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4. Liquid Biopsy in Cancer: Focus on Lymphoproliferative Disorders

Author

Savino, F, Rigali, F, Giustini, V, D'Aliberti, D, Spinelli, S, Piazza, R, Sacco, A, Roccaro, A, Savino F. D., Rigali F., Giustini V., D'Aliberti D., Spinelli S., Piazza R., Sacco A., Roccaro A. M., Savino, F, Rigali, F, Giustini, V, D'Aliberti, D, Spinelli, S, Piazza, R, Sacco, A, Roccaro, A, Savino F. D., Rigali F., Giustini V., D'Aliberti D., Spinelli S., Piazza R., Sacco A., and Roccaro A. M.

Abstract

Within the context of precision medicine, the scientific community is giving particular attention to early diagnosis and intervention, guided by non-invasive methodologies. Liquid biopsy (LBx) is a recent laboratory approach consisting of a non-invasive blood draw, which allows the detection of information about potential prognostic factors, or markers to be used for diagnostic purposes; it might also allow the clinician to establish a treatment regimen and predict a patient’s response. Since the discovery of circulating tumor cells (CTCs) in the nineteenth century, the possibility of integrating LBx into clinical practice has been explored, primarily because of its safeness and easy execution: indeed, compared to solid biopsy, sampling-related risks are less of a concern, and the quickness and repeatability of the process could help confirm a prompt diagnosis or to further corroborate the existence of a metastatic spreading of the disease. LBx’s usefulness has been consolidated in a narrow range of oncological settings, first of all, non-small cell lung carcinoma (NSCLC), and it is now gradually being assessed also in lymphoproliferative diseases, such as acute lymphocytic leukemia (ALL), B-cell lymphomas, and multiple myeloma. The present review aims to summarize LBx’s overall characteristics (such as its advantages and flaws, collection and analysis methodologies, indications, and targets of the test), and to highlight the applications of this technique within the specific field of B-cell malignancies. The perspectives on how such a simple and convenient technique could improve hemato-oncological clinical practice are broadly encouraging, yet far from a complete integration in routine clinical settings.

Published
2022

5. Targeting the immune microenvironment in Waldenström Macroglobulinemia via halting the CD40/CD40-ligand axis

Author

Sacco, A, Desantis, V, Celay, J, Giustini, V, Rigali, F, Savino, F, Cea, M, Soncini, D, Cagnetta, A, Solimando, A, D'Aliberti, D, Spinelli, S, Ramazzotti, D, Almici, C, Todoerti, K, Neri, A, Anastasia, A, Tucci, A, Motta, M, Chiarini, M, Kawano, Y, Martinez-Climent, J, Piazza, R, Roccaro, A, Sacco, Antonio, Desantis, Vanessa, Celay, Jon, Giustini, Viviana, Rigali, Fabio, Savino, Francesco D, Cea, Michele, Soncini, Debora, Cagnetta, Antonia, Solimando, Antonio Giovanni, D'Aliberti, Deborah, Spinelli, Silvia, Ramazzotti, Daniele, Almici, Camillo, Todoerti, Katia, Neri, Antonino, Anastasia, Antonella, Tucci, Alessandra, Motta, Marina, Chiarini, Marco, Kawano, Yawara, Martinez-Climent, Jose-Al, Piazza, Rocco, Roccaro, Aldo M, Sacco, A, Desantis, V, Celay, J, Giustini, V, Rigali, F, Savino, F, Cea, M, Soncini, D, Cagnetta, A, Solimando, A, D'Aliberti, D, Spinelli, S, Ramazzotti, D, Almici, C, Todoerti, K, Neri, A, Anastasia, A, Tucci, A, Motta, M, Chiarini, M, Kawano, Y, Martinez-Climent, J, Piazza, R, Roccaro, A, Sacco, Antonio, Desantis, Vanessa, Celay, Jon, Giustini, Viviana, Rigali, Fabio, Savino, Francesco D, Cea, Michele, Soncini, Debora, Cagnetta, Antonia, Solimando, Antonio Giovanni, D'Aliberti, Deborah, Spinelli, Silvia, Ramazzotti, Daniele, Almici, Camillo, Todoerti, Katia, Neri, Antonino, Anastasia, Antonella, Tucci, Alessandra, Motta, Marina, Chiarini, Marco, Kawano, Yawara, Martinez-Climent, Jose-Al, Piazza, Rocco, and Roccaro, Aldo M

Published
2023

15. Evaluation of the effectiveness of the acoustic remediation carried out on an industrial machinery

Author

Bisio, P., Savino, F., Fargione, P., Quarto, M., Bisio, Paolo, Savino, Federica, Fargione, Paolo, and Quarto, Maria

Subjects
Noise, acoustic remediation, worker’s exposure, industry
Abstract

Many workers in different occupational sectors are exposed to potentially dangerous noise levels, a careful Risk Assessment and Management, resulting quality measures and programs should be developed to protect them from noise induced hearing loss. The characterization of the noise source allows to establish a rigorous quality and control program, and can help you quickly understand when to implement noise mitigation measures. For this reason, an acoustic mitigation action was carried out on an industrial machine with a view to soundproofing the entire operating unit of the company.

Published
2021

16. Venous thromboembolism and COVID-19: a single center experience from an academic tertiary referral hospital of Northern Italy

Author

Melazzini, Federica, Colaneri, Marta, Fumoso, Federica, Freddi, Giulia, Lenti, Marco Vincenzo, Pieri, Teresa Chiara, Piloni, Davide, Noris, Patrizia, Pieresca, Carla, Preti, Paola Stefania, Russo, Mariaconcetta, Corsico, Angelo, Tavazzi, Guido, Baldanti, Fausto, Triarico, Antonio, Mojoli, Francesco, Bruno, Raffaele, Di Sabatino, Antonio, Aronico, Nicola, Bergamaschi, Gaetano, Bertolino, Giampiera, Codega, Silvia, Costanzo, Filippo, Cresci, Roberto, Delliponti, Angela, Derosa, Giuseppe, Di Stefano, Michele, Falaschi, Francesco, Iadarola, Carmine, Lovati, Elisabetta, Lucotti, Pietro Carlo, Martignoni, Alessandra, Mengoli, Caterina, Miceli, Emanuela, Mugellini, Amedeo, Muggia, Chiara, Pagani, Elisabetta, Palumbo, Ilaria, Pecci, Alessandro, Perrone, Tiziano, Sgarlata, Carmelo, Siciliani, Luisa, Staniscia, Andrea, Vjera, Francesca Torello, Achilli, Giovanna, Agostinelli, Andrea, Antoci, Valentina, Ballesio, Alessia, Banfi, Francesco, Barteselli, Chiara, Benedetti, Irene, de Andreis, Federica Borrelli, Brattoli, Michele, Calabretta, Francesca, Cambiè, Ginevra, Canta, Roberta, Conca, Federico, Coppola, Luigi, Cremonte, Elisa Maria, Croce, Gabriele, Del Rio, Virginia, Di Terlizzi, Francesco, Ferrari, Maria Giovanna, Ferrari, Sara, Fiengo, Anna, Forni, Tommaso, Frigerio, Chiara, Fusco, Alessandra, Gabba, Margherita, Garolfi, Matteo, Gentile, Antonella, Gori, Giulia, Grandi, Giacomo, Grimaldi, Paolo, Lampugnani, Alice, Lapia, Francesco, Lepore, Federica, Lettieri, Gianluca, Mambella, Jacopo, Mercanti, Chiara, Merli, Stefania, Mordà, Francesco, Nardone, Alba, Pace, Luca, Padovini, Lucia, Parodi, Alessandro, Pellegrino, Ivan, Pitotti, Lavinia, Reduzzi, Margherita, Rigano, Giovanni, Romito, Giovanni, Rotola, Giorgio, Sabatini, Umberto, Salvi, Lucia, Santacroce, Giovanni, Savioli, Jessica, Soriano, Simone, Spataro, Carmine, Stefani, Debora, Aliberti, Anna Rita, Amatu, Alessandro, Anfossi, Laura, Arisi, Eric, Baldi, Chiara, Belliato, Mirko, Bellini, Lorenzo, Benzi, Alberto, Bichisao, Germana, Bolongaro, Antonia, Bottazzi, Andrea, Broglia, Federica, Bruschi, Giacomo, Caneva, Luca, Capaccio, Emanuele, Carboni, Valeria, Cavalloro, Fabrizio, Ciceri, Maria, Civardi, Luca, Delmonte, Maria Paola, Domenegati, Elisa Lucia, Ferrari, Federica, Ferrari, Fiorenza, Ferrari, Marta, Fuardo, Marinella, Gerletti, Maddalena Margherita, Gualdana, Simonetta, Ilardi, Marcella, Lo Coco, Claudia, Maggio, Giuseppe, Mascia, Maria Benedetta, Mencherini, Simonetta, Merati, Paola Maria, Mongodi, Silvia, Mori, Anna Maria, Morgante, Federica, Niebel, Thekla Larissa, Noli, Silvano, Orlando, Anita, Pagani, Michele, Passador, Debora, Pellicori, Simona, Perotti, Luciano, Picchioni, Raffaella, Poma, Silvia, Pozzi, Marco, Preti, Emanuela, Puce, Roberta, Radolovich, Danila Katia, Ragni, Gianluca, Repossi, Filippo, Riccardi, Francesca, Rizzardi, Roberto, Rodi, Giuseppe, Roldi, Emanuela, Rossi, Cristina, Sala Gallini, Giuseppe, Sciutti, Fabio, Sportiello, Debora, Ticozzelli, Giulia, Visconti, Federico, Zizzi, Silvia, Bagliani, Alessandro, Belotti, Corrado, Bossi, Chiara, Colombo, Andrea, Colombo, Costanza Natalia Julia, Cremascoli, Luca, Dammassa, Valentino, Discepoli, Roberto, Garlando, Maria Adelaide, Grandini, Filippo, Pellegrini, Andrea, Quaranta, Cecilia, Stella, Andrea, Torresani, Francesco, Mondelli, Mario, Brunetti, Enrico, Di Matteo, Angela, Seminari, Elena, Maiocchi, Laura, Zuccaro, Valentina, Pagnucco, Layla, Mariani, Bianca, Ludovisi, Serena, Lissandrin, Raffaella, Parisi, Aldo, Sacchi, Paolo, Patruno, Savino F. A., Michelone, Giuseppe, Gulminetti, Roberto, Zanaboni, Domenico, Novati, Stefano, Maserati, Renato, Orsolini, Paolo, Vecchia, Marco, Asperges, Erika, Di Filippo, Alessandro, Sambo, Margherita, Biscarini, Simona, Lupi, Matteo, Roda, Silvia, Gallazzi, Ilaria, Sachs, Michele, Valsecchi, Pietro, Ferrari, Alessandra, Bosio, Matteo, Cascina, Alessandro, Conio, Valentina, Di Domenica, Rita, Donnetta, Anna, Fraolini, Elia, Gualtieri, Giuseppe, Mangiarotti, Patrizia, Mariani, Francesca, Meloni, Federica, Oggionni, Tiberio, Pasturenzi, Lidia, Ronzoni, Vanessa, Saracino, Laura, Stella, Giulia, Tomaselli, Stefano, Abbate, Tommaso, Accordino, Giulia, Bertuccio, Francesco, Burattini, Cecilia, Cacciatore, Elisa, Cattaneo, Elena, Chino, Vittorio, Coretti, Manuela, Della Zoppa, Matteo, Infusino, Cristina, Lettieri, Sara, Maccabruni, Valeria, Mancinelli, Silvia, Tirelli, Claudio, and Vertui, Valentina

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), 030204 cardiovascular system & hematology, Single Center, Tertiary referral hospital, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Internal Medicine, Medicine, cardiovascular diseases, Mean platelet volume, biology, SARS-CoV-2, business.industry, Pulmonary embolism, C-reactive protein, Anticoagulants, Thrombosis, equipment and supplies, medicine.disease, Im - Original, 030220 oncology & carcinogenesis, biology.protein, Emergency Medicine, Observational study, business
Abstract

Preliminary evidence supports the notion that COVID-19 patients may have an increased susceptibility to develop venous thromboembolism (VTE). However, the magnitude of this association still needs to be defined. Furthermore, clinical predictors of thrombogenesis, and the relationship with the inflammatory status are currently unknown. On this basis, we conducted a retrospective, observational study on 259 consecutive COVID-19 patients admitted to an academic tertiary referral hospital in Northern Italy between March 19th and April 6th, 2020. Records of COVID-19 patients with a definite VTE event were reviewed for demographic information, co-morbidities, risk factors for VTE, laboratory tests, and anticoagulation treatment. Twenty-five cases among 259 COVID-19 patients developed VTE (9.6%), all of them having a Padua score > 4, although being under standard anticoagulation prophylaxis since hospital admission. In the VTE subcohort, we found a significant positive correlation between platelet count (PLT) and either C reactive protein (CRP) (p p = 0.0013), while a significant inverse correlation was observed between PLT and mean platelet volume (p p p = 0.002 and p = 0.005, respectively). No significant difference was found in d-dimer levels between VTE and non VTE patients, while significantly higher levels of LDH (p = 0.04) and IL-6 (p = 0.04) were observed in VTE patients in comparison to non-VTE patients. In conclusion, our findings showed a quite high prevalence of VTE in COVID-19 patients. Raised inflammatory indexes and increased serum levels of pro-inflammatory cytokines should raise the clinical suspicion of VTE.

Published
2020
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22. SLD and pedagogical-experimental approach: 'learning to Learn' in the scientific field

Author

Molisso V., Savino F., Iovino S., Tafuri D., Quarto M., Molisso, V., Savino, F., Iovino, S., Tafuri, D., and Quarto, M.

Subjects
education, metacognition, cognitive strategie, SLD, didactic, physic
Abstract

The many ways in which learning is distinguished and characterized require new forms of teaching, which can satisfy the characteristics and peculiarities of each person. Educational contexts such as schools and universities should respect these different forms of learning by focusing at new way of teaching, which do not merely transmit knowledge as a mere accumulation of information. For subjects with Specific Learning Disabilities, there is a need to search for and prepare adequate didactic tools and strategies that can support the main needs of the subject in a personal, emotional and relational context.

Published
2019

23. ASSESSMENT OF RADIATION RISK FOR OPERATORS IN INTERVENTIONAL RADIOLOGY

Author

Savino F., Capussela T., Di Pasquale M. A., Tafuri D., Roberti G., Serra M., Quarto M., Savino, F., Capussela, T., Di Pasquale, M. A., Tafuri, D., Roberti, G., Serra, M., and Quarto, M.

Subjects
eye lens dose, TLD dosimeter, interventional radiology, radiation protection, eye lens dose, TLD dosimeter, radiation protection, interventional radiology
Abstract

The revised dose limit in interventional radiology recommended by the International Commission on Radiological Protection imposes new studies in the implementation of protocols for the radiological protection of operators. The aim is to assess the eye lens dose for different operators of interventional radiology: vascular and neuro radiologists, cardiologists, anesthetists, nurses. Dose measurements were performed with thermoluminescent dosimeters (TLDs) calibrated in Hp(0.07). The correlation between eye lens dose and environmental dose, measured by an ionizing chamber, was also investigated. A cohort of 15 operators from different interventional radiology units were enrolled. Operators of the hemodynamic unit received a much lower dose compared to the dose administered to the vascular and neuro radiology unit. A weak correlation was found between eye lens dose and environmental dose as measured in interventional suite of vascular radiology. Although it would always be better to use dosimeters calibrated in Hp (3), the use of calibrated dosimeters in Hp (0.07) can be a useful tool in the evaluation of the eye lens dose in interventional radiology. Furthermore, the results obtained emphasize that the appropriate use of protective equipment significantly lowers the absorbed eye lens dose. For this reason, this study aims to raise awareness of the importance of radiation protection in interventional radiology.

Published
2019

25. SARS Cov-2 infection in a renal-transplanted patient: A case report

Author

Seminari, Elena, Colaneri, Marta, Sambo, Margherita, Gallazzi, Ilaria, Di Matteo, Angela, Roda, Silvia, Bruno, Raffaele, Mondelli, Mario U., Brunetti, Enrico, Maiocchi, Laura, Zuccaro, Valentina, Pagnucco, Layla, Mariani, Bianca, Ludovisi, Serena, Lissandrin, Raffaella, Parisi, Aldo, Sacchi, Paolo, Patruno, Savino F. A., Michelone, Giuseppe, Gulminetti, Roberto, Zanaboni, Domenico, Novati, Stefano, Maserati, Renato, Orsolini, Paolo, Vecchia, Marco, Sciarra, Marco, Asperges, Erika, Di Filippo, Alessandro, Biscarini, Simona, Lupi, Matteo, Pieri, Teresa C., Sachs, Michele, Valsecchi, Pietro, Perlini, Stefano, Alfano, Claudia, Bonzano, Marco, Briganti, Federica, Crescenzi, Giuseppe, Falchi, Anna G., Guarnone, Roberta, Guglielmana, Barbara, Maggi, Elena, Martino, Ilaria, Pettenazza, Pietro, Pioli di Marco, Serena, Quaglia, Federica, Sabena, Anna, Salinaro, Francesco, Speciale, Francesco, Zunino, Ilaria, De Lorenzo, Marzia, Secco, Gianmarco, Dimitry, Lorenzo, Cappa, Giovanni, Maisak, Igor, Chiodi, Benedetta, Sciarrini, Massimiliano, Barcella, Bruno, Resta, Flavia, Moroni, Luca, Vezzoni, Giulia, Scattaglia, Lorenzo, Boscolo, Elisa, Zattera, Caterina, Fidel, Tassi M., Vincenzo, Capozza, Vignaroli, Damiano, Bazzini, Marco, Iotti, Giorgio, Mojoli, Francesco, Belliato, Mirko, Perotti, Luciano, Mongodi, Silvia, Tavazzi, Guido, Marseglia, Gianluigi, Licari, Amelia, Brambilla, Ilaria, Daniela, Barbarini, Antonella, Bruno, Patrizia, Cambieri, Giulia, Campanini, Giuditta, Comolli, Marta, Corbella, Rossana, Daturi, Milena, Furione, Bianca, Mariani, Roberta, Maserati, Enza, Monzillo, Stefania, Paolucci, Maurizio, Parea, Elena, Percivalle, Antonio, Piralla, Francesca, Rovida, Antonella, Sarasini, Maurizio, Zavattoni, Guy, Adzasehoun, Laura, Bellotti, Ermanna, Cabano, Giuliana, Casali, Luca, Dossena, Gabriella, Frisco, Gabriella, Garbagnoli, Alessia, Girello, Viviana, Landini, Claudia, Lucchelli, Valentina, Maliardi, Simona, Pezzaia, Marta, Premoli, Alice, Bonetti, Giacomo, Caneva, Irene, Cassaniti, Alfonso, Corcione, Di Martino, Raffella, Di Napoli, Annapia, Alessandro, Ferrari, Guglielmo, Ferrari, Loretta, Fiorina, Federica, Giardina, Alessandra, Mercato, Federica, Novazzi, Giacomo, Ratano, Beatrice, Rossi, Maria, Sciabica I., Monica, Tallarita, Edoardo, Vecchio N., Cerino, Antonella, Varchetta, Stefania, Oliviero, Barbara, Mantovani, Stefania, Mele, Dalila, Calvi, Monica, Tizzonis, Michela, Nicora, Carlo, Triarico, Antonio, Petronella, Vincenzo, Marena, Carlo, Muzzi, Alba, Lago, Paolo, Comandatore, Francesco, Bissignandi, Gherard, Gaiarsa, Stefano, Rettani, Marco, and Band, Claudio

Subjects
Male, medicine.medical_specialty, ARDS, medicine.medical_treatment, infectious disease, Disease, 030230 surgery, clinical research/practice, Asymptomatic, Tacrolimus, Kidney Failure, 03 medical and health sciences, Betacoronavirus, 0302 clinical medicine, Glomerulonephritis, medicine, Extracorporeal membrane oxygenation, Immunology and Allergy, immunosuppressant – calcineurin inhibitor: tacrolimus, infection and infectious agents – viral, COVID-19, Ceftriaxone, Coronavirus Infections, Cytokines, Glomerulonephritis, IGA, Humans, Immunosuppression Therapy, Kidney Failure, Chronic, Middle Aged, Mycophenolic Acid, Pandemics, Pneumonia, Viral, SARS-CoV-2, Treatment Outcome, Kidney Transplantation, Pharmacology (medical), Viral, Chronic, Intensive care medicine, Kidney transplantation, IGA, Mechanical ventilation, Transplantation, business.industry, Immunosuppression, Pneumonia, medicine.disease, medicine.symptom, Cytokine storm, business
Abstract

The clinical manifestation of COVID-19 can vary from an asymptomatic course to ARDS requiring invasive mechanical ventilation and extracorporeal membrane oxygenation. A kidney transplanted patient infected with SARS CoV-2 infection showed a mild disease despite immune suppression. It is possible that Immunosuppression can "be protective" as the cytokine storm is an important factor in the disease story. Despite the good outcome reported in the present case report, is remains of vital importance the solid organ transplant patients use precautions in order to avoid the infection.

Published
2020

26. PRELIMINARY COMPARISON BETWEEN AUTOMATED AND MANUALLY PLANNED TREATMENTS FOR BRAIN METASTASIS

Author

Serra, M., Savino, F., Ametrano, G., Quarto, M., Tafuri, D., Loffredo, F., Muto, P., Serra, Marcello, Savino, Federica, Ametrano, Gianluca, Quarto, Maria, Tafuri, Domenico, Loffredo, Filomena, and Muto, Paolo

Subjects
VMAT, Autoplanning, Brain metastasis, WBRT, OARs sparing, PlanIQ
Abstract

Introduction: Radiotherapy is increasingly used for the treatment of cancer patients and more and more personalized treatments are being developed to improve the patient’s quality of life. Today, the medical community is moving toward VMAT plans, which allow to deliver the prescription dose to the tumor and to spare surrounding healthy tissues. In this context the development of autoplanning system is desirable. Method and results: In this work we report the implementation, in the TPS RayStation, of the autoplanning algorithm that creates high quality plans, when brain metastases are involved. Conclusion: At the state of the art, the AP codes can be intended to lighten the work of the medical physicist so that he can refine the plan previously elaborated in AP modality or devote himself to more delicate situations.

Published
2020

27. COGNITIVE INVESTIGATION ON THE KNOWLEDGE OF THE RISK DERIVING FROM RADON EXPOSURE: PRELIMINARY RESULTS

Author

Loffredo, F., Savino, F., Serra, M., Tafuri, D., Quarto, M., Loffredo, Filomena, Savino, Federica, Serra, Marcello, Tafuri, Domenico, and Quarto, Maria

Subjects
scientific dissemination, radon, survey, radon, survey, scientific dissemination
Abstract

Introduction: For the first time, the Council Directive 2013/59/Euratom focuses on the risk to human health deriving from exposure to radon in homes, promoting the adoption of more stringent actions for the public awareness about indoor radon risk. Although the directive has not been transposed in Italy yet, some regions e.g. Campania, independently have issued a regional decree (n.13 of 2019) to comply with this lack. Method and results: In this study, the results of a survey on the public's knowledge about the risks associated with exposure to radon collected during two scientific dissemination events “Researchers' Night” (September 2019) and “Futuro Remoto” (November 2019) in Naples, South Italy, are reported.

Published
2020

40. Correction to: Venous thromboembolism and COVID-19: a single center experience from an academic tertiary referral hospital of Northern Italy

Author

Melazzini, Federica, Colaneri, Marta, Fumoso, Federica, Freddi, Giulia, Lenti, Marco Vincenzo, Pieri, Teresa Chiara, Piloni, Davide, Noris, Patrizia, Pieresca, Carla, Preti, Paola Stefania, Russo, Mariaconcetta, Corsico, Angelo, Tavazzi, Guido, Baldanti, Fausto, Triarico, Antonio, Mojoli, Francesco, Bruno, Raffaele, Di Sabatino, Antonio, Aronico, Nicola, Bergamaschi, Gaetano, Bertolino, Giampiera, Codega, Silvia, Costanzo, Filippo, Cresci, Roberto, Delliponti, Angela, Derosa, Giuseppe, Di Stefano, Michele, Falaschi, Francesco, Iadarola, Carmine, Lovati, Elisabetta, Lucotti, Pietro Carlo, Martignoni, Alessandra, Mengoli, Caterina, Miceli, Emanuela, Mugellini, Amedeo, Muggia, Chiara, Pagani, Elisabetta, Palumbo, Ilaria, Pecci, Alessandro, Perrone, Tiziano, Sgarlata, Carmelo, Siciliani, Luisa, Staniscia, Andrea, Vjera, Francesca Torello, Achilli, Giovanna, Agostinelli, Andrea, Antoci, Valentina, Ballesio, Alessia, Banfi, Francesco, Barteselli, Chiara, Benedetti, Irene, Borrelli de Andreis, Federica, Brattoli, Michele, Calabretta, Francesca, Cambiè, Ginevra, Canta, Roberta, Conca, Federico, Coppola, Luigi, Cremonte, Elisa Maria, Croce, Gabriele, Del Rio, Virginia, Di Terlizzi, Francesco, Ferrari, Maria Giovanna, Ferrari, Sara, Fiengo, Anna, Forni, Tommaso, Frigerio, Chiara, Fusco, Alessandra, Gabba, Margherita, Garolfi, Matteo, Gentile, Antonella, Gori, Giulia, Grandi, Giacomo, Grimaldi, Paolo, Lampugnani, Alice, Lapia, Francesco, Lepore, Federica, Lettieri, Gianluca, Mambella, Jacopo, Mercanti, Chiara, Merli, Stefania, Mordà, Francesco, Nardone, Alba, Pace, Luca, Padovini, Lucia, Parodi, Alessandro, Pellegrino, Ivan, Pitotti, Lavinia, Reduzzi, Margherita, Rigano, Giovanni, Romito, Giovanni, Rotola, Giorgio, Sabatini, Umberto, Salvi, Lucia, Santacroce, Giovanni, Savioli, Jessica, Soriano, Simone, Spataro, Carmine, Stefani, Debora, Aliberti, Anna Rita, Amatu, Alessandro, Anfossi, Laura, Arisi, Eric, Baldi, Chiara, Belliato, Mirko, Bellini, Lorenzo, Benzi, Alberto, Bichisao, Germana, Bolongaro, Antonia, Bottazzi, Andrea, Broglia, Federica, Bruschi, Giacomo, Caneva, Luca, Capaccio, Emanuele, Carboni, Valeria, Cavalloro, Fabrizio, Ciceri, Maria, Civardi, Luca, Delmonte, Maria Paola, Domenegati, Elisa Lucia, Ferrari, Federica, Ferrari, Fiorenza, Ferrari, Marta, Fuardo, Marinella, Gerletti, Maddalena Margherita, Gualdana, Simonetta, Ilardi, Marcella, Lo Coco, Claudia, Maggio, Giuseppe, Mascia, Maria Benedetta, Mencherini, Simonetta, Merati, Paola Maria, Mongodi, Silvia, Mori, Anna Maria, Morgante, Federica, Niebel, Thekla Larissa, Noli, Silvano, Orlando, Anita, Pagani, Michele, Passador, Debora, Pellicori, Simona, Perotti, Luciano, Picchioni, Raffaella, Poma, Silvia, Pozzi, Marco, Preti, Emanuela, Puce, Roberta, Radolovich, Danila Katia, Ragni, Gianluca, Repossi, Filippo, Riccardi, Francesca, Rizzardi, Roberto, Rodi, Giuseppe, Roldi, Emanuela, Rossi, Cristina, Sala Gallini, Giuseppe, Sciutti, Fabio, Sportiello, Debora, Ticozzelli, Giulia, Visconti, Federico, Zizzi, Silvia, Bagliani, Alessandro, Belotti, Corrado, Bossi, Chiara, Colombo, Andrea, Colombo, Costanza Natalia Julia, Cremascoli, Luca, Dammassa, Valentino, Discepoli, Roberto, Garlando, Maria Adelaide, Grandini, Filippo, Pellegrini, Andrea, Quaranta, Cecilia, Stella, Andrea, Torresani, Francesco, Mondelli, Mario, Brunetti, Enrico, Di Matteo, Angela, Seminari, Elena, Maiocchi, Laura, Zuccaro, Valentina, Pagnucco, Layla, Mariani, Bianca, Ludovisi, Serena, Lissandrin, Raffaella, Parisi, Aldo, Sacchi, Paolo, Patruno, Savino F. A., Michelone, Giuseppe, Gulminetti, Roberto, Zanaboni, Domenico, Novati, Stefano, Maserati, Renato, Orsolini, Paolo, Vecchia, Marco, Asperges, Erika, Di Filippo, Alessandro, Sambo, Margherita, Biscarini, Simona, Lupi, Matteo, Roda, Silvia, Gallazzi, Ilaria, Sachs, Michele, Valsecchi, Pietro, Ferrari, Alessandra, Bosio, Matteo, Cascina, Alessandro, Conio, Valentina, Di Domenica, Rita, Donnetta, Anna, Fraolini, Elia, Gualtieri, Giuseppe, Mangiarotti, Patrizia, Mariani, Francesca, Meloni, Federica, Oggionni, Tiberio, Pasturenzi, Lidia, Ronzoni, Vanessa, Saracino, Laura, Stella, Giulia, Tomaselli, Stefano, Abbate, Tommaso, Accordino, Giulia, Bertuccio, Francesco, Burattini, Cecilia, Cacciatore, Elisa, Cattaneo, Elena, Chino, Vittorio, Coretti, Manuela, Della Zoppa, Matteo, Infusino, Cristina, Lettieri, Sara, Maccabruni, Valeria, Mancinelli, Silvia, Tirelli, Claudio, and Vertui, Valentina

Subjects
Adult, Male, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), MEDLINE, Tertiary referral hospital, Single Center, Statistics, Nonparametric, Tertiary Care Centers, Prevalence, Internal Medicine, medicine, Humans, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), Aged, Retrospective Studies, Aged, 80 and over, Academic Medical Centers, Task force, business.industry, Correction, COVID-19, Venous Thromboembolism, Middle Aged, Northern italy, Italy, Emergency medicine, Emergency Medicine, Female, business, Venous thromboembolism
Abstract

Preliminary evidence supports the notion that COVID-19 patients may have an increased susceptibility to develop venous thromboembolism (VTE). However, the magnitude of this association still needs to be defined. Furthermore, clinical predictors of thrombogenesis, and the relationship with the inflammatory status are currently unknown. On this basis, we conducted a retrospective, observational study on 259 consecutive COVID-19 patients admitted to an academic tertiary referral hospital in Northern Italy between March 19th and April 6th, 2020. Records of COVID-19 patients with a definite VTE event were reviewed for demographic information, co-morbidities, risk factors for VTE, laboratory tests, and anticoagulation treatment. Twenty-five cases among 259 COVID-19 patients developed VTE (9.6%), all of them having a Padua score 4, although being under standard anticoagulation prophylaxis since hospital admission. In the VTE subcohort, we found a significant positive correlation between platelet count (PLT) and either C reactive protein (CRP) (p 0.0001) or lactate dehydrogenase (LDH) (p = 0.0013), while a significant inverse correlation was observed between PLT and mean platelet volume (p 0.0001). Platelet-to-lymphocyte ratio significantly correlated with CRP (p 0.0001). The majority of VTE patients was male and younger compared to non-VTE patients (p = 0.002 and p = 0.005, respectively). No significant difference was found in D-dimer levels between VTE and non VTE patients, while significantly higher levels of LDH (p = 0.04) and IL-6 (p = 0.04) were observed in VTE patients in comparison to non-VTE patients. In conclusion, our findings showed a quite high prevalence of VTE in COVID-19 patients. Raised inflammatory indexes and increased serum levels of pro-inflammatory cytokines should raise the clinical suspicion of VTE.

Published
2021
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43. MEASUREMENTS OF NOISE LEVEL IN A PAINT FACTORY: A CASE STUDY

Author

Bosio, P., Savino, F., Tafuri, D., Quarto, M., Bisio, Paolo, Savino, Federica, Tafuri, Domenico, and Quarto, Maria

Subjects
sound pressure level, occupational noise exposure, sound pressure level, noise risk, occupational noise exposure, noise risk
Abstract

Introduction: Hearing loss, arterial hypertension, stress, sleep disturbance, and impaired cognitive performance. Material and methods: The occupational noise exposure study was carried out at paint factory after the acoustic remediation action. The equivalent continuous A-weighted sound pressure level was done according to Italian legislation on occupational safety and UNI 9432:2011 standard; The daily cumulative noise exposure dose was evaluated for each group of workers with different work tasks. Results: The equivalent continuous A-weighted sound pressure levels were lower than 85 dB that is the which is the value above which the Italian law requires the use of personal protection device. The results obtained show that all the workers grouped for work tasks fall into the classes of non-significant (ICA =0) or low (ICA =1) noise risk. Conclusion: The study showed that the implementation of acoustic reclamation, if well designed, can significantly reduce worker exposure to noise.

Published
2018

45. The impact of HIV infection and men who have sex with men status on hepatitis A infection: The experience of two tertiary centres in Northern Italy during the 2017 outbreak and in the 2009‐2016 period

Author

Lombardi, Andrea, primary, Rossotti, Roberto, additional, Moioli, Maria Cristina, additional, Merli, Marco, additional, Valsecchi, Pietro, additional, Zuccaro, Valentina, additional, Vecchia, Marco, additional, Grecchi, Cecilia, additional, Patruno, Savino F. A., additional, Sacchi, Paolo, additional, Fabbiani, Massimiliano, additional, Puoti, Massimo, additional, and Bruno, Raffaele, additional

Published
2019
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46. Abstract P1-11-19: E-DomSanté study on the improvement of care in oncology through digital technology

Author

Quénel-Tueux, N, primary, Allam, V, additional, Desroches, M, additional, Duguey-Cachet, O, additional, Fillatreau, C, additional, Beaufrère, P, additional, Trézéguet, V, additional, Cassauba, S, additional, Portolan, N, additional, Caubet, C, additional, Rodrigues, J, additional, Saint-Upéry, N, additional, Gourgues, A, additional, Oukhemanou, C, additional, Savino, F, additional, Maurel, M, additional, Burbaud, T, additional, Jacques, M, additional, Lamurey, D, additional, Buyse, P-E, additional, Volpato-Coilier, M, additional, Michardière, E, additional, and Hoppe, S, additional

Published
2019
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