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Byline: Pallavi. Doda, Sukhyanti. Kerai, Kanika. Chauhan, Vineet. Manchanda, Kirti. Saxena, Anurag. Mishra Background and Aims: There is paucity of studies on preoperative risk assessment tools in patients undergoing emergency [...]

Byline: Sukhyanti. Kerai, T. Prathap, Garima. Bhatt, Prachi. Gaba, Lalit. Gupta, Kirti. Saxena Background and Aims: The passage of a Ryle's tube through the drain port on the laryngeal mask [...]

Byline: H. Prashant, Kirti. Saxena, Seema. Kapoor, Bharti. Wadhwa, Sukhyanti. Kerai, Prachi. Gaba Background and Aims: Genetic polymorphisms contribute to patients' variability in pain perception and response to opioid treatment. [...]

Objective: This study aimed to determine the correlation between pain perception and knowledge, attitude, and diet diversity in patients undergoing fixed orthodontic treatment. Methods: A total of 103 patients (15-40 yrs.; 67 females, 36 males) undergoing orthodontic treatment with a 0.022-inch slot (MBT prescription) in both arches were recruited. Information on pain perception, knowledge, attitude, and diet diversity scores was collected through validated questionnaires using visual analogue scale and close-ended questions at one time point. The correlation between variables was analyzed using the Pearson's correlation coefficient. Results: Of the patients, 48.5% were aged 15 to 19 years old, with 65% females and 73.8% of Chinese ethnicity. Approximately 90% of the orthodontic patients perceived low levels of pain from orthodontic treatment, and 98% had a positive attitude toward orthodontic treatment. The patients had a good level of knowledge (Mean: 6±0.65). Approximately 49.5% of patients reported having moderate diet diversity. No significant correlation was found between pain perception and knowledge, or pain perception and diet diversity (r=0.062, p=0.534). However, a significant weak negative correlation (r=-0.289, p<0.05) between pain perception and attitude was observed. Conclusion: Patients undergoing fixed orthodontic treatment presented with overall low pain perception, a positive attitude, and good knowledge about their treatment with moderate diet diversity. Informing the patient in advance about different orthodontic procedures encourages a positive attitude and facilitates patient cooperation. An interprofessional approach involving nutritionists can provide a holistic patient approach during orthodontic treatment. [ABSTRACT FROM AUTHOR]

Byline: Sukhyanti. Kerai, Garima. Bhatt, Kirti. Saxena, Prachi. Gaba, Bharti. Wadhwa Background and Aims: Oropharyngeal leak pressure (OLP) of LMA Protector is reported to be higher compared to other second [...]

Detection of Helicobacter pylori (H. pylori) infection, a significant risk factor for chronic gastritis, peptic ulcers, and gastric adenocarcinoma, poses a formidable challenge due to the lack of sensitive and selective sensing platforms. Herein, we report the synthesis of a zeolitic imidazolate framework‐67 (ZIF‐67) derived Co/Co3O4/C (CoNH) porous nanostructure, optimized for the electrochemical immunosensing of H. pylori‐specific antigen VacA. By calcining ZIF‐67 at elevated temperatures, we obtained CoNH with enhanced electroactivity and conductivity, crucial for signal enhancement. The synthesized CoNH was thoroughly characterized using SEM, TEM, XPS, Raman, and FT‐IR techniques. Further signal amplification was achieved by introducing gold nanoparticles (AuNPs) onto CoNH‐modified screen‐printed carbon electrodes. Systematic investigation at each modification stage led to an optimized immunosensing platform with high sensitivity and selectivity for VacA detection. The developed immunosensor demonstrated the capability to detect low concentrations of VacA (0.1 ng/ml) within a wide linear range (0.1–50 ng/ml) with long‐term stability. This highly sensitive and selective biosensor holds promise for early‐stage diagnosis of H. pylori infection and gastric cancer. [ABSTRACT FROM AUTHOR]

The management of treatment-resistant depression (TRD) is challenging. Researchers have identified novel targets, especially the glutamatergic system, in the pathogenesis of depressive disorder. N-methyl-D-aspartate (NMDA) receptor antagonists, like ketamine, have revolutionized the treatment of TRD due to their rapid antidepressant and antisuicidal effect. Various other receptor systems, including GABAergic, opioid receptors, the endogenous cannabinoid system, and cholinergic receptors, are novel targets to produce an antidepressant response. The US Food and Drug Administration (FDA) has approved intra-nasal ketamine as an add-on therapy to conventional antidepressants for TRD. Other compounds are in various stages of development. Identification and development of novel compounds by future research can help in overcoming the challenges of treating TRD. [Psychiatr Ann. 2024;54(6):e177–e181.] [ABSTRACT FROM AUTHOR]

Byline: Sukhyanti. Kerai, Prachi. Gaba, Lalit. Gupta, Kirti. Saxena Sir, Complete atrioventricular (AV) canal defect with double outlet right ventricle (DORV) and severe pulmonary stenosis (PS) is a rare complex [...]