Search

Your search keyword '"Savelyeva, Natalia"' showing total 173 results
Start Over Author "Savelyeva, Natalia"
173 results on '"Savelyeva, Natalia"'

2. Linked CD4 T Cell Help: Broadening Immune Attack Against Cancer by Vaccination

Author

Savelyeva, Natalia, Allen, Alex, Chotprakaikiat, Warayut, Harden, Elena, Jobsri, Jantipa, Godeseth, Rosemary, Wang, Yidao, Stevenson, Freda, Ottensmeier, Christian, Compans, Richard W, Series editor, Honjo, Tasuku, Series editor, Oldstone, Michael B. A., Series editor, Vogt, Peter K., Series editor, Malissen, Bernard, Series editor, Aktories, Klaus, Series editor, Kawaoka, Yoshihiro, Series editor, Rappuoli, Rino, Series editor, Galan, Jorge E., Series editor, Ahmed, Rafi, Series editor, Palme, Klaus, Series editor, Casadevall, Arturo, Series editor, Garcia-Sastre, Adolfo, Series editor, Savelyeva, Natalia, editor, and Ottensmeier, Christian, editor

Published
2017
Full Text
View/download PDF

4. DNA Vaccines to Attack Cancer

Author

Stevenson, Freda K., Ottensmeier, Christian H., Johnson, Peter, Zhu, Delin, Buchan, Sarah L., McCann, Katy J., Roddick, Joanne S., King, Andrew T., McNicholl, Feargal, Savelyeva, Natalia, and Rice, Jason

Published
2004

5. Why Fight? The Combatant Careers of the Anti‐Kyiv Fighters in the Donbas War1.

Author

Savelyeva, Natalia and Erpyleva, Svetlana

Subjects
*INTERNATIONAL conflict, *CIVIL war, *MONETARY incentives, *ECONOMIC impact, *SOCIAL context
Abstract

Based on original qualitative data on the mobilization of anti‐Kyiv combatants during the war in eastern Ukraine (started in 2014), this article suggests an approach for understanding the spontaneous mobilization of nonstate armed groups during contemporary military conflicts. This approach is based on the notion of career as a collective path of mobilization unfolding over time. It explains how different mobilization factors usually proposed in the literature on contemporary civil wars acquire their mobilization power. The article identifies five combatant careers leading to joining the anti‐Kyiv armed groups: evolving localists, disrupted outcasts, nationalist warriors, adventurous ideologues, and inspired sympathizers. It demonstrates that (1) mobilization requires the combination of factors such as economic incentives, ideological affinity, social connections, and conflict dynamics in a particularly sequenced way, (2) this combination is different for each career path, and (3) these factors acquire their mobilizing capacity only in the context of particular social trajectories. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

6. Why Fight? The Combatant Careers of the Anti‐Kyiv Fighters in the Donbas War1.

Author

Savelyeva, Natalia and Erpyleva, Svetlana

Subjects
INTERNATIONAL conflict, CIVIL war, MONETARY incentives, ECONOMIC impact, SOCIAL context
Abstract

Based on original qualitative data on the mobilization of anti‐Kyiv combatants during the war in eastern Ukraine (started in 2014), this article suggests an approach for understanding the spontaneous mobilization of nonstate armed groups during contemporary military conflicts. This approach is based on the notion of career as a collective path of mobilization unfolding over time. It explains how different mobilization factors usually proposed in the literature on contemporary civil wars acquire their mobilization power. The article identifies five combatant careers leading to joining the anti‐Kyiv armed groups: evolving localists, disrupted outcasts, nationalist warriors, adventurous ideologues, and inspired sympathizers. It demonstrates that (1) mobilization requires the combination of factors such as economic incentives, ideological affinity, social connections, and conflict dynamics in a particularly sequenced way, (2) this combination is different for each career path, and (3) these factors acquire their mobilizing capacity only in the context of particular social trajectories. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

8. Supplementary Data 3 from ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance

Author

Mellone, Massimiliano, primary, Piotrowska, Klaudia, primary, Venturi, Giulia, primary, James, Lija, primary, Bzura, Aleksandra, primary, Lopez, Maria A., primary, James, Sonya, primary, Wang, Chuan, primary, Ellis, Matthew J., primary, Hanley, Christopher J., primary, Buckingham, Josephine F., primary, Cox, Kerry L., primary, Hughes, Gareth, primary, Valge-Archer, Viia, primary, King, Emma V., primary, Beers, Stephen A., primary, Jaquet, Vincent, primary, Jones, George D.D., primary, Savelyeva, Natalia, primary, Sayan, Emre, primary, Parsons, Jason L., primary, Durant, Stephen, primary, and Thomas, Gareth J., primary

Published
2023
Full Text
View/download PDF

9. Data from NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors

Author

Ford, Kirsty, primary, Hanley, Christopher J., primary, Mellone, Massimiliano, primary, Szyndralewiez, Cedric, primary, Heitz, Freddy, primary, Wiesel, Philippe, primary, Wood, Oliver, primary, Machado, Maria, primary, Lopez, Maria-Antoinette, primary, Ganesan, Anusha-Preethi, primary, Wang, Chuan, primary, Chakravarthy, Ankur, primary, Fenton, Tim R., primary, King, Emma V., primary, Vijayanand, Pandurangan, primary, Ottensmeier, Christian H., primary, Al-Shamkhani, Aymen, primary, Savelyeva, Natalia, primary, and Thomas, Gareth J., primary

Published
2023
Full Text
View/download PDF

10. Supplementary Data 4 from ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance

Author

Mellone, Massimiliano, primary, Piotrowska, Klaudia, primary, Venturi, Giulia, primary, James, Lija, primary, Bzura, Aleksandra, primary, Lopez, Maria A., primary, James, Sonya, primary, Wang, Chuan, primary, Ellis, Matthew J., primary, Hanley, Christopher J., primary, Buckingham, Josephine F., primary, Cox, Kerry L., primary, Hughes, Gareth, primary, Valge-Archer, Viia, primary, King, Emma V., primary, Beers, Stephen A., primary, Jaquet, Vincent, primary, Jones, George D.D., primary, Savelyeva, Natalia, primary, Sayan, Emre, primary, Parsons, Jason L., primary, Durant, Stephen, primary, and Thomas, Gareth J., primary

Published
2023
Full Text
View/download PDF

11. Supplementary Data 2 from ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance

Author

Mellone, Massimiliano, primary, Piotrowska, Klaudia, primary, Venturi, Giulia, primary, James, Lija, primary, Bzura, Aleksandra, primary, Lopez, Maria A., primary, James, Sonya, primary, Wang, Chuan, primary, Ellis, Matthew J., primary, Hanley, Christopher J., primary, Buckingham, Josephine F., primary, Cox, Kerry L., primary, Hughes, Gareth, primary, Valge-Archer, Viia, primary, King, Emma V., primary, Beers, Stephen A., primary, Jaquet, Vincent, primary, Jones, George D.D., primary, Savelyeva, Natalia, primary, Sayan, Emre, primary, Parsons, Jason L., primary, Durant, Stephen, primary, and Thomas, Gareth J., primary

Published
2023
Full Text
View/download PDF

12. Supplementary Table S2 from NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors

Author

Ford, Kirsty, primary, Hanley, Christopher J., primary, Mellone, Massimiliano, primary, Szyndralewiez, Cedric, primary, Heitz, Freddy, primary, Wiesel, Philippe, primary, Wood, Oliver, primary, Machado, Maria, primary, Lopez, Maria-Antoinette, primary, Ganesan, Anusha-Preethi, primary, Wang, Chuan, primary, Chakravarthy, Ankur, primary, Fenton, Tim R., primary, King, Emma V., primary, Vijayanand, Pandurangan, primary, Ottensmeier, Christian H., primary, Al-Shamkhani, Aymen, primary, Savelyeva, Natalia, primary, and Thomas, Gareth J., primary

Published
2023
Full Text
View/download PDF

13. Supplementary Data 5 from ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance

Author

Mellone, Massimiliano, primary, Piotrowska, Klaudia, primary, Venturi, Giulia, primary, James, Lija, primary, Bzura, Aleksandra, primary, Lopez, Maria A., primary, James, Sonya, primary, Wang, Chuan, primary, Ellis, Matthew J., primary, Hanley, Christopher J., primary, Buckingham, Josephine F., primary, Cox, Kerry L., primary, Hughes, Gareth, primary, Valge-Archer, Viia, primary, King, Emma V., primary, Beers, Stephen A., primary, Jaquet, Vincent, primary, Jones, George D.D., primary, Savelyeva, Natalia, primary, Sayan, Emre, primary, Parsons, Jason L., primary, Durant, Stephen, primary, and Thomas, Gareth J., primary

Published
2023
Full Text
View/download PDF

14. Macros for image quantification from ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance

Author

Mellone, Massimiliano, primary, Piotrowska, Klaudia, primary, Venturi, Giulia, primary, James, Lija, primary, Bzura, Aleksandra, primary, Lopez, Maria A., primary, James, Sonya, primary, Wang, Chuan, primary, Ellis, Matthew J., primary, Hanley, Christopher J., primary, Buckingham, Josephine F., primary, Cox, Kerry L., primary, Hughes, Gareth, primary, Valge-Archer, Viia, primary, King, Emma V., primary, Beers, Stephen A., primary, Jaquet, Vincent, primary, Jones, George D.D., primary, Savelyeva, Natalia, primary, Sayan, Emre, primary, Parsons, Jason L., primary, Durant, Stephen, primary, and Thomas, Gareth J., primary

Published
2023
Full Text
View/download PDF

15. Supplementary Figure S4 from NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors

Author

Ford, Kirsty, primary, Hanley, Christopher J., primary, Mellone, Massimiliano, primary, Szyndralewiez, Cedric, primary, Heitz, Freddy, primary, Wiesel, Philippe, primary, Wood, Oliver, primary, Machado, Maria, primary, Lopez, Maria-Antoinette, primary, Ganesan, Anusha-Preethi, primary, Wang, Chuan, primary, Chakravarthy, Ankur, primary, Fenton, Tim R., primary, King, Emma V., primary, Vijayanand, Pandurangan, primary, Ottensmeier, Christian H., primary, Al-Shamkhani, Aymen, primary, Savelyeva, Natalia, primary, and Thomas, Gareth J., primary

Published
2023
Full Text
View/download PDF

16. Supplementary Figures and Legends from ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance

Author

Mellone, Massimiliano, primary, Piotrowska, Klaudia, primary, Venturi, Giulia, primary, James, Lija, primary, Bzura, Aleksandra, primary, Lopez, Maria A., primary, James, Sonya, primary, Wang, Chuan, primary, Ellis, Matthew J., primary, Hanley, Christopher J., primary, Buckingham, Josephine F., primary, Cox, Kerry L., primary, Hughes, Gareth, primary, Valge-Archer, Viia, primary, King, Emma V., primary, Beers, Stephen A., primary, Jaquet, Vincent, primary, Jones, George D.D., primary, Savelyeva, Natalia, primary, Sayan, Emre, primary, Parsons, Jason L., primary, Durant, Stephen, primary, and Thomas, Gareth J., primary

Published
2023
Full Text
View/download PDF

17. Supplementary Data from NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors

Author

Ford, Kirsty, primary, Hanley, Christopher J., primary, Mellone, Massimiliano, primary, Szyndralewiez, Cedric, primary, Heitz, Freddy, primary, Wiesel, Philippe, primary, Wood, Oliver, primary, Machado, Maria, primary, Lopez, Maria-Antoinette, primary, Ganesan, Anusha-Preethi, primary, Wang, Chuan, primary, Chakravarthy, Ankur, primary, Fenton, Tim R., primary, King, Emma V., primary, Vijayanand, Pandurangan, primary, Ottensmeier, Christian H., primary, Al-Shamkhani, Aymen, primary, Savelyeva, Natalia, primary, and Thomas, Gareth J., primary

Published
2023
Full Text
View/download PDF

19. IL-4 enhances expression and function of surface IgM in CLL cells

Author

Aguilar-Hernandez, Maria M., Blunt, Matthew D., Dobson, Rachel, Yeomans, Alison, Thirdborough, Stephen, Larrayoz, Marta, Smith, Lindsay D., Linley, Adam, Strefford, Jonathan C., Davies, Andrew, Johnson, Peter M.W., Savelyeva, Natalia, Cragg, Mark S., Forconi, Francesco, Packham, Graham, Stevenson, Freda K., and Steele, Andrew J.

Published
2016
Full Text
View/download PDF

20. The Donbas Dilemma: Examining Russia's Path to Full-Scale Intervention.

Author

Savelyeva, Natalia

Subjects
*RUSSIA-Ukraine Conflict, 2014-, *DILEMMA, *MILITARY occupation
Abstract

This article delves into the complex evolution of the Russian-Ukrainian conflict, focusing on the dynamics of the political, economic and institutional situation in the Russian-occupied territories during the Donbas War (2014-2022) and their far-reaching implications for Russia and Ukraine. All attempts to reintegrate those territories with Ukraine through the Minsk Process failed. By 2022, the occupied Donbas territories were de-facto economically, politically, culturally, and institutionally integrated with Russia. As a result, Russia found itself trapped in a perplexing predicament. It could not de-jure integrate the Donbas territories without significant reputational and economic losses. Yet it was equally unable to relinquish them, even as it became clear that they would not help to establish Russian control over Ukraine. As a result, Russia found itself in a situation in which attacking seemed like a viable option to overcome a deadlock. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

21. ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance

Author

Mellone, Massimiliano, primary, Piotrowska, Klaudia, additional, Venturi, Giulia, additional, James, Lija, additional, Bzura, Aleksandra, additional, Lopez, Maria A., additional, James, Sonya, additional, Wang, Chuan, additional, Ellis, Matthew J., additional, Hanley, Christopher J., additional, Buckingham, Josephine F., additional, Cox, Kerry L., additional, Hughes, Gareth, additional, Valge-Archer, Viia, additional, King, Emma V., additional, Beers, Stephen A., additional, Jaquet, Vincent, additional, Jones, George D.D., additional, Savelyeva, Natalia, additional, Sayan, Emre, additional, Parsons, Jason L., additional, Durant, Stephen, additional, and Thomas, Gareth J., additional

Published
2022
Full Text
View/download PDF

24. Transcriptional analysis highlights three distinct immune profiles of high-risk oral epithelial dysplasia

Author

Gan, Chai Phei, primary, Lee, Bernard Kok Bang, additional, Lau, Shin Hin, additional, Kallarakkal, Thomas George, additional, Zaini, Zuraiza Mohamad, additional, Lye, Bryan Kit Weng, additional, Zain, Rosnah Binti, additional, Sathasivam, Hans Prakash, additional, Yeong, Joe Poh Sheng, additional, Savelyeva, Natalia, additional, Thomas, Gareth, additional, Ottensmeier, Christian H., additional, Ariffin, Hany, additional, Cheong, Sok Ching, additional, and Lim, Kue Peng, additional

Published
2022
Full Text
View/download PDF

26. Targeting the tumor mutanome for personalized vaccination in a TMB low non-small cell lung cancer

Author

McCann, Katy, Von Witzleben, Adrian, Thomas, Jaya, Wang, Chuan, Wood, Oliver, Singh, Divya, Boukas, Konstantinos, Bendjama, Kaidre, Silvestre, Nathalie, Nielsen, Finn Cilius, Thomas, Gareth, Sanchez-Elsner, Tilman, Greenbaum, Jason, Schoenberger, Stephen, Peters, Bjoern, Vijayanand, Pandurangan, Savelyeva, Natalia, Ottensmeier, Christian, McCann, Katy, Von Witzleben, Adrian, Thomas, Jaya, Wang, Chuan, Wood, Oliver, Singh, Divya, Boukas, Konstantinos, Bendjama, Kaidre, Silvestre, Nathalie, Nielsen, Finn Cilius, Thomas, Gareth, Sanchez-Elsner, Tilman, Greenbaum, Jason, Schoenberger, Stephen, Peters, Bjoern, Vijayanand, Pandurangan, Savelyeva, Natalia, and Ottensmeier, Christian

Abstract

Background Cancer is characterized by an accumulation of somatic mutations, of which a significant subset can generate cancer-specific neoepitopes that are recognized by autologous T cells. Such neoepitopes are emerging as important targets for cancer immunotherapy, including personalized cancer vaccination strategies. Methods We used whole-exome and RNA sequencing analysis to identify potential neoantigens for a patient with non-small cell lung cancer. Thereafter, we assessed the autologous T-cell reactivity to the candidate neoantigens using a long peptide approach in a cultured interferon gamma ELISpot and tracked the neoantigen-specific T-cells in the tumor by T-cell receptor (TCR) sequencing. In parallel, identified gene variants were incorporated into a Modified Vaccinia Ankara-based vaccine, which was evaluated in the human leucocyte antigen A∗0201 transgenic mouse model (HHD). Results Sequencing revealed a tumor with a low mutational burden: 2219 sequence variants were identified from the primary tumor, of which 23 were expressed in the transcriptome, involving 18 gene products. We could demonstrate spontaneous T-cell responses to 5/18 (28%) mutated gene variants, and further analysis of the TCR repertoire of neoantigen-specific CD4 + and CD8 + T cells revealed TCR clonotypes that were expanded in both blood and tumor tissue. Following vaccination of HHD mice, de novo T-cell responses were generated to 4/18 (22%) mutated gene variants; T cells reactive against two variants were also evident in the autologous setting. Subsequently, we determined the major histocompatibility complex restriction of the T-cell responses and used in silico prediction tools to determine the likely neoepitopes. Conclusions Our study demonstrates the feasibility of efficiently identifying tumor-specific neoantigens that can be targeted by vaccination in tumors with a low mutational burden, promising successful clinical exploitation, with trials currently underway.

Published
2022

28. Targeting the tumor mutanome for personalized vaccination in a TMB low non-small cell lung cancer

Author

McCann, Katy, primary, von Witzleben, Adrian, additional, Thomas, Jaya, additional, Wang, Chuan, additional, Wood, Oliver, additional, Singh, Divya, additional, Boukas, Konstantinos, additional, Bendjama, Kaidre, additional, Silvestre, Nathalie, additional, Nielsen, Finn Cilius, additional, Thomas, Gareth, additional, Sanchez-Elsner, Tilman, additional, Greenbaum, Jason, additional, Schoenberger, Stephen, additional, Peters, Bjoern, additional, Vijayanand, Pandurangan, additional, Savelyeva, Natalia, additional, and Ottensmeier, Christian, additional

Published
2022
Full Text
View/download PDF

33. 911 Immune profiling reveals enrichment of distinct immune signatures in high-risk oral potentially malignant disorders

Author

Gan, Chai, primary, Bang Lee, Bernard Kok, additional, Lau, Shin Hin, additional, Kallarakkal, Thomas George, additional, Zaini, Zuraiza Mohamad, additional, Zain, Rosnah Binti, additional, Sathasivam, Hans Prakash, additional, Sheng Yeong, Joe Poh, additional, Savelyeva, Natalia, additional, Thomas, Gareth, additional, Ottensmeier, Christian, additional, Ariffin, Hany, additional, Cheong, Sok Ching, additional, and Lim, Kue Peng, additional

Published
2021
Full Text
View/download PDF

34. DNA Vaccines Targeting Novel Cancer-Associated Antigens Frequently Expressed in Head and Neck Cancer Enhance the Efficacy of Checkpoint Inhibitor

Author

Wang, Chuan, primary, Zainal, Nur Syafinaz, additional, Chai, San Jiun, additional, Dickie, James, additional, Gan, Chai Phei, additional, Zulaziz, Natasha, additional, Lye, Bryan Kit Weng, additional, Sutavani, Ruhcha V., additional, Ottensmeier, Christian H., additional, King, Emma V., additional, Abraham, Mannil Thomas, additional, Ismail, Siti Mazlipah binti, additional, Lau, Shin Hin, additional, Kallarakkal, Thomas George, additional, Mun, Kein Seong, additional, Zain, Rosnah binti, additional, Abdul Rahman, Zainal Ariff, additional, Thomas, Gareth J., additional, Cheong, Sok Ching, additional, Savelyeva, Natalia, additional, and Lim, Kue Peng, additional

Published
2021
Full Text
View/download PDF

35. Transcriptional analysis highlights three distinct immune profiles of high-risk oral epithelial dysplasia.

Author

Chai Phei Gan, Kok Bang Lee, Bernard, Shin Hin Lau, Kallarakkal, Thomas George, Zaini, Zuraiza Mohamad, Bryan Kit Weng Lye, Zain, Rosnah Binti, Sathasivam, Hans Prakash, Joe Poh Sheng Yeong, Savelyeva, Natalia, Thomas, Gareth, Ottensmeier, Christian H., Ariffin, Hany, Ching Cheong, and Kue Peng Lim

Subjects
REGULATORY T cells, DYSPLASIA, T cells, B cells, CELL cycle
Abstract

Oral potentially malignant disorders (OPMD) are precursors of oral squamous cell carcinoma (OSCC), and the presence of oral epithelial dysplasia (OED) in OPMD confers an increased risk of malignant transformation. Emerging evidence has indicated a role for the immune system in OPMD disease progression; however, the underlying immune mechanisms remain elusive. In this study, we used immune signatures established from cancer to delineate the immune profiles of moderate and severe OED, which are considered highrisk OPMD. We demonstrated that moderate and severe OEDs exhibit high lymphocyte infiltration and upregulation of genes involved in both immune surveillance (major histocompatibility complex-I, T cells, B cells and cytolytic activity) and immune suppression (immune checkpoints, T regulatory cells, and tumor-associated macrophages). Notably, we identified three distinct subtypes of moderate and severe OED: immune cytotoxic, non-cytotoxic and nonimmune reactive. Active immune surveillance is present in the immune cytotoxic subtype, whereas the non-cytotoxic subtype lacks CD8 immune cytotoxic response. The non-immune reactive subtype showed upregulation of genes involved in the stromal microenvironment and cell cycle. The lack of T cell infiltration and activation in the non-immune reactive subtype is due to the dysregulation of CTNNB1, PTEN and JAK2. This work suggests that moderate and severe OED that harbor the non-cytotoxic or non-immune reactive subtype are likely to progress to cancer. Overall, we showed that distinct immune responses are present in high-risk OPMD, and revealed targetable pathways that could lead to potential new approaches for non-surgical management of OED. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

37. HNSCC: tumour antigens and their targeting by immunotherapy

Author

Savelyeva, Natalia, Ottensmeier, Christian, and Wang, Chuan

Subjects
stomatognathic diseases
Abstract

Head and neck squamous cell carcinomas (HNSCC) are a heterogeneous group of malignant tumours typically caused by alcohol and tobacco consumption, although an increasing number of HNSCC arise due to persistent infection with high-risk human papilloma virus (HPV). The treatment of HNSCC remains challenging, and the first-line setting is focused on surgery and chemoradiotherapy. A substantial proportion of HNSCC patients die from their disease, especially those with recurrent and metastatic disease. Among factors linked with good outcome, immune cell infiltration appears to have a major role. HPV-driven HNSCC are often T-cell rich, reflecting the presence of HPV antigens that are immunogenic. Tumour-associated antigens that are shared between patients or that are unique to an individual person may also induce varying degrees of immune response; studying these is important for the understanding of the interaction between the host immune system and the cancer. The resulting knowledge is critical for the design of better immunotherapies. Key questions are: Which antigens lead to an adaptive immune response in the tumour? Which of these are exploitable for immunotherapy? Here, we review the current thinking regarding tumour antigens in HNSCC and what has been learned from early phase clinical trials.

Published
2020

38. List of Contributors

Author

Allavena, Paola, primary, Ascierto, Maria Libera, additional, Bedognetti, Davide, additional, Beury, Daniel W., additional, Bronte, Vincenzo, additional, van der Burg, Sjoerd H., additional, Cai, Zheng, additional, Callahan, Margaret K., additional, Car, Bruce D., additional, Chen, Gang, additional, Chioda, Mariacristina, additional, Chornoguz, Olesya, additional, Demaria, Sandra, additional, Deng, Jiehui, additional, Djeu, Julie Y., additional, Donatelli, Sarah S., additional, Drake, Charles G., additional, Dranoff, Glenn, additional, Durham, Nicholas M., additional, Eisenlohr, Laurence C., additional, Emens, Leisha A., additional, Farsaci, Benedetto, additional, Feehley, Taylor, additional, Filipazzi, Paola, additional, Galdiero, Maria Rosaria, additional, di Genova, Gianfranco, additional, Gilman, Paul B., additional, Greene, Mark I., additional, Greiner, John W., additional, Gulley, James L., additional, Hearnden, Claire, additional, Hodge, James W., additional, Huber, Veronica, additional, Jaffee, Elizabeth M., additional, Jinushi, Masahisa, additional, Jove, Richard, additional, Kershaw, Michael H., additional, Kiss, Robert, additional, Kryczek, Ilona, additional, Lake, Richard A., additional, Lash, Bradley W., additional, Lavelle, Ed C., additional, Lesterhuis, W. Joost, additional, Link, Charles J., additional, Liu, Jing, additional, Luckashenak, Nancy, additional, Madan, Ravi A., additional, Mandik-Nayak, Laura, additional, Mandruzzato, Susanna, additional, Mantovani, Alberto, additional, Marigo, Ilaria, additional, Marincola, Francesco M., additional, Mathieu, Veronique, additional, May, Kenneth F., additional, Mellor, Andrew L., additional, Merlo, Lauren M.F., additional, Metz, Richard, additional, Mocellin, Simone, additional, Morgan, Richard A., additional, Muller, Alexander J., additional, Munn, David H., additional, Nagai, Yasuhiro, additional, Nagler, Cathryn, additional, Norvell, Amanda, additional, Nowak, Anna K., additional, Ohtani, Takuya, additional, Ostrand-Rosenberg, Suzanne, additional, Ottensmeier, Christian H., additional, Palena, Claudia, additional, Parker, Katherine H., additional, Postow, Michael A., additional, Prendergast, George C., additional, Priceman, Saul J., additional, Punt, Jenni, additional, Rabinovich, Gabriel A., additional, Ramsey, W. Jay, additional, Rivoltini, Licia, additional, Rossi, Gabriela R., additional, Sahakian, Eva, additional, Samanta, Arabinda, additional, Sato-Matsushita, Marimo, additional, Savelyeva, Natalia, additional, Schlom, Jeffrey, additional, Sica, Antonio, additional, Sinha, Pratima, additional, Smith, Courtney, additional, Smyth, Mark J., additional, Sotomayor, Eduardo M., additional, Stevenson, Freda K., additional, Sundblad, Victoria, additional, Teng, Michele W.L., additional, Tsang, Kwong-Yok, additional, Tsuchiya, Hiromichi, additional, Vahanian, Nicholas N., additional, Villagra, Alejandro, additional, Wang, Ena, additional, Wang, Lin, additional, Wei, Shuang, additional, Welters, Marij J.P., additional, Westhouse, Richard A., additional, Woan, Karrune, additional, Wolchok, Jedd D., additional, Yu, Hua, additional, Zhang, Hongtao, additional, Zhao, Ende, additional, Zhu, Zhiqiang, additional, and Zou, Weiping, additional

Published
2013
Full Text
View/download PDF

44. NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors

Author

Ford, Kirsty, primary, Hanley, Christopher J., additional, Mellone, Massimiliano, additional, Szyndralewiez, Cedric, additional, Heitz, Freddy, additional, Wiesel, Philippe, additional, Wood, Oliver, additional, Machado, Maria, additional, Lopez, Maria-Antoinette, additional, Ganesan, Anusha-Preethi, additional, Wang, Chuan, additional, Chakravarthy, Ankur, additional, Fenton, Tim R., additional, King, Emma V., additional, Vijayanand, Pandurangan, additional, Ottensmeier, Christian H., additional, Al-Shamkhani, Aymen, additional, Savelyeva, Natalia, additional, and Thomas, Gareth J., additional

Published
2020
Full Text
View/download PDF

45. Cancer Vaccines

Author

Stevenson, Freda K., primary, Genova, Gianfranco di, additional, Ottensmeier, Christian, additional, and Savelyeva, Natalia, additional

Published
2007
Full Text
View/download PDF

46. Contributors

Author

Allavena, Paola, primary, Bronte, Vincenzo, additional, Bunt, Stephanie K., additional, Car, Bruce D., additional, Chang, Alfred, additional, Clements, Virginia K., additional, Genova, Gianfranco Di, additional, Djeu, Julie Y., additional, Dranoff, Glenn, additional, Emens, Leisha A., additional, Finn, Olivera J., additional, Flavell, Richard A., additional, Gajewski, Thomas F., additional, Gilman, Paul B., additional, Hanson, Erica M., additional, Hidalgo, Manuel, additional, Jaffee, Elizabeth M., additional, Jinushi, Masahisa, additional, Kim, Ryungsa, additional, Lake, Richard A., additional, Lepisto, Andrew J., additional, Li, Ming O., additional, Mandruzzato, Susanna, additional, Mantovani, Alberto, additional, McKolanis, John R., additional, Mocellin, Simone, additional, Muller, Alexander J., additional, Nowak, Anna K., additional, Ostrand-Rosenberg, Suzanne, additional, Ottensmeier, Christian, additional, Pardoll, Drew, additional, Prendergast, George C., additional, Rabinovich, Gabriel A., additional, Sallman, David A., additional, Savelyeva, Natalia, additional, Sica, Antonio, additional, Sinha, Pratima, additional, Srivastava, Minu K., additional, Stevenson, Freda K., additional, Thirumaran, Rajesh, additional, van der Most, Robbert G., additional, Wang, Rong-Fu, additional, Weekes, Colin D., additional, Wei, Shuang, additional, Westhouse, Richard A., additional, and Zou, Weiping, additional

Published
2007
Full Text
View/download PDF

49. Abstract 1466: Combination immunotherapy successfully control tumor growth in a transgenic mouse model

Author

Lim, Kue Peng, primary, Zainal, Syafinaz, additional, Zulaziz, Natasha, additional, Gan, Chai Phei, additional, Chai, San Jiun, additional, Lye, Bryan Kit Weng, additional, Wang, Chuan, additional, Sutavani, Ruhcha V., additional, Ottensmeier, Christian, additional, King, Emma, additional, Thomas, Gareth, additional, Savelyeva, Natalia, additional, and Cheong, Sok Ching, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results