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2. The association between diabetes status, HbA1c, diabetes duration, microvascular disease, and bone quality of the distal radius and tibia as measured with high-resolution peripheral quantitative computed tomography—The Maastricht Study

Author

de Waard, E. A. C., de Jong, J. J. A., Koster, A., Savelberg, H. H. C. M., van Geel, T. A., Houben, A. J. H. M., Schram, M. T., Dagnelie, P. C., van der Kallen, C. J., Sep, S. J. S., Stehouwer, C. D. A., Schaper, N. C., Berendschot, T. T. J. M., Schouten, J. S. A. G., Geusens, P. P. M. M., and van den Bergh, J. P. W.

Published
2018
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9. The association between insulin use and volumetric bone mineral density, bone micro-architecture and bone strength of the distal radius in patients with type 2 diabetes - The Maastricht study

Author

Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, de Waard, E A C, Driessen, J H M, de Jong, J J A, van Geel, T A C M, Henry, R M A, van Onzenoort, H A W, Schram, M T, Dagnelie, P C, van der Kallen, C J, Sep, S J S, Stehouwer, C D A, Schaper, N C, Koster, A, Savelberg, H H C M, Neef, C, Geusens, P P M M, de Vries, F, van den Bergh, J P W, Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, de Waard, E A C, Driessen, J H M, de Jong, J J A, van Geel, T A C M, Henry, R M A, van Onzenoort, H A W, Schram, M T, Dagnelie, P C, van der Kallen, C J, Sep, S J S, Stehouwer, C D A, Schaper, N C, Koster, A, Savelberg, H H C M, Neef, C, Geusens, P P M M, de Vries, F, and van den Bergh, J P W

Published
2017

10. The association between insulin use and volumetric bone mineral density, bone micro-architecture and bone strength of the distal radius in patients with type 2 diabetes - The Maastricht study

Author

de Waard, E. A. C., de Waard, E. A. C., Driessen, J. H. M., de Jong, J. J. A., van Geel, T. A. C. M., Henry, R. M. A., van Onzenoort, H. A. W., Schram, M. T., Dagnelie, P. C., van der Kallen, C. J., Sep, S. J. S., Stehouwer, C. D. A., Schaper, N. C., Koster, A., Savelberg, H. H. C. M., Neef, C., Geusens, P. P. M. M., de Vries, F., van den Bergh, J. P. W., de Waard, E. A. C., de Waard, E. A. C., Driessen, J. H. M., de Jong, J. J. A., van Geel, T. A. C. M., Henry, R. M. A., van Onzenoort, H. A. W., Schram, M. T., Dagnelie, P. C., van der Kallen, C. J., Sep, S. J. S., Stehouwer, C. D. A., Schaper, N. C., Koster, A., Savelberg, H. H. C. M., Neef, C., Geusens, P. P. M. M., de Vries, F., and van den Bergh, J. P. W.

Abstract

Type 2 diabetes mellitus (T2DM) has been associated with an increased risk of fractures, despite normal to increased bone mineral density (BMD). Insulin use is one of the factors linked to this increased fracture risk. However, direct negative effects of insulin on bone quality are not expected since insulin is thought to be anabolic to bone. In this cross-sectional study the association between insulin use and volumetric BMD (vBMD), bone micro architecture and bone strength of the distal radius, as measured with HR-pQCT, was examined. Data from 50 participants with T2DM of The Maastricht Study (mean age 62 +/- 7.5 years, 44% women) was used. Participants were classified as insulin user (n = 13) or non-insulin user (n = 37) based on prescription data. Linear regression analysis was used to estimate the association between current insulin use and HR-pQCF derived parameters. After adjustment for age, sex, body mass index, glycated hemoglobin Al c and T2DM duration, insulin use was associated with lower total vBMD (standardized beta (beta):-0.56 (95% CI: 0.89 to 0.24)), trabecular vBMD ((3:-0.58 (95% CI: 0.87 to 0.30)), trabecular thickness (beta: 0.55 (95% CI: 0.87 to 0.23)), cortical thickness (beta: 0.41 (95% CI: 0.74 to 0.08)), log cortical pore volume (beta: 0.43 (95% Cf: 0.73 to 0.13)), bone stiffness (beta:-0.39 (95% CI: 0.62 to 0.17)) and failure load (beta:-0.39 (95% CI: 0.60 to 0.17)) when compared to the non-insulin users. Insulin use was not associated with cortical vBMD, trabecular number, trabecular separation, cortical porosity and cortical pore diameter. This study indicates thatinsulin use is negatively associated with bone density, bone micro-architectural and bone strength parameters: These findings may partly explain the previously observed increased fracture risk in insulin users, although there may be residual confounding by other factors related to disease severity in insulin users. (C) 2017 Elsevier Inc. All rights reserved.

Published
2017

12. Erratum to: The Healthy Primary School of the Future: study protocol of a quasi-experimental study

Author

Willeboordse, M., primary, Jansen, M. W., additional, van den Heijkant, S. N., additional, Simons, A., additional, Winkens, B., additional, de Groot, R. H. M., additional, Bartelink, N., additional, Kremers, S. P., additional, van Assema, P., additional, Savelberg, H. H., additional, de Neubourg, E., additional, Borghans, L., additional, Schils, T., additional, Coppens, K. M., additional, Dietvorst, R., additional, ten Hoopen, R., additional, Coomans, F., additional, Klosse, S., additional, Conjaerts, M. H. J., additional, Oosterhoff, M., additional, Joore, M. A., additional, Ferreira, I., additional, Muris, P., additional, Bosma, H., additional, Toppenberg, H. L., additional, and van Schayck, C. P., additional

Published
2017
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13. The Healthy Primary School of the Future: study protocol of a quasi-experimental study

Author

Willeboordse, M, Willeboordse, M, Jansen, M W, van den Heijkant, S N, Simons, A, Winkens, B, de Groot, R H M, Bartelink, N, Kremers, S P, van Assema, P, Savelberg, H H, de Neubourg, E, Borghans, Lex, Schils, T, Coppens, K M, Dietvorst, R, Ten Hoopen, R, Coomans, F, Klosse, S, Conjaerts, M H J, Oosterhoff, M, Joore, M A, Ferreira, I, Muris, P, Bosma, H, Toppenberg, H L, van Schayck, C P, Willeboordse, M, Willeboordse, M, Jansen, M W, van den Heijkant, S N, Simons, A, Winkens, B, de Groot, R H M, Bartelink, N, Kremers, S P, van Assema, P, Savelberg, H H, de Neubourg, E, Borghans, Lex, Schils, T, Coppens, K M, Dietvorst, R, Ten Hoopen, R, Coomans, F, Klosse, S, Conjaerts, M H J, Oosterhoff, M, Joore, M A, Ferreira, I, Muris, P, Bosma, H, Toppenberg, H L, and van Schayck, C P

Abstract

BACKGROUND: Unhealthy lifestyles in early childhood are a major global health challenge. These lifestyles often persist from generation to generation and contribute to a vicious cycle of health-related and social problems. This design article presents a study evaluating the effects of two novel healthy school interventions. The main outcome measure will be changes in children's body mass index (BMI). In addition, lifestyle behaviours, academic achievement, child well-being, socio-economic differences, and societal costs will be examined.METHODS: In close collaboration with various stakeholders, a quasi-experimental study was developed, for which children of four intervention schools (n = 1200) in the southern part of the Netherlands are compared with children of four control schools (n = 1200) in the same region. The interventions started in November 2015. In two of the four intervention schools, a whole-school approach named 'The Healthy Primary School of the Future', is implemented with the aim of improving physical activity and dietary behaviour. For this intervention, pupils are offered an extended curriculum, including a healthy lunch, more physical exercises, and social and educational activities, next to the regular school curriculum. In the two other intervention schools, a physical-activity school approach called 'The Physical Activity School', is implemented, which is essentially similar to the other intervention, except that no lunch is provided. The interventions proceed during a period of 4 years. Apart from the effectiveness of both interventions, the process, the cost-effectiveness, and the expected legal implications are studied. Data collection is conducted within the school system. The baseline measurements started in September 2015 and yearly follow-up measurements are taking place until 2019.DISCUSSION: A whole-school approach is a new concept in the Netherlands. Due to its innovative, multifaceted nature and sound scientific fou

Published
2016

14. The Healthy Primary School of the Future: study protocol of a quasi-experimental study

Author

Willeboordse, M., primary, Jansen, M. W., additional, van den Heijkant, S. N., additional, Simons, A., additional, Winkens, B., additional, de Groot, R.H.M., additional, Bartelink, N., additional, Kremers, S. P., additional, van Assema, P., additional, Savelberg, H. H., additional, de Neubourg, E., additional, Borghans, L., additional, Schils, T., additional, Coppens, K. M., additional, Dietvorst, R., additional, ten Hoopen, R., additional, Coomans, F., additional, Klosse, S., additional, Conjaerts, M.H.J., additional, Oosterhoff, M., additional, Joore, M. A., additional, Ferreira, I., additional, Muris, P., additional, Bosma, H., additional, Toppenberg, H. L., additional, and van Schayck, C. P., additional

Published
2016
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36. KinesioTaping en spierkracht; een sterk verhaal?

Author

ten Haaf, T., IJzerman, T. H., and Savelberg, H. H. C. M.

Abstract

Copyright of Sport & Geneeskunde is the property of Arko Sports Media and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2011

46. The association between diabetes status, HbA1c, diabetes duration, microvascular disease, and bone quality of the distal radius and tibia as measured with high-resolution peripheral quantitative computed tomographyThe Maastricht Study

Author

Simone J. S. Sep, Annemarie Koster, Nicolaas C. Schaper, Johannes S. A. G. Schouten, T. van Geel, Coen D.A. Stehouwer, Hans H.C.M. Savelberg, E. A. C. de Waard, Piet Geusens, C.J.H. van der Kallen, Pieter C. Dagnelie, J.J.A. de Jong, Alfons J.H.M. Houben, Miranda T. Schram, Tos T. J. M. Berendschot, J. van den Bergh, de Waard, E. A. C., de Jong, J. J. A., KOSTER, Annemarie, Savelberg, H. H. C. M., van Geel, T. A., Houben, A. J. H. M., Schram, M. T., Dagnelie, P. C., VAN DER KALLEN, Carla, Sep, S. J. S., Stehouwer, C. D. A., Schaper, N. C., Berendschot, T. T. J. M., Schouten, J. S. A. G., GEUSENS, Piet, VAN DEN BERGH, Joop, Medical Image Analysis, RS: NUTRIM - R3 - Respiratory & Age-related Health, Interne Geneeskunde, RS: NUTRIM - R2 - Gut-liver homeostasis, Promovendi NTM, Sociale Geneeskunde, RS: CAPHRI - R4 - Health Inequities and Societal Participation, Nutrition and Movement Sciences, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, RS: CAPHRI - R5 - Optimising Patient Care, Family Medicine, Promovendi PHPC, RS: CARIM - R3.02 - Hypertension and target organ damage, MUMC+: HVC Pieken Maastricht Studie (9), RS: CARIM - R3.01 - Vascular complications of diabetes and the metabolic syndrome, Epidemiologie, MUMC+: MA Interne Geneeskunde (3), MUMC+: MA Endocrinologie (9), RS: CAPHRI - R2 - Creating Value-Based Health Care, Oogheelkunde, MUMC+: MA Oogheelkunde (9), RS: MHeNs - R3 - Neuroscience, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, and Revalidatiegeneeskunde

Subjects
0301 basic medicine, Male, Time Factors, Bone density, Endocrinology, Diabetes and Metabolism, FRACTURE RISK, Type 2 diabetes, SDG 3 – Goede gezondheid en welzijn, Glycated Hemoglobin A/analysis, High-resolution peripheral quantitative computed tomography (HR-pQCT), MELLITUS, 0302 clinical medicine, Radius/diagnostic imaging, Bone Density, STRENGTH, Prediabetes, Registries, Quantitative computed tomography, Tomography, Bone mineral, COMPLICATIONS, medicine.diagnostic_test, Tibia/diagnostic imaging, Middle Aged, X-Ray Computed, 3. Good health, Microvascular disease, Radius, medicine.anatomical_structure, POSTMENOPAUSAL WOMEN, Female, Original Article, Diabetes Mellitus, Type 2/blood, Adult, IN-VIVO ASSESSMENT, medicine.medical_specialty, Bone quality, HbA1c, Medication history, METFORMIN, Urology, 030209 endocrinology & metabolism, Diabetes duration, Diabetes status, Diabetes Complications, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Diabetes Mellitus, medicine, Humans, Tibia, Type 2/blood, Aged, Glycated Hemoglobin, business.industry, POROSITY, medicine.disease, Diabetes Complications/physiopathology, 030104 developmental biology, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Cortical bone, MINERAL DENSITY, Bone Density/physiology, business, Tomography, X-Ray Computed, MICROARCHITECTURE
Abstract

Summary In this small cross-sectional study of predominantly well-treated participants with relatively short-term type 2 diabetes duration, HbA1c > 7% (53 mmol/mol) was associated with lower cortical density and thickness and higher cortical porosity at the distal radius, lower trabecular thickness at the distal tibia, and higher trabecular number at both sites. Introduction To examine the association between diabetes status and volumetric bone mineral density (vBMD), bone microarchitecture and strength of the distal radius and tibia as assessed with HR-pQCT. Additionally—in participants with type 2 diabetes (T2DM), to examine the association between HbA1c, diabetes duration, and microvascular disease (MVD) and bone parameters. Methods Cross-sectional data from 410 (radius) and 198 (tibia) participants of The Maastricht Study (mean age 58 year, 51% female). Diabetes status (normal glucose metabolism, prediabetes, or T2DM) was based on an oral glucose tolerance test and medication history. Results After full adjustment, prediabetes and T2DM were not associated with vBMD, bone microarchitecture, and strength of the radius and tibia, except for lower trabecular number (Tb.N) of the tibia (− 4%) in prediabetes and smaller cross-sectional area of the tibia (− 7%) in T2DM. In T2DM, HbA1c > 7% was associated with lower cortical vBMD (− 5%), cortical thickness (− 16%), higher cortical porosity (+ 20%) and Tb.N (+ 9%) of the radius, and higher Tb.N (+ 9%) and lower trabecular thickness (− 13%) of the tibia. Diabetes duration > 5 years was associated with higher Tb.N (+ 6%) of the radius. The presence of MVD was not associated with any bone parameters. Conclusions In this study with predominantly well-treated T2DM participants with relatively short-term diabetes duration, inadequate blood glucose control was negatively associated with cortical bone measures of the radius. In contrast, trabecular number was increased at both sites. Studies of larger sample size are warranted for more detailed investigations of bone density and bone quality in patients with T2DM. Electronic supplementary material The online version of this article (10.1007/s00198-018-4678-3) contains supplementary material, which is available to authorized users.

Published
2018

47. The association between glucose metabolism status, diabetes severity and a history of fractures and recent falls in participants of 50 years and older-the Maastricht Study

Author

Nicolaas C. Schaper, Ronald M.A. Henry, Annemarie Koster, J. van den Bergh, T. Melai, E. A. C. de Waard, Coen D.A. Stehouwer, Hans H.C.M. Savelberg, Pieter C. Dagnelie, T. van Geel, Sebastian Köhler, Miranda T. Schram, Simone J. S. Sep, Piet Geusens, C.J.H. van der Kallen, Promovendi NTM, Interne Geneeskunde, RS: NUTRIM - R3 - Chronic inflammatory disease and wasting, RS: CAPHRI - R4 - Health Inequities and Societal Participation, Sociale Geneeskunde, Nutrition and Movement Sciences, RS: CAPHRI - R5 - Optimising Patient Care, Family Medicine, RS: CARIM - R3.01 - Vascular complications of diabetes and the metabolic syndrome, MUMC+: HVC Pieken Maastricht Studie (9), Epidemiologie, MUMC+: MA Interne Geneeskunde (3), RS: CARIM - R3.02 - Hypertension and target organ damage, RS: CAPHRI - R2 - Creating Value-Based Health Care, MUMC+: MA Endocrinologie (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Psychiatrie & Neuropsychologie, RS: NUTRIM - HB/BW section B, de Waard, E. A. C., Koster, Annemarie, Melai, T., van Geel, T. A., Henry, R. M. A., Schram, M. T., Dagnelie, P. C., VAN DER KALLEN, Carla, Sep, S. J. S., Stehouwer, C. D. A., Schaper, N. C., Kohler, S., Savelberg, H. H. C. M., GEUSENS, Piet, and VAN DEN BERGH, Joop

Subjects
Blood Glucose, Male, medicine.medical_specialty, Cross-sectional study, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Poison control, 030209 endocrinology & metabolism, Type 2 diabetes, 03 medical and health sciences, Fractures, Bone, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Type 2 diabetes mellitus, medicine, Humans, Insulin, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Aged, business.industry, Type 2 Diabetes Mellitus, Middle Aged, medicine.disease, 3. Good health, Diabetes severity, Cross-Sectional Studies, Falls, Fractures, Diabetes Mellitus, Type 2, Cohort, Physical therapy, Original Article, Accidental Falls, Female, business
Abstract

In this cohort of relatively young and well-treated participants with type 2 diabetes, we found no association between diabetes status and a history of previous fractures and recent falls. Furthermore, no association between diabetes severity and previous fractures or recent falls was found. Introduction In this study, we examined the association between glucose metabolism status and historical fractures or recent falls and the effect of diabetes severity (glucose control, insulin use, and diabetes duration) on falls and fractures in the participants with type 2 diabetes. Methods Cross-sectional data from 2005 participants of the Maastricht Study. Falls in the past 6 months and fractures >= age 50 were assessed by questionnaire. Glucose metabolism status (normal glucose metabolism, impaired glucose metabolism, or type 2 diabetes) was based on the oral glucose tolerance test and medication use. Results In the completely adjusted model, the odds for a fall were not significantly higher in those with impaired glucose metabolism status (OR (95% CI) 1.28 (0.93-1.77)) or with type 2 diabetes (OR (95% CI) 1.21 (0.80-1.81)) compared with the group with normal glucose metabolism. Within the group with type 2 diabetes, there were no significant differences with regard to reported falls between participants with HbA1c >7 % (53 mmol/mol) versus HbA1c 5 versus

Published
2016

48. Accelerometer-derived physical activity and sedentary time and cardiac biomarkers: The Maastricht Study.

Author

Vandercappellen EJ, Koster A, Savelberg HHCM, Eussen SJPM, Dagnelie PC, Schram MT, van Greevenbroek MMJ, Wesselius A, Kooman JP, Kroon AA, Henry RMA, and Stehouwer CDA

Abstract

Background: Cardiac troponins and NT-proBNP are biomarkers of cardiac injury that are used clinically in the diagnosis of myocardial infarction and heart failure. It is not known whether the amount, types and patterns of physical activity (PA) and sedentary behaviour are associated with levels of cardiac biomarkers., Methods: In the population-based Maastricht Study ( n  = 2,370, 51.3% male, 28.3% T2D) we determined cardiac biomarkers hs-cTnI, hs-cTnT, and NT-proBNP. PA and sedentary time were measured by activPAL and divided into quartiles [quartile 1 (Q1) served as reference]. The weekly pattern of moderate-to-vigorous PA (insufficiently active; regularly actives; weekend warriors) and coefficient of variation (CV) was calculated. Linear regression analyses were conducted with adjustment for demographic, lifestyle, and cardiovascular risk factors., Results: There was no consistent pattern between physical activity (different intensities: total, light, moderate-to-vigorous and vigorous) and sedentary time on the one hand and hs-cTnI and hs-cTnT on the other. Those with the highest levels of vigorous intensity PA had significantly lower levels of NT-proBNP. With regard to PA patterns, weekend warriors and regularly actives had lower levels of NT-proBNP but not with hs-cTnI and hs-cTnT (reference:insufficiently actives). A higher weekly moderate-to-vigorous PA CV (indicating more irregular activity) was associated with lower levels of hs-cTnI and higher levels of NT-proBNP, but not with hs-cTnT., Conclusions: In general, there was no consistent association between PA and sedentary time and cardiac troponins. In contrast, vigorous and possibly moderate-to-vigorous intensity PA, especially if done regularly, were associated with lower levels of NT-proBNP., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (© 2023 Vandercappellen, Koster, Savelberg, Eussen, Dagnelie, Schram, Van Greevenbroek, Wesselius, Kooman, Kroon, Henry and Stehouwer.)

Published
2023
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49. Sedentary behaviour and bone health in children, adolescents and young adults: a systematic review-supplementary presentation.

Author

Koedijk JB, van Rijswijk J, Oranje WA, van den Bergh JP, Bours SP, Savelberg HH, and Schaper NC

Subjects
Adolescent, Exercise physiology, Femur Neck physiology, Humans, Young Adult, Bone Density physiology, Health Behavior, Sedentary Behavior
Abstract

Background: Sedentary behaviour (SB) is a potential risk factor for suboptimal bone deposition in youth., Results: Total SB was negatively associated with lower extremity bone outcomes, while no association was observed with total body bone outcomes. Insufficient evidence was found for an association between total SB and lumbar spine bone outcomes., Conclusion: This review highlights the heterogeneity of the available evidence and emphasizes the need for well-designed studies.

Published
2017
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50. The association between insulin use and volumetric bone mineral density, bone micro-architecture and bone strength of the distal radius in patients with type 2 diabetes - The Maastricht study.

Author

de Waard EAC, Driessen JHM, de Jong JJA, van Geel TACM, Henry RMA, van Onzenoort HAW, Schram MT, Dagnelie PC, van der Kallen CJ, Sep SJS, Stehouwer CDA, Schaper NC, Koster A, Savelberg HHCM, Neef C, Geusens PPMM, de Vries F, and van den Bergh JPW

Subjects
Aged, Cross-Sectional Studies, Diabetes Mellitus, Type 2 metabolism, Female, Finite Element Analysis, Fractures, Bone metabolism, Humans, Male, Middle Aged, Bone Density physiology, Diabetes Mellitus, Type 2 physiopathology, Fractures, Bone physiopathology
Abstract

Type 2 diabetes mellitus (T2DM) has been associated with an increased risk of fractures, despite normal to increased bone mineral density (BMD). Insulin use is one of the factors linked to this increased fracture risk. However, direct negative effects of insulin on bone quality are not expected since insulin is thought to be anabolic to bone. In this cross-sectional study the association between insulin use and volumetric BMD (vBMD), bone micro-architecture and bone strength of the distal radius, as measured with HR-pQCT, was examined. Data from 50 participants with T2DM of The Maastricht Study (mean age 62±7.5years, 44% women) was used. Participants were classified as insulin user (n=13) or non-insulin user (n=37) based on prescription data. Linear regression analysis was used to estimate the association between current insulin use and HR-pQCT derived parameters. After adjustment for age, sex, body mass index, glycated hemoglobin A1c and T2DM duration, insulin use was associated with lower total vBMD (standardized beta (β):-0.56 (95% CI:-0.89 to -0.24)), trabecular vBMD (β:-0.58 (95% CI:-0.87 to -0.30)), trabecular thickness (β:-0.55 (95% CI:-0.87 to -0.23)), cortical thickness (β:-0.41 (95% CI:-0.74 to -0.08)), log cortical pore volume (β:-0.43 (95% CI:-0.73 to -0.13)), bone stiffness (β:-0.39 (95% CI:-0.62 to -0.17)) and failure load (β:-0.39 (95% CI:-0.60 to -0.17)) when compared to the non-insulin users. Insulin use was not associated with cortical vBMD, trabecular number, trabecular separation, cortical porosity and cortical pore diameter. This study indicates that insulin use is negatively associated with bone density, bone micro-architectural and bone strength parameters. These findings may partly explain the previously observed increased fracture risk in insulin users, although there may be residual confounding by other factors related to disease severity in insulin users., (Copyright © 2017 Elsevier Inc. All rights reserved.)

Published
2017
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