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Aggregation-induced emission (AIE) active 3-(3-(benzo[d]thiazol-2-yl)-2-hydroxyphenyl)-2-(4'-(diphenylamino)-[1,1'-biphenyl]-4-yl)acrylonitrile (BTPA) has been designed and synthesized herein, with the goal of detecting CN - ions at a low-level in semi-aqueous medium. The deliberate addition of the electron-deficient alkene BTPA increased its sensitivity and selectivity to CN - ions, with a better detection limit of 6.4 nM, unveiling the next-generation approach to creating sophisticated CN - ions selective chemosensors. The ESI-MS and NMR spectra analyses provided strong support for the structures of the chemosensors, while the UV-Vis, photoluminescence, and 1 H-NMR titration experiments provided support for the sensing efficiencies. Subsequently, PVDF/BTPA electrospun nanofibers have been effectively produced as functional films. These nanofiber films exhibit outstanding mechanical strength, photo/thermal stability, and optical responsiveness to CN - ions, making them a potential choice for on-field emerging contaminant detection., Competing Interests: Declaration of competing interest No author is having competing interest in this piece of work., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Synthesis of aluminium-based nanomaterials from aluminium-waste has received huge attention in current scientific research. Herein, an attempt was made to convert aluminium foil food container into aluminium oxyhydroxide (AlOOH) nanoparticles by a precipitation method. X-ray diffraction (XRD), spectroscopic and electron microscopic studies were employed to characterize impure AlOOH (containing sodium chloride, NaCl) and pure AlOOH samples. The band gap (E g ) of AlOOH nanoparticles was found to be 4.5 eV. The catalytic potential of AlOOH samples was evaluated using reduction of methyl orange (MO) and Eriochrome black T (EBT) dyes. Impure AlOOH nanoparticles could reduce 99.8% of MO and EBT dye within 4 min and 3 min respectively. Effect of the AlOOH dosage and NaBH 4 concentration on catalytic reduction was determined. Used aluminium foil food container-derived AlOOH nanoparticles will become a low-cost and sustainable catalyst in the catalytic treatment of azo dye contaminated waters., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2022 Elsevier Inc. All rights reserved.)

In this research work, novel perfluorooctanoic acid-modified melamine (PFOM) was synthesized as a hydrophobic filler using a facile one-pot synthesis. PFOM incorporating polyvinylidene fluoride (PVDF) solution was cast on a cellulose sheet to prepare a dual-layered membrane employing the phase-inversion technique for direct contact membrane distillation (DCMD) application. The influence of PFOM to tailor the dual-layered membrane performance was then investigated. The long perfluoro chain in PFOM hydrophobic fillers increased the surface roughness of the membranes due to its random overlapping with PVDF backbone, and these membranes exhibited a higher water contact angle value. The increase in pore size and membrane porosity did not significantly influence the liquid entry pressure of water (LEPw). The microporous membranes displayed good mechanical strength for use in the test setup. Pure water permeation was the highest (6.9 kg m -2 h -1 ) for membrane (M1) with 1 wt% of PFOM when tested with a simulated sea-water solution (3.5% w/v NaCl) in the direct contact distillation mode. These membranes also achieved the theoretical salt-rejection of 99.9%, thus confirming the potential of these membranes to be investigated for large scale membrane distillation (MD) applications like desalination of seawater., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)

Two (tetrahydrodibenzo[ a , i ]phenanthridin-5-yl)phenols that differ in their substituents at the para position ( P1 , R = H and P2 , R = NEt 2 ) were designed and synthesized. The presence of a -NEt 2 group in probe P2 facilitates the twisted intramolecular charge transfer (TICT) process, making P2 emissive, which distinctly coordinated with boron trifluoride in the presence of different amines with different electronic properties. A substantial increase in emission intensity with increasing viscosity of the surrounding environment and smooth formation of a planar complex with boron and Zn 2+ ions concluded the presence of a TICT process. The selective reactivity of P2 toward a tetracoordinated boron complex has been explored as a potential tool for colorimetric and fluorescent discrimination of aromatic primary amines, i.e., anilines. Selective detection of aniline with probe P2 can be viewed through the naked eye, and the corresponding fluorescence turn-on detection limit was found to be 12.65 nM. In addition, the detection of aniline on precoated aluminum-backed thin-layer chromatography plates and Whatman filter paper strips was found to be in good agreement with the color change of P2 in solution and in vapor phase.

A new series of 2‑styryl phenanthro[9,10‑d]oxazoles was readily accessible from the condensation reaction of 9,10‑phenanthroquinone with cinnamaldehydes in the presence of lactic acid. All these styryl dyes were isolated in good yields and characterized by various analytical and spectroscopic techniques. One of the dyes containing NO 2 group (3d) was structurally characterized by single crystal X-ray analysis. These dyes displayed emission in blue to green region with larger Stokes shift values characteristic to the nature of substituents. In addition, positive solvatochromic trend was observed by increasing the solvent polarity suggestive of a more stabilized polar excited state. Moreover, the addition of trifluoroacetic acid leads to a prominent blue-shift in visible and emission color changes owing to the protonation of the nitrogen atom of oxazole moiety. Among the all, the oxazole derivative having NMe 2 group (3b) exhibits good response to acidic pH in the range of 3.0 to 5.6 with a good linearity upon decreasing the pH from 8.0 to 2.16. The absorption studies were further supported by density functional theory calculations., (Copyright © 2018 Elsevier B.V. All rights reserved.)

2-(4-phenylquinoline-2-yl)phenol derivatives (4a-l) with COX-2 enzyme inhibition, analgesic, anti-inflammatory and antipyretic potentials were executed and reported. From the in vitro COX-2 enzyme inhibition assay, compounds 4 h (IC 50 0.026 µM) and 4j (IC 50 0.102 µM) were found as most potent COX-2 inhibitors. Consequently, to get more insight into the binding mode with COX-2, compounds 4a-l were docked into the COX-2 (PDB ID: 1CX2) active site. In the Human Red Blood Cells (HRBC) membrane stabilization assay (in vitro anti-inflammatory), compounds 4f (IC 50 0.064 µM) substituted with -OH (R 1 ) and -3Cl (R 2 ), 4 h (IC 50 0.021 µM), 4i (IC 50 0.484 µg/ml) and 4j (IC 50 0.092 µM) with -CHO containing alkanol and ether group at R1 and -4F, -4Br and -OMe at R2 (C2) were showed most potent anti-inflammatory activity. Eventually, acute toxicity studies revealed that 2-(4-phenylquinoline-2-yl)phenol derivatives (4a-l) are safe up to a toleration dose limit of 100 µg/kg body weight. In the Backer's yeast intraperitoneal injection test, compounds 4f, 4 h and 4j produced significant (p < 0.05) antipyretic activity at 1, 1.5, 2 and 2.5 h, whereas test compound 4j and the reference drug indomethacin showed significant antipyretic activity throughout the observation period up to 2.5 h. Promising in vivo results obtained were correlated with the standard non-steroidal anti-inflammatory drugs and the compounds 4f, 4 h, 4i, 4j, and 4 l were efficiently identified as therapeutically potent/fortune moieties as non-steroidal anti-inflammatory agents/analgesics. At the end, ulcerogenic study result ensured that the tested 2-(4-phenylquinoline-2-yl)phenol derivatives created no side-effect.

We are the first to report the synthesis of a new class of 2-cyanoarylacrylamide (2-CAA) derivatives and observe that the synthesized 2-CAA shows fluorescence properties due to the formation of a dimeric interaction of hydrogen bonds between carbonyl oxygens and amide hydrogens (C═O···H-N-C═O···H-N···); i.e., dimers are linked through dimeric N-H···O hydrogen bonds. The single-crystal X-ray structure shows molecules to be hydrogen-bonded dimers, which further form a parallel stacking arrangement, mediated by significant π-π interactions. The (1)H NMR and fluorescence spectral studies indicate the coexistence of amide and iminol tautomers in solution, which can be influenced by the nature of the solvent. Further, the excitation-wavelength-dependent fluorescence spectrum and the biexponential fluorescence decay profiles suggest the presence of more than one emitting species; i.e., amide and iminol tautomers coexists in solution. We have also shown that the equilibrium between the two tautomers can be tuned by the judicious choice of electron-donating or -withdrawing substituents.

A series of adamantane based aminophenol derivatives were synthesized and evaluated for their antiplasmodial activity in vitro against Plasmodium falciparum (Pf&#95;NF54) and resistant strain (Pf&#95;K1). Herein, we report compounds resulting from this work that show excellent potency against both strains. Additionally, this series displayed excellent cytotoxicity selectivity index against THP1 cell line and had acceptable in vitro DMPK properties., (Copyright © 2014 Elsevier Ltd. All rights reserved.)

A simple and efficient three components domino reaction of γ-butyrolactam (2-pyrrolidinone), aromatic aldehyde and substituted thiophenol catalyzed by elemental iodine resulted in the formation of 1-((phenylthio)(phenyl)methyl)pyrrolidin-2-one derivatives. The stability of the synthesized analogues was evaluated in stimulated gastric fluid (SGF) and bovine serum albumin (BSA). In vitro anticancer activity was investigated in the low micromolar range and a few analogues were found to possess good activity. This current protocol provides several advantages like shorter reaction time, excellent yield and convenient work-up.