20,958 results on '"Savic A"'
Search Results
2. Size and kinematics of the low-ionization broad emission line region from microlensing-induced line profile distortions in gravitationally lensed quasars
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Hutsemékers, Damien, Sluse, Dominique, and Savić, Đorđe
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Astrophysics - Astrophysics of Galaxies - Abstract
MgII or H$\alpha$ line profile distortions observed in five gravitationally lensed quasars have been compared with simulated ones. The simulations are based on three BLR models, a Keplerian disk (KD), an equatorial wind (EW), and a polar wind (PW). We find that the wide variety of observed line profile distortions can be reproduced with microlensing-induced distortions of line profiles generated by our BLR models. For three quasars, the most likely model is either KD or EW, depending on the orientation of the magnification map with respect to the BLR axis. This shows that the line profile distortions depend on the position and orientation of the BLR with respect to the caustic network, and not only on their different effective sizes. In the other quasars, the EW model is preferred. For all objects, the PW model has a lower probability. We conclude that disk geometries with kinematics dominated by either Keplerian rotation or equatorial outflow best reproduce the microlensing effects on the MgII and H$\alpha$ emission lines. The half-light radii of the MgII and H$\alpha$ BLRs are measured in the range of 3 to 25 light-days. The size of the region emitting the low-ionization lines is larger than the region emitting the high-ionization lines, with a factor of four measured between the sizes of the MgII and CIV emitting regions. The microlensing radii of the BLRs are found to be systematically below the radius-luminosity ($R -L$) relations derived from reverberation mapping, confirming that the intrinsic dispersion of the BLR radii with respect to the $R-L$ relations is large, but also revealing a selection bias that affects microlensing-based BLR size measurements., Comment: Accepted for publication in A\&A. arXiv admin note: text overlap with arXiv:2405.09476
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- 2024
3. Lattice thermal conductivity in the anharmonic overdamped regime
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Dangić, Đorđe, Caldarelli, Giovanni, Bianco, Raffaello, Savić, Ivana, and Errea, Ion
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Condensed Matter - Materials Science - Abstract
In crystalline materials, low lattice thermal conductivity is often associated with strong anharmonicity, which can cause significant deviations from the expected Lorentzian lineshape of phonon spectral functions. These deviations, occurring in an overdamped regime, raise questions about the applicability of the Boltzmann transport equation. Furthermore, strong anharmonicity can trigger structural phase transitions with temperature, which cannot be adequately described by the standard harmonic approximation. To address these challenges, we propose a novel approach for computing the lattice thermal conductivity. Our method combines the Green-Kubo linear response theory with the stochastic self-consistent harmonic approximation. The latter allows us to describe the temperature-dependent evolution of the crystal structure, including first- and second-order phase transitions, as well as the vibrational properties in highly anharmonic materials. The Green-Kubo method considers the entire lineshapes of phonon spectral functions in the calculation of the lattice thermal conductivity, thus eliminating the questionable use of phonon lifetimes in the overdamped regime, as well as naturally including coherent transport effects. Additionally, we extend our theory to model complex dynamical lattice thermal conductivity, enhancing our understanding of time-dependent thermoreflectance experiments. As a practical application, we employ this approach to calculate the lattice thermal conductivity of CsPbBr$_3$, a complex crystal known for its anomalous thermal transport behavior with a complex phase diagram. Our method is able to determine the thermal conductivity across different phases in good agreement with experiments.
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- 2024
4. Vanishing of Quadratic Love Numbers of Schwarzschild Black Holes
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Iteanu, Simon, Riva, Massimiliano Maria, Santoni, Luca, Savić, Nikola, and Vernizzi, Filippo
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General Relativity and Quantum Cosmology ,Astrophysics - Cosmology and Nongalactic Astrophysics ,High Energy Physics - Theory - Abstract
The induced conservative tidal response of self-gravitating objects in general relativity is parametrized in terms of a set of coefficients, which are commonly referred to as Love numbers. For asymptotically-flat black holes in four spacetime dimensions, the Love numbers are notoriously zero in the static regime. In this work, we show that this result continues to hold upon inclusion of nonlinearities in the theory for Schwarzschild black holes. We first solve the quadratic Einstein equations in the static limit to all orders in the multipolar expansion, including both even and odd perturbations. We show that the second-order solutions take simple analytic expressions, generically expressible in the form of finite polynomials. We then define the quadratic Love numbers at the level of the point-particle effective field theory. By performing the matching with the full solution in general relativity, we show that quadratic Love number coefficients are zero to all orders in the derivative expansion, like the linear ones., Comment: 55 pages, 3 figures
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- 2024
5. X-ray polarisation in AGN circumnuclear media. Polarisation framework and 2D torus models
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Meulen, Bert Vander, Camps, Peter, Savic, Djordje, Baes, Maarten, Matt, Giorgio, and Stalevski, Marko
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Cold gas and dust reprocess the X-ray emission of active galactic nuclei (AGN), producing spectro-polarimetric features in the X-ray band. The recent launch of IXPE allows for observations of this X-ray polarisation signal, encoding unique information on the circumnuclear medium of AGN. However, the models for interpreting these polarimetric data are under-explored and do not reach the same level of sophistication as the corresponding spectral models. We aim at closing the gap between the spectral and spectro-polarimetric modelling of AGN circumnuclear media by providing the tools for simulating X-ray polarisation in complex 3D transfer media alongside X-ray spectra. We lay out the framework for X-ray polarisation in 3D radiative transfer simulations and provide an implementation to the 3D radiative transfer code SKIRT, focussing on (de)polarisation due to scattering and fluorescent re-emission. As a first application, we studied a 2D toroidal reprocessor of cold gas, modelling the AGN circumnuclear medium. For the 2D torus model, we find a complex behaviour of the polarisation angle with photon energy, which we interpret as a balance between the reprocessed photon flux originating from different sky regions, with a direct link to the torus geometry. We calculated a large grid of AGN torus models and demonstrated how spatially resolved polarisation maps could form a useful tool for interpreting the geometrical information that is encoded in IXPE observations. With this work, we release high-resolution AGN torus templates that simultaneously describe X-ray spectra and spectro-polarimetry, for observational data fitting with XSPEC. The SKIRT code can now model X-ray polarisation simultaneously with X-ray spectra and provide synthetic spectro-polarimetric observations for complex 3D circumnuclear media, with all features of the established SKIRT framework available., Comment: 16 pages, 13 figures, accepted for publication in Astronomy & Astrophysics
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- 2024
6. When Is a Word in Good Company for Learning?
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Layla Unger, Tyler Chang, Olivera Savic, Benjamin K. Bergen, and Vladimir M. Sloutsky
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Although identifying the referents of single words is often cited as a key challenge for getting word learning off the ground, it overlooks the fact that young learners consistently encounter words in the context of other words. How does this company help or hinder word learning? Prior investigations into early word learning from children's real-world language input have yielded conflicting results, with some influential findings suggesting an advantage for words that keep a diverse company of other words, and others suggesting the opposite. Here, we sought to triangulate the source of this conflict, comparing different measures of diversity and approaches to controlling for correlated effects of word frequency across multiple languages. The results were striking: while different diversity measures on their own yielded conflicting results, once nonlinear relationships with word frequency were controlled, we found convergent evidence that contextual consistency supports early word learning.
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- 2024
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7. The equidistant dimension of some graphs of convex polytopes
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Savić, Aleksandar, Maksimović, Zoran, Bogdanović, Milena, and Kratica, Jozef
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Mathematics - Combinatorics ,05C12, 05C69 - Abstract
This paper is devoted to some rotationally symmetric classes of graphs denoted in literature as convex polytope graphs. Exact value of equidistant dimension is found for $T_n$. Next, for even $n$ exact values are found for $R''_n$ and $S''_n$, while for odd $n$ exact value is found for $S_n$. Finally, for odd $n$, lower bound are found for $R''_n$ and $S''_n$.
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- 2024
8. The Effect of STEM Research Experiences on Fields of Interest and Career Paths
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Emma Hillermann, Miloš Savic, and Rama Kothapalli
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There are studies that examine the impact of undergraduate research experiences on students, often concluding that there are benefits to such experiences. Using social career cognitive theory, our research aims to add to the literature by examining the long-term effects, including career path and inclusion in research field, of an undergraduate student research program. This research study used student testimony gathered through interviews to examine the influence of participation in an undergraduate STEM research experience for college first-year students that has been in place at the university for 10 years. Our main finding is that the influence of the experience on students' field of interest and future career aspirations solidified or changed the career paths of 19 out of 20 students, further corroborating the previous research about undergraduate research experiences as high-impact practices.
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- 2024
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9. Dose optimization of TBI-223 for enhanced therapeutic benefit compared to linezolid in antituberculosis regimen.
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Strydom, Natasha, Ernest, Jacqueline, Imperial, Marjorie, Solans, Belén, Wang, Qianwen, Tasneen, Rokeya, Tyagi, Sandeep, Soni, Heena, Garcia, Andrew, Bigelow, Kristina, Gengenbacher, Martin, Zimmerman, Matthew, Xie, Min, Sarathy, Jansy, Yang, Tian, Dartois, Véronique, Nuermberger, Eric, and Savic, Radojka
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Linezolid ,Humans ,Antitubercular Agents ,Oxazolidinones ,Diarylquinolines ,Animals ,Female ,Male ,Mycobacterium tuberculosis ,Drug Therapy ,Combination ,Adult ,Tuberculosis ,Treatment Outcome ,Middle Aged ,Mice ,Dose-Response Relationship ,Drug ,Nitroimidazoles - Abstract
TBI-223, a novel oxazolidinone for tuberculosis, is designed to provide improved efficacy and safety compared to linezolid in combination with bedaquiline and pretomanid (BPaL). We aim to optimize the dosing of TBI-223 within the BPaL regimen for enhanced therapeutic outcomes. TBI-223 is investigated in preclinical monotherapy, multidrug therapy, and lesion penetration experiments to describe its efficacy and safety versus linezolid. A translational platform incorporating linezolid and BPaL data from preclinical experiments and 4 clinical trials (NCT00396084, NCT02333799, NCT03086486, NCT00816426) is developed, enabling validation of the framework. TBI-223 preclinical and Phase 1 data (NCT03758612) are applied to the translational framework to predict clinical outcomes and optimize TBI-223 dosing in combination with bedaquiline and pretomanid. Results indicate that daily doses of 1200-2400 mg TBI-223 may achieve efficacy comparable to the BPaL regimen, with >90% of patients predicted to reach culture conversion by two months.
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- 2024
10. Developing a National-Scale Hybrid System Dynamics, Agent-Based, Model to Evaluate the Effects of Dietary Changes on the Water, Food, and Energy Nexus
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Kheirinejad, Shima, Bozorg-Haddad, Omid, Savic, Dragan, Singh, Vijay P, and Loáiciga, Hugo A
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Civil Engineering ,Engineering ,Nutrition ,Zero Hunger ,System dynamics ,Agent-based Model ,Lacto-ovo vegetarian diet ,Food security ,Water-food-energy nexus ,Environmental Engineering ,Civil engineering - Published
- 2024
11. MDA5-autoimmunity and interstitial pneumonitis contemporaneous with the COVID-19 pandemic (MIP-C)
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David, Paula, Sinha, Saptarshi, Iqbal, Khizer, De Marco, Gabriele, Taheri, Sahar, McLaren, Ella, Maisuria, Sheetal, Arumugakani, Gururaj, Ash, Zoe, Buckley, Catrin, Coles, Lauren, Hettiarachchi, Chamila, Payne, Emma, Savic, Sinisa, Smithson, Gayle, Slade, Maria, Shah, Rahul, Marzo-Ortega, Helena, Keen, Mansoor, Lawson, Catherine, Mclorinan, Joanna, Nizam, Sharmin, Reddy, Hanu, Sharif, Omer, Sultan, Shabina, Tran, Gui, Wood, Mark, Wood, Samuel, Ghosh, Pradipta, and McGonagle, Dennis
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Biomedical and Clinical Sciences ,Clinical Sciences ,Lung ,Genetics ,Autoimmune Disease ,Rare Diseases ,Emerging Infectious Diseases ,Coronaviruses ,Infectious Diseases ,2.1 Biological and endogenous factors ,Good Health and Well Being ,Humans ,COVID-19 ,Interferon-Induced Helicase ,IFIH1 ,Lung Diseases ,Interstitial ,SARS-CoV-2 ,Male ,Female ,Autoimmunity ,Middle Aged ,Autoantibodies ,Aged ,Retrospective Studies ,Pandemics ,Dermatomyositis ,Adult ,Interstitial lung disease ,Autoimmune Raynauds ,Autoimmune rashes ,MDA5-autoimmunity and interstitial pneumonitis contemporaneous with the COVID-19 ,Coronavirus-19 ,Melanoma differentiation-associated protein-5 ,Public Health and Health Services ,Clinical sciences ,Epidemiology - Abstract
BackgroundAnti-MDA5 (Melanoma differentiation-associated protein-5) positive dermatomyositis (MDA5+-DM) is characterised by rapidly progressive interstitial lung disease (ILD) and high mortality. MDA5 is an RNA sensor and a key pattern recognition receptor for the SARS-CoV-2 virus.MethodsThis is a retrospective observational study of a surge in MDA5 autoimmunity, as determined using a 15 muscle-specific autoantibodies (MSAs) panel, between Janurary 2018 and December 2022 in Yorkshire, UK. MDA5-positivity was correlated with clinical features and outcome, and regional SARS-CoV-2 positivity and vaccination rates. Gene expression patterns in COVID-19 were compared with autoimmune lung disease and idiopathic pulmonary fibrosis (IPF) to gain clues into the genesis of the observed MDA5+-DM outbreak.FindingsSixty new anti-MDA5+, but not other MSAs surged between 2020 and 2022, increasing from 0.4% in 2019 to 2.1% (2020), 4.8% (2021) and 1.7% (2022). Few (8/60) had a prior history of confirmed COVID-19, peak rates overlapped with regional SARS-COV-2 community positivity rates in 2021, and 58% (35/60) had received anti-SARS-CoV-2 vaccines. 25/60 cases developed ILD which rapidly progression with death in 8 cases. Among the 35/60 non-ILD cases, 14 had myositis, 17 Raynaud phenomena and 10 had dermatomyositis spectrum rashes. Transcriptomic studies showed strong IFIH1 (gene encoding for MDA5) induction in COVID-19 and autoimmune-ILD, but not IPF, and IFIH1 strongly correlated with an IL-15-centric type-1 interferon response and an activated CD8+ T cell signature that is an immunologic hallmark of progressive ILD in the setting of systemic autoimmune rheumatic diseases. The IFIH1 rs1990760TT variant blunted such response.InterpretationA distinct pattern of MDA5-autoimmunity cases surged contemporaneously with circulation of the SARS-COV-2 virus during COVID-19. Bioinformatic insights suggest a shared immunopathology with known autoimmune lung disease mechanisms.FundingThis work was supported in part by the National Institute for Health Research (NIHR) Leeds Biomedical Research Centre (BRC), and in part by the National Institutes of Health (NIH) grant R01-AI155696 and pilot awards from the UC Office of the President (UCOP)-RGPO (R00RG2628, R00RG2642 and R01RG3780) to P.G. S.S was supported in part by R01-AI141630 (to P.G) and in part through funds from the American Association of Immunologists (AAI) Intersect Fellowship Program for Computational Scientists and Immunologists.
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- 2024
12. Size and kinematics of the CIV broad emission line region from microlensing-induced line profile distortions in two gravitationally lensed quasars
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Hutsemékers, Damien, Sluse, Dominique, and Savić, Đorđe
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Astrophysics - Astrophysics of Galaxies - Abstract
We analyzed the CIV line profile distortions due to microlensing in two quasars, J1339 and J1138. J1339 shows a strong, asymmetric line profile deformation, while J1138 shows a more modest, symmetric deformation. To probe the CIV broad line region (BLR), we compared the observed line profile deformations to simulated ones. The simulations are based on three simple BLR models, a Keplerian disk (KD), an equatorial wind (EW), and a polar wind (PW), of various sizes, inclinations, and emissivities. We find that the line profile deformations can be reproduced with the simple BLR models under consideration, with no need for more complex geometries or kinematics. The models with disk geometries (KD and EW) are preferred, while the PW model is definitely less likely. For J1339, we find the CIV BLR half-light radii to be $r_{1/2} =$ 5.1 $^{+4.6}_{-2.9}$ light-days and $r_{1/2} =$ 6.7 $^{+6.0}_{-3.8}$ light-days from spectra obtained in 2014 and 2017, respectively. They do agree within uncertainties. For J1138, the amplitude of microlensing is smaller and more dependent on the macro-magnification factor. From spectra obtained in 2005 (single epoch), we find $r_{1/2} =$ 4.9 $^{+4.9}_{-2.7}$ light-days and $r_{1/2}= $ 12 $^{+13}_{-8}$ light-days for two extreme values of the macro-magnification factor. Combining these new measurements with those previously obtained for the quasars Q2237$+$0305 and J1004$+$4112, we show that the BLR radii estimated from microlensing do follow the CIV radius--luminosity relation obtained from reverberation mapping, although the microlensing radii seem to be systematically smaller, which could indicate either a selection bias or a real offset (abridged)., Comment: Accepted for publication in A\&A
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- 2024
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13. Probing the broad line region geometry and size of the gravitationally lensed quasar Q2237+0305 with microlensing time series
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Savić, Đ. V., Hutsemékers, D., and Sluse, D.
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Astrophysics - Astrophysics of Galaxies - Abstract
Lensed quasars are powerful cosmic laboratories; they are used to simultaneously probe various astrophysical phenomena. Microlensing by stars within distant galaxies acts as strong gravitational lenses of multiply imaged quasars, and provides a unique and direct measurement of the lensed quasar internal structure. Microlensing of the continuum emitting region as well as the broad-line region (BLR) is well characterized by four observable indices, $\mu^{cont}$, $\mu^{BLR}$, $WCI$ (wing-core), and $RBI$ (red-blue), measured directly from the spectra. During the 2004-2007 monitoring period, image A of the quadruply lensed system Q2237+0305 underwent a strong microlensing amplification, while image D remained unaffected. We used 35 epochs of archival spectrophotometric data of Q2237+0305 obtained with the Very Large Telescope of the European Southern Observatory to develop an independent microlensing method for estimating the geometry and size of the BLR. We measured the index time series for the CIV line and the continuum emission at $1450\,\unicode{x212B}$. We built a library of the simulated microlensing index time series that reproduce the observed times series based on three representative BLR models: Keplerian disk (KD), polar wind (PW), and equatorial wind (EW). After sampling the model parameter space, we find that KD is the predominant model, while PW and EW are less likely. We infer that the system is viewed at an intermediate viewing angle $i\sim 35^\circ$, and we estimate the most likely CIV BLR half-light radius $r_\mathrm{1/2}=51\pm 23$ light days. Our results are in good agreement with previous findings in the literature and extend the validity of the index-based approach to a temporal domain., Comment: 8 pages, 5 figures, 4 tables, accepted by A\&A
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- 2024
14. Enhancing Educational Efficiency: Generative AI Chatbots and DevOps in Education 4.0
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Mekić, Edis, Jovanović, Mihailo, Kuk, Kristijan, Prlinčević, Bojan, and Savić, Ana
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Computer Science - Computers and Society ,Computer Science - Artificial Intelligence ,Computer Science - Software Engineering - Abstract
This research paper will bring forth the innovative pedagogical approach in computer science education, which uses a combination of methodologies borrowed from Artificial Intelligence (AI) and DevOps to enhance the learning experience in Content Management Systems (CMS) Development. It has been done over three academic years, comparing the traditional way of teaching with the lately introduced AI-supported techniques. This had three structured sprints, each one of them covering the major parts of the sprint: object-oriented PHP, theme development, and plugin development. In each sprint, the student deals with part of the theoretical content and part of the practical task, using ChatGPT as an auxiliary tool. In that sprint, the model will provide solutions in code debugging and extensions of complex problems. The course includes practical examples like code replication with PHP, functionality expansion of the CMS, even development of custom plugins, and themes. The course practice includes versions' control with Git repositories. Efficiency will touch the theme and plugin output rates during development and mobile/web application development. Comparative analysis indicates that there is a marked increase in efficiency and shows effectiveness with the proposed AI- and DevOps-supported methodology. The study is very informative since education in computer science and its landscape change embodies an emerging technology that could have transformation impacts on amplifying the potential for scalable and adaptive learning approaches.
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- 2024
15. Hereditary Angioedema Attacks in Patients Receiving Long-Term Prophylaxis: A Systematic Review
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Longhurst, Hilary J., Cancian, Mauro, Grivcheva-Panovska, Vesna, Koleilat, Majed, Magerl, Markus, Savic, Sinisa, Stobiecki, Marcin, Tachdjian, Raffi, Healy, Bridget, Yea, Christopher M., Audhya, Paul K., and Bouillet, Laurence
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- 2024
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16. Association between Cytotoxic T-Lymphocyte-Associated Antigen 4 (CTLA-4) Locus and Early-Onset Anti-acetylcholine Receptor-Positive Myasthenia Gravis in Serbian Patients
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Djordjevic, Ivana, Garai, Nemanja, Peric, Stojan, Karanovic, Jelena, Pesovic, Jovan, Brkusanin, Milos, Lavrnic, Dragana, Apostolski, Slobodan, Savic-Pavicevic, Dusanka, and Basta, Ivana
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- 2024
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17. Desmopressin dosing in children using real-world data and pharmacokinetic/pharmacodynamic model simulations
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Yen, Kevin, Hughes, Emma, Savic, Rada, and Srinivasan, Shylaja
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- 2024
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18. Characterization of gingerbread cookies enriched with quinoa and defatted apple seed flour: nutritional, antioxidant and sensory properties
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Pejic, Lazar D., Milincic, Danijel D., Rabrenovic, Biljana B., Lalicic-Petronijevic, Jovanka G., Stanojevic, Sladjana P., Kostic, Aleksandar Z., Savic, Sladjana K., Pešic, Mirjana B., and Demin, Mirjana A.
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- 2024
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19. Reduction of false positives using zone-specific prostate-specific antigen density for prostate MRI-based biopsy decision strategies
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Hamm, Charlie A., Baumgärtner, Georg L., Padhani, Anwar R., Froböse, Konrad P., Dräger, Franziska, Beetz, Nick L., Savic, Lynn J., Posch, Helena, Lenk, Julian, Schallenberg, Simon, Maxeiner, Andreas, Cash, Hannes, Günzel, Karsten, Hamm, Bernd, Asbach, Patrick, and Penzkofer, Tobias
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- 2024
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20. PhySU-Net: Long Temporal Context Transformer for rPPG with Self-Supervised Pre-training
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Savic, Marko and Zhao, Guoying
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Remote photoplethysmography (rPPG) is a promising technology that consists of contactless measuring of cardiac activity from facial videos. Most recent approaches utilize convolutional networks with limited temporal modeling capability or ignore long temporal context. Supervised rPPG methods are also severely limited by scarce data availability. In this work, we propose PhySU-Net, the first long spatial-temporal map rPPG transformer network and a self-supervised pre-training strategy that exploits unlabeled data to improve our model. Our strategy leverages traditional methods and image masking to provide pseudo-labels for self-supervised pre-training. Our model is tested on two public datasets (OBF and VIPL-HR) and shows superior performance in supervised training. Furthermore, we demonstrate that our self-supervised pre-training strategy further improves our model's performance by leveraging representations learned from unlabeled data.
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- 2024
21. Weak chaos and mixed dynamics in the string S-matrix
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Savić, Nikola and Čubrović, Mihailo
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High Energy Physics - Theory ,Mathematical Physics ,Nonlinear Sciences - Chaotic Dynamics - Abstract
We investigate chaotic dynamics in tree-level S-matrices describing the scattering of tachyons, photons and gravitons on highly excited open and closed bosonic strings, motivated by the string/black hole complementarity. The eigenphase spacing distribution and other indicators of quantum chaotic scattering suggest that the dynamics is only weakly chaotic, consisting of both regular/Poisson and chaotic/Wigner-Dyson processes. Only for special values of momenta and (for photon scattering) scattering angles do we find strong chaos of random matrix type. These special values correspond to a crossover between two regimes of scattering, dominated by short versus long partitions of the total occupation number of the highly excited string; they also maximize the information entropy of the S-matrix. The lack of strong chaos suggests that perturbative dynamics of highly excited strings can never describe the universal properties and maximal chaos of black hole horizons., Comment: 32 pages, 11 figures; this version: minor corrections and clarifications
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- 2024
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22. Pharmacokinetics and Optimal Dosing of Levofloxacin in Children for Drug-Resistant Tuberculosis: An Individual Patient Data Meta-Analysis
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White, Yasmine N, Solans, Belen P, Denti, Paolo, van der Laan, Louvina E, Schaaf, H Simon, Vonasek, Bryan, Malik, Amyn A, Draper, Heather R, Hussain, Hamidah, Hesseling, Anneke C, Garcia-Prats, Anthony J, and Savic, Radojka M
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Biomedical and Clinical Sciences ,Clinical Sciences ,Pediatric Research Initiative ,Infectious Diseases ,Prevention ,Tuberculosis ,Emerging Infectious Diseases ,Antimicrobial Resistance ,Rare Diseases ,Pediatric ,Infection ,Good Health and Well Being ,Child ,Adult ,Infant ,Newborn ,Humans ,Infant ,Levofloxacin ,Antitubercular Agents ,Tuberculosis ,Multidrug-Resistant ,Rifampin ,Tablets ,pediatrics ,levofloxacin ,pharmacokinetics ,drug-resistant tuberculosis ,Biological Sciences ,Medical and Health Sciences ,Microbiology ,Clinical sciences - Abstract
BackgroundEach year 25 000-32 000 children develop rifampicin- or multidrug-resistant tuberculosis (RR/MDR-TB), and many more require preventive treatment. Levofloxacin is a key component of RR/MDR-TB treatment and prevention, but the existing pharmacokinetic data in children have not yet been comprehensively summarized. We aimed to characterize levofloxacin pharmacokinetics through an individual patient data meta-analysis of available studies and to determine optimal dosing in children.MethodsLevofloxacin concentration and demographic data were pooled from 5 studies and analyzed using nonlinear mixed effects modeling. Simulations were performed using current World Health Organization (WHO)-recommended and model-informed optimized doses. Optimal levofloxacin doses were identified to target median adult area under the time-concentration curve (AUC)24 of 101 mg·h/L given current standard adult doses.ResultsData from 242 children (2.8 years [0.2-16.8] was used). Apparent clearance was 3.16 L/h for a 13-kg child. Age affected clearance, reaching 50% maturation at birth and 90% maturation at 8 months. Nondispersible tablets had 29% lower apparent oral bioavailability compared to dispersible tablets. Median exposures at current WHO-recommended doses were below the AUC target for children weighing 20 mg/kg are required to ensure adequate exposure. Further studies are needed to determine safety and tolerability of these higher doses.
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- 2024
23. Vanishing of Nonlinear Tidal Love Numbers of Schwarzschild Black Holes
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Riva, Massimiliano Maria, Santoni, Luca, Savić, Nikola, and Vernizzi, Filippo
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General Relativity and Quantum Cosmology ,High Energy Physics - Theory - Abstract
It is well known that asymptotically flat Schwarzschild black holes in general relativity in four spacetime dimensions have vanishing induced linear tidal response. We extend this result beyond linear order for the polar sector, by solving the static nonlinear Einstein equations for the perturbations of the Schwarzschild metric and computing the quadratic corrections to the electric-type tidal Love numbers. After explicitly performing the matching with the point-particle effective theory at leading order in the derivative expansion, we show that the Love number couplings remain zero at higher order in perturbation theory., Comment: 11 pages, 3 figures
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- 2023
24. Comparative Analysis of Anthropometric Attributes Among Bosnian and Herzegovinian National Volleyball Team Senior and Junior Male Players: Advancing Insights into Athletic Development/Analisis Comparativo de Atributos Antropometricos entre Jugadores Masculinos Senior y Junior del Equipo Nacional de Voleibol de Bosnia y Herzegovina: Avances en el Conocimiento del Desarrollo Atletico
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Pavlovic, Ratko, Joksimovic, Marko, Savic, Vladan, Almutairi, Harun J., Ahmad, Fuzail, Iqbal, Amir, and Alghadir, Ahmad H.
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- 2024
25. The Influence of Voice and Speech Disorders on the Quality of Life of School-Age Children
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Ilic-Savic, Ivana and Petrovic-Lazic, Mirjana
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Quality of life is a construction used to measure an individual's perspective on their well-being. In modern research, voice and speech disorders have been recognized as indicators of impaired quality of life in children. The aim of this research is to analyze the characteristics of quality of life in children with voice and speech disorders and children of typical development of younger school age. The research assessed the social, emotional and functional aspects of children's quality of life. The research is anonymous, done on a sample of parents of children of younger school age. The examined sample included 100 parents of children of I (53%) and II (47%) grades of primary school. Respondents were divided into two groups, the experimental group (children who go to a speech therapist due to voice and speech pathology (M = 1.55, SD = 0.44)) and the control group (children of typical development (M = 0.57, SD = 0.47)). The Pediatric Voice Handicap Index - pVHI was used to assess the quality of life in children. One-factor multivariate ANOVA was used in statistical data processing. The results of this study show that children with voice and speech disorders have impaired quality of life compared to children of typical development (p <0.05). The social and functional use of speech is worse in children with voice and speech disorders, and the emotional discomfort associated with voice and speech in these children far exceeds the emotional discomfort in children of typical development. As we stated in our work, many studies have shown that voice and speech disorders impair the physical and mental health of children. Due to all the above, the assessment of the quality of life in children with voice and speech disorders is especially important for psychologists and speech therapists during adolescence, so that they can identify problems in a timely manner and take the necessary support measures.
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- 2023
26. Ambient polycyclic aromatic hydrocarbon exposure and breast cancer risk in a population-based Canadian case–control study
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Hinton, Patrick, Villeneuve, Paul J., Galarneau, Elisabeth, Larsen, Kristian, Wen, Deyong, Meng, Jun, Savic-Jovcic, Verica, Zhang, Junhua, and King, Will D.
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- 2024
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27. Spontane Karotisdissektion als Manifestation eines Loeys-Dietz-Syndroms Typ 1 mit unvollständiger Penetranz
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Martinovic-Savic, Sanela, Wallner-Blazek, Mirja, Dragos-Nicolae, Cires, and Schnider, Peter
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- 2024
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28. Whole exome sequencing in Serbian patients with hereditary spastic paraplegia
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Brankovic, Marija, Ivanovic, Vukan, Basta, Ivana, Khang, Rin, Lee, Eugene, Stevic, Zorica, Ralic, Branislav, Tubic, Radoje, Seo, GoHun, Markovic, Vladana, Bozovic, Ivo, Svetel, Marina, Marjanovic, Ana, Veselinovic, Nikola, Mesaros, Sarlota, Jankovic, Milena, Savic-Pavicevic, Dusanka, Jovin, Zita, Novakovic, Ivana, Lee, Hane, and Peric, Stojan
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- 2024
- Full Text
- View/download PDF
29. Transverse Emittance Reduction in Muon Beams by Ionization Cooling
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The MICE Collaboration, Bogomilov, M., Tsenov, R., Vankova-Kirilova, G., Song, Y. P., Tang, J. Y., Li, Z. H., Bertoni, R., Bonesini, M., Chignoli, F., Mazza, R., de Bari, A., Orestano, D., Tortora, L., Kuno, Y., Sakamoto, H., Sato, A., Ishimoto, S., Chung, M., Sung, C. K., Filthaut, F., Fedorov, M., Jokovic, D., Maletic, D., Savic, M., Jovancevic, N., Nikolov, J., Vretenar, M., Ramberger, S., Asfandiyarov, R., Blondel, A., Drielsma, F., Karadzhov, Y., Boyd, S., Greis, J. R., Lord, T., Pidcott, C., Taylor, I., Charnley, G., Collomb, N., Dumbell, K., Gallagher, A., Grant, A., Griffiths, S., Hartnett, T., Martlew, B., Moss, A., Muir, A., Mullacrane, I., Oates, A., Owens, P., Stokes, G., Warburton, P., White, C., Adams, D., Bayliss, V., Boehm, J., Bradshaw, T. W., Brown, C., Courthold, M., Govans, J., Hayler, T., Hills, M., Lagrange, J. B., Macwaters, C., Nichols, A., Preece, R., Ricciardi, S., Rogers, C., Stanley, T., Tarrant, J., Tucker, M., Watson, S., Wilson, A., Bayes, R., Nugent, J. C., Soler, F. J. P., Chatzitheodoridis, G. T., Dick, A. J., Ronald, K., Whyte, C. G., Young, A. R., Gamet, R., Cooke, P., Blackmore, V. J., Colling, D., Dobbs, A., Dornan, P., Franchini, P., Hunt, C., Jurj, P. B., Kurup, A., Long, K., Martyniak, J., Middleton, S., Pasternak, J., Uchida, M. A., Cobb, J. H., Booth, C. N., Hodgson, P., Langlands, J., Overton, E., Pec, V., Smith, P. J., Wilbur, S., Ellis, M., Gardener, R. B. S., Kyberd, P., Nebrensky, J. J., DeMello, A., Gourlay, S., Lambert, A., Li, D., Luo, T., Prestemon, S., Virostek, S., Palmer, M., Witte, H., Adey, D., Bross, A. D., Bowring, D., Liu, A., Neuffer, D., Popovic, M., Rubinov, P., Freemire, B., Hanlet, P., Kaplan, D. M., Mohayai, T. A., Rajaram, D., Snopok, P., Torun, Y., Cremaldi, L. M., Sanders, D. A., Coney, L. R., Hanson, G. G., and Heidt, C.
- Subjects
Physics - Accelerator Physics ,High Energy Physics - Experiment - Abstract
Accelerated muon beams have been considered for next-generation studies of high-energy lepton-antilepton collisions and neutrino oscillations. However, high-brightness muon beams have not yet been produced. The main challenge for muon acceleration and storage stems from the large phase-space volume occupied by the beam, derived from the muon production mechanism through the decay of pions from proton collisions. Ionization cooling is the technique proposed to decrease the muon beam phase-space volume. Here we demonstrate a clear signal of ionization cooling through the observation of transverse emittance reduction in beams that traverse lithium hydride or liquid hydrogen absorbers in the Muon Ionization Cooling Experiment (MICE). The measurement is well reproduced by the simulation of the experiment and the theoretical model. The results shown here represent a substantial advance towards the realization of muon-based facilities that could operate at the energy and intensity frontiers., Comment: 23 pages and 5 figures
- Published
- 2023
30. Pharmacokinetics and cardiac safety of clofazimine in children with rifampicin-resistant tuberculosis
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Ali, Ali Mohamed, Solans, Belén P, Hesseling, Anneke C, Winckler, Jana, Schaaf, H Simon, Draper, Heather R, van der Laan, Louvina, Hughes, Jennifer, Fourie, Barend, Nielsen, James, Wiesner, Lubbe, Garcia-Prats, Anthony J, and Savic, Radojka M
- Subjects
Pharmacology and Pharmaceutical Sciences ,Biomedical and Clinical Sciences ,Pediatric ,HIV/AIDS ,Tuberculosis ,Rare Diseases ,Pediatric AIDS ,Infectious Diseases ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Infection ,Good Health and Well Being ,Adult ,Humans ,Child ,Preschool ,Child ,Adolescent ,Clofazimine ,Rifampin ,Antitubercular Agents ,Tuberculosis ,Multidrug-Resistant ,HIV Infections ,pharmacokinetics ,tuberculosis ,clofazimine ,pediatrics ,QT prolongation ,Microbiology ,Medical Microbiology ,Medical microbiology ,Pharmacology and pharmaceutical sciences - Abstract
Clofazimine is recommended for the treatment of rifampicin-resistant tuberculosis (RR-TB), but there is currently no verified dosing guideline for its use in children. There is only limited safety and no pharmacokinetic (PK) data available for children. We aimed to characterize clofazimine PK and its relationship with QT-interval prolongation in children. An observational cohort study of South African children
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- 2024
31. ASCAPE: An open AI ecosystem to support the quality of life of cancer patients
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Lampropoulos, Konstantinos, Kosmidis, Thanos, Autexier, Serge, Savic, Milos, Athanatos, Manos, Kokkonidis, Miltiadis, Koutsouri, Tzortzia, Vizitiu, Anamaria, Valachis, Antonios, and Padron, Miriam Quintero
- Subjects
Computer Science - Artificial Intelligence - Abstract
The latest cancer statistics indicate a decrease in cancer-related mortality. However, due to the growing and ageing population, the absolute number of people living with cancer is set to keep increasing. This paper presents ASCAPE, an open AI infrastructure that takes advantage of the recent advances in Artificial Intelligence (AI) and Machine Learning (ML) to support cancer patients quality of life (QoL). With ASCAPE health stakeholders (e.g. hospitals) can locally process their private medical data and then share the produced knowledge (ML models) through the open AI infrastructure.
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- 2023
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32. Ultrafast measurements of mode-specific deformation potentials of Bi$_2$Te$_3$ and Bi$_2$Se$_3$
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Huang, Yijing, Querales-Flores, José D., Teitelbaum, Samuel W., Cao, Jiang, Henighan, Thomas, Liu, Hanzhe, Jiang, Mason, De la Peña, Gilberto, Krapivin, Viktor, Haber, Johann, Sato, Takahiro, Chollet, Matthieu, Zhu, Diling, Katayama, Tetsuo, Power, Robert, Allen, Meabh, Rotundu, Costel R., Bailey, Trevor P., Uher, Ctirad, Trigo, Mariano, Kirchmann, Patrick S., Murray, Éamonn D., Shen, Zhi-Xun, Savic, Ivana, Fahy, Stephen, Sobota, Jonathan A., and Reis, David A.
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Condensed Matter - Materials Science - Abstract
Quantifying electron-phonon interactions for the surface states of topological materials can provide key insights into surface-state transport, topological superconductivity, and potentially how to manipulate the surface state using a structural degree of freedom. We perform time-resolved x-ray diffraction (XRD) and angle-resolved photoemission (ARPES) measurements on Bi$_2$Te$_3$ and Bi$_2$Se$_3$, following the excitation of coherent A$_{1g}$ optical phonons. We extract and compare the deformation potentials coupling the surface electronic states to local A$_{1g}$-like displacements in these two materials using the experimentally determined atomic displacements from XRD and electron band shifts from ARPES.We find the coupling in Bi$_2$Te$_3$ and Bi$_2$Se$_3$ to be similar and in general in agreement with expectations from density functional theory. We establish a methodology that quantifies the mode-specific electron-phonon coupling experimentally, allowing detailed comparison to theory. Our results shed light on fundamental processes in topological insulators involving electron-phonon coupling.
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- 2023
33. The LSST AGN Data Challenge: Selection methods
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Savić, Đorđe V., Jankov, Isidora, Yu, Weixiang, Petrecca, Vincenzo, Temple, Matthew J., Ni, Qingling, Shirley, Raphael, Kovacevic, Andjelka B., Nikolic, Mladen, Ilic, Dragana, Popovic, Luka C., Paolillo, Maurizio, Panda, Swayamtrupta, Ciprijanovic, Aleksandra, and Richards, Gordon T.
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Development of the Rubin Observatory Legacy Survey of Space and Time (LSST) includes a series of Data Challenges (DC) arranged by various LSST Scientific Collaborations (SC) that are taking place during the projects preoperational phase. The AGN Science Collaboration Data Challenge (AGNSCDC) is a partial prototype of the expected LSST AGN data, aimed at validating machine learning approaches for AGN selection and characterization in large surveys like LSST. The AGNSC-DC took part in 2021 focusing on accuracy, robustness, and scalability. The training and the blinded datasets were constructed to mimic the future LSST release catalogs using the data from the Sloan Digital Sky Survey Stripe 82 region and the XMM-Newton Large Scale Structure Survey region. Data features were divided into astrometry, photometry, color, morphology, redshift and class label with the addition of variability features and images. We present the results of four DC submitted solutions using both classical and machine learning methods. We systematically test the performance of supervised (support vector machine, random forest, extreme gradient boosting, artificial neural network, convolutional neural network) and unsupervised (deep embedding clustering) models when applied to the problem of classifying/clustering sources as stars, galaxies or AGNs. We obtained classification accuracy 97.5% for supervised and clustering accuracy 96.0% for unsupervised models and 95.0% with a classic approach for a blinded dataset. We find that variability features significantly improve the accuracy of the trained models and correlation analysis among different bands enables a fast and inexpensive first order selection of quasar candidates, Comment: Accepted by ApJ. 21 pages, 14 figures, 5 tables
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- 2023
34. Deep learning of quasar lightcurves in the LSST era
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Kovacevic, Andjelka B., Ilic, Dragana, Popovic, Luka C., Mitrovic, Nikola Andric, Nikolic, Mladen, Pavlovic, Marina S., Hajdinjak, Iva Cvorovic, Knezevic, Miljan, and Savic, Djordje V.
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
Deep learning techniques are required for the analysis of synoptic (multi-band and multi-epoch) light curves in massive data of quasars, as expected from the Vera C. Rubin Observatory Legacy Survey of Space and Time (LSST). In this follow-up study, we introduced an upgraded version of a conditional neural process (CNP) embedded in a multistep approach for analysis of large data of quasars in the LSST Active Galactic Nuclei Scientific Collaboration data challenge database. We present a case study of a stratified set of the u-band light curves for 283 quasars with very low variability $\sim 0.03$. In this sample, CNP average mean square error is found to be $\sim 5\% $($\sim 0.5$ mag). Interestingly, beside similar level of variability there are indications that individual light curves show flare like features. According to preliminary structure function analysis, these occurrences may be associated to microlensing events with larger time scales $5-10$ years., Comment: accepted for publication by the MDPI Universe Special Issue A Multimessenger View of Supermassive Black Holes and the Quasar Main Sequence, Eds. Ascension Del Olmo and Paola Marziani
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- 2023
35. Lung microenvironments harbor Mycobacterium tuberculosis phenotypes with distinct treatment responses.
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Walter, Nicholas, Ernest, Jackie, Dide-Agossou, Christian, Bauman, Allison, Ramey, Michelle, Rossmassler, Karen, Massoudi, Lisa, Pauly, Samantha, Al Mubarak, Reem, Voskuil, Martin, Kaya, Firat, Sarathy, Jansy, Zimmerman, Matthew, Dartois, Véronique, Podell, Brendan, Robertson, Gregory, and Savic, Radojka
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granuloma ,pharmacodynamics ,pharmacokinetics ,tolerance ,Mice ,Animals ,Humans ,Mycobacterium tuberculosis ,Antitubercular Agents ,Mice ,Inbred C3H ,Tuberculosis ,Lung ,Mice ,Inbred Strains - Abstract
Tuberculosis lung lesions are complex and harbor heterogeneous microenvironments that influence antibiotic effectiveness. Major strides have been made recently in understanding drug pharmacokinetics in pulmonary lesions, but the bacterial phenotypes that arise under these conditions and their contribution to drug tolerance are poorly understood. A pharmacodynamic marker called the RS ratio® quantifies ongoing rRNA synthesis based on the abundance of newly synthesized precursor rRNA relative to mature structural rRNA. Application of the RS ratio in the C3HeB/FeJ mouse model demonstrated that Mycobacterium tuberculosis populations residing in different tissue microenvironments are phenotypically distinct and respond differently to drug treatment with rifampin, isoniazid, or bedaquiline. This work provides a foundational basis required to address how anatomic and pathologic microenvironmental niches may contribute to long treatment duration and drug tolerance during the treatment of human tuberculosis.
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- 2023
36. Pharmacokinetic analysis across studies to drive knowledge-integration: A tutorial on individual patient data meta-analysis (IPDMA).
- Author
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Solans, Belén, van Wijk, Rob, Imperial, Marjorie, and Savic, Radojka
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Humans ,Databases ,Factual ,Pharmacokinetics ,Drug Development ,Meta-Analysis as Topic - Abstract
Answering challenging questions in drug development sometimes requires pharmacokinetic (PK) data analysis across different studies, for example, to characterize PKs across diverse regions or populations, or to increase statistical power for subpopulations by combining smaller size trials. Given the growing interest in data sharing and advanced computational methods, knowledge integration based on multiple data sources is increasingly applied in the context of model-informed drug discovery and development. A powerful analysis method is the individual patient data meta-analysis (IPDMA), leveraging systematic review of databases and literature, with the most detailed data type of the individual patient, and quantitative modeling of the PK processes, including capturing heterogeneity of variance between studies. The methodology that should be used in IPDMA in the context of population PK analysis is summarized in this tutorial, highlighting areas of special attention compared to standard PK modeling, including hierarchical nested variability terms for interstudy variability, and handling between-assay differences in limits of quantification within a single analysis. This tutorial is intended for any pharmacological modeler who is interested in performing an integrated analysis of PK data across different studies in a systematic and thorough manner, to answer questions that transcend individual primary studies.
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- 2023
37. Mood disorders and 5-HTR2A genetic variants – the moderator effect of inflammation on expression of affective polarity phenotype
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Pantovic-Stefanovic, Maja, Karanovic, Jelena, Jurisic, Vladimir, Dunjic-Kostic, Bojana, Nesic, Milica, Dodic, Sara, Gostiljac, Marta, Puric, Marija, Savic Pavicevic, Dusanka, and Ivkovic, Maja
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- 2024
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38. Risk-stratified treatment for drug-susceptible pulmonary tuberculosis
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Chang, Vincent K., Imperial, Marjorie Z., Phillips, Patrick P. J., Velásquez, Gustavo E., Nahid, Payam, Vernon, Andrew, Kurbatova, Ekaterina V., Swindells, Susan, Chaisson, Richard E., Dorman, Susan E., Johnson, John L., Weiner, Marc, Sizemore, Erin E., Whitworth, William, Carr, Wendy, Bryant, Kia E., Burton, Deron, Dooley, Kelly E., Engle, Melissa, Nsubuga, Pheona, Diacon, Andreas H., Nhung, Nguyen Viet, Dawson, Rodney, and Savic, Radojka M.
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- 2024
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39. Utilising primary care electronic health records to deliver the ALABAMA randomised controlled trial of penicillin allergy assessment
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Ahmed, Shadia, Fielding, Joanne, Porter, Catherine E., Armitage, Kelsey F., Wanat, Marta, Bates, Chris, Engonidou, Lazarina, West, Robert M., Yu, Ly-Mee, Galal, Ushma, Howard, Philip, Butler, Christopher C., Savic, Sinisa, Boards, Jenny, Tonkin-Crine, Sarah, Parry, John, Pavitt, Sue A., and Sandoe, Jonathan T.
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- 2024
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40. Twenty four-month follow-up after bullectomy, unilateral and bilateral lung volume reduction surgery: a single-center retrospective analysis of consecutive cases
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Bascarevic, Slavisa, Ercegovac, Maja, Hoda, Mir Alireza, Savic, Milan, Vesovic, Radomir, Milenkovic, Vladimir, Moromila, Marina, Popovic, Marko, Gompelmann, Daniela, and Madzarevic, Petar
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- 2024
- Full Text
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41. Investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment
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Bhattarai, Kashi Raj, Mobley, Robert J., Barnett, Kelly R., Ferguson, Daniel C., Hansen, Baranda S., Diedrich, Jonathan D., Bergeron, Brennan P., Yoshimura, Satoshi, Yang, Wenjian, Crews, Kristine R., Manring, Christopher S., Jabbour, Elias, Paietta, Elisabeth, Litzow, Mark R., Kornblau, Steven M., Stock, Wendy, Inaba, Hiroto, Jeha, Sima, Pui, Ching-Hon, Cheng, Cheng, Pruett-Miller, Shondra M., Relling, Mary V., Yang, Jun J., Evans, William E., and Savic, Daniel
- Published
- 2024
- Full Text
- View/download PDF
42. Brain computer interface training with motor imagery and functional electrical stimulation for patients with severe upper limb paresis after stroke: a randomized controlled pilot trial
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Brunner, Iris, Lundquist, Camilla Biering, Pedersen, Asger Roer, Spaich, Erika G., Dosen, Strahinja, and Savic, Andrej
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- 2024
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43. The use of cultured human alveolar basal cells to mimic honeycomb formation in idiopathic pulmonary fibrosis
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Blumer, Sabrina, Khan, Petra, Artysh, Nataliia, Plappert, Linda, Savic, Spasenija, Knudsen, Lars, Jonigk, Danny, Kuehnel, Mark P., Prasse, Antje, and Hostettler, Katrin E.
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- 2024
- Full Text
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44. Geographic variation of mutagenic exposures in kidney cancer genomes
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Senkin, Sergey, Moody, Sarah, Díaz-Gay, Marcos, Abedi-Ardekani, Behnoush, Cattiaux, Thomas, Ferreiro-Iglesias, Aida, Wang, Jingwei, Fitzgerald, Stephen, Kazachkova, Mariya, Vangara, Raviteja, Le, Anh Phuong, Bergstrom, Erik N., Khandekar, Azhar, Otlu, Burçak, Cheema, Saamin, Latimer, Calli, Thomas, Emily, Atkins, Joshua Ronald, Smith-Byrne, Karl, Cortez Cardoso Penha, Ricardo, Carreira, Christine, Chopard, Priscilia, Gaborieau, Valérie, Keski-Rahkonen, Pekka, Jones, David, Teague, Jon W., Ferlicot, Sophie, Asgari, Mojgan, Sangkhathat, Surasak, Attawettayanon, Worapat, Świątkowska, Beata, Jarmalaite, Sonata, Sabaliauskaite, Rasa, Shibata, Tatsuhiro, Fukagawa, Akihiko, Mates, Dana, Jinga, Viorel, Rascu, Stefan, Mijuskovic, Mirjana, Savic, Slavisa, Milosavljevic, Sasa, Bartlett, John M. S., Albert, Monique, Phouthavongsy, Larry, Ashton-Prolla, Patricia, Botton, Mariana R., Silva Neto, Brasil, Bezerra, Stephania Martins, Curado, Maria Paula, Zequi, Stênio de Cássio, Reis, Rui Manuel, Faria, Eliney Ferreira, de Menezes, Nei Soares, Ferrari, Renata Spagnoli, Banks, Rosamonde E., Vasudev, Naveen S., Zaridze, David, Mukeriya, Anush, Shangina, Oxana, Matveev, Vsevolod, Foretova, Lenka, Navratilova, Marie, Holcatova, Ivana, Hornakova, Anna, Janout, Vladimir, Purdue, Mark P., Rothman, Nathaniel, Chanock, Stephen J., Ueland, Per Magne, Johansson, Mattias, McKay, James, Scelo, Ghislaine, Chanudet, Estelle, Humphreys, Laura, de Carvalho, Ana Carolina, Perdomo, Sandra, Alexandrov, Ludmil B., Stratton, Michael R., and Brennan, Paul
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- 2024
- Full Text
- View/download PDF
45. Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions
- Author
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Purdue, Mark P., Dutta, Diptavo, Machiela, Mitchell J., Gorman, Bryan R., Winter, Timothy, Okuhara, Dayne, Cleland, Sara, Ferreiro-Iglesias, Aida, Scheet, Paul, Liu, Aoxing, Wu, Chao, Antwi, Samuel O., Larkin, James, Zequi, Stênio C., Sun, Maxine, Hikino, Keiko, Hajiran, Ali, Lawson, Keith A., Cárcano, Flavio, Blanchet, Odile, Shuch, Brian, Nepple, Kenneth G., Margue, Gaëlle, Sundi, Debasish, Diver, W. Ryan, Folgueira, Maria A. A. K., van Bokhoven, Adrie, Neffa, Florencia, Brown, Kevin M., Hofmann, Jonathan N., Rhee, Jongeun, Yeager, Meredith, Cole, Nathan R., Hicks, Belynda D., Manning, Michelle R., Hutchinson, Amy A., Rothman, Nathaniel, Huang, Wen-Yi, Linehan, W. Marston, Lori, Adriana, Ferragu, Matthieu, Zidane-Marinnes, Merzouka, Serrano, Sérgio V., Magnabosco, Wesley J., Vilas, Ana, Decia, Ricardo, Carusso, Florencia, Graham, Laura S., Anderson, Kyra, Bilen, Mehmet A., Arciero, Cletus, Pellegrin, Isabelle, Ricard, Solène, Scelo, Ghislaine, Banks, Rosamonde E., Vasudev, Naveen S., Soomro, Naeem, Stewart, Grant D., Adeyoju, Adebanji, Bromage, Stephen, Hrouda, David, Gibbons, Norma, Patel, Poulam, Sullivan, Mark, Protheroe, Andrew, Nugent, Francesca I., Fournier, Michelle J., Zhang, Xiaoyu, Martin, Lisa J., Komisarenko, Maria, Eisen, Timothy, Cunningham, Sonia A., Connolly, Denise C., Uzzo, Robert G., Zaridze, David, Mukeria, Anush, Holcatova, Ivana, Hornakova, Anna, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Jinga, Viorel, Rascu, Stefan, Mijuskovic, Mirjana, Savic, Slavisa, Milosavljevic, Sasa, Gaborieau, Valérie, Abedi-Ardekani, Behnoush, McKay, James, Johansson, Mattias, Phouthavongsy, Larry, Hayman, Lindsay, Li, Jason, Lungu, Ilinca, Bezerra, Stephania M., Souza, Aline G., Sares, Claudia T. G., Reis, Rodolfo B., Gallucci, Fabio P., Cordeiro, Mauricio D., Pomerantz, Mark, Lee, Gwo-Shu M., Freedman, Matthew L., Jeong, Anhyo, Greenberg, Samantha E., Sanchez, Alejandro, Thompson, R. Houston, Sharma, Vidit, Thiel, David D., Ball, Colleen T., Abreu, Diego, Lam, Elaine T., Nahas, William C., Master, Viraj A., Patel, Alpa V., Bernhard, Jean-Christophe, Freedman, Neal D., Bigot, Pierre, Reis, Rui M., Colli, Leandro M., Finelli, Antonio, Manley, Brandon J., Terao, Chikashi, Choueiri, Toni K., Carraro, Dirce M., Houlston, Richard, Eckel-Passow, Jeanette E., Abbosh, Philip H., Ganna, Andrea, Brennan, Paul, Gu, Jian, and Chanock, Stephen J.
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- 2024
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46. Improvement of fatigue in generalised myasthenia gravis with zilucoplan
- Author
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Weiss, Michael D., Freimer, Miriam, Leite, M. Isabel, Maniaol, Angelina, Utsugisawa, Kimiaki, Bloemers, Jos, Boroojerdi, Babak, Howard, Emily, Savic, Natasa, and Howard, Jr, James F.
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- 2024
- Full Text
- View/download PDF
47. Gender Incongruence and Autistic Traits: Cerebral and Behavioral Underpinnings
- Author
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Khorashad, Behzad S., Wang, Yanlu, Holmberg, Mats, Dhejne, Cecilia, and Savic, Ivanka
- Published
- 2024
- Full Text
- View/download PDF
48. The Voronoi Diagram of Rotating Rays with applications to Floodlight Illumination
- Author
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Alegría, Carlos, Mantas, Ioannis, Papadopoulou, Evanthia, Savić, Marko, Seara, Carlos, and Suderland, Martin
- Subjects
Computer Science - Computational Geometry ,Computer Science - Data Structures and Algorithms - Abstract
We study the Voronoi Diagram of Rotating Rays, a Voronoi structure where the input sites are rays and the distance function between a point and a site/ray, is the counterclockwise angular distance. This novel Voronoi diagram is motivated by illumination or coverage problems, where a domain must be covered by floodlights/wedges of uniform angle, and the goal is to find the minimum angle necessary to cover the domain. We study the diagram in the plane, and we present structural properties, combinatorial complexity bounds, and a construction algorithm. If the rays are induced by a convex polygon, we show how to construct the Voronoi diagram within this polygon in linear time. Using this information, we can find in optimal linear time the Brocard angle, the minimum angle required to illuminate a convex polygon with floodlights of uniform angle.
- Published
- 2023
- Full Text
- View/download PDF
49. Constructing a Searchable Knowledge Repository for FAIR Climate Data
- Author
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Roantree, Mark, Lalic, Branislava, Savic, Stevan, Milosevic, Dragan, and Scriney, Michael
- Subjects
Computer Science - Digital Libraries - Abstract
The development of a knowledge repository for climate science data is a multidisciplinary effort between the domain experts (climate scientists), data engineers whos skills include design and building a knowledge repository, and machine learning researchers who provide expertise on data preparation tasks such as gap filling and advise on different machine learning models that can exploit this data. One of the main goals of the CA20108 cost action is to develop a knowledge portal that is fully compliant with the FAIR principles for scientific data management. In the first year, a bespoke knowledge portal was developed to capture metadata for FAIR datasets. Its purpose was to provide detailed metadata descriptions for shareable \micro data using the WMO standard. While storing Network, Site and Sensor metadata locally, the system passes the actual data to Zenodo, receives back the DOI and thus, creates a permanent link between the Knowledge Portal and the storage platform Zenodo. While the user searches the Knowledge portal (metadata), results provide both detailed descriptions and links to data on the Zenodo platform., Comment: 5pp
- Published
- 2023
50. Polarimetry of the potential binary supermassive black hole system in J1430+2303
- Author
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Marin, F., Hutsemékers, D., Liodakis, I., Antonucci, R., Mandarakas, N., Lindfors, E., Blinov, D., Barnouin, T., and Savic, D.
- Subjects
Astrophysics - Astrophysics of Galaxies ,J.2 - Abstract
The growth of supermassive black holes (SMBHs) through merging has long been predicted but its detection remains elusive. However, a promising target has been discovered in the Seyfert-1 galaxy J1430+2303. If a binary system truly lies at the center of J1430+2303, the usual symmetry expected from pole-on views in active galactic nuclei (AGNs) responsible for the observed low ($\le$ 1\%) optical linear polarization in the continuum of these objects is expected to be broken. This should lead to higher-than-usual polarization degrees, together with time-dependent variations of the polarization signal. We used the specialized photopolarimeters RoboPol mounted on the 1.3m telescope at the Skinakas Observatory and the Alhambra Faint Object Spectrograph and Camera (ALFOSC) mounted on the 2.56m Nordic Optical Telescope (NOT) at the "Roque de los Muchachos" Observatory to measure the B-, V-, R-, and I-band polarization of J1430+2303. Observations were complemented using the FORS2 spectropolarimeter mounted on the VLT to acquire 3500 -- 8650 Angs polarized spectra. We compared our set of observations to Monte Carlo radiative-transfer predictions to look for the presence of a SMBH binary. The observed linear continuum polarization of J1430+2303 in the V and R bands is $\sim$ 0.4\% with an associated polarization angle of slightly larger than 0$^\circ$. We detected no significant changes in polarization or photometry between May, June, and July of 2022. In addition, there is no significant difference between the polarization of H$\alpha$ and the polarization of the continuum. A single SMBH at the center of an AGN model is able to reproduce the observed spectrum and polarization, while the binary hypothesis is rejected with a probability of $\sim$85\%., Comment: 10 pages, 8 figures 6 tables, accepted for publication in A&A
- Published
- 2023
- Full Text
- View/download PDF
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