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8 results on '"Saur, F."'

3. Use of a Laser-Doppler electrophoresis method in bacteriology (preliminary results)

Author

Duvivier C, Weber M, Saur F, Stoltz Jf, Malher E, and Janot C

Subjects
Electrophoresis, Staphylococcus aureus, Physiology, medicine.drug_class, Proteus vulgaris, Antibiotics, Microbial Sensitivity Tests, Bacterial Physiological Phenomena, medicine.disease_cause, Microbiology, Physiology (medical), Escherichia coli, medicine, Bacteriology, Bacteriological Techniques, Bacteria, biology, Chemistry, Lasers, Spiramycin, Doppler Effect, Laser Doppler velocimetry, biology.organism_classification, Anti-Bacterial Agents, Klebsiella pneumoniae, medicine.drug
Abstract

A new electrophoresis system using Laser Doppler velocimetry has been developed. This technic allows fast measurements, (1 minute) over a large number of particles (several thousand or more). Furthermore, the small size of the particles is no longer a limitation of the measurement. These qualities made it possible to study the electrokinetic properties of cells. In this paper the authors present the first application obtained on different types of bacteria (Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Proteus vulgaris) submitted to five antibiotics (gentamycin, minocyclin, cephalotin, spiramycin, sobramycin). After four hours of incubation at 37 degrees C, important decreases of electrophoretic mobility were observed on bacteria treated with antibiotics to which they were sensitive. On the other hand, no significant modification appeared on bacteria treated with antibiotics to which they were not sensitive. In conclusion, the electrophoretic mobility test seems to be useful to study the response of bacteria to antibiotics and perhaps could be used to set antibiograms.

Published
1984
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4. Use of a Laser-Doppler electrophoresis method in bacteriology (preliminary results)

Author

Stoltz, J.F., Janot, C., Saur, F., Weber, M., Malher, E., and Duvivier, C.

Abstract

A new electrophoresis system using Laser Doppler velocimetry has been developed. This technic allows fast measurements (1 minute) over a large number of particles (several thousand or more). Furthermore, the small size of the particles is no longer a limitation of the measurement. These qualities made it possible to study the electrokinetic properties of cells. In this paper the authors present the first application obtained on different types of bacteria (Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Proteus vulgaris) submitted to five antibiotics (gentamycin, minocyclin, cephalotin, spiramycin, sobramycin). After four hours or incubation at 37°C, important decreases of electrophoretic mobility were observed on bacteria treated with antibiotics to which they were sensitive. On the other hand, no significant modification appeared on bacteria treated with antibiotics to which they were not sensitive. In conclusion, the electrophoretic mobility test seems to be useful to study the response of bacteria to antibiotics and perhaps could be used to set antibiograms.

Published
1984
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6. Chromatin compartmentalization regulates the response to DNA damage.

Author

Arnould C, Rocher V, Saur F, Bader AS, Muzzopappa F, Collins S, Lesage E, Le Bozec B, Puget N, Clouaire T, Mangeat T, Mourad R, Ahituv N, Noordermeer D, Erdel F, Bushell M, Marnef A, and Legube G

Subjects
Animals, Ataxia Telangiectasia Mutated Proteins metabolism, Cell Line, DNA Breaks, Double-Stranded, DNA Repair, DNA-Activated Protein Kinase metabolism, G1 Phase, Histones metabolism, Neoplasms genetics, R-Loop Structures, Tumor Suppressor p53-Binding Protein 1 metabolism, Chromatin genetics, Chromatin metabolism, DNA Damage, Cell Compartmentation
Abstract

The DNA damage response is essential to safeguard genome integrity. Although the contribution of chromatin in DNA repair has been investigated 1,2 , the contribution of chromosome folding to these processes remains unclear 3 . Here we report that, after the production of double-stranded breaks (DSBs) in mammalian cells, ATM drives the formation of a new chromatin compartment (D compartment) through the clustering of damaged topologically associating domains, decorated with γH2AX and 53BP1. This compartment forms by a mechanism that is consistent with polymer-polymer phase separation rather than liquid-liquid phase separation. The D compartment arises mostly in G1 phase, is independent of cohesin and is enhanced after pharmacological inhibition of DNA-dependent protein kinase (DNA-PK) or R-loop accumulation. Importantly, R-loop-enriched DNA-damage-responsive genes physically localize to the D compartment, and this contributes to their optimal activation, providing a function for DSB clustering in the DNA damage response. However, DSB-induced chromosome reorganization comes at the expense of an increased rate of translocations, also observed in cancer genomes. Overall, we characterize how DSB-induced compartmentalization orchestrates the DNA damage response and highlight the critical impact of chromosome architecture in genomic instability., (© 2023. The Author(s).)

Published
2023
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7. [Mosaicism--Trisomy 8].

Author

Rützler L, Briner J, Saur F, and Schmid W

Subjects
Child, Dermatoglyphics, Growth Disorders diagnostic imaging, Humans, Karyotyping, Male, Radiography, Abnormalities, Multiple diagnosis, Chromosomes, Human, 6-12 and X, Mosaicism, Trisomy
Published
1974

8. [Hyperosmolar nonketotic diabetic coma in children].

Author

Stolz U, Saur F, and Gugler E

Subjects
Down Syndrome metabolism, Female, Humans, Hyperglycemic Hyperosmolar Nonketotic Coma drug therapy, Hyperglycemic Hyperosmolar Nonketotic Coma metabolism, Infant, Insulin therapeutic use, Diabetic Coma complications, Down Syndrome complications, Hyperglycemic Hyperosmolar Nonketotic Coma complications
Abstract

Nonketotic hyperosmolar diabetic coma is a rare manifestation of juvenile diabetes, in contrast to adult onset diabetes. To date only 20 cases have been published, the majority of them infants and toddlers. This type of diabetic coma is seen with unusual frequency in children with Down's syndrome and psychomotor retardation. The clinical picture is characterised by severe dehydration, hyperglycemia with often extremely high blood sugar levels, hyperosmolarity and glucosuria without ketonuria. Mortality in children has been high (24%). This paper reports the case of a 14-month-old girl with Down's syndrome. Clinical and therapeutic as well as pathogenetic aspects are discussed.

Published
1977

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