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Registration of Pharmaceutical drug product in Emerging Market is most demanding task. Regulatory requirements are harmonized in regulated countries by Common technical document (CTD) filing, while there is diversity of requirements in emerging markets. International conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) has brought regulatory authorities and pharmaceutical industries of US, Japan and Europe together for various aspects of drug registration but there are is no such harmonized guideline for emerging market except Association of Southeast Asian Nations (ASEAN) and Gulf Co-operation Council (GCC) where harmonization exist in clusters with their mutual concern. The optimization and harmonization requirements has become mandatory and can be examined by the incidence of higher cost involved in availability of drugs, quality requirement of premise and research and development, regional registration requirements. Quality, Safety and Efficacy data has significance importance in dossier registration. Pharmaceutical Industries has to comply with regulatory requirement in Emerging market and for betterment of public Health and safety. The review also explains a brief about different regulatory requirement for Registration of drug product in Emerging market and comparative data for registration of dossier application in Emerging market.

To realize molecular-scale electrical operations beyond the von Neumann bottleneck, new types of multifunctional switches are needed that mimic self-learning or neuromorphic computing by dynamically toggling between multiple operations that depend on their past. Here, we report a molecule that switches from high to low conductance states with massive negative memristive behaviour that depends on the drive speed and number of past switching events, with all the measurements fully modelled using atomistic and analytical models. This dynamic molecular switch emulates synaptic behavior and Pavlovian learning, all within a 2.4-nm-thick layer that is three orders of magnitude thinner than a neuronal synapse. The dynamic molecular switch provides all the fundamental logic gates necessary for deep learning because of its time-domain and voltage-dependent plasticity. The synapse-mimicking multifunctional dynamic molecular switch represents an adaptable molecular-scale hardware operable in solid-state devices, and opens a pathway to simplify dynamic complex electrical operations encoded within a single ultracompact component.

INTRODUCTION: The skin being largest organ of the body has vast spectrum of disorders which can be difcult to diagnose correctly solely on the basis of clinical features. Hence histopathological examination is necessary to categorise skin lesions. The aim was to study relative frequency of various skin lesions and distribution of these lesions according to age and sex. METHODS: This is a retrospective descriptive hospital based study. The skin biopsies samples which came in the duration of two years from January 2019 to December 2020 at the Department of Pathology, Sardar Patel Medical college and associated group of hospitals, Bikaner, Rajasthan were taken in this study. All skin biopsies that showed denite histopathological diagnosis were included. After proper xing and staining procedures these lesions were examined under light microscopy and categorized as non-neoplastic and neoplastic. Relative frequency of various lesions, distribution of lesions according to age and sex was analyzed. The data collected was tabulated, interpreted and compared with other similar studies. RESULTS: Out of 346 patients, incidence of neoplastic lesions 259 (74.9%) were higher than non-neoplastic lesions 87(25.1%). Males were affected more compared to females with male to female ratio 1.45:1. Non-neoplastic lesions were mostly caused because of infectious etiologies among which leprosy was the most common infection. Keratinocytic tumors 99(52.2%) constituted most common type of neoplastic lesion. Benign tumors 191(73.7%) outnumbered malignant tumors 68(26.3%). The cases of benign tumors were seen more in younger population while that of malignant tumors were seen in older age groups. Among the keratinocytic type of malignant skin tumors squamous cell carcinoma (63.5%) was the most common variant which was followed by basal cell carcinoma 19(36.5%). Male predominance was observed in both squamous cell carcinoma and basal cell carcinoma. CONCLUSION: A wide heterogenesity of skin lesions was observed in the present study . These skin lesions were mostly affecting age group of 10-30 years. Inspite of extensive programmes and research, leprosy and tuberculosis remains a rampant cause of infectious non-neoplastic skin lesions. Sometimes ignorance by patient for a very small appearing skin lesions becomes life threatening. Hence early clinician consultation with proper examination and accurate histopathological diagnosis becomes the mainstay in early treatment and recovery.

Eutectic gallium–indium (EGaIn), a liquid metal with a melting point close to or below room temperature, has attracted extensive attention in recent years due to its excellent properties such as fluidity, high conductivity, thermal conductivity, stretchability, self-healing capability, biocompatibility, and recyclability. These features of EGaIn can be adjusted by changing the experimental condition, and various composite materials with extended properties can be further obtained by mixing EGaIn with other materials. In this review, not only the are unique properties of EGaIn introduced, but also the working principles for the EGaIn-based devices are illustrated and the developments of EGaIn-related techniques are summarized. The applications of EGaIn in various fields, such as flexible electronics (sensors, antennas, electronic circuits), molecular electronics (molecular memory, opto-electronic switches, or reconfigurable junctions), energy catalysis (heat management, motors, generators, batteries), biomedical science (drug delivery, tumor therapy, bioimaging and neural interfaces) are reviewed. Finally, a critical discussion of the main challenges for the development of EGaIn-based techniques are discussed, and the potential applications in new fields are prospected.

This paper describes the conductance of single-molecules and self-assembled monolayers comprising an oligophenyleneethynylene core, functionalized with acenes of increasing length that extend conjugation perpendicular to the path of tunneling electrons. In the Mechanically Controlled Break Junction (MCBJ) experiment, multiple conductance plateaus were identified. The high conductance plateau, which we attribute to the single molecule conformation, shows an increase of conductance as a function of acene length, in good agreement with theoretical predictions. The lower plateau is attributed to multiple molecules bridging the junctions with intermolecular interactions playing a role. In junctions comprising a self-assembled monolayer with eutectic Ga–In top-contacts (EGaIn), the pentacene derivative exhibits unusually low conductance, which we ascribe to the inability of these molecules to pack in a monolayer without introducing significant intermolecular contacts. This hypothesis is supported by the MCBJ data and theoretical calculations showing suppressed conductance through thePCfilms. These results highlight the role of intermolecular effects and junction geometries in the observed fluctuations of conductance values between single-molecule and ensemble junctions, and the importance of studying molecules in both platforms.

This study describes the modulation of tunneling probabilities in molecular junctions by switching one of two parallel intramolecular pathways. A linearly conjugated molecular wire provides a rigid framework that allows a second, cross‐conjugated pathway to be effectively switched on and off by protonation, affecting the total conductance of the junction. This approach works because a traversing electron interacts with the entire quantum‐mechanical circuit simultaneously; Kirchhoff's rules do not apply. We confirm this concept by comparing the conductances of a series of compounds with single or parallel pathways in large‐area junctions using EGaIn contacts and single‐molecule break junctions using gold contacts. We affect switching selectively in one of two parallel pathways by converting a cross‐conjugated carbonyl carbon into a trivalent carbocation, which replaces destructive quantum interference with a symmetrical resonance, causing an increase in transmission in the bias window., Manipulating conductance in parallel molecular pathways is a crucial element in molecular electronics. We explore intramolecular parallel pathways with different bond topology, in form of a quantum circuit, in tunneling junctions comprising self‐assembled monolayers. We employ quantum‐interference switching/gating with an acid, without any structural changes, in single‐molecular junctions.

This paper describes an experimental approach to eliminating the loss of reversibility that surface-bound spiropyrans exhibit when switched with light. Although such fatigue can be controlled in other contexts, on surfaces, the photochromic compounds are held in close proximity to each other and relatively few molecules modulate the properties of a device, leading to a loss of functionality after only a few switching cycles. The switching process was characterized by photoelectron spectroscopy and differences in tunneling currents in the spiropyran and merocyanine forms using eutectic Ga-In. Self-assembled monolayers comprising only the photochromic compounds degraded rapidly, while mixed monolayers with hexanethiol showed different behaviors depending on the relative humidity. Under dry conditions, no chemical degradation was observed and the switching process was reversible over at least 100 cycles. Under humid conditions, no degradation occurred, but the switching process became irreversible. The absence of degradation observed in mixed monolayers is ascribed to the lack of solvation, which increases the barrier to a key bond rotation past the available thermal energy. These results highlight important differences in the contexts in which photochromic compounds are utilized and demonstrate that they can be leveraged to extract device-relevant functionality from surface-bound switches by suppressing fatigue and irreversibility.

This review focuses on molecular ensemble junctions in which the individual molecules of a monolayer each span two electrodes. This geometry favors quantum mechanical tunneling as the dominant mechanism of charge transport, which translates perturbances on the scale of bond lengths into nonlinear electrical responses. The ability to affect these responses at low voltages and with a variety of inputs, such as de/protonation, photon absorption, isomerization, oxidation/reduction, etc., creates the possibility to fabricate molecule-scale electronic devices that augment; extend; and, in some cases, outperform conventional semiconductor-based electronics. Moreover, these molecular devices, in part, fabricate themselves by defining single-nanometer features with atomic precision via self-assembly. Although these junctions share many properties with single-molecule junctions, they also possess unique properties that present a different set of problems and exhibit unique properties. The primary trade-off of ensemble junctions is complexity for functionality; disordered molecular ensembles are significantly more difficult to model, particularly atomistically, but they are static and can be incorporated into integrated circuits. Progress toward useful functionality has accelerated in recent years, concomitant with deeper scientific insight into the mediation of charge transport by ensembles of molecules and experimental platforms that enable empirical studies to control for defects and artifacts. This review separates junctions by the trade-offs, complexity, and sensitivity of their constituents; the bottom electrode to which the ensembles are anchored and the nature of the anchoring chemistry both chemically and with respect to electronic coupling; the molecular layer and the relationship among electronic structure, mechanism of charge transport, and electrical output; and the top electrode that realizes an individual junction by defining its geometry and a second molecule–electrode interface. Due to growing interest in and accessibility of this interdisciplinary field, there is now sufficient variety in each of these parts to be able to treat them separately. When viewed this way, clear structure–function relationships emerge that can serve as design rules for extracting useful functionality.

Background: leiomyosarcoma of uterus are notorious for their aggressive nature and poor prognosis. The relative rarity of uterine leiomyosarcomas, as well as their pathological diversity, hinders studies aimed at improving understanding of the disease and makes it difficult to define the optimum management. Methods: This retrospective study is conducted over a period of three year from January 2017 to December 2020. All the hysterectomy specimens received at the Department of Pathology were processed and included in the study during the study period. We report here the Prevalence of leiomyosarcoma of uterus at Bikaner region. Results: We received a total of 952 hysterectomy specimens at Department of Pathology during the study period. Out of which 546 were operated and sent with the clinical diagnosis of uterine fibroid. Two patients were diagnosed with histopathological features of leiomyosarcoma which is 0.37% of all uterine fibroids and 0.21% of all hysterectomies at Bikaner region. Conclusion: Uterine leiomyosarcomas are rare but highly malignant tumors which are difficult to diagnose preoperatively and mostly mimic clinical features of benign uterine fibroids. The leiomyosarcomas show poor prognosis. This makes it important to investigate uterine malignancies histopathologically to rule out leiomyosarcomas so that appropriate treatment can be started early. Keywords: Uterine leiomyosarcoma, uterine fibroid.

This thesis presents an investigation of the electrical properties of about 70 different molecules in molecular tunneling junctions (MTJs). It begins by presenting the field of molecular electronics (ME) -- from the advent of quantum mechanics to the first conception of ideas and experiments in ME. Then it discusses different steps in the fabrication of self-assembled monolayers (SAMs) and their incorporation in large-area MTJ, followed by data acquisition and analysis of current-voltage characteristics. Further, the theoretical methodology, which uses density functional theory in conjunction with non-equilibrium Green's function approach to simulate charge transport probability through MTJs, is reported. After the introduction of several concepts, an in-depth study of quantum interference (QI) effect on a series of molecular wires, comprising backbones with different conjugation patterns, is reported. Continuing with the QI studies, having established the effect of functional groups on QI, another approach to modulate the tunneling probabilities in MTJs by switching QI ON and OFF in one of the two parallel intramolecular pathways is presented. Next, the thesis discusses the non-linear tunneling current decay in sigma-pi molecular structures (oligothiophene-terminated butanethiols) with increasing molecular lengths, explained using a two-barrier model. Finally, the final chapter describes a generalized single-level model that compares the degree of electronic coupling between molecules and electrodes across 40 different large-area EGaIn-based MTJs from different laboratories. Thus, starting from the introduction of several ME concepts, experiments, and simulations, this thesis enables the reader through investigations on a big library of molecules that serve manifold purposes in ME.

In this perspective, we discuss complex charge transport behaviours induced by redox-reactions in molecular tunnelling junctions by gauging the development of charge transport theories which allow for more unified approaches between temperature-dependent and -independent transport. A context is drawn for current experimental works which previously demonstrated behaviours that could not have been explained by traditional Marcus and Landauer theories. The work discusses not only the reported temperature-independent long-range tunnelling and their corresponding theoretical explanations but also correlates the influence of structural and thermodynamic factors that influence such peculiar temperature dependencies in molecular junctions.

Despite their ubiquity, self-assembled monolayers (SAMs) of thiols on coinage metals are difficult to study and are still not completely understood, particularly with respect to the nature of thiol-metal bonding. Recent advances in molecular electronics have highlighted this deficiency due to the sensitivity of tunneling charge-transport to the subtle differences in the overall composition of SAMs and the chemistry of their attachment to surfaces. These advances have also challenged assumptions about the spontaneous formation of covalent thiol-metal bonds. This paper describes a series of experiments that correlate changes in the physical properties of SAMs to photoelectron spectroscopy to unambiguously assign binding energies of noncovalent interactions to physisorbed disulfides. These disulfides can be converted to covalent metal-thiolate bonds by exposure to free thiols, leading to the remarkable observation of the total loss and recovery of length-dependent tunneling charge-transport. The identification and assignment of physisorbed disulfides solve a long-standing mystery and reveal new, dynamic properties in SAMs of thiols.

The improvement in optical technology over long distance communication has been regulated over past few decades, and it took drastic enhancement in one the major parameter for joining two OFC cable (fusion splicing) and use of new variant of optical fibers. The different experiments performed in order to bring about the result that use of different optical cables and splicing technique can give approximately 0dB splice loss and fast communication speed at lower cost. The objective of this paper is to determine how low splice loss can be obtain in joining two single mode or multimode optical fiber, such that long distance communication that required multiple infrastructure assembly for its operational unit can be made re-locatable as there is large investment and material and electronic circuitry is associated to it, therefore to reduce that cost we have sets of analysis that splicing loss can be reduced to 0dB for SMF-SMF end face connection, as the result of the tested experiment.

Quantum interference effects (QI) are of interest in nano-scale devices based on molecular tunneling junctions because they can affect conductance exponentially through minor structural changes. However, their utilization requires the prediction and deterministic control over the position and magnitude of QI features, which remains a significant challenge. In this context, we designed and synthesized three benzodithiophenes based molecular wires; one linearly-conjugated, one crossconjugated and one cross-conjugated quinone. Using eutectic Ga-In (EGaIn) and CP-AFM, we compared them to a well-known anthraquinone in molecular junctions comprising self-assembled monolayers (SAMs). By combining density functional theory and transition voltage spectroscopy, we show that the presence of an interference feature and its position can be controlled independently by manipulating bond topology and electronegativity. This is the first study to separate these two parameters experimentally, demonstrating that the conductance of a tunneling junction depends on the position and depth of a QI feature, both of which can be controlled synthetically.

In order to translate molecular properties in molecular-electronic devices, it is necessary to create design principles that can be used to achieve better structure–function control oriented toward device fabrication., In order to translate molecular properties in molecular-electronic devices, it is necessary to create design principles that can be used to achieve better structure–function control oriented toward device fabrication. In molecular tunneling junctions, cross-conjugation tends to give rise to destructive quantum interference effects that can be tuned by changing the electronic properties of the molecules. We performed a systematic study of the tunneling charge-transport properties of a series of compounds characterized by an identical cross-conjugated anthraquinoid molecular skeleton but bearing different substituents at the 9 and 10 positions that affect the energies and localization of their frontier orbitals. We compared the experimental results across three different experimental platforms in both single-molecule and large-area junctions and found a general agreement. Combined with theoretical models, these results separate the intrinsic properties of the molecules from platform-specific effects. This work is a step towards explicit synthetic control over tunneling charge transport targeted at specific functionality in (proto-)devices.

Large‐area molecular tunneling junctions comprising self‐assembled monolayers of redox‐active molecules are described that exhibit two‐terminal bias switching. The as‐prepared monolayers undergo partial charge transfer to the underlying metal substrate (Au, Pt, or Ag), which converts their cores from a quinoid to a hydroquinoid form. The resulting rearomatization converts the bond topology from a cross‐conjugated to a linearly conjugated π system. The cross‐conjugated form correlates to the appearance of an interference feature in the transmission spectrum that vanishes for the linearly conjugated form. Owing to the presence of electron‐withdrawing nitrile groups, the reduction potential and the interference feature lie close to the work function and Fermi level of the metallic substrate. We exploited the relationship between conjugation patterns and quantum interference to create nonvolatile memory in proto‐devices using eutectic Ga–In as the top contact.

Three different benzodithiophene derivatives were designed to isolate the effects of bond topology from that of functional groups in quantum interference to examine the role of the quinone functionality separate from cross-conjugation., Quantum interference effects (QI) are of interest in nano-scale devices based on molecular tunneling junctions because they can affect conductance exponentially through minor structural changes. However, their utilization requires the prediction and deterministic control over the position and magnitude of QI features, which remains a significant challenge. In this context, we designed and synthesized three benzodithiophenes based molecular wires; one linearly-conjugated, one cross-conjugated and one cross-conjugated quinone. Using eutectic Ga–In (EGaIn) and CP-AFM, we compared them to a well-known anthraquinone in molecular junctions comprising self-assembled monolayers (SAMs). By combining density functional theory and transition voltage spectroscopy, we show that the presence of an interference feature and its position can be controlled independently by manipulating bond topology and electronegativity. This is the first study to separate these two parameters experimentally, demonstrating that the conductance of a tunneling junction depends on the position and depth of a QI feature, both of which can be controlled synthetically.

The journal of physical chemistry / C 121(27), 14920-14928 (2017). doi:10.1021/acs.jpcc.7b03853, Published by American Chemical Society, Washington, DC

Correction for ‘Systematic experimental study of quantum interference effects in anthraquinoid molecular wires’ by Marco Carlotti et al., Nanoscale Adv., 2019, DOI: 10.1039/c8na00223a.

The ever increasing growth of databases in the real time application is a major issue for the handling of large data. The data mining of the same is also a tedious task. The feature subset selection is a process for finding the irrelevant and redundant data and handling them. The proposed algorithm IFSSImproved Feature Subset Selection works in 2 major steps: 1. Find the irrelevant features and 2. Evaluate its fitness with Ant Colony Optimization (ACO). The Computation time taken to derive the results is taken to compare with different FSS algorithms.

Molecular tunneling junctions should enable the tailoring of charge-transport at the quantum level through synthetic chemistry but are hindered by the dominance of the electrodes. We show that the frontier orbitals of molecules can be decoupled from the electrodes, preserving their relative energies in self-assembled monolayers even when a top-contact is applied. This decoupling leads to the remarkable observation of tunneling probabilities that increase with distance in a series of oligothiophenes, which we explain using a two-barrier tunneling model. This model is generalizable to any conjugated oligomers for which the frontier orbital gap can be determined and predicts that the molecular orbitals that dominate tunneling charge-transport can be positioned via molecular design rather than by domination of Fermi-level pinning arising from strong hybridization. The ability to preserve the electronic structure of molecules in tunneling junctions facilitates the application of well-established synthetic design rules to tailor the properties of molecular-electronic devices.