Search

Your search keyword '"Sathirachinda, Ataya"' showing total 23 results
Start Over Author "Sathirachinda, Ataya"
23 results on '"Sathirachinda, Ataya"'

6. Supplementary Methods, Figures 1-5, Tables 1-2 from Pharmacokinetically Stabilized Cystine Knot Peptides That Bind Alpha-v-Beta-6 Integrin with Single-Digit Nanomolar Affinities for Detection of Pancreatic Cancer

Author

Kimura, Richard H., primary, Teed, Robert, primary, Hackel, Benjamin J., primary, Pysz, Marybeth A., primary, Chuang, Courtney Z., primary, Sathirachinda, Ataya, primary, Willmann, Jürgen K., primary, and Gambhir, Sanjiv S., primary

Published
2023
Full Text
View/download PDF

8. R-loop-derived cytoplasmic RNA–DNA hybrids activate an immune response

Author

Crossley, Magdalena P., primary, Song, Chenlin, additional, Bocek, Michael J., additional, Choi, Jun-Hyuk, additional, Kousorous, Joseph, additional, Sathirachinda, Ataya, additional, Lin, Cindy, additional, Brickner, Joshua R., additional, Bai, Gongshi, additional, Lans, Hannes, additional, Vermeulen, Wim, additional, Abu-Remaileh, Monther, additional, and Cimprich, Karlene A., additional

Published
2022
Full Text
View/download PDF

9. Abstract LB560: Engineering genetically-encoded synthetic biomarkers for breath-based cancer detection

Author

Vermesh, Ophir, primary, D'Souza, Aloma, additional, Alam, Israt, additional, Wardak, Mirwais, additional, McLaughlin, Theresa, additional, El Rami, Fadi, additional, Sathirachinda, Ataya, additional, Bell, John, additional, Pitteri, Sharon, additional, James, Michelle, additional, Hori, Sharon, additional, Gross, Eric, additional, and Gambhir, Sanjiv, additional

Published
2022
Full Text
View/download PDF

11. Engineering genetically-encoded synthetic biomarkers for breath-based cancer detection

Author

Vermesh, Ophir, primary, D’Souza, Aloma L., additional, Alam, Israt S., additional, Wardak, Mirwais, additional, McLaughlin, Theresa, additional, El Rami, Fadi, additional, Sathirachinda, Ataya, additional, Bell, John C., additional, James, Michelle L., additional, Hori, Sharon S., additional, Gross, Eric R., additional, and Gambhir, Sanjiv Sam, additional

Published
2021
Full Text
View/download PDF

12. Molecular Imaging of Chimeric Antigen Receptor T Cells by ICOS-ImmunoPET

Author

Simonetta, Federico, primary, Alam, Israt S., additional, Lohmeyer, Juliane K., additional, Sahaf, Bita, additional, Good, Zinaida, additional, Chen, Weiyu, additional, Xiao, Zunyu, additional, Hirai, Toshihito, additional, Scheller, Lukas, additional, Engels, Pujan, additional, Vermesh, Ophir, additional, Robinson, Elise, additional, Haywood, Tom, additional, Sathirachinda, Ataya, additional, Baker, Jeanette, additional, Malipatlolla, Meena B., additional, Schultz, Liora M., additional, Spiegel, Jay Y., additional, Lee, Jason T., additional, Miklos, David B., additional, Mackall, Crystal L., additional, Gambhir, Sanjiv S., additional, and Negrin, Robert S., additional

Published
2021
Full Text
View/download PDF

15. Development and Validation of an Immuno-PET Tracer as a Companion Diagnostic Agent for Antibody-Drug Conjugate Therapy to Target the CA6 Epitope

Author

Ilovich, Ohad, primary, Natarajan, Arutselvan, additional, Hori, Sharon, additional, Sathirachinda, Ataya, additional, Kimura, Richard, additional, Srinivasan, Ananth, additional, Gebauer, Mathias, additional, Kruip, Jochen, additional, Focken, Ingo, additional, Lange, Christian, additional, Carrez, Chantal, additional, Sassoon, Ingrid, additional, Blanc, Veronique, additional, Sarkar, Susanta K., additional, and Gambhir, Sanjiv S., additional

Published
2015
Full Text
View/download PDF

17. A Transgenic Tri-Modality Reporter Mouse

Author

Yan, Xinrui, primary, Ray, Pritha, additional, Paulmurugan, Ramasamy, additional, Tong, Ricky, additional, Gong, Yongquan, additional, Sathirachinda, Ataya, additional, Wu, Joseph C., additional, and Gambhir, Sanjiv S., additional

Published
2013
Full Text
View/download PDF

18. Development and validation of an immuno-PET tracer for patient stratification and therapy monitoring of antibody-drug conjugate therapy.

Author

Ilovich, Ohad, primary, Natarajan, Arutselvan, additional, Sathirachinda, Ataya, additional, Kimura, Richard, additional, Srinivasan, Ananth, additional, Gebauer, Mathias, additional, Kruip, Jochen, additional, Carrez, Chantal, additional, Sassoon, Ingrid, additional, Blanc, Veronique, additional, Sarkar, Susanta K., additional, and Gambhir, Sanjiv Sam, additional

Published
2013
Full Text
View/download PDF

21. Evaluation of Zr-rituximab Tracer by Cerenkov Luminescence Imaging and Correlation with PET in a Humanized Transgenic Mouse Model to Image NHL.

Author

Natarajan, Arutselvan, Habte, Frezghi, Liu, Hongguang, Sathirachinda, Ataya, Hu, Xiang, Cheng, Zhen, Nagamine, Claude, and Gambhir, Sanjiv

Subjects
RITUXIMAB, CHERENKOV radiation, LUMINESCENCE, POSITRON emission tomography, LYMPHOMAS, GENE expression, LABORATORY mice
Abstract

Purpose: This research aimed to study the use of Cerenkov luminescence imaging (CLI) for non-Hodgkin's lymphoma (NHL) using Zr-rituximab positron emission tomography (PET) tracer with a humanized transgenic mouse model that expresses human CD20 and the correlation of CLI with PET. Procedures: Zr-rituximab (2.6 MBq) was tail vein-injected into transgenic mice that express the human CD20 on their B cells (huCD20TM). One group ( n = 3) received 2 mg/kg pre-dose (blocking) of cold rituximab 2 h prior to tracer; a second group ( n = 3) had no pre-dose (non-blocking). CLI was performed using a cooled charge-coupled device optical imager. We also performed PET imaging and ex vivo studies in order to confirm the in vivo CLI results. At each time point (4, 24, 48, 72, and 96 h), two groups of mice were imaged in vivo and ex vivo with CLI and PET, and at 96 h, organs were measured by gamma counter. Results: huCD20 transgenic mice injected with Zr-rituximab demonstrated a high-contrast CLI image compared to mice blocked with a cold dose. At various time points of 4-96 h post-radiotracer injection, the in vivo CLI signal intensity showed specific uptake in the spleen where B cells reside and, hence, the huCD20 biomarker is present at very high levels. The time-activity curve of dose decay-corrected CLI intensity and percent injected dose per gram of tissue of PET uptake in the spleen were increased over the time period (4-96 h). At 96 h, the Zr-rituximab uptake ratio (non-blocking vs blocking) counted (mean ± standard deviation) for the spleen was 1.5 ± 0.6 for CLI and 1.9 ± 0.3 for PET. Furthermore, spleen uptake measurements (non-blocking and blocking of all time points) of CLI vs PET showed good correlation ( R = 0.85 and slope = 0.576), which also confirmed the corresponding correlations parameter value ( R = 0.834 and slope = 0.47) obtained for ex vivo measurements. Conclusions: CLI and PET of huCD20 transgenic mice injected with Zr-rituximab demonstrated that the tracer was able to target huCD20-expressing B cells. The in vivo and ex vivo tracer uptake corresponding to the CLI radiance intensity from the spleen is in good agreement with PET. In this report, we have validated the use of CLI with PET for NHL imaging in huCD20TM. [ABSTRACT FROM AUTHOR]

Published
2013
Full Text
View/download PDF

23. HLTF Prevents G4 Accumulation and Promotes G4-induced Fork Slowing to Maintain Genome Stability.

Author

Bai G, Endres T, Kühbacher U, Greer BH, Peacock EM, Crossley MP, Sathirachinda A, Cortez D, Eichman BF, and Cimprich KA

Abstract

G-quadruplexes (G4s) form throughout the genome and influence important cellular processes, but their deregulation can challenge DNA replication fork progression and threaten genome stability. Here, we demonstrate an unexpected, dual role for the dsDNA translocase HLTF in G4 metabolism. First, we find that HLTF is enriched at G4s in the human genome and suppresses G4 accumulation throughout the cell cycle using its ATPase activity. This function of HLTF affects telomere maintenance by restricting alternative lengthening of telomeres, a process stimulated by G4s. We also show that HLTF and MSH2, a mismatch repair factor that binds G4s, act in independent pathways to suppress G4s and to promote resistance to G4 stabilization. In a second, distinct role, HLTF restrains DNA synthesis upon G4 stabilization by suppressing PrimPol-dependent repriming. Together, the dual functions of HLTF in the G4 response prevent DNA damage and potentially mutagenic replication to safeguard genome stability.

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results