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745 results on '"Sawada, Norimasa"'

2. Identification of Coiled-Coil Domain–Containing Protein 180 and Leucine-Rich Repeat–Containing Protein 4 as Potential Immunohistochemical Markers for Liposarcoma Based on Proteomic Analysis Using Formalin-Fixed, Paraffin-Embedded Tissue

Author

Aoyama, Tomoyuki, Takasawa, Akira, Takasawa, Kumi, Ono, Yusuke, Emori, Makoto, Murata, Masaki, Hayasaka, Takahiro, Fujitani, Naoki, Osanai, Makoto, Yamashita, Toshihiko, Hasegawa, Tadashi, and Sawada, Norimasa

Published
2019
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6. Emerging roles of transmembrane‐type tight junction proteins in cancers.

Author

Takasawa, Akira, Takasawa, Kumi, Murata, Masaki, Osanai, Makoto, and Sawada, Norimasa

Subjects
TIGHT junctions, EXTRACELLULAR matrix, CLAUDINS, ENDOTHELIAL cells, DRUG target, CELL adhesion
Abstract

Tight junctions (TJs) are the most apical components of the cell–cell adhesion machinery in epithelial and endothelial cells and they play essential roles in homeostasis. Recent studies have revealed that aberrant expression of tight junction proteins (TJPs) is frequently observed in various type of cancers. Here we review cancer‐associated aberrant expression of TJPs with focus on transmembrane‐type TJPs including claudins, junctional adhesion molecule‐A (JAM‐A), and occludin. Some transmembrane‐type TJPs are upregulated at the early neoplastic stage and their expression persists during dedifferentiation. Aberrant expression of TJPs contributes to proliferation, invasion, and dysregulated signaling of cancer cells. In addition to an increase in their expression level, their localization is altered from a TJ‐restricted pattern to distribution throughout the whole cell membrane, making them suitable as therapeutic targets. Extracellular domains of transmembrane‐type TJPs can be approached by target drugs not only from the lumen side (apical side) but also from the extracellular matrix side (basal side), including blood vessels. Aberrantly expressed TJPs are potential useful diagnostic markers as well as therapeutic targets for cancers. [ABSTRACT FROM AUTHOR]

Published
2023
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11. Pancreatic regeneration: basic research and gene regulation

Author

Okita, Kenji, Mizuguchi, Toru, Shigenori, Ota, Ishii, Masayuki, Nishidate, Toshihiko, Ueki, Tomomi, Meguro, Makoto, Kimura, Yasutoshi, Tanimizu, Naoki, Ichinohe, Norihisa, Torigoe, Toshihiko, Kojima, Takashi, Mitaka, Toshihiro, Sato, Noriyuki, Sawada, Norimasa, and Hirata, Koichi

Published
2016
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42. Elevated expression of G protein-coupled receptor 30 (GPR30) is associated with poor prognosis in patients with uterine cervical adenocarcinoma

Author

Tagami, Yohei, Ino, Yoshihiko, Akimoto, Taishi, Takasawa, Akira, Takasawa, Kumi, Aoyama, Tomoyuki, Ueda, Asako, Ota, Misaki, Magara, Kazufumi, Murata, Masaki, Hasegawa, Tadashi, Saito, Tsuyoshi, Sawada, Norimasa, and Osanai, Makoto

Subjects
Invasion front, 6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología [CDU], Cervical adenocarcinoma, Estrogen receptor, G protein-coupled receptor 30 (GPR30), Prognosis, G protein-coupled estrogen receptor 1 (GPER1)
Abstract

Uterine cervical adenocarcinoma has a worse prognosis than that of squamous cell carcinoma and useful diagnostic and prognostic markers are needed. Estrogen is one of the key regulators of several cancers, however, the estrogen signaling has not been focused on in cervical adenocarcinoma. Here, we shows expression profile of classical estrogen receptor (ER) and a novel membrane type estrogen receptor, G protein-coupled receptor 30 (GPR30), in surgical specimens (n=53). GPR30 was strongly expressed on the cell membrane and in the cytoplasm in adenocarcinoma in situ (AIS) and adenocarcinoma, and its expression was especially strong at the invasion front in most of the cases of GPR30-positive adenocarcinoma. Nuclear staining of ER was strong in non-neoplastic glands, whereas it was almost absent in most of the AIS and adenocarcinoma cases. There was a weak but statistically significant negative correlation between immunoreactivity of GPR30 and that of ER in cervical AIS and adenocarcinoma lesions (Spearman’s correlation, r=- 0.324, p=0.017). ROC curve analysis revealed that immunoreactivity of GPR30 successfully distinguished neoplasms from non-neoplastic glands with high specificity (100%) and sensitivity (75.5%). GPR30 positivity was significantly correlated with histological type (p=0.009), tumor diameter (p=0.003), tumor size (p

Published
2020

45. The nuclear receptor hepatocyte nuclear factor 4[alpha] acts as a morphogen to induce the formation of microvilli

Author

Chiba, Hideki, Sakai, Naoyuki, Murata, Masaki, Osanai, Makoto, Ninomiya, Takafumi, Kojima, Takashi, and Sawada, Norimasa

Subjects
RNA -- Physiological aspects, Mucous membrane -- Anatomy, Mucous membrane -- Physiological aspects, Biological sciences
Abstract

Microvilli are actin-based organelles found on apical plasma membranes that are involved in nutrient uptake and signal transduction. Numerous components, including ezrin/radixin/moesin (ERM) proteins, have been identified that link filamentous actins to transmembrane proteins, but the signals driving microvillus biogenesis are not known. In this study, we show that the conditional and/or ectopic expression of a nuclear receptor, hepatocyte nuclear factor 4[alpha] (HNF4[alpha]), triggers microvillus morphogenesis. We also demonstrate that HNF4[alpha] expression induces ERM-binding phosphoprotein 50 (EBP50) expression and that attenuation of EBP50 using RNA interference inhibits microvillus development. We conclude that HNF4[alpha] acts as a morphogen to trigger microvillus formation.

Published
2006

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