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2. Machine/deep learning‐assisted hemoglobin level prediction using palpebral conjunctival images.

Author

Kato, Shota, Chagi, Keita, Takagi, Yusuke, Hidaka, Moe, Inoue, Shutaro, Sekiguchi, Masahiro, Adachi, Natsuho, Sato, Kaname, Kawai, Hiroki, and Kato, Motohiro

Subjects
SENSITIVITY & specificity (Statistics), ARTIFICIAL intelligence, REGRESSION analysis, DEEP learning, STATISTICAL correlation
Abstract

Summary: Palpebral conjunctival hue alteration is used in non‐invasive screening for anaemia, whereas it is a qualitative measure. This study constructed machine/deep learning models for predicting haemoglobin values using 150 palpebral conjunctival images taken by a smartphone. The median haemoglobin value was 13.1 g/dL, including 10 patients with <11 g/dL. A segmentation model using U‐net was successfully constructed. The segmented images were subjected to non‐convolutional neural network (CNN)‐based and CNN‐based regression models for predicting haemoglobin values. The correlation coefficients between the actual and predicted haemoglobin values were 0.38 and 0.44 in the non‐CNN‐based and CNN‐based models, respectively. The sensitivity and specificity for anaemia detection were 13% and 98% for the non‐CNN‐based model and 20% and 99% for the CNN‐based model. The performance of the CNN‐based model did not improve with a mask layer guiding the model's attention towards the conjunctival regions, however, slightly improved with correction by the aspect ratio and exposure time of input images. The gradient‐weighted class activation mapping heatmap indicated that the lower half area of the conjunctiva was crucial for haemoglobin value prediction. In conclusion, the CNN‐based model had better results than the non‐CNN‐based model. The prediction accuracy would improve by using more input data with anaemia. [ABSTRACT FROM AUTHOR]

Published
2024
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4. 視覚障害を呈した副鼻腔嚢胞の臨床的検討

Author

Oki, Yamato, primary, Kijima, Natsumi, additional, Fukui, Kenta, additional, Yamada, Masahiro, additional, Iwamura, Tai, additional, Ninomiya, Hiroaki, additional, Matsumoto, Yu, additional, Kuwahara, Tatsu, additional, Sato, Kaname, additional, Isono, Yasuhiro, additional, Niwa, Kazutomo, additional, Oba, Mayu, additional, Hatakeyama, Hiromitsu, additional, and Oridate, Nobuhiko, additional

Published
2024
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6. Spin-charge-coupled transverse resistance in an ambipolar conductor YH2-based Hall-bar structure with perpendicularly magnetized current-injection electrodes

Author

Sato, Kaname, primary, Takahashi, Yutaro, additional, Akisato, Shujiro, additional, Mikami, Ryota, additional, Suganuma, Nao, additional, Ashizawa, Yugo, additional, Kawaguchi, Hayate, additional, Nakajima, Yoshikata, additional, Ukai, Tomofumi, additional, Fuji, Yasuhiko, additional, Hanajiri, Tatsuro, additional, Kaneko, Junya, additional, Nakamura, Osamu, additional, Thach, Pham Van, additional, Awano, Hiroyuki, additional, Hasegawa, Shigehiko, additional, and Sakai, Masamichi, additional

Published
2023
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7. The Clinical Course and Treatment of a Case of Refractory Systemic Juvenile Myasthenia Gravis Successfully Treated with Thymectomy

Author

Shibuya, Moriei, primary, Shichiji, Minobu, additional, Ikeda, Miki, additional, Kodama, Kaori, additional, Miyabayashi, Takuya, additional, Sato, Ryo, additional, Okubo, Yukimune, additional, Endo, Wakaba, additional, Inui, Takehiko, additional, Togashi, Noriko, additional, Nagao, Mika, additional, Sato, Kaname, additional, Sato, Takatoshi, additional, Kanzaki, Masato, additional, Segawa, Osamu, additional, Masui, Kenta, additional, Ishigaki, Keiko, additional, and Haginoya, Kazuhiro, additional

Published
2023
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12. Predictors of Pain in Patients with Noninvasive Fungal Sinusitis

Author

Oki, Yamato, additional, Kuwahara, Tatsu, additional, Hukui, Kenta, additional, Kijima, Natsumi, additional, Yamada, Masahiro, additional, Ninomiya, Hiroaki, additional, Matsumoto, Yu, additional, Sato, Kaname, additional, Isono, Yasuhiro, additional, Niwa, Kazutomo, additional, Hatakeyama, Hiromitsu, additional, and Oridate, Nobuhiko, additional

Published
2022
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13. A Case of Sinus Actinomycosis Cured without Surgery

Author

Oki, Yamato, primary, Hatakeyama, Hiromitsu, additional, Ninomiya, Hiroaki, additional, Hukui, Kenta, additional, Matsumoto, Yu, additional, Kuwahara, Tatsu, additional, Sato, Kaname, additional, Isono, Yasuhiro, additional, Niwa, Kazutomo, additional, and Oridate, Nobuhiko, additional

Published
2022
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14. FosL1 Regulates Regional Metastasis of Head and Neck Squamous Cell Carcinoma by Promoting Cell Migration, Invasion, and Proliferation

Author

HYAKUSOKU, HIROSHI, primary, SAWAKUMA, KAE, additional, SANO, DAISUKE, additional, TAKAHASHI, HIDEAKI, additional, HATANO, TAKASHI, additional, SATO, KANAME, additional, ISONO, YASUHIRO, additional, SHIMADA, SHOKO, additional, TAKADA, KENTARO, additional, KUWAHARA, TATSU, additional, AIZAWA, YOSHIHIRO, additional, and ORIDATE, NOBUHIKO, additional

Published
2021
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15. Establishment of PDX ‐derived salivary adenoid cystic carcinoma cell lines using organoid culture method

Author

Takada, Kentaro, primary, Aizawa, Yoshihiro, additional, Sano, Daisuke, additional, Okuda, Ryo, additional, Sekine, Keisuke, additional, Ueno, Yasuharu, additional, Yamanaka, Shoji, additional, Aoyama, Jun, additional, Sato, Kaname, additional, Kuwahara, Tatsu, additional, Hatano, Takashi, additional, Takahashi, Hideaki, additional, Arai, Yasuhiro, additional, Nishimura, Goshi, additional, Taniguchi, Hideki, additional, and Oridate, Nobuhiko, additional

Published
2020
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16. Establishment of PDX‐derived salivary adenoid cystic carcinoma cell lines using organoid culture method.

Author

Takada, Kentaro, Aizawa, Yoshihiro, Sano, Daisuke, Okuda, Ryo, Sekine, Keisuke, Ueno, Yasuharu, Yamanaka, Shoji, Aoyama, Jun, Sato, Kaname, Kuwahara, Tatsu, Hatano, Takashi, Takahashi, Hideaki, Arai, Yasuhiro, Nishimura, Goshi, Taniguchi, Hideki, and Oridate, Nobuhiko

Subjects
ADENOID cystic carcinoma, CELL lines, SUBMANDIBULAR gland, CELL culture, ANIMAL models in research
Abstract

To generate a reliable preclinical model system exhibiting the molecular features of salivary adenoid cystic carcinoma (ACC) whose biology is still unclear due to the paucity of stable cell cultures. To develop new in vitro and in vivo models of ACC, the techniques of organoid culture and patient‐derived tumor xenograft (PDX), which have attracted attention in other malignancies in recent years, were applied. Tumor specimens from surgically resected salivary ACC were proceeded for the preparation of PDX and organoid culture. The orthotopic transplantation of patient‐derived or PDX‐derived organoids was demonstrated into submandibular glands of NSG mice and those histology was evaluated. PDX‐derived organoid cells were evaluated for the presence of MYB‐mediated fusion genes and proceeded for in vitro drug sensitivity assay. Human ACC‐derived organoids were successfully generated in three‐dimensional culture and confirmed the ability of these cells to form tumors by orthotopic injection. Short‐term organoid cell cultures from two individual ACC PDX tumors were also established that maintain the characteristic MYBL1 translocation and histological features of the original parent and PDX tumors. Finally, the establishment of drug sensitivity tests on these short‐term cultured cells was confirmed using three different agents. This is the first to report an approach for the generation of human ACC‐derived organoids as in vitro and in vivo cancer models, providing insights into understanding of the ACC biology and creating personalized therapy design for patients with ACC. What's new? The biological underpinnings of salivary adenoid cystic carcinoma (ACC) remain largely unknown, owing to a lack of preclinical model systems. In this study, the authors describe the successful generation of human salivary ACC cell lines from organoid culture and the subsequent development of an in vivo salivary ACC mouse model. The orthotopic xenograft mouse model was established efficiently from ACC organoid cells from patient‐derived xenografts (PDX). Short‐term cultures of PDX‐derived ACC organoid cells further were amenable for in vitro drug‐sensitive studies with several agents. This novel approach could be useful for investigating personalized therapies for patients with salivary ACC. [ABSTRACT FROM AUTHOR]

Published
2021
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18. Molecular characterization of genes encoding isoamylase-type debranching enzyme in tuberous root of sweet potato, Ipomoea batatas (L.) Lam

Author

Nabemoto, Moe, Watanabe, Riho, Ohsu, Mizuho, Sato, Kaname, Otani, Motoyasu, Nakayachi, Osamu, and Watanabe, Masao

Subjects
Original Paper, fungi, food and beverages
Abstract

Isoamylase (ISA) is a starch debranching enzyme that removes α-1,6-glucosidic linkages in α-polyglucans such as amylopectin. From previous studies, plant isoamylases have been shown to play a crucial role in amylopectin biosynthesis; however, little is known about their function in storage root tissues of plants such as cassava, yam and sweet potato. In this study, we isolated cDNA clones and characterized the cDNA nucleotide sequences of three genes (IbISA1, IbISA2, IbISA3) encoding isoamylase from sweet potato (Ipomoea batatas (L.) cv. White Star). Deduced amino acid sequences of the three isolated IbISAs have the specific regions that are highly conserved among the α-amylase family members. The product of IbISA2 is predicted to be enzymatically inactive, like other plant ISA2s, due to replacement of amino acid residues that are important for hydrolytic reaction. qRT-PCR analysis demonstrated that expression of IbISA2 was higher than that of the other two IbISAs (IbISA1 and IbISA3) in tuberous root at 109 days after planting, at which stage of tuberous root was at which stage tuberous roots were almost fully developed almost developed. This expression pattern observed in our experiments was different from that in other sink organs, such as seeds (endosperms), indicating that orchestration of ISA gene expression may depend on the differences in sink organ type between tuberous roots and seeds. The molecular characterization of three IbISA genes and their expression analysis in this study will contribute to further studies on starch biosynthesis in sweet potato, especially in storage root.

Published
2016

49. QUENCHING OF FLUORESCENCE OF POLYESTERS HAVING PENDANT ANTHRYL GROUPS BY POLYESTERS HAVING PENDANT N,N-DIMETHYLANILINO GROUPS

Author

Tazuke, Shigeo, Sato, Kaname, and Banba, Fumio

Abstract

Fluorescence of various polyesters prepared from 2-(9-anthryl)methylpropane-1,3-diol was quenched by various polyesters prepared from 2-(4-dimethylaminobenzyl)propane-1,3-diol. The sequence of quenching constants(Kq) was discussed with special reference to the polymer structures of fluorescers and quenchers. When terephthalate groups were incorporated in the main chain of quencher, Kqincreased very much, which was interpreted by cooperative quenching action of donor(amine) and acceptor(terephthalate). This concept was unequivocally evidenced by separate experiments.

Published
1975
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50. POLYMER EFFECTS ON ELECTRON TRANSPORT SEMSITIZATION: A KINETIC ATTEMPT TO MIMIC THE PRIMARY ACTION OF CHLOROPHYLL

Author

Tazuke, Shigeo, Tomono, Haruo, Kitamura, Noboru, Sato, Kaname, and Hayashi, Naoya

Abstract

Photooxidation of Leuco Crystal Violet to the dye cation using polymer bound anthryl and pyrenyl groups as electron transport sensitizers showed that all of anthryl polymers were more efficient than their monomer model compound whereas pyrenyl polymers were not. The positive polymer effect was attributed to energy migration along polymer chain to increase the energy utilization efficiency.

Published
1979
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