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3-hydroxy benzoic acid is an organic chemical which can be obtained naturally as well as synthetically. The literature survey reveals its various biological properties viz. antimicrobial, antialgal, antimutagenic, antiestrogenic, hypoglycemic, anti-inflammatory, anti-platelet aggregating, nematicidal, antiviral, antioxidant etc. It is also reported to be used as a preservative in many drugs, cosmetic products, pharmaceuticals, food and beverages. Some derivatives of 3-hydroxybenzoic acid are found to possess direct action on Hbs molecules, inhibit acetic acidinduced oedema and used in the management of sickle cell disease. It also has wide applications in perfumery industries. In this paper, novel ester / hybrid derivative of 3-Hydroxy benzoic acid was synthesized and tested for its potential antibacterial activity. This combinatorial synthesis of novel 3-Hydroxy benzoic ester/hybrid derivative can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates. [ABSTRACT FROM AUTHOR]

Vanillic acid (4-hydroxy-3-methoxy benzoic acid) is a dihydroxybenzoic acid derivative used as a flavoring agent. It is used in the synthesis of various active pharmaceutical ingredients such as Etamivan, Modecainide, Brovanexine, Vanitiolide, Vanyldisulfamide etc. In this paper, novel ester / hybrid derivatives of vanillic acid were synthesized and tested for potential antibacterial activity. This combinatorial synthesis of novel vanillic ester / hybrid derivatives can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates. [ABSTRACT FROM AUTHOR]

Dehydrodiisoeugenol constitute a new group of antimitotic and potential anticancer agents that inhibit tubulin polymerization. It is a benzofuranoid type neolignan have been synthesized and diversified to its respective ether (K2CO3 / Acetone / Alkyl / Aryl halide) derivatives using conventional methods and characterized by 1H NMR and mass spectral data. These synthesized compounds were screened for their potential antibacterial activity against Gram positive and Gram negative cultures. Few of them possess promising antibacterial activity. [ABSTRACT FROM AUTHOR]

Several novel esters/hybrid derivatives of caffeic acid were synthesized and tested for potential antibacterial activity. This combinatorial synthesis of novel caffeic ester / hybrid derivatives can be a useful approach to generate potent chemotherapeutic agents in developing new drug candidates. [ABSTRACT FROM AUTHOR]