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We present the case of a patient who was diagnosed with “premonitory depression.” It is well known that cancer patients have higher rates of depression than general population. This is particularly true for those who suffer from pancreatic cancer, and such patients have a high incidence of depression compared to those who suffer from other malignancies. According to some hypotheses depression disorder associated with pancreatic cancer may be related to immunological interference with the activity of serotonin.

The formation process of dome shaped bottom cold water mass in summer Suo-Nada was investigated numerically. The observed field of water temperature and salinity were reproduced well by taking into account of tidal flow, while mere density current without tidal oscillation could not obtain enough accuracy. In the objective case, forming process of cold water mass could not be described only by mid-layer intrusion of well mixed Houyo Strait water to highly stratified water in Suo-Nada. It was suggested that the on-shore residual current near the bottom of Suo-Nada is playing important rolls to isolate the cold bottom water and suspend it to keep out of sinking into deep sea.

We have developed the long-period wave absorption structure by the experimental studies. On planning to apply it to actual fields, we propose the advanced type structure adding to upright wave absorbing blocks to dissipate not only long-period waves but also short-period one. The hydraulic performance such as reflection rates is verified through experiments. Furthermore, we reproduce the hydraulic performance of the structure with the numerical analysis based on the non-linear shallow water theory and demonstrate that it is useful for practical design of the structures.

Beneficial use of shell for constitutive materials of beach is proposed instead of its disposal. Since the shape of shell fragment is oblate, the knowledge on littoral drift of sand with spherical shape could not be applied directly for understanding of its behavior under waves. In this study, critical shields number and fall velocity of shell fragment are evaluated changing oblate shapes of the fragments, and the characteristics of bed load transport of shell and shell-mixed sand beds are examined by a movable-bed experiment. From the experiments, the effects of oblateness on the increase of resistance to wave and current are elucidated. It is found that the interaction of sand and shell on their movements has an effect on the bed - load rate changing the height of sand ripples.

Beneficial use of shell for constitutive materials of beach or tidal flat is proposed instead of its disposal. Since the shape of shell fragment is oblate, the knowledge on littoral drift of sand with spherical shape could not be applied directly for understanding of its behavior under waves. In this study, critical shields number and settling velocity of shell fragment are evaluated changing oblate shapes of the fragments, and the characteristics of bed load transport of shell and shell-mixed sand beds are examined by a movable-bed experiment. From the experiments, the effects of oblateness on the increase of resistance to wave and current are elucidated. It is found that the interaction of sand and shell on their movements has an effect on the bed-load rate changing the height of sand ripples.

In recent years, some of researchers have reported that most of nutrients in Suo nada are derived from open ocean through the Bungo Channel and Iyo nada. If these nutrients flow into euphotic zone of Suo nada, they can provide primary production and play an important role in Suo nada. We investigated pathway from Iyo nada to Suo nada by using observation data such as temperature, salinity, density and nutrients. As the result, we confirm existence of inflow from Iyo nada at euphotic zone in Suo nada. However, it is presented that less of contribution to primary production in Suo nada because of low nutrients in Iyo nada.