1. The impact of oculomotor functioning on neuropsychological performance in Huntington disease
- Author
-
William Mallonee, Thomas T. Warner, Vicki L. Wheelock, Emily P. Freney, Stephen M. Rao, Vincent A. Magnotta, Alma Macaraeg, Sigurd D. Süßmuth, Paula Wasserman, Shineeka Smith, Phil Danzer, Anne Elizabeth Rosser, Michael D. Geschwind, Brenton Maxwell, Kelsey Montross, Gabriella Satris, Albie Law, Daniel S. O'Leary, David J. Moser, Thomas Brashers-Krug, Janessa O. Carvalho, Hans J. Johnson, Martha Nance, Anita M.Y. Goh, Mark Guttman, J. Preston, Janet K. Williams, Judith Bek, Susan Perlman, Alanna Sheinberg, Wenjing Lu, Christine Reece, Pietro Mazzoni, Nadine Yoritomo, Elizabeth Aylward, W.R. Wayne Martin, Megan M. Smith, Phyllis Chua, J. Decolongon, Breanna Nickels, Pamela King, Deborah L. Harrington, Roland Zschiegner, Brian Clemente, David G. Gunn, Alex Bura, Vivien Vaughan, Samantha M Loi, Maggie Burrows, Kimberly A. Quaid, Jillian McMillan, Jason Evans, Michael Orth, Mary Wodarski, Courtney Shadrick, Sarah L Mason, H. Jeremy Bockholt, Marguerite Wieler, Elizabeth Howard, Melissa Wesson, Kathy Price, Lisa Kjer, Daniela Rae, Lynn A. Raymond, Roger A. Barker, Edmond Chiu, Holly Westervalt, Joanne Wojcieszek, Stephanie Antonopoulos, Ji In Kim, Jane S. Paulsen, Maryjane Ong, Spencer Lourens, Maria Tedesco, Katrin Barth, Christina Reeves, Jane Griffith, Peter K. Panegyres, Sarah Hunt, Cathy Wood-Siverio, David Craufurd, Holly James Westervelt, Zosia Miedzybrodzka, A. Coleman, Irita Karmalkar, Joseph W. Y. Lee, Carolin Eschenbach, Greg Suter, Christopher A. Ross, Satwinder Sran, Sharon J. Sha, Daniela Schwenk, Joel S. Perlmutter, Ali Samii, James A. Mills, Mark Varvaris, Amanda Miller, Frederick J. Marshall, Amy M. Chesire, Isabella De Soriano, Ying Zhang, Natalie Valle Guzman, Angela Komiti, Oksana Suchowersky, Clement T. Loy, Diane Erickson, Karen Marder, Lyla Mourany, Joseph Winer, Anwar Ahmed, Jatin G. Vaidya, Eun Young Kim, Stacey K. Barton, Cheryl Erwin, Sonja Trautmann, Amanda Martin, Stewart A. Factor, Elizabeth McCusker, Mariella D'Alessandro, Jeffrey D. Long, Randi Jones, Nancy R. Downing, Jared M. Bruce, Charlyne Hickey, Rajeev Kumar, Mannie Fan, and Sarah E Tomaszewski Farias
- Subjects
Adult ,Male ,Elementary cognitive task ,medicine.medical_specialty ,genetic structures ,Disease ,Audiology ,Article ,050105 experimental psychology ,Ocular Motility Disorders ,Executive Function ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,0501 psychology and cognitive sciences ,Psychiatry ,Psychomotor learning ,Multiple sclerosis ,05 social sciences ,Neuropsychology ,Cognition ,Middle Aged ,medicine.disease ,Clinical Psychology ,Huntington Disease ,Neurology ,Schizophrenia ,Female ,Neurology (clinical) ,Cognition Disorders ,Psychology ,Psychomotor Performance ,030217 neurology & neurosurgery - Abstract
Huntington disease (HD) is a neurodegenerative condition with prominent motor (including oculomotor), cognitive, and psychiatric effects. While neuropsychological deficits are present in HD, motor impairments may impact performance on neuropsychological measures, especially those requiring a speeded response, as has been demonstrated in multiple sclerosis and schizophrenia. The current study is the first to explore associations between oculomotor functions and neuropsychological performance in HD. Participants with impaired oculomotor functioning performed worse than those with normal oculomotor functioning on cognitive tasks requiring oculomotor involvement, particularly on psychomotor speed tasks, controlling for covariates. Consideration of oculomotor dysfunction on neuropsychological performance is critical, particularly for populations with motor deficits.
- Published
- 2016
- Full Text
- View/download PDF