38 results on '"Saud Alshammari"'
Search Results
2. An investigation of heat transfer and optimization of entropy in bio-convective flow of Eyring-Powell nanomaterial with gyrotactic microorganisms
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Kiran Batool, Fazal Haq, Saima Zainab, Saba Anwar, Jihad Younis, Arshad Hussain, Anoud Saud Alshammari, and Zeinhom M. El-Bahy
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Eyring-powell nanofluid ,Microorganisms ,Bioconvection ,Entropy generation ,Finite difference scheme ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
Entropy generation in nanofluid flows is a critical parameter that influences the performance, efficiency, and sustainability of thermal systems. Understanding and optimizing entropy creation can lead to noteworthy advancements in numerous engineering applications, from renewable energy systems to industrial processes and biomedical equipments. The purpose of this article is to examine the entropy produced in the bioconvection flow of Eyring-Powell nanomaterial with gyrotactic microorganisms. The mathematical equations representing the flow are modeled considering the flow towards a porous surface of a cylinder. Together with the effects of the governing parameters, the mass and heat transfer components of the problem are discussed. The thermal effects of different natures are used in a new way. Overall, entropy creation is designed with regard to the second law of thermodynamics. Activation energy, chemical reaction, thermal radiation, and internal friction force effects are accounted for the development of the mathematical model. Coupled non-linear dimensional equations have been altered into ordinary differential equations (ODEs) and then treated using the MATLAB Finite Difference Method (FDM). Consequence of diverse sundry parameters on entropy production, thermal field, mass concentration profile, Bejan quantity, and motile density of microorganisms is deliberated via plots. Through tables, engineering quantities are analyzed. According to the findings, the velocity profile rises as the curvature and Eyring-Powell fluid parameters rise, while it falls when the magnetic parameter is enhanced. Additionally, it is noted that as the curvature variable enhances, the rate of heat transfer and skin friction coefficient decays.
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- 2024
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3. Design, Synthesis, and Evaluation of Amphiphilic Cyclic and Linear Peptides Composed of Hydrophobic and Positively-Charged Amino Acids as Antibacterial Agents
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Neda Riahifard, Saghar Mozaffari, Taibah Aldakhil, Francisco Nunez, Qamar Alshammari, Saud Alshammari, Jason Yamaki, Keykavous Parang, and Rakesh Kumar Tiwari
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amphiphilic cyclic peptide ,cationic ,E. coli ,hydrophobicity ,methicillin-resistant Staphylococcus aureus ,Organic chemistry ,QD241-441 - Abstract
Antimicrobial peptides (AMPs) contain amphipathic structures and are derived from natural resources. AMPs have been found to be effective in treating the infections caused by antibiotic-resistant bacteria (ARB), and thus, are potential lead compounds against ARB. AMPs’ physicochemical properties, such as cationic nature, amphiphilicity, and their size, will provide the opportunity to interact with membrane bilayers leading to damage and death of microorganisms. Herein, AMP analogs of [R4W4] were designed and synthesized by changing the hydrophobicity and cationic nature of the lead compound with other amino acids to provide insights into a structure-activity relationship against selected model Gram-negative and Gram-positive pathogens. Clinical resistant strains of methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) were used in the studies. Our results provided information about the structural requirements for optimal activity of the [R4W4] template. When tryptophan was replaced with other hydrophobic amino acids, such as phenylalanine, tyrosine, alanine, leucine, and isoleucine, the antibacterial activities were significantly reduced with MIC values of >128 µg/mL. Furthermore, a change in stereochemistry caused by d-arginine, and use of N-methyltryptophan, resulted in a two-fold reduction of antibacterial activity. It was found that the presence of tryptophan is critical for antibacterial activity, and could not be substituted with other hydrophobic residues. The study also confirmed that cyclic peptides generally showed higher antibacterial activities when compared with the corresponding linear counterparts. Furthermore, by changing tryptophan numbers in the compound while maintaining a constant number of arginine, we determined the optimal number of tryptophan residues to be four, as shown when the number of tryptophan residues increased, a decrease in activity was observed.
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- 2018
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4. A Systematic Method to Analyze Force Majeure in Construction Claims
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Saud Alshammari, Khalid Al-Gahtani, Ibrahim Alhammad, and Nuhu Braimah
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construction delays ,force majeure ,entitlement ,delay claims ,excusable non-compensable delay ,Building construction ,TH1-9745 - Abstract
In construction delay claims, force majeure is normally recognized as an excusable risk that entitles contractors only to time extensions, but neither of the contracting parties is entitled to monetary compensation to recover delay damages. However, there are instances where contractors are entitled to both time and cost compensations, as evidenced by some court cases relating to force majeure claims. Such instances involve attributing the occurrence of the force majeure to the effect of other prior delay events that pushed project performance into the period of the force majeure. Existing delay analysis methods are not capable of addressing this issue, as none take the impact of other delays into consideration when analyzing force majeure claims. Stimulated by this gap, this study proposes an improved and sound method for fairly analyzing the responsibility of force majeure delay claims amongst contracting parties. This method was implemented on a case project to help demonstrate its application and also ascertain its practicability. The contribution of this paper is twofold. First, it has highlighted the situation of force majeure delay that can be compensable, creating more awareness among researchers and industry practitioners. The second is a proposed systematic process to appropriately analyze its responsibility, which equitably addresses claims from such delays with little or no chance of dispute ensuing.
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- 2017
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5. Oil Palm Biomass Sap-Rotten Rice as a Source to Remove Metal Ions and Generate Electricity as By-Products through Microbial Fuel Cell Technology
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Anoud Saud Alshammari, Ghada Mohamed Aleid, Alamri Rahmah Dhahawi Ahmad, Asma D. Alomari, Shehu Sa’ad Abdullahi, and Rania Edrees Adam Mohammad
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Chemistry ,QD1-999 - Abstract
Microbial fuel cell (MFC) is a new and interesting technology that can be used to treat wastewater without using electricity. The current research focuses on electron generation, which is one of the technique’s major challenges. According to the latest literature, the study was planned to successfully remove the metals from artificial wastewater at high concentrations and generate electricity. On average, after 18 days of operation, it offered 610 mV with 1000 ῼ constant external resistance. The internal resistance was found to be 520 ῼ. The achieved power density was 3.164 mW/m2 at an external resistance of 1000 ῼ. The achieved removal efficiencies of Pb2+, Cd2+, Cr3+, and Ni2+ were 83.67%, 84.10%, 84.55%, and 95.99%, respectively. The operation lasted for 25 days. The cyclic voltameter studies show that there is a gradual oxidation rate of organic substances, while on day 25, the removal efficiency reached its maximum. The specific capacitance was found to be high between days 15 and 20, i.e., 0.0000540 F/g. It also indicated that biofilm was stable around day 18. Furthermore, the biological characterization also demonstrated that MFC operation was very smooth throughout the process, even at high concentrations (100 mg/L) of metal ions. Finally, there is the MFC method, as well as some new challenges and future recommendations.
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- 2024
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6. The influence of social support on sleep and fatigue level among patients receiving hemodialysis in Saudi Arabia: a cross-sectional correlational design
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Bushra Alshammari, Sameer A. Alkubati, Eddieson Pasay-an, Awatif Alrasheeday, Norah Madkhali, J. Silvia Edison, Venkat Bakthavatchaalam, Marim Saud Alshammari, Amnah Ayed AlRashidi, and Farhan Alshammari
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social support ,fatigue ,sleep quality ,hemodialysis ,Saudi Arabia ,Psychology ,BF1-990 - Abstract
BackgroundPatients on hemodialysis (HD) are more likely to experience sleep problems and fatigue that may affect their health outcomes. Management of these patients with social support may improve their sleep quality and fatigue as well as their health.AimThis study aimed to assess the influence of social support on sleep quality and fatigue levels among HD patients.MethodsA cross-correlational study was conducted among 260 conveniently sampled HD patients from four dialysis centers in Hail and Al-Qassim cities of Saudi Arabia from Jun 2022 to January 2023. Besides sociodemographic data, the Pittsburgh Sleep Quality Index (PSQI), the Multidimensional Assessment of Fatigue (MAF) and the Oslo Social Support Scale (OSSS-3) were used to assess sleep quality, fatigue levels and social support, respectively. Chi-square test was used to determine the association between categorical variables, while Pearson’s correlation coefficient was used to test the correlation between sleep quality, fatigue, and social support.ResultsPoor sleep and high fatigue were significantly higher in older patients compared to younger patients (p
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- 2023
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7. Selenium and COVID-19: A spotlight on the clinical trials, inventive compositions, and patent literature
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Mohammed Kanan Alshammari, Waseem Fatima, Reem Ahmed Alraya, A. Khuzaim Alzahrani, Mehnaz Kamal, Reem Saud Alshammari, Sarah Ayad Alshammari, Lina Mohammed Alharbi, Norah Saad Alsubaie, Rakan Bijad Alosaimi, Syed Mohammed Basheeruddin Asdaq, and Mohd. Imran
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Selenium ,COVID-19 ,SARS-CoV-2 ,Clinical trials ,Patent ,Infectious and parasitic diseases ,RC109-216 ,Public aspects of medicine ,RA1-1270 - Abstract
Selenium is an indispensable trace element for all living organisms. It is an essential structural component of several selenium-dependent enzymes, which support the human body’s defense mechanism. Recently, the significance of selenium in preventing/treating COVID-19 has been documented in the literature. This review highlights the clinical studies, compositions, and patent literature on selenium to prevent/treat COVID-19. Selenium exerts its anti-COVID-19 action by reducing oxidative stress, declining the expression of the ACE-2 receptor, lowering the discharge of pro-inflammatory substances, and inhibiting the 3CLPro (main protease) and PLpro enzyme of SARS-CoV-2. The data of clinical studies, inventive compositions, and patent literature revealed that selenium monotherapy and its compositions with other nutritional supplements/drugs (vitamin, iron, zinc, copper, ferulic acid, resveratrol, spirulina, N-acetylcysteine, fish oil, many herbs, doxycycline, azithromycin, curcumin, quercetin, etc.,) might be practical to prevent/treat COVID-19. The studies have also suggested a correlation between COVID-19 and selenium deficiency. This indicates that adequate selenium supplementation may provide promising treatment outcomes in COVID-19 patients. The authors foresee the development and commercialization of Selenium-based compositions and dosage forms (spray, inhalers, control release dosage forms, etc.) to battle COVID-19. We also trust that numerous selenium-based compositions are yet to be explored. Accordingly, there is good scope for scientists to work on developing novel and inventive selenium-based compositions to fight against COVID-19. However, there is also a need to consider the narrow therapeutic window and chemical interaction of selenium before developing selenium-based compositions.
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- 2022
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8. Degradation of Metal Ions with Electricity Generation by Using Fruit Waste as an Organic Substrate in the Microbial Fuel Cell
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Ghada Mohamed Aleid, Anoud Saud Alshammari, Asma D. Alomari, Shehu Sa’ad Abdullahi, Rania Edrees Adam Mohammad, and Rokhsana Mohammed Ismail Abdulrahman
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Chemical engineering ,TP155-156 - Abstract
A potential and developing green technology for producing renewable energy and treating wastewater is the microbial fuel cell (MFC). Despite several advancements, there are still several serious problems with this approach. In the present work, we addressed the problem of the organic substrate in MFC, which is necessary for the degradation of metal ions in conjunction with the production of energy. The utilization of fruit waste as a carbon source was strongly suggested in earlier research. Hence, the mango peel was used as a substrate in the current study. Within 25 days of operation, a 102-mV voltage was achieved in 13 days, while the degradation efficiency of Cr3+ was 69.21%, Co2+ was 72%, and Ni2+ was 70.11%. The procedure is carried out in the batch mode, and there is no continuous feeding of the organic substrate. In addition, a detailed explanation of the hypothesized mechanism for this investigation is provided, which focuses on the process of metal ion degradation. Lastly, future and concluding remarks are also enclosed.
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- 2023
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9. A mixed-method analysis to identify the current focus, trends, and gaps in health science research in Saudi Arabia
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Asma Ayyed AL-Shammary, Sehar un-Nisa Hassan, Fahad Saud Alshammari, and Modi Rataan Rifai Alshammari
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medical research ,gaps ,trends ,health research ,Saudi Arabia ,mixed-method analysis ,Public aspects of medicine ,RA1-1270 - Abstract
BackgroundThe identification of current gaps in high-impact medical research in Saudi Arabia has international significance due to the trend of collaborative research in the field of health and medicine and the focus on knowledge-sharing. The purpose of this study is to assess the current focus, gaps, and priorities in health research in Saudi Arabia.MethodsWe employed a mixed-method research approach to achieve research objectives. (1) a systematic review of scientific research studies that are published between January 2020 to January 2022 in the top fifty Q1 medical science journals (2) a cross-sectional survey collected data from professionals employed in various organizations including the Ministry of Health (MoH), Ministry of Education (MoE), health organizations and universities, and the health industry. The close-ended survey questions inquired about the broad and specific areas of ongoing health research projects by these researchers and organizations in Saudi Arabia.ResultsThe literature search on databases identified Science Direct (n = 741), Pub Med (n = 244) and Google Scholar (n = 15,600). After screening, (n = 26) original studies were selected for detailed evaluation and synthesis. Among these (n = 7) studied infectious diseases, (n = 7) cancer, and cardiac disease (n = 5). These studies focused on the etiology, treatment management and therapy outcomes of these health conditions. The survey was completed by (n = 384) respondents from these organizations. Most of the ongoing research projects focus on clinical sciences (27%) followed by basic sciences (24%) and public health research (24%) and a limited number of researchers were involved in healthcare management (2%) and informatics (2%). Most research focused on kidney and liver disorders (80%), obesity (74%), diabetes (74%), hormonal diseases (64%), and infectious disease (66%); it is equally important to design and fund research in some of the neglected areas including reproductive health (3%), physical and mental disabilities (1%).ConclusionFindings suggest that current gaps in original research from Saudi Arabia are in healthcare service quality, reproductive health, physical and mental disabilities and health informatics. Researchers and funding agencies and international collaborative projects should prioritize these areas.
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- 2023
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10. Investigating the Role of Temperature in Laser Assisted Chemical Bath Deposition for ZnO Growth for Photodetector Application
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Naser M. Ahmed, Loh Xue Qi, Anoud Saud Alshammari, Amel Muhson Naji, Humberto Cabrera, Ayed M. Binzowaimil, Osamah A. Aldaghri, and Khalid H. Ibnaouf
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ZnO micro-nanostructures ,blue laser ,CBD ,UV photodetector ,laser assisted ,Applied optics. Photonics ,TA1501-1820 - Abstract
ZnO microrods (ZnO-MRs) have unique properties that make them highly attractive for applications such as optoelectronics, electronics, and sensors. This work demonstrates the successful synthesis of high-quality ZnO-MRs using a laser-assisted chemical bath deposition method. The optimal growth temperature for high-quality ZnO-MRs was found to be 61.10 °C, considerably lower than that required for conventional chemical methods. Various characterization techniques, including X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy Dispersive X-ray (EDX), and UV-Vis spectrometry, confirmed the structural and optical properties of the synthesized ZnO-MRs. The UV detection potentialities of the fabricated ZnO-MRs were investigated. All samples exhibited good UV detection capabilities with the sample grown at 61.10 °C showing the best performance with fast response and recovery times of 1.260 s and 1.398 s, respectively. These findings hold immense potential for developing more efficient methods for synthesizing ZnO-MRs for use in various applications.
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- 2023
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11. Burden of COVID-19: a preliminary analysis in the population of Saudi Arabia
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Syed Mohammed Basheeruddin Asdaq, Syed Imam Rabbani, Mohammed Kanan Alshammari, Reem Saud Alshammari, Mehnaz Kamal, Mohd Imran, Noufah Aqeel AlShammari, May Faiz Al Twallah, and Abdulmjeed Hussain Alshahrani
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COVID-19 ,Burden ,Saudi Arabia ,Mortality ,DALY ,Relative risk ,Medicine ,Biology (General) ,QH301-705.5 - Abstract
Background Coronavirus infection (COVID-19) has resulted in an unprecedented number of human deaths and economic losses. Analyzing the role of disease in different groups of people is useful for determining the burden of disease. As a result, the purpose of this study was to investigate the influence of COVID-19 on the Saudi Arabian population’s quality of life, with a particular emphasis on the likely fall in their life expectancy. Methods A cross-sectional and retrospective analysis of 2,988 patients’ databases was performed to assess COVID-19-induced mortality and complications in the community. The data was gathered from official websites that track the disease’s impact daily between July and October 2021. On the acquired data, disability-adjusted life years (DALYs) and relative risk analysis were performed. The data was statistically analyzed using SPSS IBM 25. The Pearson’s correlation test was used to examine the relationship between age and disease impact. The significance of the findings was determined by using a P value of less than 0.05. Results The data from the study indicated that the positive test rate, infection rate, and mortality rate in the population were 1.84% [+0.11/-0.39 of 95% confidence interval (CI)], 1.54% (+0.38/-0.52 of CI), and 1.59% (+0.4/-0.7 of CI), respectively. Highest percentage of mortality was observed in Riyadh (17%), followed by Jeddah (8.7%) and Makkah (7.5%). The DALYs/100,000 inhabitants increased progressively as the age of the population increased, and the highest value was found for those over 70 years old (25.73 ± 2.09). Similarly, the risk outcome (55%) increased significantly (p = 0.037) from 40 years onwards, and the maximum was observed at above 70 years (184%, p = 0.006). The correlation analysis indicated a significant association (p = 0.032) between age and COVID-19 induced mortality from the 40-year-old population onwards. Conclusion The current study found that the COVID-19 load in Saudi Arabia was comparable to that in nations that were said to have performed well during the pandemic. DALYs increased from 40 years to 60 years, although people over 60 years had a lower life expectancy and were more susceptible to infection. After 60 years, the occurrence of numerous co-morbid illnesses may have added to the population’s burden of COVID-19. Further research in this area may yield a more precise estimate of the COVID-19-induced burden on the entire population.
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- 2022
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12. Time-Series Analysis and Healthcare Implications of COVID-19 Pandemic in Saudi Arabia
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Rafat Zrieq, Souad Kamel, Sahbi Boubaker, Fahad D. Algahtani, Mohamed Ali Alzain, Fares Alshammari, Fahad Saud Alshammari, Badr Khalaf Aldhmadi, Suleman Atique, Mohammad A. A. Al-Najjar, and Sandro C. Villareal
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COVID-19 ,data analytics ,Times series ,ARIMA ,Prophet ,baseline ,Medicine - Abstract
The first case of coronavirus disease 2019 (COVID-19) in Saudi Arabia was reported on 2 March 2020. Since then, it has progressed rapidly and the number of cases has grown exponentially, reaching 788,294 cases on 22 June 2022. Accurately analyzing and predicting the spread of new COVID-19 cases is critical to develop a framework for universal pandemic preparedness as well as mitigating the disease’s spread. To this end, the main aim of this paper is first to analyze the historical data of the disease gathered from 2 March 2020 to 20 June 2022 and second to use the collected data for forecasting the trajectory of COVID-19 in order to construct robust and accurate models. To the best of our knowledge, this study is the first that analyzes the outbreak of COVID-19 in Saudi Arabia for a long period (more than two years). To achieve this study aim, two techniques from the data analytics field, namely the auto-regressive integrated moving average (ARIMA) statistical technique and Prophet Facebook machine learning technique were investigated for predicting daily new infections, recoveries and deaths. Based on forecasting performance metrics, both models were found to be accurate and robust in forecasting the time series of COVID-19 in Saudi Arabia for the considered period (the coefficient of determination for example was in all cases more than 0.96) with a small superiority of the ARIMA model in terms of the forecasting ability and of Prophet in terms of simplicity and a few hyper-parameters. The findings of this study have yielded a realistic picture of the disease direction and provide useful insights for decision makers so as to be prepared for the future evolution of the pandemic. In addition, the results of this study have shown positive healthcare implications of the Saudi experience in fighting the disease and the relative efficiency of the taken measures.
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- 2022
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13. Predictability of COVID-19 Infections Based on Deep Learning and Historical Data
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Rafat Zrieq, Souad Kamel, Sahbi Boubaker, Fahad D. Algahtani, Mohamed Ali Alzain, Fares Alshammari, Badr Khalaf Aldhmadi, Fahad Saud Alshammari, and Marcos J. Araúzo-Bravo
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COVID-19 prediction ,deep learning (DL) ,long short-term memory (LSTM) ,gated recurrent unit (GRU) ,recurrent neural network (RNN) ,performance metrics ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The COVID-19 disease has spread worldwide since 2020, causing a high number of deaths as well as infections, and impacting economic, social and health systems. Understanding its dynamics may facilitate a better understanding of its behavior, reducing the impact of similar diseases in the future. Classical modeling techniques have failed in predicting the behavior of this disease, since they have been unable to capture hidden features in the data collected about the disease. The present research benefits from the high capacity of modern computers and new trends in artificial intelligence (AI), specifically three deep learning (DL) neural networks: recurrent neural network (RNN), gated recurrent unit (GRU), and long short-term memory (LSTM). We thus modelled daily new infections of COVID-19 in four countries (Saudi Arabia, Egypt, Italy, and India) that vary in their climates, cultures, populations, and health systems. The results show that a simple-structure RNN algorithm is better at predicting daily new infections and that DL techniques have promising potential in disease modeling and can be used efficiently even in the case of limited datasets.
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- 2022
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14. Critical Management of Accelerated Idioventricular Rhythm in Emergency Sitting, Review Article
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Fahad Bahaidarah, null Mohammed Madani S Alawfi, null Thurya saud alshammari, null Meshari Nada Alotaibi, Ali Mohammed Alnuwaysir, null Mohammed Ghafil Alghafil, null Abdullah Abdulaziz Alsaqabi, null Ahmed Mohammed M Abdali, null Qussi Jaffer Al-Rebh, null Suwaydi Essa alsalami, null Albaraa Ahmed Mohammed Johali, null Abdulmajeed Mohammad S Alibrahem, and null Amjad Atiah M Alruwaili
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The terminology "accelerated idioventricular rhythm" refers to an ectopic ventricular rhythm with three or more consecutive premature ventricular monomorphic beats with slow onset and end. That is slower than ventricular tachycardia but faster than the typical intrinsic escape rate of the ventricles, which is 30 to 40 beats per minute. Accelerated idioventricular rhythm differentiates from ventricular tachycardia in addition to having a positive outcome, a long coupling period at the beginning, a gradual drop-in ventricular rate at the conclusion, and an increase in sinus rate. After thrombolysis upon acute myocardial infarction, its presence is a sign that reperfusion was successful. Since malignant ventricular tachycardias are not commonly linked with accelerated idioventricular rhythm and the condition is typically hemodynamically well tolerated, no special therapy is typically required beyond managing the underlying heart condition. Accelerated idioventricular rhythm (AIVR) is usually benign, transitory, and untreatable. The goal of this observational study is to learn more about the clinical signs, prognosis, and therapy of frequent AIVR.
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- 2022
15. CORONAVIRUS AND VACCINE EFFECT
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baraqaan, Hani Abdullah, primary, Salem, Salman khalaf, additional, Ibrahim Howishan, Mohammed, additional, sattam Al oufi, Mohammed, additional, Abdul fattah Zamzami, Ammar, additional, Alarbeed, SulimanAbdulaziz, additional, ghazi Alanazi, Abdulkareem, additional, AbdoHazazi, Ibrahim, additional, Saud Alshammari, Sanad, additional, and Al ruwaili, ADEL Hazzaa, additional
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- 2023
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16. FACTOR ANALYSIS AND REGRESSION ANALYSIS TO FIND OUT THE INFLUENCING FACTORS THAT LED TO THE COUNTRIES’ DEBT CRISIS
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Alanazi Talal Abdulrahman and Njood Saud Alshammari
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General Medicine - Published
- 2022
17. Prevalence of Compliance on Asthma Action Plan Among Asthmatic Children in PSMMC and Associated Factors with Good and Poor Compliance
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Mohammed Saud Alshammari, Tarek Elsaid, Mashael Albargawi, and Mostafa Ahmed Kofi
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General Engineering - Published
- 2022
18. Prevalence of Irritable Bowel Syndrome IBS and Its Risk Factors among Medical Students in Hail University
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Fatmah Fahad Alreshidi, Munira Abdulkarim Alsammari, Arin Essa Almallahi, Khulud Saud Alshammari, Ebtehaj Saud Almughais, Farida Habib Khan, Sadaf Anwar, and Dalal Alayed
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- 2022
19. Influence of Crown Height of Dental Implant on Marginal Bone Loss: A Retrospective Study
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Nawaf Sulaiman AlHussainan, Waleed Mohammad AlHossan, Rema Suleman AlMusallam, Zainah Mohammed Sambawa, Alanoud Saud AlShammari, Shuaa Fahad AlHusaan, and Reem Sami AlKeraye
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General Medicine - Published
- 2022
20. Awareness of Hail Region Population about Facial Nerve Palsy (Seventh Cranial Nerve Palsy)
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Ghorashy Eltayeb Yousif, Turki Saud Alshammari, and Hamoud Abdelkarim Almarshadi
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Complementary and alternative medicine ,Pharmaceutical Science ,Pharmacology (medical) - Published
- 2022
21. Protection of Users Kids on Twitter Platform Using Naïve Bayes
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Saud Alshammari, Eman Aljabarti, and Yusliza Yusoff
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- 2023
22. Knowledge and Attitude towards Vitamin D among Saudi Female university students at Princess Nourah University
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Fatimah Abdullah Alwehibi, Mashael Abdulmohsin Aldrees, Rima Salman Bnfadliah, Amira Saud Alshammari, Sarah Mohammed Alasgah, and Yomna Khaled Ramadan
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education - Abstract
Aims: The purpose of this study was to assess the knowledge and attitude towards vitamin D and sunlight exposure among female university students. Study Design: Cross Sectional study design. Place and Duration of Study: The study was conducted among 500 female Saudi students in Princess Nourah Bint Abdulrahman University (PNU). Methodology: A self-administered questionnaire was used to assess the knowledge about vitamin D sources, health benefits and effects of vitamin D deficiency and assessing the attitude towards vitamin D and sunlight exposure. Results: The present study recognized that health college students (52.7%) had better knowledge than non-health college students (47.3%). Although PNU students had good knowledge about vitamin D, only 6.0% of them knew the current recommended daily dose. Female students showed good behavior and attitude in terms of high frequency of sunlight exposure daily (34.8%). Educational institutions were the main sources of information about vitamin D (43%). Hot weather (54.8%) and fear of pigmentation (51.2) were the main reasons for limited sunlight exposure among students. Conclusion: There was a good level of knowledge (52.2%) about vitamin D sources, benefits and effects of vitamin D deficiency among female students. In fact, health college students had better knowledge about vitamin D than non-health college students. Hot weather (54.8%) and fear of pigmentation (51.2%) were the main barriers to sunlight exposure.
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- 2021
23. Properties of phosphoric acid doped crystalline silicon with different light-trapping schemes for solar cells
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Anoud Saud Alshammari, Auwal Abdulkadir, and Aryam Saud Alshammari
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Mechanics of Materials ,Mechanical Engineering ,General Materials Science ,Condensed Matter Physics - Published
- 2023
24. Parental Awareness and Knowledge toward their Children\'s Oral Health in the City of Dammam, Saudi Arabia
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Motieah Hathal Alshammari, Rehab Ali Alshammari, Abdullah Faraj AlShammari, Faisal Abdullah Al Sineedi, Malak Farraj Alshammari, Fatimah Saud Alshammari, Azhar Khairallah Alibrahim, and Khlood Abdulkader Alkurdi
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medicine.medical_specialty ,business.industry ,Dental health ,Saudi Arabia ,Psychological intervention ,Parental awareness ,Orthodontics ,Validated questionnaire ,Oral health ,Oral hygiene ,stomatognathic diseases ,Family medicine ,Pediatrics, Perinatology and Child Health ,Periodontics ,Medicine ,Oral Surgery ,Young adult ,Dammam region ,business ,Inclusion (education) ,Research Article - Abstract
Introduction Two main factors have a great influence on the youth's oral well-being. These are their dental health and age. These two factors are significantly directed by parents through establishing a system of proper oral hygiene and a preventative routine for those young adults. Aim and objective The following study was run in the Dammam region, Saudi Arabia, to assess guardian awareness of youngster's dental health. Materials and methods This community-based study was designed in a cross-sectional pattern, where a sample size of 248 parents who fulfilled inclusion criteria was selected and a well-designed validated questionnaire was used for the collected database using SPSS (VER. 24). Results The main found included that, about 51% of participants were fathers and 49% were mothers, 90% of them above the age of 26 years old and most of the participants had a secondary certificate or university degree, 38% and 45%, respectively, only 64% of parents have checked their children teeth, the average of overall knowledge of parents toward dental health was medium 7.97 points out of 16.0 points and there was a statistically significant relationship between parents type, educational level, and overall knowledge related to oral health. Conclusion From our study, it was acknowledged that the perception of children's oral health status by their parents in the Dammam region is relatively medium, so general awareness of parents' knowledge should be raised by conducting effective oral health programs and interventions. How to cite this article Alshammari FS, Alshammari RA, Alshammari MH, et al. Parental Awareness and Knowledge toward their Children's Oral Health in the City of Dammam, Saudi Arabia. Int J Clin Pediatr Dent 2021;14(1):100-103.
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- 2021
25. Enhancement of luminous flux of InGaAlP-based low-power SMD LEDs using substrates with different thermal resistances
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Mutharasu Devarajan, Shahrom Mahmud, Muna E. Raypah, and Anoud Saud AlShammari
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Materials science ,Thermal resistance ,chemistry.chemical_element ,02 engineering and technology ,Heat sink ,01 natural sciences ,law.invention ,law ,0103 physical sciences ,Thermal ,0202 electrical engineering, electronic engineering, information engineering ,Electrical and Electronic Engineering ,Diode ,010302 applied physics ,business.industry ,020208 electrical & electronic engineering ,Condensed Matter Physics ,Atomic and Molecular Physics, and Optics ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Luminous flux ,chemistry ,Heat transfer ,Optoelectronics ,business ,Indium ,Light-emitting diode - Abstract
Purpose Optimization of light-emitting diodes’ (LEDs’) design together with long-term reliability is directly correlated with their photometric, electric and thermal characteristics. For a given thermal layout of the LED system, the maximum luminous flux occurs at an optimal electrical input power and can be determined using a photo-electro-thermal (PET) theory. The purpose of this study is to extend the application of the luminous flux equation in PET theory for low-power (LP) LEDs. Design/methodology/approach LP surface-mounted device LEDs were mounted on substrates of different thermal resistances. Three LEDs were attached to substrates which were flame-retardant fiberglass epoxy (FR4) and two aluminum-based metal core printed circuit boards (MCPCBs) with thermal conductivities of about 1.0 W/m.K, 2.0 W/m.K and 5.0 W/m.K, respectively. The conjunction of thermal transient tester and thermal and radiometric characterization of LEDs system was used to measure the thermal and optical parameters of the LEDs at a certain range of input current and temperature. Findings The validation of the extended application of the luminous flux equation was confirmed via a good agreement between the practical and theoretical results. The outcomes show that the optimum luminous flux is 25.51, 31.91 and 37.01 lm for the LEDs on the FR4 and the two MCPCBs, respectively. Accordingly, the stipulated maximum electrical input power in the LED datasheet (0.185 W) is shifted to 0.6284, 0.6963 and 0.8838 W between the three substrates. Originality/value Using a large number of LP LEDs is preferred than high-power (HP) LEDs for the same system power to augment the heat transfer and provide a higher luminous flux. The PET theory equations have been applied to HP LEDs using heatsinks with various thermal resistances. In this work, the PET theory luminous flux equation was extended to be used for Indium Gallium Aluminum Phosphide LP LEDs attached to the substrates with dissimilar thermal resistances.
- Published
- 2020
26. Elucidating the Awareness of Dental Doctors in Following Dental Protocol by M.O.H about the COVID-19 Pandemic in KSA
- Author
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Lamia Nafea AlShammari, Motieah Hathal Alshammari, Fatima Sultana, Malak Farraj Altwalah, Nada Nasser AlMansour, Aisha Zakaria Hashem Mostafa, Fatimah Saud Alshammari, and Beshaeir Klaeif Albalwi
- Subjects
Protocol (science) ,Psychiatry and Mental health ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Pandemic ,medicine ,Medical emergency ,medicine.disease ,business - Published
- 2020
27. Social Skills Improvement in Children with Autism Spectrum Disorders تحسین المهارات الاجتماعیة لدى الأطفال المصابین باضطراب طیف التوحد
- Author
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Dalal Fadawi Saud Alshammari, Ahad Bahaekm, and Moana Barnawi
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Arabic ,Peer support ,medicine.disease ,Special education ,language.human_language ,Developmental psychology ,Normal functioning ,Native english ,Social skills ,Autism spectrum disorder ,medicine ,language ,Autism ,Psychology - Abstract
Autism is a developmental disability that affects the normal functioning of the brain. Autism is present from birth and has an effect on how an individual learns. Individuals with autism often have difficulty with communication skills, social skills, and reasoning. Integrating students with Autism Spectrum Disorder (ASD) in inclusive classrooms with peers without disabilities is a common strategy for increasing social. Research has demonstrated that peers can help teach social skills to students with autism. The sample of the study will be selected non-randomly. There will be 24 students in this study. Also, three special education teachers will be in this study. All participants are native English speakers. The purpose of this study is to identify the best way to increase social skills for students with autism through inclusive classrooms تهدف هذه الدراسة الى التعرف الى أفضل طريقة لزيادة المهارات الاجتماعية للطلاب ذوي اضطراب التوحد وذلک من خلال دمجهم في الفصول الدراسية العامة مع أقرانهم العاديين. تم اختيار عينة بشکل عشوائي. سيکون هناک ٢٤طالب و٣ معلمين من الفصول العامة. جميع المشارکين لغتهم الأصلية هي اللغة العربية. تم مقابلة معلمي الفصول العامة من خلال استخدام استبيان لتحديد تأثير وفاعلية المهارات الاجتماعية في الفصول الدراسية. وقد أظهرت استجابة المعلمين بشکل إيجابي في فاعلية دعم الأقران في زيادة المهارات الاجتماعية لذوي اضطراب التوحد من خلال الأنشطة اليومية
- Published
- 2020
28. Analysis of the Factors to Search for the Actual Causes That Led to the Accumulation of Debts on Individuals
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Alanazi Talal Abdulrahman, Njood Saud Alshammari, Dalia Kamal Alnagar, and Ishfaq Ahmad
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Article Subject ,General Mathematics ,education ,General Engineering ,health care economics and organizations ,humanities - Abstract
Background. Financial crises become more probable and severe when debt levels exceed specific thresholds. This finding strongly indicates that debt can become excessive in some circumstances. All the above are from previous studies that mentioned the statistics of debts, financial crises, and defaults in countries without mentioning the reasons that led to the debts. Objective. The aim of this study is to identify the causes that led to the accumulation of debts by individuals. Methods and Materials. A cross-sectional survey was administered to the common populace in KSA, utilizing Google shapes to gather information. The target group comprised 143 males (34.5%) and 272 females (65.5%) responders. Statistical analysis methods were based on factor analysis and regression analysis of fractional factorials. Results. The results of the analysis were summarized by the factors for the first stage: the reasons that led to the debt crisis for individuals were S1, S2, and S5–S13. The results of the second method, regression analysis, show that the reasons that led to the debt crisis for individuals are S4 and S11. Conclusion. Referring to the results of the analysis of the two methods, it was found that there is a common factor between them, S11, and thus, S11 (poor management and inefficiency) becomes the actual cause that led to the debt crisis for individuals.
- Published
- 2022
- Full Text
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29. Longest 9 5/8? Casing Cementing in ERD Well, A Worldwide-Record
- Author
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De la Cruz Sasso, Alejandro, additional, Alzaki, Hussien A., additional, Masoud Zuleta, Rodny, additional, and Saud AlShammari, Nawaf, additional
- Published
- 2022
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30. Burden of COVID-19: a preliminary analysis in the population of Saudi Arabia
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Syed Mohammed Basheeruddin Asdaq, Syed Imam Rabbani, Mohammed Kanan Alshammari, Reem Saud Alshammari, Mehnaz Kamal, Mohd Imran, Noufah Aqeel AlShammari, May Faiz Al Twallah, and Abdulmjeed Hussain Alshahrani
- Subjects
General Neuroscience ,General Medicine ,General Agricultural and Biological Sciences ,General Biochemistry, Genetics and Molecular Biology - Abstract
Background Coronavirus infection (COVID-19) has resulted in an unprecedented number of human deaths and economic losses. Analyzing the role of disease in different groups of people is useful for determining the burden of disease. As a result, the purpose of this study was to investigate the influence of COVID-19 on the Saudi Arabian population’s quality of life, with a particular emphasis on the likely fall in their life expectancy. Methods A cross-sectional and retrospective analysis of 2,988 patients’ databases was performed to assess COVID-19-induced mortality and complications in the community. The data was gathered from official websites that track the disease’s impact daily between July and October 2021. On the acquired data, disability-adjusted life years (DALYs) and relative risk analysis were performed. The data was statistically analyzed using SPSS IBM 25. The Pearson’s correlation test was used to examine the relationship between age and disease impact. The significance of the findings was determined by using a P value of less than 0.05. Results The data from the study indicated that the positive test rate, infection rate, and mortality rate in the population were 1.84% [+0.11/-0.39 of 95% confidence interval (CI)], 1.54% (+0.38/-0.52 of CI), and 1.59% (+0.4/-0.7 of CI), respectively. Highest percentage of mortality was observed in Riyadh (17%), followed by Jeddah (8.7%) and Makkah (7.5%). The DALYs/100,000 inhabitants increased progressively as the age of the population increased, and the highest value was found for those over 70 years old (25.73 ± 2.09). Similarly, the risk outcome (55%) increased significantly (p = 0.037) from 40 years onwards, and the maximum was observed at above 70 years (184%, p = 0.006). The correlation analysis indicated a significant association (p = 0.032) between age and COVID-19 induced mortality from the 40-year-old population onwards. Conclusion The current study found that the COVID-19 load in Saudi Arabia was comparable to that in nations that were said to have performed well during the pandemic. DALYs increased from 40 years to 60 years, although people over 60 years had a lower life expectancy and were more susceptible to infection. After 60 years, the occurrence of numerous co-morbid illnesses may have added to the population’s burden of COVID-19. Further research in this area may yield a more precise estimate of the COVID-19-induced burden on the entire population.
- Published
- 2021
31. INFLUENCE OF SEVERAL FACTORS ON REFRACTIVE ERRORS CORRECTION AMONG PRIMARY SCHOOL CHILDREN IN SAUDI ARABIA
- Author
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Rashed Raja Alshammari *, Sulaiman Saud Alsamaan , Turki Saad Aljuhani , Abdullah Saud Alshammari , Hamoud Hussein Al-Sunitan , Dr. Abrar Wazzan
- Subjects
education ,eye diseases - Abstract
The aim of this study is to determine the prevalence of uncorrected refractive errors (URE) among children 3-10 years of age and to confirm the need for a national school-based visual screening program for school-aged children. Due to quarantine in Saudi Arabia due to the spread of Coronavirus, this study is dependent on previous studies, and the researcher analyzes the results of previous studies related to the subject so that the researcher uses the inductive approach with the use of citations for all sources. The main study discussed was a retrospective cross-sectional study conducted in Medina, Saudi Arabia in 2015. Children were selected through multi-stage stratified random sampling from 8 kindergartens and 8 primary schools. Those included were screened to diagnose UREs using a visual acuity chart and an auto-refractometer as per American guidelines. Prevalence and types of UREs have been estimated. The results of this study are based on the results of (Alrahili et al., 2017) which found that 1893 of the 2121 children listed had been examined, yielding a response rate of 89.3 per cent. The prevalence of URE was 34.9 per cent (95 per cent CI = 32.8 per cent-37.1 per cent), with significant differences in different age groups. The prevalence of astigmatism (25.3 per cent) was higher than that of anisometropia (7.4 per cent), hypermetropia (1.5 per cent) and myopia (0.7 per cent). The risk of incorrect refractive error was positively associated with age, and this was mentioned in astigmatism, myopia, and anisometropia. In addition, the risk of hypermetropy was associated with boys and the risk of myopia was associated with girls. To conclude, the prevalence of URE, in particular astigmatism, was high among children 3-10 years of age in Medina, with significant age differences. Vision screening programs targeting kindergartens and primary school children are crucial in reducing the risk of the preventable visual impairment according to URE. Key words: Refractive Error, School Children, Astigmatism.
- Published
- 2020
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32. Proteomic Evaluation and Cytotoxicity of Red Maple (Acer rubrum) Leaves
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Saud Alshammari
- Subjects
Gel electrophoresis ,Maple ,Chromatography ,Antioxidant ,Maple syrup ,Chemistry ,medicine.medical_treatment ,Size-exclusion chromatography ,engineering.material ,Proteomics ,High-performance liquid chromatography ,food.food ,food ,engineering ,medicine ,Cellular compartment - Abstract
Red maple (Acer rubrum), also known as swamp, water or soft maple, is endemic to eastern and central North America and was widely used as traditional medicine by the first peoples. Commercially, its well-known products include maple syrup and high-quality lumber. The potential medicinal benefits of phenolic compounds extracted from the red maple plant, such as glucitol-core containing gallotannins, include antioxidant, and antiglycation effects as well as their importance in cosmetic applications. Plant-derived proteins and peptides are important biomolecules; however to date, there is no published data on the identification of proteins/peptides from red maple leaves. Therefore, the present study focuses on the activity guided purification of proteins from red maple leaves collected in spring and fall seasons. In addition, the focus of this project was in the evaluation of maple leaves employing bottom-up proteomics and De Novo protein profiling by PEAKS Studio-X and Gene Ontology Bioinformatics. The red maple leaves were grounded, defatted in hexane and proteins extracted in 25 mM sodium phosphate buffer pH 6.5. The extracted crude proteins were recovered by precipitation in 80% ammonium sulfate. The first-dimensional chromatography of crude extracted proteins was performed on a gel filtration column (HiLoad 16/600 Superdex200). The separation of crude extract and the partially purified gel filtration fraction was conducted by reversed-phase HPLC. The crude and eluted fractions were analyzed by SDS-PAGE gel electrophoresis. The extract was screened for cytotoxicity activity on Michigan Cancer Foundation-7 breast cancer (MCF-7), M.D. Anderson Metastasis Breast (MDA-MB-231) cancer cell lines and anti-inflammatory activity on murine macrophage (RAW 264.7) cell line from American Type Culture Collection (ATCC). The drug Doxorubicin was used as a positive control whereas untreated cells as a negative control in these experiments Preliminary data revealed that active protein fractions were eluted at two different regions of gel filtration chromatography both in spring and fall leaves. Bottom-up proteomics of crude and active fractions by PEAKS Studio-X and MASCOT bioinformatics database identified over 54 proteins. The Gene Ontology Annotation classified these proteins involved in the biological processing, cellular compartment, and molecular functions.
- Published
- 2020
33. Awareness and Knowledge of Poor Vision among Students in Hail University
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Manal Zayed Alshammary, Tahany Faisal Alshammari, Abdullah S Alshammari, Hadeah Salem Alsahammari, Mona Shaheen, and Fatimah Saud Alshammari
- Subjects
medicine.medical_specialty ,genetic structures ,business.industry ,Visual impairment ,Eye care ,eye diseases ,Impaired Vision ,03 medical and health sciences ,0302 clinical medicine ,Poor vision ,Family medicine ,Eye health ,030221 ophthalmology & optometry ,medicine ,University education ,Observational study ,030212 general & internal medicine ,medicine.symptom ,business ,Female students - Abstract
Background: Awareness of common eye diseases particularly impaired vision and their prevention and treatment can play an important role in encouraging people to seek timely eye care and can therefore help in reducing the burden of visual impairment. Objective: This cross sectional observational study was carried out to assess the level of awareness and knowledge about the problem of poor vision among Saudi students in Hail University. Methods: A standardized questionnaire was randomly distributed to students aged 18-24 years of both sexes. A total of 1484 subjects agreed to participate, answered the questionnaire and were involved in the study. Results: Findings showed that1330 students considered poor vision to be a problem. Most of them considered elders the most susceptible age group followed by teenagers. More than half of the students did not know which gender is more affected by poor vision. More than one-third (37.5%) of them considered poor vision as a genetic disorder. Others reported errors of refraction, cataract and senility (10.6%, 8.4% and 6.55%respectively). However, 28.3% of the students did not know exactly the predisposing causes of poor vision. Two-thirds of the study population thought that poor vision could be prevented. Regular periodic examination of the eyes and prevention of the predisposing factors were recommended (31.3% and 32.7% respectively) as the best methods to prevent poor vision. There was significant association between the level of awareness and knowledge of the students about poor vision and the gender, type and level of education. Conclusion: The detected levels of knowledge is still not the optimum especially among female students, non-scientific colleges and in the earlier levels of university education. This emphasizes the need to involve such students in a proper eye health education program. This will help increasing the awareness of the community at large.
- Published
- 2018
34. The effect of spray cycles on the morphological, structural, and optical properties of rGO thin film deposited using spray pyrolysis technique
- Author
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Muna E. Raypah, Mohd Mahadi Halim, Khaled M. Chahrour, Noor Haida Mohd Kaus, Fong Kwong Yam, and Anoud Saud AlShammari
- Subjects
Materials science ,Band gap ,Oxide ,Photodetector ,02 engineering and technology ,Substrate (electronics) ,01 natural sciences ,law.invention ,chemistry.chemical_compound ,law ,Sputtering ,0103 physical sciences ,General Materials Science ,Thin film ,010302 applied physics ,business.industry ,Graphene ,Mechanical Engineering ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Surface coating ,chemistry ,Mechanics of Materials ,Optoelectronics ,0210 nano-technology ,business - Abstract
This study proposed a facile and cost-effective approach to synthesize reduced graphene oxide (rGO) thin film from graphene oxide (GO) water dispersion. The rGO thin films were deposited on glass substrates via spray pyrolysis technique (SPT) by using different numbers of spray cycles (i.e. 2 to 10). The structure, morphology, thickness, and optical properties of GO and rGO thin films were characterized using different techniques. The optical analysis showed that the energy band gap of GO and rGO thin films reduced from 4.2 to 3.27 eV as the spray cycles were increased from 2 to 10, which confirms the effect of surface coating thickness on conductivity. To test the performance of the rGO thin film as a UV photodetector device, metal-semiconductor-metal (MSM) configuration was achieved by incorporating Al metal using RF sputtering on the thin film sample prepared with 10 spray cycles. For the device, the photoresponse (R) were found to be 0.0038, 0.0084, 0.01700, and 0.0284 (A/W), while photodetector gain (G) values were 1.956, 2.05, 2.15, and 2.31 at bias voltages of 1, 2, 3, and 4 V, respectively. At the same range of bias voltages, the rise times of the photodetector were 0.08, 0.075, 0.055, and 0.055 s, while the fall time were 0.055, 0.066, 0.06 and 0.06 s, respectively, under 375 nm UV illumination (0.37 mW/cm2). The maximum sensitivity (S%) was found to be 131.84 at 4 V. The photoelectric properties and photodetection performances indicate that rGO thin film deposited on glass substrate by SPT could be a potential candidate for the development of advanced MSM optoelectronic devices.
- Published
- 2021
35. Research on dynamic thermal performance of high-power ThinGaN vertical light-emitting diodes with different submounts
- Author
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Mutharasu Devarajan, Shahrom Mahmud, Anoud Saud AlShammari, and Muna E. Raypah
- Subjects
Materials science ,business.industry ,Wafer bonding ,Time constant ,Condensed Matter Physics ,Electronic, Optical and Magnetic Materials ,Power (physics) ,law.invention ,law ,Thermal ,Materials Chemistry ,Optoelectronics ,Electrical and Electronic Engineering ,business ,Light-emitting diode - Abstract
Investigation of dynamic thermal performance is a key to improve the heat management of high-power (HP) vertical light-emitting diodes (VLEDs). Specifically, the thermal time constant is a crucial parameter for optimizing the design and reliability of HP LEDs. Herein, the dynamic thermal behavior of seven HP ThinGaN VLEDs with different constructions was demonstrated. The LEDs’ thermal parameters were measured through the thermal transient tester system by a forward voltage technique. A three-stage of multiexponential function model was applied to divide the transient response curve into three regions with different thermal properties. This study focused on analyzing the first region that involved the chip region (epitaxial layer, wafer bonding layer, and submount) and chip bonding layer. The submounts of the LEDs under consideration include silicon carbide (SiC), silicon (Si), sapphire (Al2O3), and germanium (Ge). The results revealed that with a qualified wafer bonding layer, the LED packages with SiC, Si, and Al2O3 submount presented the optimum thermal time constant, which was 85, 69, 75, and 81 ms, respectively.
- Published
- 2020
36. Design, Synthesis, and Evaluation of Amphiphilic Cyclic and Linear Peptides Composed of Hydrophobic and Positively-Charged Amino Acids as Antibacterial Agents
- Author
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Francisco J. Nuñez, Saghar Mozaffari, Qamar Alshammari, Saud Alshammari, Rakesh Tiwari, Taibah Aldakhil, Neda Riahifard, Jason Yamaki, and Keykavous Parang
- Subjects
0301 basic medicine ,Pharmaceutical Science ,Phenylalanine ,Chemistry Techniques, Synthetic ,urologic and male genital diseases ,E. coli ,01 natural sciences ,Analytical Chemistry ,Drug Discovery ,Amino Acids ,Alanine ,chemistry.chemical_classification ,Molecular Structure ,Cyclic peptide ,female genital diseases and pregnancy complications ,Amino acid ,Anti-Bacterial Agents ,Chemistry (miscellaneous) ,Molecular Medicine ,Antibacterial activity ,Hydrophobic and Hydrophilic Interactions ,hormones, hormone substitutes, and hormone antagonists ,Stereochemistry ,Antimicrobial peptides ,Microbial Sensitivity Tests ,methicillin-resistant Staphylococcus aureus ,Peptides, Cyclic ,Article ,lcsh:QD241-441 ,03 medical and health sciences ,Structure-Activity Relationship ,lcsh:Organic chemistry ,cardiovascular diseases ,Physical and Theoretical Chemistry ,amphiphilic cyclic peptide ,hydrophobicity ,Bacteria ,010405 organic chemistry ,Organic Chemistry ,Tryptophan ,0104 chemical sciences ,030104 developmental biology ,chemistry ,Drug Design ,cationic ,Isoleucine ,Peptides ,Antimicrobial Cationic Peptides - Abstract
Antimicrobial peptides (AMPs) contain amphipathic structures and are derived from natural resources. AMPs have been found to be effective in treating the infections caused by antibiotic-resistant bacteria (ARB), and thus, are potential lead compounds against ARB. AMPs&rsquo, physicochemical properties, such as cationic nature, amphiphilicity, and their size, will provide the opportunity to interact with membrane bilayers leading to damage and death of microorganisms. Herein, AMP analogs of [R4W4] were designed and synthesized by changing the hydrophobicity and cationic nature of the lead compound with other amino acids to provide insights into a structure-activity relationship against selected model Gram-negative and Gram-positive pathogens. Clinical resistant strains of methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) were used in the studies. Our results provided information about the structural requirements for optimal activity of the [R4W4] template. When tryptophan was replaced with other hydrophobic amino acids, such as phenylalanine, tyrosine, alanine, leucine, and isoleucine, the antibacterial activities were significantly reduced with MIC values of >, 128 µ, g/mL. Furthermore, a change in stereochemistry caused by d-arginine, and use of N-methyltryptophan, resulted in a two-fold reduction of antibacterial activity. It was found that the presence of tryptophan is critical for antibacterial activity, and could not be substituted with other hydrophobic residues. The study also confirmed that cyclic peptides generally showed higher antibacterial activities when compared with the corresponding linear counterparts. Furthermore, by changing tryptophan numbers in the compound while maintaining a constant number of arginine, we determined the optimal number of tryptophan residues to be four, as shown when the number of tryptophan residues increased, a decrease in activity was observed.
- Published
- 2018
37. A Systematic Method to Analyze Force Majeure in Construction Claims
- Author
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Khalid S. Al-Gahtani, Nuhu Braimah, Ibrahim A. Alhammad, and Saud Alshammari
- Subjects
Actuarial science ,Compensation (psychology) ,0211 other engineering and technologies ,Delay analysis ,02 engineering and technology ,Building and Construction ,Entitlement ,force majeure ,010501 environmental sciences ,construction delays ,entitlement ,delay claims ,excusable non-compensable delay ,01 natural sciences ,lcsh:TH1-9745 ,021105 building & construction ,Architecture ,Damages ,Force majeure ,Systematic process ,Business ,lcsh:Building construction ,0105 earth and related environmental sciences ,Civil and Structural Engineering - Abstract
In construction delay claims, force majeure is normally recognized as an excusable risk that entitles contractors only to time extensions, but neither of the contracting parties is entitled to monetary compensation to recover delay damages. However, there are instances where contractors are entitled to both time and cost compensations, as evidenced by some court cases relating to force majeure claims. Such instances involve attributing the occurrence of the force majeure to the effect of other prior delay events that pushed project performance into the period of the force majeure. Existing delay analysis methods are not capable of addressing this issue, as none take the impact of other delays into consideration when analyzing force majeure claims. Stimulated by this gap, this study proposes an improved and sound method for fairly analyzing the responsibility of force majeure delay claims amongst contracting parties. This method was implemented on a case project to help demonstrate its application and also ascertain its practicability. The contribution of this paper is twofold. First, it has highlighted the situation of force majeure delay that can be compensable, creating more awareness among researchers and industry practitioners. The second is a proposed systematic process to appropriately analyze its responsibility, which equitably addresses claims from such delays with little or no chance of dispute ensuing.
- Published
- 2017
- Full Text
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38. Oil Palm Biomass Sap-Rotten Rice as a Source to Remove Metal Ions and Generate Electricity as By-Products through Microbial Fuel Cell Technology
- Author
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Saud Alshammari, Anoud, Mohamed Aleid, Ghada, Rahmah Dhahawi Ahmad, Alamri, D. Alomari, Asma, Sa’ad Abdullahi, Shehu, and Edrees Adam Mohammad, Rania
- Abstract
Microbial fuel cell (MFC) is a new and interesting technology that can be used to treat wastewater without using electricity. The current research focuses on electron generation, which is one of the technique’s major challenges. According to the latest literature, the study was planned to successfully remove the metals from artificial wastewater at high concentrations and generate electricity. On average, after 18 days of operation, it offered 610 mV with 1000 ῼ constant external resistance. The internal resistance was found to be 520 ῼ. The achieved power density was 3.164 mW/m2 at an external resistance of 1000 ῼ. The achieved removal efficiencies of Pb2+, Cd2+, Cr3+, and Ni2+ were 83.67%, 84.10%, 84.55%, and 95.99%, respectively. The operation lasted for 25 days. The cyclic voltameter studies show that there is a gradual oxidation rate of organic substances, while on day 25, the removal efficiency reached its maximum. The specific capacitance was found to be high between days 15 and 20, i.e., 0.0000540 F/g. It also indicated that biofilm was stable around day 18. Furthermore, the biological characterization also demonstrated that MFC operation was very smooth throughout the process, even at high concentrations (100 mg/L) of metal ions. Finally, there is the MFC method, as well as some new challenges and future recommendations.
- Published
- 2024
- Full Text
- View/download PDF
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