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273 results on '"Savel’eva, E."'

5. Separation and Preconcentration Methods for the Determination of Highly Toxic Organic Compounds (Poisons)

Author

Leninskii, M. A., Shachneva, M. D., Savel'eva, E. I., and Koryagina, N. L.

Subjects
International cooperation -- Methods -- Analysis, Hazardous substances -- Analysis -- Methods, Sulfur compounds -- Methods -- Analysis, Gases, Asphyxiating and poisonous -- War use, Nerve gas -- Methods -- Analysis, Chemistry, Organisation for the Prohibition of Chemical Weapons
Abstract

The review considers and summarizes separation and preconcentration methods used in the determination of toxicants of the 1st hazard class, namely, organophosphorus nerve agents (a group of Vx isomers, sarin, cyclosarin, soman, and tabun) and blister agents (sulfur mustard)., Author(s): M. A. Leninskii [sup.1], M. D. Shachneva [sup.1], E. I. Savel'eva [sup.1], N. L. Koryagina [sup.1] Author Affiliations: (1) grid.465277.5, Research Institute of Hygiene, Occupational Pathology, and Human Ecology, [...]

Published
2021
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7. Simultaneous Determination of Sulfur Mustard Adducts with Guanine and Acetylcysteine in Urine by High-Resolution High-Performance Liquid Chromatography-Tandem Mass Spectrometry

Author

Orlova, O. I., Karakashev, G. V., and Savel'eva, E. I.

Subjects
Acetylcysteine -- Analysis, Poisoning -- Analysis, Guanine -- Analysis, Mass spectrometry -- Analysis, High performance liquid chromatography -- Analysis, Sulfur -- Analysis, Sulfides -- Analysis, Chemistry
Abstract

We propose a procedure for the simultaneous determination of biomarkers of the action of sulfur mustard (SM, 2,2'-dichlorodiethyl sulfide), namely, a depurinized adduct with DNA (N7-hydroxyethylthioethyl guanine) and an adduct with acetylcysteine (ACC) (1,1'-sulfonylbis[2-S-(N-acetylcysteinyl)ethane]), in urine by high-resolution HPLC-tandem mass spectrometry with electrospray ionization. The limit of quantification reached for both analytes is 10 ng/mL. The calibration plots are linear in the range 10-200 ng/mL. The procedure was tested in the analysis of urine samples obtained after the subcutaneous administration of sulfur mustard to rats in nonlethal dose (2 mg/kg) both in the absence of therapy and in using ACC as a scavenger (antidote). The positive effect of ACC therapy on the kinetics of sulfur mustard excretion from a body in the first hours after poisoning was found at the molecular level for the first time, and the protective effect of ACC on DNA in case of damage with sulfur mustard was substantiated., Author(s): O. I. Orlova [sup.1], G. V. Karakashev [sup.1], E. I. Savel'eva [sup.1] Author Affiliations: (1) Research Institute of Hygiene, Occupational Pathology, and Human Ecology, Federal Medical and Biological Agency [...]

Published
2020
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