Search

Your search keyword '"Savola Suvi"' showing total 265 results
Start Over Author "Savola Suvi"
265 results on '"Savola Suvi"'

1. Hallmarks of a genomically distinct subclass of head and neck cancer

Author

Muijlwijk, Tara, Nauta, Irene H., van der Lee, Anabel, Grünewald, Kari J. T., Brink, Arjen, Ganzevles, Sonja H., Baatenburg de Jong, Robert J., Atanesyan, Lilit, Savola, Suvi, van de Wiel, Mark A., Peferoen, Laura A. N., Bloemena, Elisabeth, van de Ven, Rieneke, Leemans, C. René, Poell, Jos B., and Brakenhoff, Ruud H.

Published
2024
Full Text
View/download PDF

2. PersonALL: a genetic scoring guide for personalized risk assessment in pediatric B-cell precursor acute lymphoblastic leukemia

Author

Bedics, Gábor, Egyed, Bálint, Kotmayer, Lili, Benard-Slagter, Anne, de Groot, Karel, Bekő, Anna, Hegyi, Lajos László, Bátai, Bence, Krizsán, Szilvia, Kriván, Gergely, Erdélyi, Dániel J., Müller, Judit, Haltrich, Irén, Kajtár, Béla, Pajor, László, Vojcek, Ágnes, Ottóffy, Gábor, Ujfalusi, Anikó, Szegedi, István, Tiszlavicz, Lilla Györgyi, Bartyik, Katalin, Csanádi, Krisztina, Péter, György, Simon, Réka, Hauser, Péter, Kelemen, Ágnes, Sebestyén, Endre, Jakab, Zsuzsanna, Matolcsy, András, Kiss, Csongor, Kovács, Gábor, Savola, Suvi, Bödör, Csaba, and Alpár, Donát

Published
2023
Full Text
View/download PDF

3. An integrated analysis of miRNA and gene copy numbers in xenografts of Ewing's sarcoma

Author

Mosakhani Neda, Guled Mohamed, Leen Gayle, Calabuig-Fariñas Silvia, Niini Tarja, Machado Isidro, Savola Suvi, Scotlandi Katia, López-Guerrero José, Llombart-Bosch Antonio, and Knuutila Sakari

Subjects
Ewing's sarcoma xenograft, MicroRNA, Copy number, Microarray, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Xenografts have been shown to provide a suitable source of tumor tissue for molecular analysis in the absence of primary tumor material. We utilized ES xenograft series for integrated microarray analyses to identify novel biomarkers. Method Microarray technology (array comparative genomic hybridization (aCGH) and micro RNA arrays) was used to screen and identify copy number changes and differentially expressed miRNAs of 34 and 14 passages, respectively. Incubated cells used for xenografting (Passage 0) were considered to represent the primary tumor. Four important differentially expressed miRNAs (miR-31, miR-31*, miR-145, miR-106) were selected for further validation by real time polymerase chain reaction (RT-PCR). Integrated analysis of aCGH and miRNA data was performed on 14 xenograft passages by bioinformatic methods. Results The most frequent losses and gains of DNA copy number were detected at 9p21.3, 16q and at 8, 15, 17q21.32-qter, 1q21.1-qter, respectively. The presence of these alterations was consistent in all tumor passages. aCGH profiles of xenograft passages of each series resembled their corresponding primary tumors (passage 0). MiR-21, miR-31, miR-31*, miR-106b, miR-145, miR-150*, miR-371-5p, miR-557 and miR-598 showed recurrently altered expression. These miRNAS were predicted to regulate many ES-associated genes, such as genes of the IGF1 pathway, EWSR1, FLI1 and their fusion gene (EWS-FLI1). Twenty differentially expressed miRNAs were pinpointed in regions carrying altered copy numbers. Conclusion In the present study, ES xenografts were successfully applied for integrated microarray analyses. Our findings showed expression changes of miRNAs that were predicted to regulate many ES associated genes, such as IGF1 pathway genes, FLI1, EWSR1, and the EWS-FLI1 fusion genes.

Published
2012
Full Text
View/download PDF

4. Combined use of expression and CGH arrays pinpoints novel candidate genes in Ewing sarcoma family of tumors

Author

Picci Piero, Serra Massimo, Niini Tarja, Tripathi Abhishek, Klami Arto, Savola Suvi, Kaski Samuel, Zambelli Diana, Scotlandi Katia, and Knuutila Sakari

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Ewing sarcoma family of tumors (ESFT), characterized by t(11;22)(q24;q12), is one of the most common tumors of bone in children and young adults. In addition to EWS/FLI1 gene fusion, copy number changes are known to be significant for the underlying neoplastic development of ESFT and for patient outcome. Our genome-wide high-resolution analysis aspired to pinpoint genomic regions of highest interest and possible target genes in these areas. Methods Array comparative genomic hybridization (CGH) and expression arrays were used to screen for copy number alterations and expression changes in ESFT patient samples. A total of 31 ESFT samples were analyzed by aCGH and in 16 patients DNA and RNA level data, created by expression arrays, was integrated. Time of the follow-up of these patients was 5–192 months. Clinical outcome was statistically evaluated by Kaplan-Meier/Logrank methods and RT-PCR was applied on 42 patient samples to study the gene of the highest interest. Results Copy number changes were detected in 87% of the cases. The most recurrent copy number changes were gains at 1q, 2, 8, and 12, and losses at 9p and 16q. Cumulative event free survival (ESFT) and overall survival (OS) were significantly better (P < 0.05) for primary tumors with three or less copy number changes than for tumors with higher number of copy number aberrations. In three samples copy number imbalances were detected in chromosomes 11 and 22 affecting the FLI1 and EWSR1 loci, suggesting that an unbalanced t(11;22) and subsequent duplication of the derivative chromosome harboring fusion gene is a common event in ESFT. Further, amplifications on chromosomes 20 and 22 seen in one patient sample suggest a novel translocation type between EWSR1 and an unidentified fusion partner at 20q. In total 20 novel ESFT associated putative oncogenes and tumor suppressor genes were found in the integration analysis of array CGH and expression data. Quantitative RT-PCR to study the expression levels of the most interesting gene, HDGF, confirmed that its expression was higher than in control samples. However, no association between HDGF expression and patient survival was observed. Conclusion We conclude that array CGH and integration analysis proved to be effective methods to identify chromosome regions and novel target genes involved in the tumorigenesis of ESFT.

Published
2009
Full Text
View/download PDF

5. Copy number evolution and its relationship with patient outcome—an analysis of 178 matched presentation-relapse tumor pairs from the Myeloma XI trial

Author

Croft, James, Ellis, Sidra, Sherborne, Amy L., Sharp, Kim, Price, Amy, Jenner, Matthew W., Drayson, Mark T., Owen, Roger G., Chown, Sally, Lindsay, Jindriska, Karunanithi, Kamaraj, Hunter, Hannah, Gregory, Walter M., Davies, Faith E., Morgan, Gareth J., Cook, Gordon, Atanesyan, Lilit, Savola, Suvi, Cairns, David A., Jackson, Graham, Houlston, Richard S., and Kaiser, Martin F.

Published
2021
Full Text
View/download PDF

7. Comprehensive profiling of disease-relevant copy number aberrations for advanced clinical diagnostics of pediatric acute lymphoblastic leukemia

Author

Kiss, Richárd, Gángó, Ambrus, Benard-Slagter, Anne, Egyed, Bálint, Haltrich, Irén, Hegyi, Lajos, de Groot, Karel, Király, Péter Attila, Krizsán, Szilvia, Kajtár, Béla, Pikó, Henriett, Pajor, László, Vojcek, Ágnes, Matolcsy, András, Kovács, Gábor, Szuhai, Károly, Savola, Suvi, Bödör, Csaba, and Alpár, Donát

Published
2020
Full Text
View/download PDF

14. Supplementary Figures from MAX Inactivation in Small Cell Lung Cancer Disrupts MYC–SWI/SNF Programs and Is Synthetic Lethal with BRG1

Author

Romero, Octavio A., primary, Torres-Diz, Manuel, primary, Pros, Eva, primary, Savola, Suvi, primary, Gomez, Antonio, primary, Moran, Sebastian, primary, Saez, Carmen, primary, Iwakawa, Reika, primary, Villanueva, Alberto, primary, Montuenga, Luis M., primary, Kohno, Takashi, primary, Yokota, Jun, primary, and Sanchez-Cespedes, Montse, primary

Published
2023
Full Text
View/download PDF

15. Supplementary Material and Methods from MAX Inactivation in Small Cell Lung Cancer Disrupts MYC–SWI/SNF Programs and Is Synthetic Lethal with BRG1

Author

Romero, Octavio A., primary, Torres-Diz, Manuel, primary, Pros, Eva, primary, Savola, Suvi, primary, Gomez, Antonio, primary, Moran, Sebastian, primary, Saez, Carmen, primary, Iwakawa, Reika, primary, Villanueva, Alberto, primary, Montuenga, Luis M., primary, Kohno, Takashi, primary, Yokota, Jun, primary, and Sanchez-Cespedes, Montse, primary

Published
2023
Full Text
View/download PDF

16. Supplementary Tables from MAX Inactivation in Small Cell Lung Cancer Disrupts MYC–SWI/SNF Programs and Is Synthetic Lethal with BRG1

Author

Romero, Octavio A., primary, Torres-Diz, Manuel, primary, Pros, Eva, primary, Savola, Suvi, primary, Gomez, Antonio, primary, Moran, Sebastian, primary, Saez, Carmen, primary, Iwakawa, Reika, primary, Villanueva, Alberto, primary, Montuenga, Luis M., primary, Kohno, Takashi, primary, Yokota, Jun, primary, and Sanchez-Cespedes, Montse, primary

Published
2023
Full Text
View/download PDF

17. Data from MAX Inactivation in Small Cell Lung Cancer Disrupts MYC–SWI/SNF Programs and Is Synthetic Lethal with BRG1

Author

Romero, Octavio A., primary, Torres-Diz, Manuel, primary, Pros, Eva, primary, Savola, Suvi, primary, Gomez, Antonio, primary, Moran, Sebastian, primary, Saez, Carmen, primary, Iwakawa, Reika, primary, Villanueva, Alberto, primary, Montuenga, Luis M., primary, Kohno, Takashi, primary, Yokota, Jun, primary, and Sanchez-Cespedes, Montse, primary

Published
2023
Full Text
View/download PDF

18. Supplementary Data from Genomic Profiling of Chondrosarcoma: Chromosomal Patterns in Central and Peripheral Tumors

Author

Hallor, Karolin H., primary, Staaf, Johan, primary, Bovée, Judith V.M.G., primary, Hogendoorn, Pancras C.W., primary, Cleton-Jansen, Anne-Marie, primary, Knuutila, Sakari, primary, Savola, Suvi, primary, Niini, Tarja, primary, Brosjö, Otte, primary, Bauer, Henrik C.F., primary, Vult von Steyern, Fredrik, primary, Jonsson, Kjell, primary, Skorpil, Mikael, primary, Mandahl, Nils, primary, and Mertens, Fredrik, primary

Published
2023
Full Text
View/download PDF

19. Supplementary Table 2 from KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer

Author

Simó-Riudalbas, Laia, primary, Pérez-Salvia, Montserrat, primary, Setien, Fernando, primary, Villanueva, Alberto, primary, Moutinho, Catia, primary, Martínez-Cardús, Anna, primary, Moran, Sebastian, primary, Berdasco, Maria, primary, Gomez, Antonio, primary, Vidal, Enrique, primary, Soler, Marta, primary, Heyn, Holger, primary, Vaquero, Alejandro, primary, de la Torre, Carolina, primary, Barceló-Batllori, Silvia, primary, Vidal, August, primary, Roz, Luca, primary, Pastorino, Ugo, primary, Szakszon, Katalin, primary, Borck, Guntram, primary, Moura, Conceição S., primary, Carneiro, Fátima, primary, Zondervan, Ilse, primary, Savola, Suvi, primary, Iwakawa, Reika, primary, Kohno, Takashi, primary, Yokota, Jun, primary, and Esteller, Manel, primary

Published
2023
Full Text
View/download PDF

20. Supplementary Table 1 from KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer

Author

Simó-Riudalbas, Laia, primary, Pérez-Salvia, Montserrat, primary, Setien, Fernando, primary, Villanueva, Alberto, primary, Moutinho, Catia, primary, Martínez-Cardús, Anna, primary, Moran, Sebastian, primary, Berdasco, Maria, primary, Gomez, Antonio, primary, Vidal, Enrique, primary, Soler, Marta, primary, Heyn, Holger, primary, Vaquero, Alejandro, primary, de la Torre, Carolina, primary, Barceló-Batllori, Silvia, primary, Vidal, August, primary, Roz, Luca, primary, Pastorino, Ugo, primary, Szakszon, Katalin, primary, Borck, Guntram, primary, Moura, Conceição S., primary, Carneiro, Fátima, primary, Zondervan, Ilse, primary, Savola, Suvi, primary, Iwakawa, Reika, primary, Kohno, Takashi, primary, Yokota, Jun, primary, and Esteller, Manel, primary

Published
2023
Full Text
View/download PDF

21. Data from PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion

Author

Bonastre, Ester, primary, Verdura, Sara, primary, Zondervan, Ilse, primary, Facchinetti, Federica, primary, Lantuejoul, Sylvie, primary, Chiara, Maria Dolores, primary, Rodrigo, Juan Pablo, primary, Carretero, Julian, primary, Condom, Enric, primary, Vidal, Agustin, primary, Sidransky, David, primary, Villanueva, Alberto, primary, Roz, Luca, primary, Brambilla, Elisabeth, primary, Savola, Suvi, primary, and Sanchez-Cespedes, Montse, primary

Published
2023
Full Text
View/download PDF

22. Supplementary Figure 6 from KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer

Author

Simó-Riudalbas, Laia, primary, Pérez-Salvia, Montserrat, primary, Setien, Fernando, primary, Villanueva, Alberto, primary, Moutinho, Catia, primary, Martínez-Cardús, Anna, primary, Moran, Sebastian, primary, Berdasco, Maria, primary, Gomez, Antonio, primary, Vidal, Enrique, primary, Soler, Marta, primary, Heyn, Holger, primary, Vaquero, Alejandro, primary, de la Torre, Carolina, primary, Barceló-Batllori, Silvia, primary, Vidal, August, primary, Roz, Luca, primary, Pastorino, Ugo, primary, Szakszon, Katalin, primary, Borck, Guntram, primary, Moura, Conceição S., primary, Carneiro, Fátima, primary, Zondervan, Ilse, primary, Savola, Suvi, primary, Iwakawa, Reika, primary, Kohno, Takashi, primary, Yokota, Jun, primary, and Esteller, Manel, primary

Published
2023
Full Text
View/download PDF

23. Supplementary Figure 3 from KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer

Author

Simó-Riudalbas, Laia, primary, Pérez-Salvia, Montserrat, primary, Setien, Fernando, primary, Villanueva, Alberto, primary, Moutinho, Catia, primary, Martínez-Cardús, Anna, primary, Moran, Sebastian, primary, Berdasco, Maria, primary, Gomez, Antonio, primary, Vidal, Enrique, primary, Soler, Marta, primary, Heyn, Holger, primary, Vaquero, Alejandro, primary, de la Torre, Carolina, primary, Barceló-Batllori, Silvia, primary, Vidal, August, primary, Roz, Luca, primary, Pastorino, Ugo, primary, Szakszon, Katalin, primary, Borck, Guntram, primary, Moura, Conceição S., primary, Carneiro, Fátima, primary, Zondervan, Ilse, primary, Savola, Suvi, primary, Iwakawa, Reika, primary, Kohno, Takashi, primary, Yokota, Jun, primary, and Esteller, Manel, primary

Published
2023
Full Text
View/download PDF

24. Supplementary Methods from PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion

Author

Bonastre, Ester, primary, Verdura, Sara, primary, Zondervan, Ilse, primary, Facchinetti, Federica, primary, Lantuejoul, Sylvie, primary, Chiara, Maria Dolores, primary, Rodrigo, Juan Pablo, primary, Carretero, Julian, primary, Condom, Enric, primary, Vidal, Agustin, primary, Sidransky, David, primary, Villanueva, Alberto, primary, Roz, Luca, primary, Brambilla, Elisabeth, primary, Savola, Suvi, primary, and Sanchez-Cespedes, Montse, primary

Published
2023
Full Text
View/download PDF

25. Supplementary Figure 8 from KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer

Author

Simó-Riudalbas, Laia, primary, Pérez-Salvia, Montserrat, primary, Setien, Fernando, primary, Villanueva, Alberto, primary, Moutinho, Catia, primary, Martínez-Cardús, Anna, primary, Moran, Sebastian, primary, Berdasco, Maria, primary, Gomez, Antonio, primary, Vidal, Enrique, primary, Soler, Marta, primary, Heyn, Holger, primary, Vaquero, Alejandro, primary, de la Torre, Carolina, primary, Barceló-Batllori, Silvia, primary, Vidal, August, primary, Roz, Luca, primary, Pastorino, Ugo, primary, Szakszon, Katalin, primary, Borck, Guntram, primary, Moura, Conceição S., primary, Carneiro, Fátima, primary, Zondervan, Ilse, primary, Savola, Suvi, primary, Iwakawa, Reika, primary, Kohno, Takashi, primary, Yokota, Jun, primary, and Esteller, Manel, primary

Published
2023
Full Text
View/download PDF

26. Supplementary Table 3 from KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer

Author

Simó-Riudalbas, Laia, primary, Pérez-Salvia, Montserrat, primary, Setien, Fernando, primary, Villanueva, Alberto, primary, Moutinho, Catia, primary, Martínez-Cardús, Anna, primary, Moran, Sebastian, primary, Berdasco, Maria, primary, Gomez, Antonio, primary, Vidal, Enrique, primary, Soler, Marta, primary, Heyn, Holger, primary, Vaquero, Alejandro, primary, de la Torre, Carolina, primary, Barceló-Batllori, Silvia, primary, Vidal, August, primary, Roz, Luca, primary, Pastorino, Ugo, primary, Szakszon, Katalin, primary, Borck, Guntram, primary, Moura, Conceição S., primary, Carneiro, Fátima, primary, Zondervan, Ilse, primary, Savola, Suvi, primary, Iwakawa, Reika, primary, Kohno, Takashi, primary, Yokota, Jun, primary, and Esteller, Manel, primary

Published
2023
Full Text
View/download PDF

27. Supplementary Figure Legends from PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion

Author

Bonastre, Ester, primary, Verdura, Sara, primary, Zondervan, Ilse, primary, Facchinetti, Federica, primary, Lantuejoul, Sylvie, primary, Chiara, Maria Dolores, primary, Rodrigo, Juan Pablo, primary, Carretero, Julian, primary, Condom, Enric, primary, Vidal, Agustin, primary, Sidransky, David, primary, Villanueva, Alberto, primary, Roz, Luca, primary, Brambilla, Elisabeth, primary, Savola, Suvi, primary, and Sanchez-Cespedes, Montse, primary

Published
2023
Full Text
View/download PDF

28. Supplementary Figure 5 from KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer

Author

Simó-Riudalbas, Laia, primary, Pérez-Salvia, Montserrat, primary, Setien, Fernando, primary, Villanueva, Alberto, primary, Moutinho, Catia, primary, Martínez-Cardús, Anna, primary, Moran, Sebastian, primary, Berdasco, Maria, primary, Gomez, Antonio, primary, Vidal, Enrique, primary, Soler, Marta, primary, Heyn, Holger, primary, Vaquero, Alejandro, primary, de la Torre, Carolina, primary, Barceló-Batllori, Silvia, primary, Vidal, August, primary, Roz, Luca, primary, Pastorino, Ugo, primary, Szakszon, Katalin, primary, Borck, Guntram, primary, Moura, Conceição S., primary, Carneiro, Fátima, primary, Zondervan, Ilse, primary, Savola, Suvi, primary, Iwakawa, Reika, primary, Kohno, Takashi, primary, Yokota, Jun, primary, and Esteller, Manel, primary

Published
2023
Full Text
View/download PDF

29. Supplementary Table 1 - 5 from PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion

Author

Bonastre, Ester, primary, Verdura, Sara, primary, Zondervan, Ilse, primary, Facchinetti, Federica, primary, Lantuejoul, Sylvie, primary, Chiara, Maria Dolores, primary, Rodrigo, Juan Pablo, primary, Carretero, Julian, primary, Condom, Enric, primary, Vidal, Agustin, primary, Sidransky, David, primary, Villanueva, Alberto, primary, Roz, Luca, primary, Brambilla, Elisabeth, primary, Savola, Suvi, primary, and Sanchez-Cespedes, Montse, primary

Published
2023
Full Text
View/download PDF

30. Supplementary Figure 7 from KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer

Author

Simó-Riudalbas, Laia, primary, Pérez-Salvia, Montserrat, primary, Setien, Fernando, primary, Villanueva, Alberto, primary, Moutinho, Catia, primary, Martínez-Cardús, Anna, primary, Moran, Sebastian, primary, Berdasco, Maria, primary, Gomez, Antonio, primary, Vidal, Enrique, primary, Soler, Marta, primary, Heyn, Holger, primary, Vaquero, Alejandro, primary, de la Torre, Carolina, primary, Barceló-Batllori, Silvia, primary, Vidal, August, primary, Roz, Luca, primary, Pastorino, Ugo, primary, Szakszon, Katalin, primary, Borck, Guntram, primary, Moura, Conceição S., primary, Carneiro, Fátima, primary, Zondervan, Ilse, primary, Savola, Suvi, primary, Iwakawa, Reika, primary, Kohno, Takashi, primary, Yokota, Jun, primary, and Esteller, Manel, primary

Published
2023
Full Text
View/download PDF

31. Data from KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer

Author

Simó-Riudalbas, Laia, primary, Pérez-Salvia, Montserrat, primary, Setien, Fernando, primary, Villanueva, Alberto, primary, Moutinho, Catia, primary, Martínez-Cardús, Anna, primary, Moran, Sebastian, primary, Berdasco, Maria, primary, Gomez, Antonio, primary, Vidal, Enrique, primary, Soler, Marta, primary, Heyn, Holger, primary, Vaquero, Alejandro, primary, de la Torre, Carolina, primary, Barceló-Batllori, Silvia, primary, Vidal, August, primary, Roz, Luca, primary, Pastorino, Ugo, primary, Szakszon, Katalin, primary, Borck, Guntram, primary, Moura, Conceição S., primary, Carneiro, Fátima, primary, Zondervan, Ilse, primary, Savola, Suvi, primary, Iwakawa, Reika, primary, Kohno, Takashi, primary, Yokota, Jun, primary, and Esteller, Manel, primary

Published
2023
Full Text
View/download PDF

32. Supplementary Figures 1 - 8 from PARD3 Inactivation in Lung Squamous Cell Carcinomas Impairs STAT3 and Promotes Malignant Invasion

Author

Bonastre, Ester, primary, Verdura, Sara, primary, Zondervan, Ilse, primary, Facchinetti, Federica, primary, Lantuejoul, Sylvie, primary, Chiara, Maria Dolores, primary, Rodrigo, Juan Pablo, primary, Carretero, Julian, primary, Condom, Enric, primary, Vidal, Agustin, primary, Sidransky, David, primary, Villanueva, Alberto, primary, Roz, Luca, primary, Brambilla, Elisabeth, primary, Savola, Suvi, primary, and Sanchez-Cespedes, Montse, primary

Published
2023
Full Text
View/download PDF

33. Supplementary Figure 1 from KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer

Author

Simó-Riudalbas, Laia, primary, Pérez-Salvia, Montserrat, primary, Setien, Fernando, primary, Villanueva, Alberto, primary, Moutinho, Catia, primary, Martínez-Cardús, Anna, primary, Moran, Sebastian, primary, Berdasco, Maria, primary, Gomez, Antonio, primary, Vidal, Enrique, primary, Soler, Marta, primary, Heyn, Holger, primary, Vaquero, Alejandro, primary, de la Torre, Carolina, primary, Barceló-Batllori, Silvia, primary, Vidal, August, primary, Roz, Luca, primary, Pastorino, Ugo, primary, Szakszon, Katalin, primary, Borck, Guntram, primary, Moura, Conceição S., primary, Carneiro, Fátima, primary, Zondervan, Ilse, primary, Savola, Suvi, primary, Iwakawa, Reika, primary, Kohno, Takashi, primary, Yokota, Jun, primary, and Esteller, Manel, primary

Published
2023
Full Text
View/download PDF

34. Supplementary Figure 2 from KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer

Author

Simó-Riudalbas, Laia, primary, Pérez-Salvia, Montserrat, primary, Setien, Fernando, primary, Villanueva, Alberto, primary, Moutinho, Catia, primary, Martínez-Cardús, Anna, primary, Moran, Sebastian, primary, Berdasco, Maria, primary, Gomez, Antonio, primary, Vidal, Enrique, primary, Soler, Marta, primary, Heyn, Holger, primary, Vaquero, Alejandro, primary, de la Torre, Carolina, primary, Barceló-Batllori, Silvia, primary, Vidal, August, primary, Roz, Luca, primary, Pastorino, Ugo, primary, Szakszon, Katalin, primary, Borck, Guntram, primary, Moura, Conceição S., primary, Carneiro, Fátima, primary, Zondervan, Ilse, primary, Savola, Suvi, primary, Iwakawa, Reika, primary, Kohno, Takashi, primary, Yokota, Jun, primary, and Esteller, Manel, primary

Published
2023
Full Text
View/download PDF

35. Supplementary Figure 4 from KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer

Author

Simó-Riudalbas, Laia, primary, Pérez-Salvia, Montserrat, primary, Setien, Fernando, primary, Villanueva, Alberto, primary, Moutinho, Catia, primary, Martínez-Cardús, Anna, primary, Moran, Sebastian, primary, Berdasco, Maria, primary, Gomez, Antonio, primary, Vidal, Enrique, primary, Soler, Marta, primary, Heyn, Holger, primary, Vaquero, Alejandro, primary, de la Torre, Carolina, primary, Barceló-Batllori, Silvia, primary, Vidal, August, primary, Roz, Luca, primary, Pastorino, Ugo, primary, Szakszon, Katalin, primary, Borck, Guntram, primary, Moura, Conceição S., primary, Carneiro, Fátima, primary, Zondervan, Ilse, primary, Savola, Suvi, primary, Iwakawa, Reika, primary, Kohno, Takashi, primary, Yokota, Jun, primary, and Esteller, Manel, primary

Published
2023
Full Text
View/download PDF

37. Frequent Coamplification of Receptor Tyrosine Kinase and Downstream Signaling Genes in Japanese Primary Gastric Cancer and Conversion in Matched Lymph Node Metastasis

Author

Silva, Arnaldo N. S., Coffa, Jordy, Menon, Varsha, Hewitt, Lindsay C., Das, Kakoli, Miyagi, Yohei, Bottomley, Dan, Slaney, Hayley, Aoyama, Toru, Mueller, Wolfram, Arai, Tomio, Tan, Iain B., Deng, Niantao, Chan, Xiu B., Tan, Patrick, Tsuburaya, Akira, Sakamaki, Kentaro, Hayden, Jeremy D., Yoshikawa, Takaki, Zondervan, Ilse, Savola, Suvi, and Grabsch, Heike I.

Published
2018
Full Text
View/download PDF

40. “Atypical” Pleomorphic Lipomatous Tumor: A Clinicopathologic, Immunohistochemical and Molecular Study of 21 Cases, Emphasizing its Relationship to Atypical Spindle Cell Lipomatous Tumor and Suggesting a Morphologic Spectrum (Atypical Spindle Cell/Pleomorphic Lipomatous Tumor)

Author

Creytens, David, Mentzel, Thomas, Ferdinande, Liesbeth, Lecoutere, Evelyne, van Gorp, Joost, Atanesyan, Lilit, de Groot, Karel, Savola, Suvi, Van Roy, Nadine, Van Dorpe, Jo, and Flucke, Uta

Published
2017
Full Text
View/download PDF

45. Risk prediction for metastasis of clear cell renal cell carcinoma using digital multiplex ligation‐dependent probe amplification

Author

Yoshikawa, Yoshie, primary, Yamada, Yusuke, additional, Emi, Mitsuru, additional, Atanesyan, Lilit, additional, Smout, Jan, additional, de Groot, Karel, additional, Savola, Suvi, additional, Nakanishi‐Shinkai, Yukako, additional, Kanematsu, Akihiro, additional, Nojima, Michio, additional, Ohmuraya, Masaki, additional, Hashimoto‐Tamaoki, Tomoko, additional, and Yamamoto, Shingo, additional

Published
2021
Full Text
View/download PDF

49. The genomic landscape of teenage and young adult T‐cell acute lymphoblastic leukemia

Author

Mansur, Marcela B., primary, Furness, Caroline L., additional, Nakjang, Sirintra, additional, Enshaei, Amir, additional, Alpar, Donat, additional, Colman, Sue M., additional, Minto, Lynne, additional, Irving, Julie, additional, Poole, Beth V., additional, Noronha, Elda P., additional, Savola, Suvi, additional, Iqbal, Sameena, additional, Gribben, John, additional, Pombo‐de‐Oliveira, Maria S., additional, Ford, Tony M., additional, Greaves, Mel F., additional, and Delft, Frederik W., additional

Published
2021
Full Text
View/download PDF

50. Working together for the family: determination of HER oncogene co-amplifications in breast cancer

Author

Laurito Sergio, Roqué Maria, Campoy Emanuel, Branham María Teresita, Glatstein Telma, Savola Suvi, Atanesyan Lilit, Gago Francisco, Real Sebastián, Cueto Juan, De la Iglesia Paola, Urrutia Guillermo, and Tello Olga

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, CO-AMPLIFICATION, purl.org/becyt/ford/1 [https], 03 medical and health sciences, 0302 clinical medicine, Breast cancer, breast cancer, BREAST CANCER, Trastuzumab, Internal medicine, medicine, Digital polymerase chain reaction, Multiplex ligation-dependent probe amplification, HER oncogenes, purl.org/becyt/ford/1.6 [https], CISH, skin and connective tissue diseases, DIGITAL PCR, HER ONCOGENES, biology, Oncogene, business.industry, digital PCR, medicine.disease, MLPA, 030104 developmental biology, 030220 oncology & carcinogenesis, biology.protein, Immunohistochemistry, co-amplification, Antibody, business, medicine.drug, Research Paper
Abstract

HER2 is a well-studied tyrosine kinase (TK) membrane receptor which functions as a therapeutic target in invasive ductal breast carcinomas (IDC). The standard of care for the treatment of HER2-positive breast is the antibody trastuzumab. Despite specific treatment unfortunately, 20% of primary and 70% of metastatic HER2 tumors develop resistance. HER2 belongs to a gene family, with four members (HER1-4) and these members could be involved in resistance to anti-HER2 therapies. In this study we designed a probemix to detect the amplification of the four HER oncogenes in a single reaction. In addition, we developed a protocol based on the combination of MLPA with ddPCR to detect the tumor proportion of co-amplified HERs. On 111 IDC, the HER2 MLPA results were validated by FISH (Adjusted r2 = 0,91, p < 0,0001), CISH (Adjusted r2 = 0,938, p < 0,0001) and IHC (Adjusted r2 = 0,31, p < 0,0001). HER1-4 MLPA results were validated by RT-qPCR assays (Spearman Rank test p < 0,05). Of the 111 samples, 26% presented at least one HER amplified, of which 23% showed co-amplifications with other HERs. The percentage of cells with HER2 co-amplified varied among the tumors (from 2-72,6%). Independent in-silico findings show that the outcome of HER2+ patients is conditioned by the status of HER3 and HER4. Our results encourage further studies to investigate the relationship with patient's response to single or combined treatment. The approach could serve as proof of principle for other tumors in which the HER oncogenes are involved. Fil: Laurito, Sergio Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina Fil: Branham, Maria Teresita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina Fil: Campoy, Emanuel Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina Fil: Real Varela, Sebastián Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina Fil: Cueto, Juan Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Urrutia, Guillermo. Medical College Of Wisconsin; Estados Unidos Fil: Gago, Francisco Eduardo. No especifíca; Fil: Tello, Olga. No especifíca; Fil: Glatstein, Telma Beatriz. No especifíca; Fil: De la Iglesia, Paola. Hospital Italiano; Argentina Fil: Atanesyan, Lilit. MRC-Holland BV, Department of Oncogenetics, Amsterdam; Países Bajos Fil: Savola, Suvi. No especifíca; Fil: Roque Moreno, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results