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143 results on '"Saxena, Nakul"'

6. Impact of ixazomib‐lenalidomide‐dexamethasone therapy on overall survival in multiple myeloma patients: Analysis of the emerging‐markets subgroup of the TOURMALINE‐MM1 trial

Author

Spencer, Andrew, primary, Samoilova, Olga, additional, Chng, Wee‐Joo, additional, Labotka, Richard, additional, Li, Cong, additional, Wu, Kwang‐Wei, additional, Saxena, Nakul, additional, Yan, Xu, additional, Lee, Jae Hoon, additional, and Beksac, Meral, additional

Published
2022
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14. Virtual Patient Simulations in Health Professions Education: Systematic Review and Meta-Analysis by the Digital Health Education Collaboration

Author

Kononowicz, Andrzej A., Woodham, Luke A., Edelbring, Samuel, Stathakarou, Natalia, Davies, David, Saxena, Nakul, Car, Lorainne Tudor, Carlstedt-Duke, Jan, Car, Josip, Zary, Nabil, Kononowicz, Andrzej A., Woodham, Luke A., Edelbring, Samuel, Stathakarou, Natalia, Davies, David, Saxena, Nakul, Car, Lorainne Tudor, Carlstedt-Duke, Jan, Car, Josip, and Zary, Nabil

Abstract

Background: Virtual patients are interactive digital simulations of clinical scenarios for the purpose of health professions education. There is no current collated evidence on the effectiveness of this form of education. Objective: The goal of this study was to evaluate the effectiveness of virtual patients compared with traditional education, blended with traditional education, compared with other types of digital education, and design variants of virtual patients in health professions education. The outcomes of interest were knowledge, skills, attitudes, and satisfaction. Methods: We performed a systematic review on the effectiveness of virtual patient simulations in pre- and postregistration health professions education following Cochrane methodology. We searched 7 databases from the year 1990 up to September 2018. No language restrictions were applied. We included randomized controlled trials and cluster randomized trials. We independently selected studies, extracted data, and assessed risk of bias and then compared the information in pairs. We contacted study authors for additional information if necessary. All pooled analyses were based on random-effects models. Results: A total of 51 trials involving 4696 participants met our inclusion criteria. Furthermore, 25 studies compared virtual patients with traditional education, 11 studies investigated virtual patients as blended learning, 5 studies compared virtual patients with different forms of digital education, and 10 studies compared different design variants. The pooled analysis of studies comparing the effect of virtual patients to traditional education showed similar results for knowledge (standardized mean difference [SMD]=0.11, 95% CI -0.17 to 0.39, I-2=74%, n=927) and favored virtual patients for skills (SMD=0.90, 95% CI 0.49 to 1.32, I-2=88%, n=897). Studies measuring attitudes and satisfaction predominantly used surveys with item-by-item comparison. Trials comparing virtual patients with different fo

Published
2019
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15. Virtual Reality for Health Professions Education : Systematic Review and Meta-Analysis by the Digital Health Education Collaboration

Author

Kyaw, Bhone Myint, Saxena, Nakul, Posadzki, Pawel, Vseteckova, Jitka, Nikolaou, Charoula Konstantia, George, Pradeep Paul, Divakar, Ushashree, Masiello, Italo, Kononowicz, Andrzej A., Zary, Nabil, Car, Lorainne Tudor, Kyaw, Bhone Myint, Saxena, Nakul, Posadzki, Pawel, Vseteckova, Jitka, Nikolaou, Charoula Konstantia, George, Pradeep Paul, Divakar, Ushashree, Masiello, Italo, Kononowicz, Andrzej A., Zary, Nabil, and Car, Lorainne Tudor

Abstract

Background: Virtual reality (VR) is a technology that allows the user to explore and manipulate computer-generated real or artificial three-dimensional multimedia sensory environments in real time to gain practical knowledge that can be used in clinical practice. Objective: The aim of this systematic review was to evaluate the effectiveness of VR for educating health professionals and improving their knowledge, cognitive skills, attitudes, and satisfaction. Methods: We performed a systematic review of the effectiveness of VR in pre- and postregistration health professions education following the gold standard Cochrane methodology. We searched 7 databases from the year 1990 to August 2017. No language restrictions were applied. We included randomized controlled trials and cluster-randomized trials. We independently selected studies, extracted data, and assessed risk of bias, and then, we compared the information in pairs. We contacted authors of the studies for additional information if necessary. All pooled analyses were based on random-effects models. We used the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach to rate the quality of the body of evidence. Results: A total of 31 studies (2407 participants) were included. Meta-analysis of 8 studies found that VR slightly improves postintervention knowledge scores when compared with traditional learning (standardized mean difference [SMD]=0.44; 95% CI 0.18-0.69; I-2=49%; 603 participants; moderate certainty evidence) or other types of digital education such as online or offline digital education (SMD=0.43; 95% CI 0.07-0.79; I-2=78%; 608 participants [8 studies]; low certainty evidence). Another meta-analysis of 4 studies found that VR improves health professionals' cognitive skills when compared with traditional learning (SMD=1.12; 95% CI 0.81-1.43; I-2=0%; 235 participants; large effect size; moderate certainty evidence). Two studies compared the effect of VR with other forms of di

Published
2019
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17. Virtual Patient Simulations in Health Professions Education: Systematic Review and Meta-Analysis by the Digital Health Education Collaboration (Preprint)

Author

Kononowicz, Andrzej A, primary, Woodham, Luke A, additional, Edelbring, Samuel, additional, Stathakarou, Natalia, additional, Davies, David, additional, Saxena, Nakul, additional, Tudor Car, Lorainne, additional, Carlstedt-Duke, Jan, additional, Car, Josip, additional, and Zary, Nabil, additional

Published
2019
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18. Online Digital Education for Postregistration Training of Medical Doctors: Systematic Review by the Digital Health Education Collaboration

Author

George, Pradeep Paul, primary, Zhabenko, Olena, additional, Kyaw, Bhone Myint, additional, Antoniou, Panagiotis, additional, Posadzki, Pawel, additional, Saxena, Nakul, additional, Semwal, Monika, additional, Tudor Car, Lorainne, additional, Zary, Nabil, additional, Lockwood, Craig, additional, and Car, Josip, additional

Published
2019
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19. Virtual Reality for Health Professions Education: Systematic Review and Meta-Analysis by the Digital Health Education Collaboration

Author

Kyaw, Bhone Myint, primary, Saxena, Nakul, additional, Posadzki, Pawel, additional, Vseteckova, Jitka, additional, Nikolaou, Charoula Konstantia, additional, George, Pradeep Paul, additional, Divakar, Ushashree, additional, Masiello, Italo, additional, Kononowicz, Andrzej A, additional, Zary, Nabil, additional, and Tudor Car, Lorainne, additional

Published
2019
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20. Online Digital Education for Postregistration Training of Medical Doctors: Systematic Review by the Digital Health Education Collaboration (Preprint)

Author

George, Pradeep Paul, primary, Zhabenko, Olena, additional, Kyaw, Bhone Myint, additional, Antoniou, Panagiotis, additional, Posadzki, Pawel, additional, Saxena, Nakul, additional, Semwal, Monika, additional, Tudor Car, Lorainne, additional, Zary, Nabil, additional, Lockwood, Craig, additional, and Car, Josip, additional

Published
2019
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21. Cost-effectiveness of anti-oxidant vitamins plus zinc treatment to prevent the progression of intermediate age-related macular degeneration. A Singapore perspective

Author

Saxena, Nakul, George, Pradeep, Heng, Bee, Lim, Tock, and Yong, Shao

Subjects
Macular degeneration -- Economic aspects -- Development and progression -- Prevention -- Physiological aspects, Zinc (Nutrient) -- Health aspects, Vitamins -- Usage -- Health aspects, Health
Abstract

Byline: Nakul. Saxena, Pradeep. George, Bee. Heng, Tock. Lim, Shao. Yong Purpose: To determine if providing high dose anti-oxidant vitamins and zinc treatment age-related eye disease study (AREDS formulation) to [...]

Published
2015

22. Virtual Reality for Health Professions Education: Systematic Review and Meta-Analysis by the Digital Health Education Collaboration (Preprint)

Author

Kyaw, Bhone Myint, primary, Saxena, Nakul, additional, Posadzki, Pawel, additional, Vseteckova, Jitka, additional, Nikolaou, Charoula Konstantia, additional, George, Pradeep Paul, additional, Divakar, Ushashree, additional, Masiello, Italo, additional, Kononowicz, Andrzej A, additional, Zary, Nabil, additional, and Tudor Car, Lorainne, additional

Published
2018
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23. Virtual reality environments for health professional education

Author

Saxena, Nakul, primary, Kyaw, Bhone Myint, additional, Vseteckova, Jitka, additional, Dev, Parvati, additional, Paul, Pradeep, additional, Lim, Kenneth Teck Kiat, additional, Kononowicz, Andrzej A, additional, Masiello, Italo, additional, Tudor Car, Lorainne, additional, Nikolaou, Charoula K, additional, Zary, Nabil, additional, and Car, Josip, additional

Published
2018
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25. Virtual patient simulations for health professional education

Author

Kononowicz, Andrzej A, primary, Woodham, Luke, additional, Georg, Carina, additional, Edelbring, Samuel, additional, Stathakarou, Natalia, additional, Davies, David, additional, Masiello, Italo, additional, Saxena, Nakul, additional, Tudor Car, Lorainne, additional, Car, Josip, additional, and Zary, Nabil, additional

Published
2018
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28. Virtual reality environments for health professional education (Protocol)

Author

Saxena, Nakul, Kyaw, Bhone M., Vseteckova, Jitka, Dev, Parvati, Paul, Pradeep, Lim, Kenneth Teck Kiat, Kononowicz, Andrezej, Masiello, Italo, Tudor Car, Lorainne, Nikolaou, Charoula K., Zary, Nabil, and Car, Josip

Subjects
biochemical phenomena, metabolism, and nutrition
Abstract

Objectives: To assess the effects of virtual reality environment (VRE)-based educational interventions for health professionals on knowledge, skills, and participants’ attitude towards and satisfaction with the interventions. Additionally, this review will assess the interventions' economic impact (cost and cost effectiveness), patient-related outcomes and unintended adverse effects of VRE-based educational interventions for post-registration healthcare providers.

Published
2016

29. Evaluation of an integrated primary care-led dementia shared care program in Singapore: An effectiveness and cost-effectiveness study

Author

Saxena, Nakul, primary, George, Pradeep Paul, additional, Teo, Kelvin WS, additional, Tan, Woan Shin, additional, Ng, Charis, additional, Heng, Bee Hoon, additional, Yeo, Cindy Ying Ying, additional, Anthony, Philomena, additional, Tan, Colin, additional, Low, Kang Yih, additional, Wu, Valerie, additional, Ali, Noorhazlina Binte, additional, and Chong, Mei Sian, additional

Published
2017
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31. Virtual patient simulations for health professional education

Author

Kononowicz, Andrzej A., Woodham, Luke, Georg, Carina, Edelbring, Samuel, Stathakarou, Natalia, Davies, David, Masiello, Italo, Saxena, Nakul, Tudor Car, Lorainne, Car, Josip, Zary, Nabil, Kononowicz, Andrzej A., Woodham, Luke, Georg, Carina, Edelbring, Samuel, Stathakarou, Natalia, Davies, David, Masiello, Italo, Saxena, Nakul, Tudor Car, Lorainne, Car, Josip, and Zary, Nabil

Abstract

This is the protocol for a review and there is no abstract. The objectives are as follows: The objective of this review is to evaluate the effectiveness of virtual patient simulation as an educational intervention versus traditional learning, other types of e-Learning interventions and other forms of virtual patient simulation interventions for delivering pre-registration and post-registration healthcare professional education. We will primarily assess the impact of these interventions on learners knowledge, skills and attitudes. Our secondary objective is to assess the cost-effectiveness of these interventions., Funding Agencies:Karolinska Institutet, Stockholm, Sweden; NTU Lee Kong Chian School of Medicine, Singapore; Health Services and Outcomes Research (HSOR) National Healthcare Group, Singapore; Department of Primary Care and Public Health, Imperial College London, UK; National Institute for Health Research (NIHR) under the Collaborations for Leadership in Applied Health Research and Care (CLAHRC) programme for North West London

Published
2016
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35. Virtual patient simulations for health professional education

Author

Kononowicz, Andrzej A, primary, Woodham, Luke, additional, Georg, Carina, additional, Edelbring, Samuel, additional, Stathakarou, Natalia, additional, Davies, David, additional, Masiello, Italo, additional, Saxena, Nakul, additional, Tudor Car, Lorainne, additional, Car, Josip, additional, and Zary, Nabil, additional

Published
2016
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37. Virtual reality environments for health professional education

Author

Saxena, Nakul, primary, Kyaw, Bhone M, additional, Vseteckova, Jitka, additional, Dev, Parvati, additional, Paul, Pradeep, additional, Lim, Kenneth Teck Kiat, additional, Kononowicz, Andrzej, additional, Masiello, Italo, additional, Tudor Car, Lorainne, additional, Nikolaou, Charoula K, additional, Zary, Nabil, additional, and Car, Josip, additional

Published
2016
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38. Setting up a regional health system database for seamless population health management in Singapore

Author

Gunapal, Pradeep Paul George, primary, Kannapiran, Palvannan, additional, Teow, Kiok Liang, additional, Zhu, Zhecheng, additional, Xiaobin You, Alex, additional, Saxena, Nakul, additional, Singh, Vinay, additional, Tham, Linus, additional, Choo, Philip Wee Jin, additional, Chong, Phui-Nah, additional, Sim, Joe Heng Joo, additional, Eu Li Wong, John, additional, Ong, Benjamin Kian Chung, additional, Soh, Eugene Fidelis, additional, Foo, Hee Jug, additional, and Heng, Bee Hoon, additional

Published
2015
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39. Singapore's regional health systems-a data-driven perspective on frequent admitters and cross utilization of healthcare services in three systems

Author

Saxena, Nakul, primary, You, Alex Xiaobin, additional, Zhu, Zhecheng, additional, Sun, Yan, additional, George, Pradeep Paul, additional, Teow, Kiok Liang, additional, Chong, Phui-Nah, additional, Sim, Joe, additional, Wong, John Eu Li, additional, Ong, Benjamin, additional, Foo, Hee Jug, additional, Soh, Eugene Fidelis, additional, Tham, Linus, additional, Heng, Bee Hoon, additional, and Choo, Philip, additional

Published
2015
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45. Abstract 2460: Extracellular matrix protein expression is associated with chemotherapy resistance in breast cancer

Author

Wang, Tingting, primary, Guo, Tiannan, additional, Sze, Siu Kwan, additional, Hartman, Mikael, additional, Buhari, Shaik Ahmad, additional, Chan, Ching-Wan, additional, Iau, Philip, additional, Khin, Lay Wai, additional, Saxena, Nakul, additional, Wong, Andrea, additional, Tan, Sing-Huang, additional, Goh, Boon-Cher, additional, and Lee, Soo-Chin, additional

Published
2012
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46. Ethnic Differences in Survival after Breast Cancer in South East Asia

Author

Bhoo-Pathy, Nirmala, primary, Hartman, Mikael, additional, Yip, Cheng-Har, additional, Saxena, Nakul, additional, Taib, Nur Aishah, additional, Lim, Siew-Eng, additional, Iau, Philip, additional, Adami, Hans-Olov, additional, Bulgiba, Awang M., additional, Lee, Soo-Chin, additional, and Verkooijen, Helena M., additional

Published
2012
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47. Diabetes-related lower extremity amputations in Singapore

Author

Ang, Yee, Yap, Chun Wei, Saxena, Nakul, Lin, Lee-Kai, and Heng, Bee Hoon

Abstract

Background: Lower extremity amputation (LEA) is defined as the complete loss in the transverse anatomical plane of any part of the lower limb. The objective of this study is to look at the trend and mortality trend of LEA performed in diabetes patients from 2008 to 2013.Methods: All patients age 15 and above with diabetes mellitus who had undergone LEAs (both major and minor) in Tan Tock Seng Hospital, Singapore from 1 January 2008 to 31 December 2013 were included. The outcomes of interest were deaths from all causes within 30 days and within 1 year.Results: Major LEA rate has increased from 11.0 per 100,000 population in 2008 to 13.3 per 100,000 population in 2013. The 30-day mortality rate ranges from 6.0% to 11.1% and the 1-year mortality rate ranges from 24.3% to 30.6%. Minor LEA rate has increased from 10.8 per 100,000 population in 2008 to 13.9 per 100,000 population in 2013. The 30-day mortality rate ranges from 1.5% to 3.7% and the 1-year mortality rate ranges from 9.7% to 18.3%.Conclusions: The trends in major and minor LEA are increasing. The 30-day and 1-year mortality for both major and minor LEA are comparable to figures reported worldwide. There is a need to re-look at preventive strategies to reduce LEA in diabetes patients in Singapore.

Published
2017
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48. Prognostic value of axillary lymph node status after neoadjuvant chemotherapy. Results from a multicentre study

Author

Saxena, Nakul, primary, Hartman, Mikael, additional, Aziz, Rezal, additional, Rapiti, Elisabetta, additional, Bhoo Pathy, Nirmala, additional, Lim, Siew Eng, additional, Iau, Philip, additional, Taib, Nur Aisha, additional, Schaffar, Robin, additional, Neyroud-Caspar, Isabelle, additional, Yip, Cheng Har, additional, Lee, Soo Chin, additional, and Verkooijen, Helena M., additional

Published
2011
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50. Setting up a regional health system database for seamless population health management in Singapore

Author

Gunapal, Pradeep Paul George, Kannapiran, Palvannan, Teow, Kiok Liang, Zhu, Zhecheng, Xiaobin You, Alex, Saxena, Nakul, Singh, Vinay, Tham, Linus, Choo, Philip Wee Jin, Chong, Phui-Nah, Sim, Joe Heng Joo, Eu Li Wong, John, Ong, Benjamin Kian Chung, Soh, Eugene Fidelis, Foo, Hee Jug, and Heng, Bee Hoon

Abstract

Objective: Understanding the health and health service utilization of the population is critical for Regional Health System’s (RHS) population health management (PHM) initiatives in Singapore. The RHS database is a collaborative effort toward developing a national architecture for healthcare utilization data across diverse clinical systems with disparate data models. This manuscript describes the setup of an RHS database which would facilitate big data analytics for proactive population health management and health services research.Materials and methods: The RHS database is a conglomeration of four isolated databases from the three RHSs. It contains linked National Healthcare Group (NHG) polyclinic visit records, specialist outpatient clinic visit records, hospital discharge records from Tan Tock Seng Hospital (TTSH), National University Hospital (NUH) and Alexandra Hospital (AH), chronic disease management system (CDMS) records and mortality records from local registries. The data linkage process was conducted using the unique identification number (NRIC) as the linking variable. The final anonymized database has multiple interconnected tables that includes patient demographics, chronic disease and healthcare utilization information.Results: Over 2.8 million patients had contact with the three RHSs from 2008 to 2013. The database facilitated risk stratification of patients based on their past healthcare utilization and chronic disease information. This database aids in understanding the cross-utilization of healthcare services across the three RHSs and can help address the challenges of setting up a distinct geographical boundary for individual RHSs.Conclusions: The RHS database has been established with the intention to support the secondary use of administrative health data in health services research and proactive PHM in Singapore.

Published
2016
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