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1. Treatment of Prepubertal Labial Adhesions with Topical Estriol + Testosterone: A Case Report.

Author

Murina, Filippo, Fochesato, Cecilia, and Savasi, Valeria Maria

Subjects
TISSUE adhesions, TOPICAL drug administration, ANDROGEN receptors, ESTRIOL, CONSERVATIVE treatment
Abstract

Background: Labial adhesions, a frequent gynecological condition in prepubertal girls, occur when the labia minora adhere along the midline. The prevailing hypothesis about their etiology suggests that labial adhesion may occur when the delicate and non-estrogenized labia minora undergo an inflammatory response, triggered by exposure to an irritant environment. Therefore, conservative treatment involves the application of topical estrogen or betamethasone cream. The role of androgens has not been considered yet in the pathophysiology or therapy of this condition. However, some studies have shown that androgen receptors are prevalent in the labia minora and vulvar vestibule. Case summary: We present the case of a 29-month-old girl with symptomatic labial adhesions. She was first ineffectively treated with topical estriol, and then she was treated with a galenic cream containing both estriol and testosterone with complete recovery and without side-effects. Conclusions: Both androgens and estrogens play a significant role in maintaining the physiological trophic state of the vulva and vagina, even during childhood. Topical estriol+testosterone could be considered an alternative treatment for prepubertal labial adhesions refractory to standard topical therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Immune Response and Transplacental Antibody Transfer in Pregnant Women after COVID-19 Vaccination

Author

Lubrano, Chiara, primary, Mancon, Alessandro, additional, Anelli, Gaia Maria, additional, Gagliardi, Gloria, additional, Corneo, Roberta, additional, Bianchi, Micol, additional, Coco, Chiara, additional, Dal Molin, Giulia, additional, Vignali, Michele, additional, Schirripa, Irene, additional, Di Simone, Nicoletta, additional, Pavone, Giulia, additional, Pellegrino, Antonio, additional, Gismondo, Maria Rita, additional, Savasi, Valeria Maria, additional, and Cetin, Irene, additional

Published
2023
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4. Performance of an extended triage questionnaire to detect suspected cases of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in obstetric patients: Experience from two large teaching hospitals in Lombardy, Northern Italy

Author

Ornaghi, S, Callegari, C, Milazzo, R, La Milia, L, Brunetti, F, Lubrano, C, Tasca, C, Livio, S, Savasi, V, Cetin, I, Vergani, P, Ornaghi, Sara, Callegari, Clelia, Milazzo, Roberta, La Milia, Laura, Brunetti, Federica, Lubrano, Chiara, Tasca, Chiara, Livio, Stefania, Savasi, Valeria Maria, Cetin, Irene, Vergani, Patrizia, Ornaghi, S, Callegari, C, Milazzo, R, La Milia, L, Brunetti, F, Lubrano, C, Tasca, C, Livio, S, Savasi, V, Cetin, I, Vergani, P, Ornaghi, Sara, Callegari, Clelia, Milazzo, Roberta, La Milia, Laura, Brunetti, Federica, Lubrano, Chiara, Tasca, Chiara, Livio, Stefania, Savasi, Valeria Maria, Cetin, Irene, and Vergani, Patrizia

Abstract

Objectives 1. To assess the performance of an extended questionnaire in identifying cases of SARSCoV- 2 infection among obstetric patients. 2. To evaluate the rate of infection among healthcare workers involved in women’s care. Study design A prospective cohort study of obstetric patients admitted to MBBM Foundation and Buzzi Hospital (Lombardy, Northern Italy) from March 16th to May 22nd, 2020. Women were screened on admission by a questionnaire investigating major and minor symptoms of infection and high-risk contacts in the last 14 days. SARS-CoV-2 assessment was performed by RT-PCR on nasopharyngeal swabs. Till April 7th, a targeted SARS-CoV-2 testing triggered by a positive questionnaire was used; from April 8th, a universal testing approach was implemented. Results There were 1,177 women screened by the questionnaire, which yielded a positive result in 130 (11.0%) cases. SARS-CoV-2 RT-PCR was performed in 865 (73.5%) patients, identifying 51 (5.9%) infections. During the first period, there were 29 infected mothers, 4 (13.8%) of whom had a negative questionnaire. After universal testing implementation, there were 22 (3%, 95% CI 1.94% - 4.04%) infected mothers, 13 (59.1%) of whom had a negative questionnaire; rate of infection among asymptomatic women was 1.9%. Six of the 17 SARSCoV- 2-positive women with a negative questionnaire reported symptoms more than 14 but within 30 days before admission. Isolated olfactory or taste disorders were identified in 15.7% of infected patients. Rate of infection among healthcare workers was 5.8%. Conclusions An exhaustive triage questionnaire can effectively discriminate women at low risk of SARSCoV- 2 infection in the context of a targeted and a universal viral testing approach. In 15.7% of infected women, correct classification as a suspected case of infection was due to investigation of olfactory and taste disorders. Extension of the assessed time-frame to 30 days may be worth considering to increase the questionnaire’s pe

Published
2020

6. Performance of an extended triage questionnaire to detect suspected cases of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in obstetric patients: Experience from two large teaching hospitals in Lombardy, Northern Italy

Author

Ornaghi, Sara, primary, Callegari, Clelia, additional, Milazzo, Roberta, additional, La Milia, Laura, additional, Brunetti, Federica, additional, Lubrano, Chiara, additional, Tasca, Chiara, additional, Livio, Stefania, additional, Savasi, Valeria Maria, additional, Cetin, Irene, additional, and Vergani, Patrizia, additional

Published
2020
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7. Prevalence, Correlates and Outcomes of Smoking in Pregnant Women with HIV: A National Observational Study in Italy

Author

Floridia, Marco, primary, Ravizza, Marina, additional, Masuelli, Giulia, additional, Tassis, Beatrice, additional, Savasi, Valeria Maria, additional, Liuzzi, Giuseppina, additional, Sansone, Matilde, additional, Simonazzi, Giuliana, additional, Franceschetti, Laura, additional, Meloni, Alessandra, additional, Vimercati, Antonella, additional, Guaraldi, Giovanni, additional, Pinnetti, Carmela, additional, Dalzero, Serena, additional, and Tamburrini, Enrica, additional

Published
2020
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8. Preliminary metabolomics analysis of placenta in maternal obesity

Author

Fattuoni, Claudia, primary, Mandò, Chiara, additional, Palmas, Francesco, additional, Anelli, Gaia Maria, additional, Novielli, Chiara, additional, Parejo Laudicina, Estefanìa, additional, Savasi, Valeria Maria, additional, Barberini, Luigi, additional, Dessì, Angelica, additional, Pintus, Roberta, additional, Fanos, Vassilios, additional, Noto, Antonio, additional, and Cetin, Irene, additional

Published
2018
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10. Weight Gain during Pregnancy in Women with HIV Receiving Different Antiretroviral Regimens

Author

Floridia, Marco, Masuelli, Giulia, Tassis, Beatrice, Franceschetti, Laura, Savasi, Valeria Maria, Spinillo, Arsenio, Tamburrini, Enrica, Guaraldi, Giovanni, Dalzero, Serena, Sansone, Matilde, Chiodo, Antonella, Antoni, Anna Maria Degli, Pinnetti, Carmela, Liuzzi, Giuseppina, Ravizza, Marina, Floridia, M., Ravizza, M., Tamburrini, E., Ravizza, M., Tamburrini, E., Lorenzo, F. Di, Sterrantino, G., Meli, M., Campolmi, I., Vichi, F., Pin, B. Del, Marocco, R., Mastroianni, C., Mercurio, V.S., Zanaboni, D., Guaraldi, G., Nardini, G., Stentarelli, C., Beghetto, B., Antoni, A.M. Degli, Molinari, A., Crisalli, M.P., Donisi, A., Ruggieri, A., Piepoli, M., Cerri, V., Zuccotti, G., Giacomet, V., Paradiso, L., Forlanini, F., Longoni, E., Placido, G., Milini, P., Savalli, F., Portelli, V., Sabbatini, F., Francisci, D., Papalini, C., Bernini, L., Grossi, P., Rizzi, L., Maso, G., Bernardon, M., Bussolaro, S., Pietà, I. Della, Sorz, A., Meloni, A., Chiodo, A., Dedoni, M., Ortu, F., Piano, P., Citernesi, A., Vicini, I. Bordoni, Luzi, K., Spinillo, A., Roccio, M., Vimercati, A., Calabretti, D., Gigante, S., Guerra, B., Cervi, F., Simonazzi, G., Margarito, E., Capretti, M.G., Marsico, C., Faldella, G., Sansone, M., Martinelli, P., Agangi, A., Capone, A., Maruotti, G.M., Tibaldi, C., Trentini, L., Todros, T., Masuelli, G., Frisina, V., Savasi, V., Cardellicchio, E., Giaquinto, C., Fiscon, M., Rubino, E., Franceschetti, L., Badolato, R., Forleo, M.A., Tassis, B., Ruggiero, M., Genovese, O., Cafforio, C., Pinnetti, C., Liuzzi, G., Casadei, A.M., Cavaliere, A.F., Cellini, M., Marconi, A.M., Dalzero, S., Ierardi, M., Simonetti, S.C., Alfieri, N., Agrati, S., Polizzi, C., Mattei, A., Pirillo, M.F., Amici, R., Galluzzo, C.M., Donnini, S., Baroncelli, S., Floridia, M., Cerioli, A., Martino, M. De, Parazzini, F., Tamburrini, E., Vella, S., Martinelli, P., and Ravizza, M.

Abstract

Background No published studies have evaluated in pregnant women with HIV weight gain with different antiretroviral drug classes.Methods Data from a national cohort study were used. We compared absolute weight gain and occurrence of excessive weight gain in women with HIV who received during pregnancy integrase inhibitors (INSTI), protease inhibitors (PI), or non-nucleoside reverse transcriptase inhibitors (NNRTI). Excessive weight gain was defined according to the Institute of Medicine recommendations. Possible predictors of weight gain were assessed using univariate and multivariate analyses.Results Among 273 cases (PI: 191, NNRTI: 43, INSTI: 39), the mean weight increase was 11.3 kg, and 25.4% of the mothers had an excessive weight increase. No significant differences were found among the three treatment groups for absolute weight increase, occurrence of excessive weight gain, infant birthweight, and other pregnancy and laboratory outcomes. The comparisons of individual drugs, although based on a limited number of cases, suggested no major differences. A significant positive correlation was found between weight gain and CD4+T-cell increase during pregnancy. In multivariate analyses, drug class and nucleoside backbone were not associated with absolute or excessive weight increase. Excessive weight increase was significantly associated with week of delivery (adjusted odds ratio: 1.74, 95% CI 1.15, 2.63), obesity (5.21, 95% CI 1.85, 14.64), overweight (7.95, 95% CI 3.26, 19.39), recent substance use (5.96, 95% CI 1.13, 31.40) and fasting 2nd trimester hyperglycaemia (3.94, 95% CI 1.14, 13.65).Conclusions No significant differences in absolute weight change or occurrence of excessive weight gain were found among women with HIV who received during pregnancy different classes of antiretroviral drugs.

Published
2020
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