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A key technology enabling the success of catheter ablation treatment for atrial tachycardia is activation mapping, which relies on manual local activation time (LAT) annotation of all acquired intracardiac electrogram (EGM) signals. This is a time-consuming and error-prone procedure, due to the difficulty in identifying the signal activation peaks for fractionated signals. This work presents a Deep Learning approach for the automated classification of EGM signals into three different types: normal, abnormal, and unclassified, which forms part of the LAT annotation pipeline, and contributes towards bypassing the need for manual annotations of the LAT. The Deep Learning network, the CNN-LSTM model, is a hybrid network architecture which combines convolutional neural network (CNN) layers with long short-term memory (LSTM) layers. 1452 EGM signals from a total of 9 patients undergoing clinically-indicated 3D cardiac mapping were used for the training, validation and testing of our models. From our findings, the CNN-LSTM model achieved an accuracy of 81% for the balanced dataset. For comparison, we separately developed a rule-based Decision Trees model which attained an accuracy of 67% for the same balanced dataset. Our work elucidates that analysing the EGM signals using a set of explicitly specified rules as proposed by the Decision Trees model is not suitable as EGM signals are complex. The CNN-LSTM model, on the other hand, has the ability to learn the complex, intrinsic features within the signals and identify useful features to differentiate the EGM signals., Comment: 34 pages, 10 figures

Quality assessment of prenatal ultrasonography is essential for the screening of fetal central nervous system (CNS) anomalies. The interpretation of fetal brain structures is highly subjective, expertise-driven, and requires years of training experience, limiting quality prenatal care for all pregnant mothers. With recent advancement in Artificial Intelligence (AI), specifically deep learning (DL), assistance in precise anatomy identification through semantic segmentation essential for the reliable assessment of growth and neurodevelopment, and detection of structural abnormalities have been proposed. However, existing works only identify certain structures (e.g., cavum septum pellucidum, lateral ventricles, cerebellum) from either of the axial views (transventricular, transcerebellar), limiting the scope for a thorough anatomical assessment as per practice guidelines necessary for the screening of CNS anomalies. Further, existing works do not analyze the generalizability of these DL algorithms across images from multiple ultrasound devices and centers, thus, limiting their real-world clinical impact. In this study, we propose a DL based segmentation framework for the automated segmentation of 10 key fetal brain structures from 2 axial planes from fetal brain USG images (2D). We developed a custom U-Net variant that uses inceptionv4 block as a feature extractor and leverages custom domain-specific data augmentation. Quantitatively, the mean (10 structures; test sets 1/2/3/4) Dice-coefficients were: 0.827, 0.802, 0.731, 0.783. Irrespective of the USG device/center, the DL segmentations were qualitatively comparable to their manual segmentations. The proposed DL system offered a promising and generalizable performance (multi-centers, multi-device) and also presents evidence in support of device-induced variation in image quality (a challenge to generalizibility) by using UMAP analysis., Comment: SPIE Medical Imaging 2022: Computer Aided Diagnosis (12033-75), 11 pages, 7 figures