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It is well known that synchronization patterns and coherence have a major role in the functioning of brain networks, both in pathological and in healthy states. In particular, in the perception of sound, one can observe an increase in coherence between the global dynamics in the network and the auditory input. In this perspective article, we show that synchronization scenarios are determined by a fine interplay between network topology, the location of the input, and frequencies of these cortical input signals. To this end, we analyze the influence of an external stimulation in a network of FitzHugh-Nagumo oscillators with empirically measured structural connectivity, and discuss different areas of cortical stimulation, including the auditory cortex., Comment: 7 pages, 5 figures. arXiv admin note: text overlap with arXiv:2204.00562, arXiv:2103.13804

Adaptivity is a dynamical feature that is omnipresent in nature, socio-economics, and technology. For example, adaptive couplings appear in various real-world systems like the power grid, social, and neural networks, and they form the backbone of closed-loop control strategies and machine learning algorithms. In this article, we provide an interdisciplinary perspective on adaptive systems. We reflect on the notion and terminology of adaptivity in different disciplines and discuss which role adaptivity plays for various fields. We highlight common open challenges, and give perspectives on future research directions, looking to inspire interdisciplinary approaches., Comment: 46 pages, 9 figures

We analyze the influence of music in a network of FitzHugh-Nagumo oscillators with empirical structural connectivity measured in healthy human subjects. We report an increase of coherence between the global dynamics in our network and the input signal induced by a specific music song. We show that the level of coherence depends crucially on the frequency band. We compare our results with experimental data, which also describe global neural synchronization between different brain regions in the gamma-band range and its increase just before transitions between different parts of the musical form (musical high-level events). The results also suggest a separation in musical form-related brain synchronization between high brain frequencies, associated with neocortical activity, and low frequencies in the range of dance movements, associated with interactivity between cortical and subcortical regions., Comment: 26 pages, 10 figures. arXiv admin note: text overlap with arXiv:2103.13804

In this work, we propose a dynamical systems perspective on the modeling of sepsis and its organ-damaging consequences. We develop a functional two-layer network model for sepsis based upon the interaction of parenchymal cells and immune cells via cytokines, and the coevolutionary dynamics of parenchymal, immune cells, and cytokines. By means of the simple paradigmatic model of phase oscillators in a two-layer system, we analyze the emergence of organ threatening interactions between the dysregulated immune system and the parenchyma. We demonstrate that the complex cellular cooperation between parenchyma and stroma (immune layer) either in the physiological or in the pathological case can be related to dynamical patterns of the network. In this way we explain sepsis by the dysregulation of the healthy homeostatic state (frequency synchronized) leading to a pathological state (desynchronized or multifrequency cluster) in the parenchyma. We provide insight into the complex stabilizing and destabilizing interplay of parenchyma and stroma by determining critical interaction parameters. The coupled dynamics of parenchymal cells (metabolism) and nonspecific immune cells (response of the innate immune system) is represented by nodes of a duplex layer. Cytokine interaction is modeled by adaptive coupling weights between nodes representing immune cells (with fast adaptation timescale) and parenchymal cells (slow adaptation timescale), and between pairs of parenchymal and immune cells in the duplex network (fixed bidirectional coupling). The proposed model allows for a functional description of organ dysfunction in sepsis and the recurrence risk in a plausible pathophysiological context.

In this study, we provide a dynamical systems perspective to the modelling of pathological states induced by tumors or infection. A unified disease model is established using the innate immune system as the reference point. We propose a two-layer network model for carcinogenesis and sepsis based upon the interaction of parenchymal cells and immune cells via cytokines, and the co-evolutionary dynamics of parenchymal, immune cells, and cytokines. Our aim is to show that the complex cellular cooperation between parenchyma and stroma (immune layer) in the physiological and pathological case can be qualitatively and functionally described by a simple paradigmatic model of phase oscillators. By this, we explain carcinogenesis, tumor progression, and sepsis by destabilization of the healthy homeostatic state (frequency synchronized), and emergence of a pathological state (desynchronized or multifrequency cluster). The coupled dynamics of parenchymal cells (metabolism) and nonspecific immune cells (reaction of innate immune system) are represented by nodes of a duplex layer. The cytokine interaction is modeled by adaptive coupling weights between the nodes representing the immune cells (with fast adaptation time scale) and the parenchymal cells (slow adaptation time scale) and between the pairs of parenchymal and immune cells in the duplex network (fixed bidirectional coupling). Thereby, carcinogenesis, organ dysfunction in sepsis, and recurrence risk can be described in a correct functional context., Comment: 27 pages, 9 figures

We study various relay synchronization scenarios in a three-layer network, where the middle (relay) layer is a single node, i.e. a hub, The two remote layers consist of non-locally coupled rings of FitzHugh-Nagumo oscillators modelling neuronal dynamics. All nodes of the remote layers are connected to the hub. The role of the hub and its importance for the existence of chimera states is investigated in dependence on the inter-layer coupling strength and inter-layer time delay. Tongue-like regions in the parameter plane exhibiting double chimeras, i.e., chimera states in the remote layers whose coherent cores are synchronized with each other, and salt-and-pepper states are found. At very low intra-layer coupling strength, when chimera states do not exist in single layers, these may be induced by the hub. Also the influence of dilution of links between the remote layers and the hub upon the dynamics is investigated. The greatest effect of dilution is observed when links to the coherent domain of the chimeras are removed., Comment: 9 pages, 7 figures

We analyze the influence of an external sound source in a network of FitzHugh-Nagumo oscillators with empirical structural connectivity measured in healthy human subjects. We report synchronization patterns, induced by the frequency of the sound source. We show that the level of synchrony can be enhanced by choosing the frequency of the sound source and its amplitude as control parameters for synchronization patterns. We discuss a minimum model elucidating the modalities of the influence of music on the human brain., Comment: 6 Figures

Relay synchronization in complex networks is characterized by the synchronization of remote parts of the network due to their interaction via a relay. In multilayer networks, distant layers that are not connected directly can synchronize due to signal propagation via relay layers. In this work, we investigate relay synchronization of partial synchronization patterns like chimera states in three-layer networks of interacting FitzHugh-Nagumo oscillators. We demonstrate that the phenomenon of relay synchronization is robust to topological random inhomogeneities of small-world type in the layer networks. We show that including randomness in the connectivity structure either of the remote network layers, or of the relay layer, increases the range of interlayer coupling strength where relay synchronization can be observed.

We propose a concept to generate and stabilize diverse partial synchronization patterns (phase clusters) in adaptive networks which are widespread in neuro- and social sciences, as well as biology, engineering, and other disciplines. We show by theoretical analysis and computer simulations that multiplexing in a multi-layer network with symmetry can induce various stable phase cluster states in a situation where they are not stable or do not even exist in the single layer. Further, we develop a method for the analysis of Laplacian matrices of multiplex networks which allows for insight into the spectral structure of these networks enabling a reduction to the stability problem of single layers. We employ the multiplex decomposition to provide analytic results for the stability of the multilayer patterns. As local dynamics we use the paradigmatic Kuramoto phase oscillator, which is a simple generic model and has been successfully applied in the modeling of synchronization phenomena in a wide range of natural and technological systems.

One of the most challenging types of ill-posedness in global optimization is the presence of insensitivity regions in design parameter space, so the identification of their shape will be crucial, if ill-posedness is irrecoverable. Such problems may be solved using global stochastic search followed by post-processing of a local sample and a local objective approximation. We propose a new approach of this type composed of Hierarchic Memetic Strategy (HMS) powered by the Covariance Matrix Adaptation Evolutionary Strategy (CMA-ES) well-known as an effective, self-adaptable stochastic optimization algorithm and we leverage the distribution density knowledge it accumulates to better identify and separate insensitivity regions. The results of benchmarks prove that the improved HMS-CMA-ES strategy is effective in both the total computational cost and the accuracy of insensitivity region approximation. The reference data for the tests was obtained by means of a well-known effective strategy of multimodal stochastic optimization called the Niching Evolutionary Algorithm 2 (NEA2), that also uses CMA-ES as a component., Comment: presented at OLA2019 conference

We analyze partial synchronization patterns in a network of FitzHugh-Nagumo oscillators with empirical structural connectivity measured in healthy human subjects. We report a dynamical asymmetry between the hemispheres, induced by the natural structural asymmetry. We show that the dynamical asymmetry can be enhanced by introducing the inter-hemispheric coupling strength as a control parameter for partial synchronization patterns. We specify the possible modalities for existence of unihemispheric sleep in human brain, where one hemisphere sleeps while the other remains awake. In fact, this state is common among migratory birds and mammals like aquatic species., Comment: 7 pages, 6 figures

Complex multiplex networks consist of several subnetwork layers, which interact via pairwise inter-layer connections. Relay synchronization between distant layers which are not directly connected, but only via a relay layer, can be observed in multiplex networks. We study three-layer networks of discrete logistic maps, where each individual layer is a nonlocally coupled ring, and demonstrate scenarios of relay synchronization of complex patterns in the outer layers which interact via an intermediate layer. We find regimes of relay synchronization for chimera states, i.e., patterns of coexisting coherent and incoherent domains, and a transition from phase chimeras to amplitude chimeras for increasing inter-layer coupling. We determine analytically the approximate critical coupling strengths for the existence of phase chimeras.

We study chimera states, which are partial synchronization patterns consisting of spatially coexisting domains of coherent (synchronized) and incoherent (desynchronized) dynamics, in ring networks of FitzHugh-Nagumo oscillators with fractal connectivities. In particular, we focus on the interplay of time delay in the coupling term and the network topology. In the parameter plane of coupling strength and delay time we find tongue-like regions of existence of chimera states alternating with regions of coherent dynamics. We show analytically and numerically that the period of the synchronized dynamics as a function of delay is characterized by a sequence of piecewise linear branches. In between these branches various chimera states and other partial synchronization patterns are induced by the time delay. By varying the time delay one can deliberately choose and stabilize desired spatio-temporal patterns., Comment: 12 pages, 5 figures. arXiv admin note: substantial text overlap with arXiv:1703.02936

We study remote (or relay) synchronization in multilayer networks between parts of one layer and their counterparts in a second layer, where these two layers are not directly connected. A simple realization of such a system is a triplex network where a relay layer in the middle, which is generally not synchronized, acts as a transmitter between two outer layers. We establish time delay in the inter-layer coupling as a powerful tool to control various partial synchronization patterns, in particular chimera states, i.e., complex patterns of coexisting coherent and incoherent domains. We demonstrate that the three-layer structure of the network allows for synchronization of the coherent domains of chimera states in the first layer with their counterparts in the third layer, whereas the incoherent domains either remain desynchronized or synchronized. By varying the topology of the relay layer, we study its influence on the remote synchronization in the outer layers. As model dynamics we use the paradigmatic FitzHugh-Nagumo system., Comment: 6 pages, 3 figures, added references

We investigate synchronization of coupled organ pipes. Synchronization and reflection in the organ lead to undesired weakening of the sound in special cases. Recent experiments have shown that sound interaction is highly complex and nonlinear, however, we show that two delay-coupled Van-der-Pol oscillators appear to be a good model for the occurring dynamical phenomena. Here the coupling is realized as distance-dependent, or time-delayed, equivalently. Analytically, we investigate the synchronization frequency and bifurcation scenarios which occur at the boundaries of the Arnold tongues. We successfully compare our results to experimental data.

Chimera states are an example of intriguing partial synchronization patterns emerging in networks of identical oscillators. They consist of spatially coexisting domains of coherent (synchronized) and incoherent (desynchronized) dynamics. We analyze chimera states in networks of Van der Pol oscillators with hierarchical connectivities, and elaborate the role of time delay introduced in the coupling term. In the parameter plane of coupling strength and delay time we find tongue-like regions of existence of chimera states alternating with regions of existence of coherent travelling waves. We demonstrate that by varying the time delay one can deliberately stabilize desired spatio-temporal patterns in the system., Comment: arXiv admin note: text overlap with arXiv:1603.00171

Chimera states are complex spatio-temporal patterns that consist of coexisting domains of coherent and incoherent dynamics. We study chimera states in a network of non-locally coupled Stuart-Landau oscillators. We investigate the impact of initial conditions in combination with non-local coupling. Based on an analytical argument, we show how the coupling phase and the coupling strength are linked to the occurrence of chimera states, flipped profiles of the mean phase velocity, and the transition from a phase- to an amplitude-mediated chimera state., Comment: arXiv admin note: text overlap with arXiv:1603.00171