Elif Nurgül, additional, İnci Kenar, Ayşe Nur, additional, Ersoy, Sevde Afife, additional, Gürok, Mehmet Gürkan, additional, Yildiz, Sevler, additional, Korucu, Tuba, additional, Keles, Denizhan Danaci, additional, Atmaca, Murad, additional, Hoşoğlu, Esra, additional, Kılınç, Kübra, additional, Şen, Barış, additional, Örnek, Erdem, additional, Çelebi, Cengiz, additional, Kani, Ayşe Sakallı, additional, Yanartaş, Ömer, additional, Şenkal, Zeynep, additional, Akvardar, Yıldız, additional, Kora, Kaan, additional, Egilmez, Ümran, additional, Kandeğer, Ali, additional, Güler, Özkan, additional, Yazici, Kemal Utku, additional, Kösker, Selcen Dogru, additional, Budak, Elif Ates, additional, Karasin, Zeliha Deveci, additional, Güleken, Mehmet Diyaddin, additional, Celik, Mustafa, additional, Yıldırım, Hande, additional, Güler, Burçin, additional, Veznedaroğlu, Baybars, additional, Lale, Funda, additional, Çak Esen, Halime Tuna, additional, Haliloğlu, Göknur, additional, Ekinci, Nuran, additional, Bilgili, Gamze Özçürümez, additional, Seneger, Volkan, additional, Elbay, Rümeysa Yeni, additional, Işık, Ümit, additional, Aşut, Gonca, additional, Yaylacı, Elif Tatlıdil, additional, Asan, Ömer, additional, Güneş, Serkan, additional, Çiftçi, Ebru, additional, Yaşar, Sehure Azra, additional, İnanlı, İkbal, additional, Sertçelik, Sencan, additional, Avci, Selma Hilal, additional, Yaşar, Alişan Burak, additional, Karatepe, Hasan Turan, additional, Dönmez, Melike, additional, Topçuoğlu, Volkan, additional, Bilgiç, Ayhan, additional, Doğru, Volkan, additional, Bozkurt, Abdullah, additional, Kalyoncu, Tuğba, additional, Çıldır, Deniz Argüz, additional, Beşer, Can, additional, Fiş, Neşe Perdahlı, additional, Ulgar, Şermin Bilgen, additional, Ayaydın, Hamza, additional, Takatak, Hatice, additional, Ayaydin, Hamza, additional, Çobanoğlu, Cansu, additional, Müjdeci, Mahmut, additional, Gümüş, Yusuf Yasin, additional, Akbaş, Betül, additional, Sevgen, Feyza Hatice, additional, Öncü, Fatih, additional, Şahin, Nilfer, additional, Balkan, Damla, additional, Coşkun, Fatma, additional, Yılmaz, Savaş, additional, Çelikkol, Çağla, additional, Emlik, Ganime Dilek, additional, Çaksen, Hüseyin, additional, Arslan, Derya, additional, Arısoy, Özden, additional, Şair, Ahmet, additional, Şair, Yaşan Bilge, additional, Sarı, Dilek, additional, Ispir, Mustafa, additional, Algul, Ayhan, additional, Ölmeztoprak, Vuslat Kara, additional, Zayman, Esra Porgalı, additional, Ünal, Süheyla, additional, Öztürk, Ali Hakan, additional, Karabucak, Başak, additional, Çengel Kültür, Ebru Sadriye, additional, Çak Esen, Tuna Halime, additional, Özaktaç, İpek Fatma, additional, Altın, Murat, additional, Sarıdoğan, Ayşe Sena, additional, Buluş, Eser, additional, Güneş, Sevilay, additional, Koyuncu, Zehra, additional, Bingöl, Rahime Hülya, additional, Uzgel, Mine, additional, Ayas, Selahattin, additional, Kıvrak, Yüksel, additional, Şahbal, Yiğit, additional, Kocagöz, Kübra, additional, Kutlu, Gamze, additional, Baz, Ali, additional, Cansız, Mehmet Akif, additional, Kalyoncu, Tugba, additional, Sağlam, Ebru, additional, Önen, Özlem, additional, Kutlu, Ayşe, additional, Aşık, Ecenur Aydın, additional, Sapmaz, Şermin Yalın, additional, Erermiş, Serpil, additional, Şişmanlar, Şahika Gülen, additional, Karka, İsmail, additional, Kilicaslan, Fethiye, additional, Hürmeydan, Ceren Enüstün, additional, Onur, Özge Şahmelikoğlu, additional, Onur, Ozge Sahmelikoğlu, additional, Sarı, Didem Nagehan, additional, Kılıç, Bahar, additional, Kurt, Elif Merve, additional, Ak, İsmail, additional, Şevik, Ali Emre, additional, Yalçın, Ayşe Dilara, additional, Tural, Ümit, additional, Yaşar, Hilmi, additional, Korkmaz, Şükrü Alperen, additional, Karaaslan, Münir, additional, Kizilağaç, Fatih, additional, Öznur, Taner, additional, Baran Tanri̇kulu, Ali̇, additional, Yildiz, Mustafa Çağri, additional, İnanli, İkbal, additional, Öztürk, Seher Serez, additional, Özbek, Seda, additional, Çiçek, İsmet Esra, additional, Karlıdağ, Rıfat, additional, Akan, Mustafa, additional, İnce, Lara Utku, additional, Reyhani, İsmail, additional, Tetik, Dilek Çağlar, additional, Büyükaslan, Ayşe, additional, Yılanlı, Musa, additional, Cesur, Ender, additional, Belger, Fatma, additional, Başay, Bürge Kabukçu, additional, Şen, Cansu Pinar, additional, Ceylan, Mehmet Fatih, additional, Hesapcioglu, Selma Tural, additional, Teksin, Gülşen, additional, Kupeli, Nese Yorguner, additional, Ergun, Serhat, additional, Atlı, Abdullah, additional, Okan İbiloğlu, Aslıhan, additional, Akıl, Öznur, additional, and İbilioğlu, Aslıhan Okan, additional

Published
2017
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39. Dietary Selenium and Vitamin E Intakes Alter [Beta]-Adrenergic Response of L-Type Ca-Current and [Beta]-Adrenoceptor-Adenylate Cyclase Coupling in Rat Heart

Author

Sayar, Kemal, Ugur, Mehmet, Gurdal, Hakan, Onaran, Ongun, Hotomaroglu, Omer, and Turan, Belma

Subjects
Selenium -- Physiological aspects, Vitamin E -- Physiological aspects, Beta adrenoceptors -- Physiological aspects, Adenylate cyclase -- Physiological aspects, Heart -- Physiological aspects, Calcium channels -- Research, Food/cooking/nutrition
Abstract

Previously we have shown that both insufficient (combined with vitamin E deficiency) and excess intake of selenium (Se) impairs isoproterenol (ISO)-induced contractions of rat papillary muscle. In the present study, we used patch-clamp and biochemical techniques to investigate mechanisms of this effect in rats fed a Se-and vitamin E-deficient, a Se-excess or a normal diet. Whole-cell configuration of patch-clamp technique was used to investigate L-type [Ca.sup.2+] currents ([I.sub.Ca, L]) and their regulation by [Beta]-adrenergic receptor stimulation in enzymatically isolated single rat ventricular myocytes. Alteration of Se and vitamin E intake did not affect peak [I.sub.Ca, L], but the threshold potential of activation was significantly different among groups. Maximal [I.sub.Ca, L] responses to ISO were depressed in both experimental groups, but the [EC.sub.50] values were not affected. In the Se-deficient group, basal, ISO- or forskolin-induced adenylate cyclase (AC) activity, measured in cardiac membrane preparations, was reduced when compared to the control, whereas 5' guanylyimidodphosphate (GppNHp) stimulated activity was unaffected. Decreased [Beta]-adrenoceptor density and reduced GppNHp-induced affinity shift in ISO binding were also observed in the deficient group. No such differences were present in the excess group. These results suggest that combined Se and vitamin E deficiency interferes with [Beta]-adrenoceptor-AC coupling, whereas excess intake of Se does not affect it. Thus, in the deficient group, the impairment of [I.sub.Ca] responses to ISO may be a result of a defect in [Beta]-adrenoceptor-AC pathway. Impairment of [I.sub.Ca] response in the excess group, however, appears to have a different underlying mechanism. J. Nutr. 130: 733-740, 2000. KEY WORDS: * trace element * selenium * vitamin E * receptor-adenylate cyclase coupling * rat cardiac myoctes

Published
2000

40. Treatment differences between bipolar disorder I and II depression

Author

SAYAR, Kemal

Subjects
iki uçlu bozukluk,depresyon,tedavi, mental disorders, sense organs, bipolar disorder,depression,treatment
Abstract

The clinical phenomenology of bipolar 1 and 2 depressions may be different. Whether treatments of bipolar 1 and bipolar 2 depressions differ is a matter of dispute. There is yet not enough evidence regarding the treatment of bipolar 2 depression, however, emerging data show that there must be some difference in the treatment of these two conditions. One should be cautious especially with antidepressants., İki uçlu bozukluk 1 ve 2 depresyonları, klinik açıdan farklılıklar gösterebilmektedir. İki uçlu bozukluk 2 ve iki uçlu bozukluk 1 depresyonların tedavisi arasındaki farklar ise tartışmalı bir alandır. Henüz İki uçlu bozukluk 2 depresyon tedavisi konusunda yeterince kanıt birikmemişse de ilk veriler her iki durumun tedavisinde farklar olması gerektiğini düşündürmektedir. Özellikle antidepresan kullanımı konusunda dikkatli olmak gerekmektedir.

Published
2014

41. Manic episode during methylphenidate augmentation treatment

Author

Yanartaş, Ömer, Şenkal, Zeynep, Gündüz, Anıl, and Sayar, Kemal

Subjects
mental disorders, metilfenidat,psikoz,mani,venlafaksin, behavioral disciplines and activities, methylphenidate,psychosis,mania,venlafaxine
Abstract

Methyphenidate is used in treating patients with depression, narcolepsy, traumatic brain injury, cancer pains and HIV related cognitive impairment as well as treatment of Attention Deficit Hyperacivity Disorder(ADHD) in adults and children. It is known that usage of psychostimulants in high dosages may exacerbate manic and psychotic symptoms. This is a case presenting with manic symptoms after long acting methylphenidate is added to venlafaxine treatment for depression. 25 year old male, brought with complaints of increased religious activity, saying God is making him do things, increase of appetite, being talkative, greeting cemetaries and decreased sleep. In psychiatric assessment, his psychomotor activity was high, speech was pressured, had auditory hallucinations; had delusions of referance, grandieur and control, had no insight. He had been on venlafaxine treatment for depression for the last three months, 225mg/day for the last two. Methylphenidate 36mg/day was added to treatment 2 months before. His presenting symptoms started after it was increased to 54mg/day. Our diagnosis was manic episode (with psychotic features). One of the potential adverse effects of methylphenidate is exacerbation of manic symptoms. ADHD and Bipolar Disorder comorbidity may reach to 40%. However, our case did not have a comorbid ADHD. We associated manic symptoms with use of methylphenidate since the sypmtoms have started at the fourth month of venlafaxine treatment and after the increase of dosages of methylphenidate dosage., Metilfenidat depresyon, narkolepsi, travmatik beyin hasarı, kanser ağrısı, HIV ile ilişkili bilişsel yıkımın yanısıra çocuklarda ve yetişkinlerde dikkat eksikliği ve hiperaktivite bozukluğunda (DEHAB) kullanılmaktadır. Yüksek dozlarda psikostimulan kullanımının manik ve psikotik belirtileri arttırdığı bilinmektedir. Bu vaka sunumunda depresyon tanısı nedeniyle venlafaksin kullanmaktayken tedavisine uzun salınımlı metilfenidat eklenmesi ile manik belirti geliştiren olguyu sunmayı amaçladık. Olgumuz 25 yaşında erkek hasta dini aktivite artışı, Tanrının ona bir şey yaptırdığını söylemesi, iştah artışı, çok konuşma, mezarlıkla selamlaşmak gibi davranışlar sergileme ve uykuda azalma şikayetleri ile yakınları tarafından getirildi. Yapılan psikiyatrik değerlendirmede psikomotor aktivitesi artmış, konuşması basınçlı, işitsel hallüsinasyonu mevcut, grandiyöz, referans ve kontrol edilme hezeyanları mevcuttu ve içgörüsü yoktu. Olgumuz son üç aydır depresif yakınması nedeniyle venlafaksin tedavisi almaktaydı ve son iki aydır da 225 mg/gün kullanmaktaydı. Metilfenidat 36 mg/gün tedavisi de son iki aydır mevcut tedavisine eklenmişti. Hastamızın belirtileri metilfenidat tedavisi 54 mg/gün dozuna arttırılınca ortaya çıktı. Bizim olgumuza koyduğumuz teşhis psikotik özellikli manik hecmeydi. Metilfenidatın potansiyel olumsuz etkilerinden biri manik belirtilerin alevlenmesidir. DEHAB ve ikiuçlu mizaç bozukluğu birlikteliği %40’lara kadar ulaşabilmektedir. Fakat bizim olgumuzda DEHAB ekhastalığı yoktu. Biz metilfenidat kullanımı ile manik hecme birlikteliğini; belirtilerin gelişiminin venlafaksin kullanımının dördüncü ayında ve özellikle de metilfenidat dozununun arttırılmasından sonra dramatik biçimde ortaya çıkması ile ilişkilendirdik.

Published
2014

42. Psychopathology and depression in the middle east

Author

SAYAR, Kemal and KOSE, Samet

Subjects
psikopatoloji,depresyon,psikoterapi,modernizasyon,hüzün
Abstract

Batı Dünyası’nın bakış açısıyla şekillenmiş günümüz psikoterapi yöntemleri, sosyal ve kültürel farklılıkları yeteri kadar işaret edemeyebilir. Oysaki sosyal ve kültürel farklılıklar Batı toplumları dışındaki topluluklarda hayat normlarının daha farklı belirlenmesine sebep olmaktadır. Ortadoğu toplumlarında kişinin ruh sağlığı ve bozukluğu, bu sebeple Batı toplumlarındaki gibi değerlendirilmez. Bu durum Ortadoğu toplumlarında Batı toplumlarından farklı psikopatolojilerin görülmesine neden olur. Bu şartlar altında psikoterapi yöntemlerinin de sosyal ve kültürel bir elekten geçirilmesi zorunludur. Yazarlar ayrıca günümüzde acı çekmenin medikalizasyonu, hastalık kategorilerinin nesneleştirilmesi ve varoluşun ahlaki anlamını kaybetmenin etkilerini tartışmaktadırlar.

Published
2014

46. Schneider Belirtileri ve DSM 5: İlişkili İki Olgu Sunumu.

Author

Yanartaş, Ömer, Ergün, Serhat, Akça, Erdoğdu, Hicri, Nurşin, Can Gürsoy, Süha, and Sayar, Kemal

Abstract

Copyright of Journal of Mood Disorders is the property of Yerkuere Tantim ve Yayincilik A.S. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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47. Long And Short Distance Movements Of Beta(2)-Adrenoceptor In Cell Membrane Assessed By Photoconvertible Fluorescent Protein Dendra2-Beta(2)-Adrenoceptor Fusion

Author

Kaya, Ali I., Ugur, Ozlem, Altuntas, Olga, Sayar, Kemal, and Onaran, H. Ongun

Abstract

Local movements of receptors in the plasma membrane have been extensively studied, as it is generally believed that the dynamics of membrane distribution of receptors regulate their functions. However, the properties of large-scale (>5 mu m) receptor movements in the membrane are relatively obscure. In the present study, we addressed the question as to whether the large-scale movement of receptor in the plasma membrane at the whole cell level can be explained quantitatively by its local diffusive properties. We used HEK 293 cells transfected with human beta 2-adrenoceptor fused to photoconvertible fluorescent protein dendra2 as a model system; and found that 1) functional integrity of the dendra2-tagged receptor remains apparently intact; 2) in a mesoscopic scale (similar to 4 mu m), similar to 90% of the receptors are mobile on average, and receptor influx to, and out-flux from a membrane area can be symmetrically explained by a diffusion-like process with an effective diffusion coefficient of similar to 0.1 mu m(2)/s; 3) these mobility parameters are not affected by the activity state of the receptor (assessed by using constitutively active receptor mutants); 4) in the macroscopic scale (4-40 mu m), although a slowly diffusing fraction of receptors (with D

Published
2011

50. The relationship between psychopathology and cognitive functions with cytokines in clinically stable patients with schizophrenia

Author

Ergün, Serhat, Yanartaş, Ömer, Kandemir, Güler, Yaman, Ali, Yıldız, Mesut, Haklar, Goncagül, and Sayar, Kemal

Abstract

ABSTRACTOBJECTIVESInflammation and the cytokine hypotheses have been proposed for schizophrenia. Several proinflammatory and anti-inflammatory cytokines have been studied in drug-naive, first-episode, and/or chronic schizophrenia patients. However, there were limited data on clinical stable outpatients reflecting daily routine. The aim of this study was to compare the serum levels of cytokines, including transforming growth factor-beta (TGF-β), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-α), between clinically stable patients with schizophrenia and healthy controls, as well as to examine the relationship between these inflammation parameters and clinical variables (positive and negative symptom severity and cognitive functions).METHODSThirty clinically stable outpatients with schizophrenia and 30 healthy controls with similar sex and age were included in this study. Serum IL-6, TGF-β, and TNF-α levels were assessed by enzyme-linked immunosorbent assay (ELISA) and immunoenzyme microplate measurement, respectively. Illness severity was evaluated using the Positive and Negative Syndrome Scale (PANSS), and the cognitive functions of the participants were assessed using a broad neuropsychological test battery.RESULTSThe serum levels of IL-6 and TGF-β were significantly higher in patients with schizophrenia compared to healthy controls (p = .048, p = .012). There was no significant difference between groups in terms of TNF-α levels (p = .726). Global impairment of cognitive functions was observed in the patient group compared to healthy controls, and PANSS scores and cognitive functions showed no correlation with cytokine levels (IL-6, TNF-α, and TGF-β).CONCLUSIONSThe present study demonstrated an increased inflammatory response in clinically stable patients with schizophrenia compared to healthy controls. However, symptom severity and cognitive functions showed no correlation with cytokine levels. Further research studies are needed to clarify the effects of cytokine levels on schizophrenia symptomatology and etiopathogenesis.

Published
2018
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