1. Maternal Stress During Pregnancy Predicts Infant Infectious and Noninfectious Illness
- Author
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Bush, Nicole R, Savitz, Jennifer, Coccia, Michael, Jones-Mason, Karen, Adler, Nancy, Boyce, W Thomas, Laraia, Barbara, and Epel, Elissa
- Subjects
Reproductive Medicine ,Biomedical and Clinical Sciences ,Prevention ,Maternal Health ,Behavioral and Social Science ,Mental Health ,Pregnancy ,Perinatal Period - Conditions Originating in Perinatal Period ,Women's Health ,Pediatric ,Mental Illness ,Depression ,Brain Disorders ,Reproductive health and childbirth ,Good Health and Well Being ,Adolescent ,Adult ,Female ,Humans ,Incidence ,Infant ,Newborn ,Infant ,Newborn ,Diseases ,Infections ,Middle Aged ,Postpartum Period ,Pregnancy Complications ,Retrospective Studies ,Stress ,Psychological ,United States ,Young Adult ,HPA axis ,atopy ,developmental origins of health and disease ,fetal programming ,illness ,immune system ,infant ,infectious illness ,maternal stress ,prenatal programming ,Human Movement and Sports Sciences ,Paediatrics and Reproductive Medicine ,Pediatrics ,Paediatrics - Abstract
ObjectivesTo examine the association between prenatal stress and infant physical health in the first year of life within an understudied, racially and ethnically diverse, highly stressed community sample. We expected that greater stress exposure would predict higher rates of infant illness.Study designLow-income, racially/ethnically diverse, overweight women with low medical risk pregnancies were recruited (2011-2014) during pregnancy. Pregnancy Stressful Life Events were assessed retrospectively (mean, 11.88 months postpartum). Perceived stress was assessed twice during pregnancy (at a mean of 17.4 weeks and again at a mean of 25.6 weeks) and at 6 months postpartum. Women with live births (n = 202) were invited; 162 consented to the offspring study. Medical records from pediatric clinics and emergency departments for 148 infants were abstracted for counts of total infectious illnesses, total noninfectious illness, and diversity of illnesses over the first year of life.ResultsThe final analytic sample included 109 women (mean age, 28.08 years) and their infants. In covariate-adjusted negative binomial models, maternal perceptions of stress across pregnancy were positively associated with infant illness. Each 1-point increase in average stress was associated with a 38% increase in incidence of infant infections (Incidence rate ratio, 1.38; 95% CI, 1.01-1.88; P
- Published
- 2021